cycloheximide has been researched along with methotrexate in 59 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (64.41) | 18.7374 |
| 1990's | 12 (20.34) | 18.2507 |
| 2000's | 7 (11.86) | 29.6817 |
| 2010's | 2 (3.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Boesche, M; Crowther, GJ; Dasari, KS; Drewes, G; El Bakkouri, M; Fox, AM; Ghidelli-Disse, S; He, P; Hillesland, HK; Hui, R; Jones, JC; Keyloun, KR; Krahn, MM; Lafuente-Monasterio, MJ; Leonard, SE; Leroy, D; Maly, DJ; Mo, JS; Ojo, KK; Reid, MC; Rivas, KL; Van Voorhis, WC | 1 |
| Kaminskas, E; Nussey, AC | 1 |
| Azizkhan, JC; Goode, D; Speeg, KV; Stromberg, K | 1 |
| Roth, JJ; Roth, JS | 1 |
| Klem, EB | 1 |
| Andersen, O; Rønne, M | 1 |
| Siminovitch, L | 1 |
| Mueller, GC; Planck, SR | 1 |
| Grzelakowska-Sztabert, B | 1 |
| Mueller, GC; Seki, S | 1 |
| Bonney, RJ; Maley, F | 1 |
| Rossman, TG; Wolosin, D | 1 |
| Abonyi, M; Hata, Y; Nakamura, H; Prajda, N; Weber, G | 1 |
| Pain, J; Sirotnak, FM; Yang, CH | 1 |
| Boman, HG; Gudmundsson, GH; Schlenstedt, G; Zimmermann, R | 1 |
| Klaunig, JE; Pereira, MA; Ruch, RJ | 1 |
| Akiyama, Y; Kiriyama, Y; Kito, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Boiocchi, M; Broggini, M; D'Incalci, M; Erba, E; Lorico, A; Rappa, G; Toffoli, G | 1 |
| Schimke, RT; Schumacher, RI; Sherwood, SW | 1 |
| Barrueco, JR; Poser, RE; Sirotnak, FM | 1 |
| Ayusawa, D; Hori, T; Koyama, H; Seno, T; Shimizu, K; Takeishi, K | 1 |
| Kidwell, WR | 1 |
| Bertino, JR; Hillcoat, BL; Swett, V | 1 |
| Gauldie, J; Hiebert, M; Hillcoat, BL; Marshall, L | 1 |
| Hillcoat, BL; Marshall, L | 1 |
| Hackenthal, E; Schmidt-Gayk, H; Seyberth, HW | 1 |
| Cox, RP; Malathi, VG; Meyers, R; Silber, R | 1 |
| Heischkeil, R | 1 |
| Bertino, JR; Hillcoat, BL | 1 |
| Bishop, CF; Melnykovych, G | 1 |
| Abrams, R; Lieberman, I; Turner, MK | 1 |
| Labow, R; Maley, F; Maley, GF | 1 |
| Berry, RJ | 1 |
| Maul, DM; Schuster, SM | 1 |
| Faine, S; Graves, S; Steiner, B; Wong, GH | 1 |
| Dardick, I; Dubsky, M; Kiss, G; Setterfield, G; Sheinin, R | 1 |
| Goren, HJ; Hollenberg, MD; Lederis, K; Okabe, T | 1 |
| Inoue, M; Tan, YH | 1 |
| Carr, BI; Laishes, BA | 1 |
| Hershman, JM; Melmed, S; Park, J | 1 |
| Morris, ID; Stephen, TM | 1 |
| Palmer, S; Panasci, L; Polizzi, G | 1 |
| Kaminskas, E | 1 |
| Darzynkiewicz, Z; Gorczyca, W; Melamed, MR; Pizzolo, JG; Qiao, L | 1 |
| Craig, EA; Hönlinger, A; Keil, P; Nelson, RJ; Pfanner, N | 1 |
| Prajda, N; Singhal, RL; Weber, G | 1 |
| Prajda, N; Weber, G | 1 |
| Fujiki, M; Verner, K | 1 |
| Daxenbichler, G; Lang, T; Marth, C; Müller-Holzner, E; Widschwendter, M | 1 |
| Debatin, KM; Friesen, C; Herr, I; Krammer, PH | 1 |
| Brôco, N; Sá-Correia, I; Tenreiro, S; Viegas, CA | 1 |
| Desaki, M; Kawasaki, S; Kohyama, T; Okazaki, H; Takizawa, H; Yamamoto, K; Yamauchi, Y | 1 |
| Coffino, P; Hoyt, MA; MacDonald, AI; Zhang, M | 1 |
| Hirade, K; Ishisaki, A; Ito, H; Kato, K; Kozawa, O; Niwa, M; Shimizu, K; Yoshida, M | 1 |
| Bassel, GW; Chow, TF; Cutler, SR; Foong, JA; Fung, P; Provart, NJ | 1 |
| Ambudkar, SV; Manoharlal, R; Prasad, R; Prasad, T; Puri, N; Sharma, M; Shukla, S | 1 |
3 review(s) available for cycloheximide and methotrexate
| Article | Year |
|---|---|
On the nature of hereditable variation in cultured somatic cells.
