cycloheximide has been researched along with sirolimus in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (20.00) | 18.2507 |
| 2000's | 25 (41.67) | 29.6817 |
| 2010's | 23 (38.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Forrest, MJ; Jewell, ME; Koo, GC; Sigal, NH | 1 |
| Lin, J; Raffaniello, RD; Raufman, JP | 1 |
| Finn, PW; Guan, G; He, H; Listman, J; Perkins, DL; Wang, Y; Wang, Z | 1 |
| Sewell, WA; Valentine, JE | 1 |
| Low, SY; Rennie, MJ; Taylor, PM | 1 |
| Eyers, PA; Hundal, HS; McDowell, HE | 1 |
| Bushell, M; Clemens, MJ; Morley, SJ | 1 |
| Johnson, LR; Patel, TB; Ray, RM; Viar, MJ | 1 |
| Bandyopadhyay, A; Bandyopadhyay, J; Choi, HS; Chung, J; Kwon, HB | 1 |
| Gingras, AC; Khaleghpour, K; Pyronnet, S; Sonenberg, N | 1 |
| Miyamoto, S; Safer, B | 1 |
| Cardenas, ME; Cutler, NS; Di Como, CJ; Heitman, J; Lorenz, MC | 1 |
| Cotter, TG; Knox, KA; McGahon, AJ; McKenna, SL; O'Gorman, DM | 1 |
| Bitterman, PB; Gingras, AC; Manivel, JC; Peterson, M; Polunovsky, VA; Rubins, JB; Sonenberg, N; Tan, A | 1 |
| Gesbert, F; Griffin, JD; Loda, M; Sellers, WR; Signoretti, S | 1 |
| Abeliovich, H; Dunn, WA; Kim, J; Klionsky, DJ | 1 |
| Ishigaki, Y; Maquat, LE; Nagy, E; Pal, M | 1 |
| Beugnet, A; Proud, CG; Taylor, PM; Tee, AR | 1 |
| Baraban, JM; Beretta, L; Dy, M; Grolleau, A; Machavoine, F; Rolli-Derkinderen, M | 1 |
| Camougrand, N; Deffieu, M; Kissová, I; Manon, S | 1 |
| Cao, X; Kambe, F; Moeller, LC; Refetoff, S; Seo, H | 1 |
| Colello, RJ; de Bittencourt-Navarrete, RE; Krahe, TE; Medina, AE; Ramoa, AS | 1 |
| Attardo, GM; Hansen, IA; Park, JH; Raikhel, AS | 1 |
| Bauer, AL; Czyzyk-Krzeska, MF; Hui, AS; Schnell, PO; Striet, JB | 1 |
| Finlay, D; Lipina, C; Perrier, S; Ruiz-Alcaraz, AJ; Sutherland, C | 1 |
| Akiyama, I; Hirose, H; Kimura, N; Shimizu, YI; Takahashi, S; Takahashi, Y; Tonaki, D; Watatani, Y | 1 |
| Bjornsti, MA; Guo, H; Lancaster, CS; Shen, C; Shi, B; Thimmaiah, P | 1 |
| Al-Younes, H; Braun, PR; Gussmann, J; Klein, J; Meyer, TF; Schneider, E | 1 |
| Hafiz, F; Hands, S; King, MA; Mizushima, N; Tolkovsky, AM; Wyttenbach, A | 1 |
| Barbone, D; Broaddus, VC; Bueno, R; Gordon, GJ; Jablons, DM; Nishimura, SL; Sugarbaker, DJ; Wilson, SM; Yang, TM | 1 |
| Arayatrakoollikit, U; Pavasant, P; Yongchaitrakul, T | 1 |
| Huang, BP; Proud, CG; Wang, X; Wang, Y; Wang, Z | 1 |
| Ariav, Y; Bachar, E; Cerasi, E; Kaiser, N; Ketzinel-Gilad, M; Leibowitz, G | 1 |