Topics: Amanitins; Azaguanine; Bromodeoxyuridine; Cell Line; Cells, Cultured; Chromosomes; Colchicine; Cycloheximide; Diploidy; Drug Resistance; Genes; Genes, Lethal; Genes, Recessive; Genetic Variation; Hybrid Cells; Hydroxyurea; Immunoglobulins; Lectins; Methotrexate; Mutation; Ouabain; Phenotype; Polyploidy; Temperature | 1976 |
Thymineless death and genetic events in mammalian cells.
Topics: Animals; Cell Survival; Centrifugation, Density Gradient; Chromosome Aberrations; Cycloheximide; Dactinomycin; DNA; DNA Replication; Humans; Interphase; Methotrexate; Methyltransferases; Mice; Mitosis; Mutation; Recombination, Genetic; Sister Chromatid Exchange; Thymidine; Thymidine Monophosphate; Thymidylate Synthase; Ultrafiltration | 1985 |
Antimetabolites reduce the activities of enzymes with short half-lives in addition to inhibiting their specific targets.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Cycloheximide; Enzyme Inhibitors; Fluorouracil; Half-Life; Humans; Isoxazoles; Methotrexate; Prodrugs; Purines; Pyrimidines; Ribavirin; Signal Transduction | 1994 |
56 other study(ies) available for cycloheximide and methotrexate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
Topics: Antimalarials; Calcium; Cell Line, Tumor; Hep G2 Cells; Humans; Malaria, Falciparum; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Plasmodium falciparum; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protozoan Proteins | 2016 |
Effects of methotrexate and of environmental factors on glycolysis and metabolic energy state in cultured Ehrlich ascites carcinoma cells.
Topics: Adenine Nucleotides; Amino Acids; Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Culture Media; Cycloheximide; Dactinomycin; Energy Metabolism; Glucose; Glycolysis; Hydrogen-Ion Concentration; Hypoxanthines; Methotrexate; Phosphates; Thymidine | 1978 |
Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis.
Topics: Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Cycloheximide; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Floxuridine; Humans; Hydroxyurea; Methotrexate; Neoplasm Proteins; Neoplasms, Experimental; Pregnancy; Uterine Neoplasms | 1979 |
Thymidylate synthetase activity in the Novikoff hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Cycloheximide; Dactinomycin; Folic Acid; Liver Neoplasms; Male; Methotrexate; Methyltransferases; Neoplasms, Experimental; Puromycin; Rats; Tetrahydrofolates; Thymidylate Synthase | 1976 |
Effects of antipsoriasis drugs and metabolic inhibitors on the growth of epidermal cells in culture.
Topics: Animals; Anthralin; Antimetabolites; Azauridine; Cell Division; Cells, Cultured; Cycloheximide; Cytarabine; Dactinomycin; Daunorubicin; Guinea Pigs; Hydroxyurea; Methotrexate; Mycophenolic Acid; Psoriasis; Puromycin; Skin | 1978 |
In vitro induction of uncoiled chromosomes with inhibitors of RNA and protein synthesis.
Topics: Amanitins; Chromosome Banding; Chromosomes, Human; Cycloheximide; Humans; Interphase; Lymphocytes; Metaphase; Methotrexate; Puromycin | 1978 |
Deoxyribonucleic acid chain growth and organization of replicating units in HeLa cells.