| Ammerer, G; Dohnal, I; Lempiäinen, H; Loewith, R; Shore, D; Uotila, A; Urban, J | 1 |
| Aebersold, R; Bodenmiller, B; Gerrits, B; Huber, A; Loewith, R; Stahl, M; Uotila, A; Wanka, S | 1 |
| Betta, PG; Biffo, S; Grosso, S; Patrone, M; Ranzato, E; Viarengo, A | 1 |
| Binda, M; Bonfils, G; De Virgilio, C; Loewith, R; Panchaud, N; Péli-Gulli, MP; Sturgill, TW; Urban, J | 1 |
| Bandhakavi, S; Griffin, TJ; Jun, CB; Kim, DH; Kim, YM; Onsongo, G; Ro, SH; Xie, H | 1 |
| Greene, LA; Jackson-Lewis, V; Jin, ZH; Malagelada, C; Przedborski, S | 1 |
| Gerber, J; Griesenbeck, J; Milkereit, P; Philippi, A; Reiter, A; Steinbauer, R; Tschochner, H | 1 |
| Dange, T; Krügel, U; Lopez, AD; Ros, IG; Schmidt, M; Tar, K | 1 |
| Hu, L; Li, G; Si, L; Sun, M; Xue, K; Yang, X; Zhai, X | 1 |
| Crespo, JL; Díaz-Troya, S; Florencio, FJ; Jeno, P; Moes, S; Pérez-Martín, M; Pérez-Pérez, ME | 1 |
| Cottrell, JE; Kass, IS; Meng, F; Sacktor, TC; Wang, J | 1 |
| Clapp, C; Ebner, P; Eid, R; Greenwood, MT; Khoury, C; Madeo, F; Mandato, CA; Norman, G; Portt, L; Sheibani, S; Vali, H | 1 |
| Chen, K; Chen, R; Cui, D; Huang, Z; Li, W; Li, Y; Liu, D; Liu, Y; Pan, X; Shi, X; Sucgang, RS; Tang, J; Wang, H; Zhang, J | 1 |
| Ginzberg, MB; Kafri, R; Kirschner, MW; Lahav, G; Levy, J; Oh, S | 1 |
| Carvalho, LM; Christoff, RR; Jobim, PF; Maurmann, N; Pedroso, TR; Reolon, GK; Roesler, R; Werenicz, A | 1 |
| Chen, Y; Dai, CL; Gong, CX; Iqbal, K; Liu, F; Shi, J | 1 |
| Steinert, M; Ünal, CM | 1 |
| Argon, Y; Falk, MJ; Felix, CA; Gasser, DL; Kwon, YJ; Licata, J; Marty, E; Ostrovsky, J; Peng, M; Polyak, E; Thomas, J; Tsukikawa, M; Xiao, R; Zhang, Z | 1 |
| Hsueh, YP; Shih, YT | 1 |
| Cen, S; Chen, Z; Deng, H; Hou, J; Li, J; Li, W; Liu, Z; Ouyang, Y; Shen, H; Song, B; Wang, P; Wu, Y; Xie, Z; Yang, R | 1 |
| Boyle, LM; Goldenberg, MC; Lipton, JO; Madsen, JR; Pascual-Leone, A; Rotenberg, A; Sahin, M; Sun, Y | 1 |
| Kays, J; Khorodova, A; Nicol, GD; Strichartz, G; Zhang, YH | 1 |
| Alpers, J; Giavalisco, P; Hincha, DK; Jüppner, J; Mubeen, U | 1 |
| Deng, L; Fan, S; Lesinski, GB; Owonikoko, TK; Qian, G; Ramalingam, SS; Sun, SY; Zhang, S; Zheng, H | 1 |
| Arslan, M; Çakar, ZP; Holyavkin, C; Kısakesen, Hİ; Sürmeli, Y; Topaloğlu, A | 1 |
| Biyanee, A; Eberhardt, W; Haeussler, K; Nasrullah, U; Pfeilschifter, J; Wittig, I | 1 |
1 review(s) available for cycloheximide and sirolimus
| Article | Year |
|---|---|
FKBPs in bacterial infections.
Topics: Animals; Bacteria; Bacterial Infections; Bacterial Proteins; Cycloheximide; Humans; Peptidylprolyl Isomerase; Sirolimus; Tacrolimus; Tacrolimus Binding Proteins; Virulence Factors | 2015 |
59 other study(ies) available for cycloheximide and sirolimus
| Article | Year |
|---|---|
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
FK-506 and cyclosporin A: selective inhibition of calcium ionophore-induced polymorphonuclear leukocyte degranulation.
Topics: Anti-Bacterial Agents; Calcimycin; Cycloheximide; Cyclosporins; Dactinomycin; Humans; Immune Tolerance; Ionomycin; Lactoferrin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Polyenes; Signal Transduction; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate | 1991 |
Calcineurin mediates calcium-induced potentiation of adenylyl cyclase activity in dispersed chief cells from guinea pig stomach. Further evidence for cross-talk between signal transduction pathways that regulate pepsinogen secretion.
Topics: Adenylyl Cyclases; Animals; Calcimycin; Calcineurin; Calcium; Calmodulin-Binding Proteins; Carbachol; Cells, Cultured; Cholecystokinin; Cholera Toxin; Cyclic AMP; Cycloheximide; Cyclosporine; Ethers, Cyclic; Guinea Pigs; Male; Okadaic Acid; Pepsinogens; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Polyenes; Signal Transduction; Sirolimus; Stomach; Tacrolimus | 1996 |
Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability.
Topics: Abatacept; Animals; Antigens, CD; Antigens, Differentiation; CD28 Antigens; Cell Line; CTLA-4 Antigen; Cycloheximide; Cyclosporine; Flow Cytometry; Gene Expression Regulation; Immunoconjugates; Mice; Polyenes; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; RNA, Messenger; Sirolimus; Transcription, Genetic | 1997 |
Induction of IL-5 expression by IL-2 is resistant to the immunosuppressive agents cyclosporin A and rapamycin.
Topics: Adjuvants, Immunologic; Cells, Cultured; Cycloheximide; Cyclosporine; Drug Resistance; Humans; Immunosuppressive Agents; Interleukin-2; Interleukin-4; Interleukin-5; Leukocytes, Mononuclear; Phytohemagglutinins; Polyenes; Recombinant Proteins; RNA, Messenger; Sirolimus | 1997 |
Signaling elements involved in amino acid transport responses to altered muscle cell volume.
Topics: Amino Acid Transport Systems, Basic; Amino Acids; Androstadienes; Animals; Animals, Newborn; Carrier Proteins; Cells, Cultured; Cholera Toxin; Culture Media, Conditioned; Cycloheximide; Enzyme Inhibitors; Glutamine; GTP-Binding Proteins; Intercellular Signaling Peptides and Proteins; Kinetics; Lysophospholipids; Models, Biological; Muscle, Skeletal; Osmolar Concentration; Peptides; Phosphatidylinositol 3-Kinases; Polyenes; Protein Kinase Inhibitors; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Sodium Chloride; Virulence Factors, Bordetella; Wortmannin | 1997 |
Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress.
Topics: Amino Acids; Androstadienes; Animals; Arsenites; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cycloheximide; Enzyme Inhibitors; Flavonoids; Hot Temperature; Insulin; Kinetics; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Rats; Signal Transduction; Sirolimus; Sodium Compounds; Wortmannin | 1998 |
Degradation of eukaryotic polypeptide chain initiation factor (eIF) 4G in response to induction of apoptosis in human lymphoma cell lines.
Topics: Amino Acid Chloromethyl Ketones; Antibodies; Apoptosis; Caspase Inhibitors; Caspases; Culture Media, Serum-Free; Cycloheximide; Etoposide; Eukaryotic Initiation Factor-4E; fas Receptor; Half-Life; Humans; Jurkat Cells; Lymphoma; Molecular Weight; Neoplasm Proteins; Oligopeptides; Peptide Initiation Factors; Poly(A)-Binding Proteins; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; RNA-Binding Proteins; Sirolimus; Tumor Cells, Cultured | 1998 |
Interaction of asparagine and EGF in the regulation of ornithine decarboxylase in IEC-6 cells.
Topics: Animals; Asparagine; Cell Line; Cycloheximide; Dactinomycin; Drug Stability; Epidermal Growth Factor; Intestinal Mucosa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Synthesis Inhibitors; RNA, Messenger; Sirolimus | 1999 |
Inhibition of S6 kinase by rapamycin blocks maturation of Rana dybowskii oocytes.
Topics: Animals; Cycloheximide; Cyclosporine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Immunosuppressive Agents; Oocytes; Precipitin Tests; Progesterone; Protein Kinases; Protein Synthesis Inhibitors; Ranidae; Ribosomal Protein S6 Kinases; Scintillation Counting; Sirolimus; Time Factors | 1999 |
Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Anisomycin; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell Line, Transformed; Cycloheximide; Eukaryotic Initiation Factors; Immunoblotting; Mice; Models, Biological; Oncogene Protein v-akt; Ornithine Decarboxylase; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Retroviridae Proteins, Oncogenic; Ribosomal Protein S6 Kinases; Sirolimus; Tetracycline; Time Factors | 1999 |
Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation.
Topics: Actins; Cycloheximide; Dactinomycin; Gene Expression Regulation; Humans; Immunosuppressive Agents; Ionomycin; Protein Biosynthesis; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1999 |
The TOR signaling cascade regulates gene expression in response to nutrients.
Topics: Culture Media; Cycloheximide; Drosophila Proteins; Fungal Proteins; Gene Expression Regulation, Fungal; Genotype; Humans; Mitochondria; Nitrogen; Receptor Protein-Tyrosine Kinases; Ribosomal Proteins; Saccharomyces cerevisiae; Signal Transduction; Sirolimus; Transcription, Genetic | 1999 |
Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.
Topics: Androstadienes; Antineoplastic Agents; Apigenin; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Camptothecin; Carrier Proteins; Cell Survival; Chromones; Cycloheximide; Dactinomycin; Dimerization; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Flavonoids; Genes, bcl-2; HL-60 Cells; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitoxantrone; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Wortmannin | 2000 |
Translational control of the antiapoptotic function of Ras.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carrier Proteins; Cell Cycle Proteins; Cell Line, Transformed; Cell Transformation, Neoplastic; Cloning, Molecular; Cycloheximide; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factors; Fibroblasts; Gene Expression Regulation; Genes, ras; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Nude; Peptide Initiation Factors; Phosphoproteins; Protein Biosynthesis; ras Proteins; Rats; Signal Transduction; Sirolimus; Transfection | 2000 |
BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway.
Topics: Animals; Anti-Bacterial Agents; Benzamides; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Separation; Chromones; Cyclin-Dependent Kinase Inhibitor p27; Cycloheximide; Dose-Response Relationship, Drug; Down-Regulation; Doxycycline; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Genes, abl; Imatinib Mesylate; Interleukin-3; Mice; Microtubule-Associated Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Piperazines; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA; S Phase; Signal Transduction; Sirolimus; Time Factors; Transfection; Tumor Suppressor Proteins | 2000 |
Dissection of autophagosome biogenesis into distinct nucleation and expansion steps.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Aminopeptidases; Antifungal Agents; Autophagy; Autophagy-Related Protein 8 Family; Autophagy-Related Proteins; Cell Cycle Proteins; Cycloheximide; Cytoplasm; Fungal Proteins; Gene Expression Regulation, Fungal; Lipoproteins; Membrane Proteins; Microscopy, Electron; Microtubule-Associated Proteins; Mutation; Nitrogen; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus; Vacuoles; Vesicular Transport Proteins | 2000 |
Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway.
Topics: Androstadienes; Cell Line; Cycloheximide; HeLa Cells; Humans; Kidney; Kinetics; Phosphatidylinositol 3-Kinases; Phosphorylation; Polyribosomes; Recombinant Proteins; RNA Helicases; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus; Subcellular Fractions; Trans-Activators; Transfection; Wortmannin | 2001 |
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.
Topics: Adenine; Amino Acids; Animals; Anisomycin; Blotting, Western; Carrier Proteins; CHO Cells; Cricetinae; Cycloheximide; Enzyme Inhibitors; Gene Expression Regulation; Immunosuppressive Agents; Insulin; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Synthesis Inhibitors; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2003 |
ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1.
Topics: Adaptor Proteins, Signal Transducing; Base Sequence; Blotting, Northern; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell Line; Chromones; Cycloheximide; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine; Histidine Decarboxylase; Humans; Hypotonic Solutions; Immediate-Early Proteins; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphoserine; Promoter Regions, Genetic; Repressor Proteins; Response Elements; RNA, Messenger; Sirolimus; Tetradecanoylphorbol Acetate; Transcription Factors | 2003 |
Uth1p is involved in the autophagic degradation of mitochondria.
Topics: Alkaline Phosphatase; Aspartic Acid Endopeptidases; Autophagy; Blotting, Western; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cycloheximide; Green Fluorescent Proteins; Heat-Shock Proteins; Intracellular Membranes; Luminescent Proteins; Membrane Proteins; Microscopy, Fluorescence; Mitochondria; Mitochondrial Proteins; Nitrogen; Plasmids; Saccharomyces cerevisiae Proteins; Sirolimus; Spectrometry, Fluorescence; Time Factors | 2004 |
Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts.
Topics: Active Transport, Cell Nucleus; Cells, Cultured; Cycloheximide; Enzyme Activation; Fibroblasts; Gene Expression Regulation; Humans; Ligands; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoserine; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Protein Subunits; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Thyroid Hormone Receptors beta; Time Factors; TOR Serine-Threonine Kinases; Triiodothyronine | 2005 |
Protein synthesis-independent plasticity mediates rapid and precise recovery of deprived eye responses.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Cell Count; Cerebral Cortex; Cycloheximide; Diagnostic Imaging; Dominance, Ocular; Eye; Ferrets; In Vitro Techniques; Leucine; Neuronal Plasticity; Neurons; Orientation; Protein Synthesis Inhibitors; Proteins; Recovery of Function; Sensory Deprivation; Sirolimus; Tetrodotoxin; Time Factors; Tritium | 2005 |
GATA factor translation is the final downstream step in the amino acid/target-of-rapamycin-mediated vitellogenin gene expression in the anautogenous mosquito Aedes aegypti.
Topics: Aedes; Animals; Base Sequence; Binding Sites; Blotting, Western; Cell Line; Chromosomes; Cloning, Molecular; Cycloheximide; DNA Fragmentation; Drosophila; GATA Transcription Factors; Gene Expression Regulation; Humans; Immunohistochemistry; Lac Operon; Microscopy, Confocal; Models, Genetic; Molecular Sequence Data; Phospholipids; Promoter Regions, Genetic; Protein Binding; Protein Biosynthesis; Protein Kinases; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases; RNA; RNA Interference; RNA, Messenger; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transcription, Genetic; Transcriptional Activation; Transfection; Vitellogenins | 2006 |
Calcium signaling stimulates translation of HIF-alpha during hypoxia.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Benzylamines; Butadienes; Calcium Signaling; Carbazoles; Cell Hypoxia; Cell Line; Cycloheximide; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Ionomycin; Isoquinolines; Kidney; Nitriles; PC12 Cells; Polyribosomes; Protein Biosynthesis; Protein Kinase C-alpha; Protein Kinases; Protein Synthesis Inhibitors; Rats; RNA Caps; RNA, Messenger; RNA, Small Interfering; Sirolimus; Sulfonamides; TOR Serine-Threonine Kinases | 2006 |
A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression.
Topics: Animals; Cycloheximide; Down-Regulation; Gene Expression Regulation; Insulin; Insulin-Like Growth Factor Binding Protein 1; Liver; Models, Biological; Phosphatidylinositol 3-Kinases; Protein Kinases; Rats; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2006 |
Amino acid limitation induces expression of ATF5 mRNA at the post-transcriptional level.
Topics: Activating Transcription Factors; Amino Acids; Blotting, Northern; Cell Culture Techniques; Cell Line, Tumor; Cycloheximide; Dactinomycin; DNA, Complementary; Humans; Protein Kinase Inhibitors; Protein Kinases; RNA Processing, Post-Transcriptional; RNA, Messenger; Sirolimus; TOR Serine-Threonine Kinases | 2007 |
TOR signaling is a determinant of cell survival in response to DNA damage.
Topics: Adult; Cell Cycle Proteins; Cell Survival; Checkpoint Kinase 2; Cycloheximide; DNA Damage; Humans; Methyl Methanesulfonate; Multiprotein Complexes; Mutagens; Protein Serine-Threonine Kinases; Protein Subunits; Ribonucleoside Diphosphate Reductase; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus; Transcription Factors | 2007 |
Competitive inhibition of amino acid uptake suppresses chlamydial growth: involvement of the chlamydial amino acid transporter BrnQ.
Topics: Amino Acid Transport Systems; Amino Acids; Bacterial Proteins; Biological Transport; Cell Survival; Chlamydia; Chromatography, High Pressure Liquid; Cycloheximide; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Glycine; HeLa Cells; Humans; Isoleucine; Leucine; Methionine; Microscopy, Confocal; Microscopy, Electron, Transmission; Oligonucleotide Array Sequence Analysis; Phenylalanine; Reverse Transcriptase Polymerase Chain Reaction; Serine; Sirolimus; Threonine | 2008 |
Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis.
Topics: Animals; Anti-Bacterial Agents; Autophagy; Autophagy-Related Protein 5; Cells, Cultured; Cycloheximide; Fibroblasts; Gene Deletion; Green Fluorescent Proteins; Humans; Huntingtin Protein; Inclusion Bodies; Mice; Microtubule-Associated Proteins; Nerve Tissue Proteins; Nuclear Proteins; Peptides; Protein Biosynthesis; Protein Structure, Quaternary; Protein Transport; Recombinant Fusion Proteins; Sirolimus; Sodium Dodecyl Sulfate; Solubility; Ubiquitin; Vimentin | 2008 |
mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.
Topics: Cell Line, Tumor; Cell Survival; Chromones; Cycloheximide; Deoxycytidine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gemcitabine; Humans; Mesothelioma; Morpholines; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; RNA, Small Interfering; Signal Transduction; Sirolimus; Spheroids, Cellular; TNF-Related Apoptosis-Inducing Ligand; TOR Serine-Threonine Kinases | 2008 |
Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3'-kinase/mammalian target of rapamycin pathway in human periodontal ligament cells.
Topics: Anti-Bacterial Agents; Blotting, Western; Cells, Cultured; Cycloheximide; Gene Expression Regulation; Humans; Osteoprotegerin; Periodontal Ligament; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-akt; RANK Ligand; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; Sirolimus; Thrombin; TOR Serine-Threonine Kinases | 2008 |
Blocking eukaryotic initiation factor 4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes.
Topics: Animals; Binding Sites; Cardiomegaly; Carrier Proteins; Cell Enlargement; Cells, Cultured; Cycloheximide; Eukaryotic Initiation Factor-4F; Eukaryotic Initiation Factor-4G; Intracellular Signaling Peptides and Proteins; Male; Mutation; Myocytes, Cardiac; Phenylephrine; Phosphoproteins; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sirolimus; Transcription Factors | 2009 |
Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Line; Cycloheximide; Diabetes Mellitus, Type 2; Endoplasmic Reticulum; Enzyme Activation; Gerbillinae; Glucose; Insulin-Secreting Cells; JNK Mitogen-Activated Protein Kinases; Male; Mechanistic Target of Rapamycin Complex 1; Membrane Proteins; Mice; Multiprotein Complexes; Oxidative Stress; Palmitates; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors | 2009 |
Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.
Topics: Adaptor Proteins, Signal Transducing; Cell Nucleus; Chromatin Immunoprecipitation; Cycloheximide; DNA-Binding Proteins; Feedback, Physiological; Immunoprecipitation; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus | 2009 |
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.
Topics: Adaptor Proteins, Signal Transducing; Antifungal Agents; Cycloheximide; Phosphorylation; Protein Binding; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Protein Transport; Proteome; RNA Polymerase I; RNA Polymerase III; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus; Transcription Factors | 2009 |
Spreading of mesothelioma cells is rapamycin-sensitive and requires continuing translation.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Movement; Cell Proliferation; Culture Media, Serum-Free; Cycloheximide; Fibronectins; Humans; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mesothelioma; Multiprotein Complexes; Neoplasm Metastasis; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors | 2009 |
The Vam6 GEF controls TORC1 by activating the EGO complex.
Topics: Adaptor Proteins, Vesicular Transport; Amino Acid Transport Systems; Amino Acids; Cycloheximide; DNA-Binding Proteins; Endosomes; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Guanosine Triphosphate; Intracellular Membranes; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Mutation; Protein Binding; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Protein Transport; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus; Time Factors; Transcription Factors; Vacuoles | 2009 |
Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response.
Topics: Cell Nucleus; Cycloheximide; DNA Damage; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Isotope Labeling; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proteome; Proteomics; Radiation Tolerance; Radiation, Ionizing; Reproducibility of Results; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2010 |
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Cell Death; Cycloheximide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; PC12 Cells; Protein Serine-Threonine Kinases; Rats; Serine; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transcription Factors; Transfection; Tyrosine 3-Monooxygenase | 2010 |
Reduction in ribosomal protein synthesis is sufficient to explain major effects on ribosome production after short-term TOR inactivation in Saccharomyces cerevisiae.
Topics: Base Sequence; Cycloheximide; DNA, Fungal; Genes, Fungal; Genes, rRNA; Protein Serine-Threonine Kinases; Ribosomal Proteins; Ribosomes; RNA Polymerase I; RNA Precursors; RNA, Fungal; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus | 2011 |
Proteasomal degradation of Sfp1 contributes to the repression of ribosome biogenesis during starvation and is mediated by the proteasome activator Blm10.
Topics: Cell Nucleus; Cycloheximide; DNA-Binding Proteins; Drug Resistance, Fungal; Gene Deletion; Gene Expression Regulation, Fungal; Phenotype; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Ribosomal Proteins; Ribosomes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Trans-Activators; Transcription, Genetic | 2011 |
Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: linear correlation with o
Topics: Animals; Area Under Curve; Biological Availability; Chromatography, Liquid; Cycloheximide; Drug Delivery Systems; Emulsions; Ileum; Intestinal Absorption; Jejunum; Lymphatic Vessels; Male; Perfusion; Permeability; Polyethylene Glycols; Propylene Glycol; Rats; Rats, Sprague-Dawley; Sirolimus; Tandem Mass Spectrometry; Triglycerides | 2011 |
Inhibition of protein synthesis by TOR inactivation revealed a conserved regulatory mechanism of the BiP chaperone in Chlamydomonas.
Topics: Binding Sites; Chlamydomonas reinhardtii; Cycloheximide; Endoplasmic Reticulum Chaperone BiP; Glycosylation; Heat-Shock Proteins; Heat-Shock Response; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Sirolimus; Threonine; TOR Serine-Threonine Kinases; Tunicamycin | 2011 |
Metabotropic actions of the volatile anaesthetic sevoflurane increase protein kinase M synthesis and induce immediate preconditioning protection of rat hippocampal slices.
Topics: Anesthetics, Inhalation; Animals; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hippocampus; Immunosuppressive Agents; Ischemic Preconditioning; Methyl Ethers; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Sevoflurane; Sirolimus; TOR Serine-Threonine Kinases | 2012 |
14-3-3 protects against stress-induced apoptosis.
Topics: 14-3-3 Proteins; Apoptosis; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Proteins; bcl-2-Associated X Protein; Cadmium; Cycloheximide; Gene Library; Humans; Protein Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus | 2012 |
A functional variomics tool for discovering drug-resistance genes and drug targets.
Topics: Alleles; Amphotericin B; Antifungal Agents; Cell Cycle Proteins; Cycloheximide; Drug Resistance, Microbial; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteolipids; Ribosomal Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus | 2013 |
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.
Topics: Cell Count; Cell Cycle; Cell Line; Cell Proliferation; Cell Size; Cycloheximide; Dimethyl Sulfoxide; Feedback, Physiological; G1 Phase; HeLa Cells; Humans; Leupeptins; Phosphoproteins; S Phase; Single-Cell Analysis; Sirolimus | 2013 |
Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening.
Topics: Amygdala; Animals; Avoidance Learning; Conditioning, Classical; Cycloheximide; Extinction, Psychological; Fear; Male; Memory; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT).
Topics: Animals; Chromones; Cycloheximide; Enzyme Activation; HEK293 Cells; Humans; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proteolysis; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Sirolimus; Substrate Specificity; Tumor Suppressor Protein p53 | 2013 |
Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease.
Topics: Animals; Autophagy; Cell Survival; Cycloheximide; Cytosol; Disease Models, Animal; Electron Transport; Endoplasmic Reticulum Stress; Enzyme Activation; Gene Expression Profiling; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Mitochondria; Mitochondrial Diseases; Models, Biological; Multiprotein Complexes; Phosphorylation; Probucol; Protein Biosynthesis; Ribosomal Protein S6 Kinases; Sirolimus; TOR Serine-Threonine Kinases; Transcriptome | 2015 |
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation.
Topics: Adenosine Triphosphatases; Animals; Cell Cycle Proteins; Cycloheximide; Dendritic Spines; Endoplasmic Reticulum; Gene Knock-In Techniques; Gene Knockdown Techniques; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Ion Channels; Leucine; Membrane Proteins; Mice; Mutation; Neurons; Protein Biosynthesis; Proteins; Proteolysis; rab GTP-Binding Proteins; Rats; Sirolimus; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; Synapses; Valosin Containing Protein | 2016 |
Autophagy Plays a Protective Role in Tumor Necrosis Factor-α-Induced Apoptosis of Bone Marrow-Derived Mesenchymal Stem Cells.
Topics: Adenine; Adult; Apoptosis; Autophagy; Beclin-1; Bone Marrow Cells; Cell Differentiation; Cycloheximide; Female; Humans; Male; Mesenchymal Stem Cells; Multipotent Stem Cells; Phenotype; RNA, Small Interfering; Sirolimus; Tumor Necrosis Factor-alpha | 2016 |
Direct current stimulation induces mGluR5-dependent neocortical plasticity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzamides; Bicuculline; Cycloheximide; Electric Stimulation; Excitatory Postsynaptic Potentials; Humans; Imidazoles; Long-Term Synaptic Depression; Male; Mice; Neocortex; Neuronal Plasticity; Pyrazoles; Pyridines; Receptor, Metabotropic Glutamate 5; Sirolimus; TOR Serine-Threonine Kinases; Transcranial Direct Current Stimulation | 2016 |
Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor.
Topics: Action Potentials; Animals; Cells, Cultured; Cycloheximide; Ganglia, Spinal; Hyperalgesia; Male; Nerve Growth Factor; Pain Threshold; Protein Biosynthesis; Protein Kinase C; Protein Synthesis Inhibitors; Rats, Sprague-Dawley; Sensory Receptor Cells; Sirolimus | 2018 |
Target of Rapamycin Inhibition in
Topics: Algal Proteins; Amino Acids; Ammonium Compounds; Batch Cell Culture Techniques; Carbon; Chlamydomonas reinhardtii; Cycloheximide; Isotope Labeling; Nitrogen; Nitrogen Isotopes; Protein Biosynthesis; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation.
Topics: A549 Cells; B7-H1 Antigen; Benzoxazoles; beta-Transducin Repeat-Containing Proteins; Cycloheximide; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; Humans; Leupeptins; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Morpholines; Naphthyridines; Neoplasms; Protein Stability; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2019 |
Evolutionary engineering and molecular characterization of a caffeine-resistant Saccharomyces cerevisiae strain.
Topics: Acrolein; Antimycin A; ATP-Binding Cassette Transporters; Caffeine; Cell Cycle Proteins; Cycloheximide; DNA-Binding Proteins; Drug Resistance, Fungal; Mutagenesis; Polymorphism, Single Nucleotide; Protein Engineering; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Stress, Physiological; Transcription Factors; Transcriptome; Whole Genome Sequencing | 2019 |
Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis.
Topics: Antineoplastic Agents; Caspase 2; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cycloheximide; Cysteine Endopeptidases; Dactinomycin; Doxorubicin; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; Loss of Function Mutation; Protein Stability; Sirolimus; Transcription Factors; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2019 |