Topics: Bromodeoxyuridine; Cycloheximide; DNA Replication; DNA, Neoplasm; Genes; HeLa Cells; Methotrexate; Molecular Weight; Temperature; Thymidine | 1977 |
Uptake of folate and its analogue-amethopterin by mouse L-cells.
Topics: Animals; Cells, Cultured; Chloromercuribenzoates; Cycloheximide; Dactinomycin; Folic Acid; Kinetics; L Cells; Methionine; Methotrexate; Mice; Vitamin B 12 | 1976 |
A requirement for RNA, protein and DNA synthesis in the establishment of DNA replicase activity in synchronized HeLa cells.
Topics: Cell Division; Cycloheximide; DNA Nucleotidyltransferases; DNA Replication; DNA, Neoplasm; HeLa Cells; Methotrexate; Neoplasm Proteins; Protein Biosynthesis; Puromycin; RNA, Neoplasm; Time Factors; Transcription, Genetic | 1975 |
Effect of methotrexate on thymidylate synthetase in cultured parenchymal cells isolated from regenerating rat liver.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Liver; Liver Regeneration; Methotrexate; Methyltransferases; Protein Biosynthesis; Puromycin; Rats; Stimulation, Chemical; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Thymidylate Synthase | 1975 |
Differential susceptibility to carcinogen-induced amplification of SV40 and dhfr sequences in SV40-transformed human keratinocytes.
Topics: Aphidicolin; Carcinogens; Cell Line, Transformed; Cell Transformation, Viral; Cycloheximide; Drug Resistance; Gene Amplification; Genes, Viral; Humans; Hydroxyurea; Keratinocytes; Methotrexate; Mitomycin; Proto-Oncogene Mas; Simian virus 40; Tetrahydrofolate Dehydrogenase; Time Factors; Ultraviolet Rays; X-Rays | 1992 |
Methotrexate decreases thymidine kinase activity.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Count; Cycloheximide; Dactinomycin; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Methotrexate; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidine Kinase | 1992 |
Alteration of folate analogue transport inward after induced maturation of HL-60 leukemia cells. Molecular properties of the transporter in an overproducing variant and evidence for down-regulation of its synthesis in maturating cells.
Topics: Affinity Labels; Biological Transport; Cycloheximide; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Folic Acid; Kinetics; Membrane Proteins; Methotrexate; Tumor Cells, Cultured | 1992 |
A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosome, and post-translationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomes.
Topics: Amino Acid Sequence; Animals; Cycloheximide; Dogs; Folic Acid Antagonists; Insect Hormones; Insect Proteins; Kinetics; Methotrexate; Microsomes; Molecular Sequence Data; Pancreas; Plasmids; Protein Biosynthesis; Protein Precursors; Protein Processing, Post-Translational; Protein Sorting Signals; Ribonucleoproteins; Ribosomes; Tetrahydrofolate Dehydrogenase; Transcription, Genetic; Trypsin | 1990 |
Selective resistance to cytotoxic agents in hepatocytes isolated from partially hepatectomized and neoplastic mouse liver.
Topics: Animals; Cell Survival; Cells, Cultured; Cycloheximide; Drug Resistance; Hepatectomy; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Male; Methotrexate; Mice; Mice, Inbred Strains; Species Specificity | 1985 |
Sequential combination of methotrexate and 1-beta-D-arabinofuranosylcytosine shows synergistic effect on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
Topics: Arabinofuranosylcytosine Triphosphate; Cycloheximide; Cytarabine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Thymidine; Tumor Cells, Cultured | 1989 |
Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid.
Topics: Cell Cycle; Cell Survival; Cycloheximide; DNA; DNA Damage; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Proteins; Quinazolines; Thymidine | 1988 |
Effect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Cycloheximide; DNA Replication; Drug Resistance; Female; Hydroxyurea; Methotrexate; Ovary | 1988 |
Enhancement of folate analogue transport inward in L1210 cells during methotrexate therapy of leukemic mice: evidence of the nature of the effect, possible host mediation, and pharmacokinetic significance.
Topics: Affinity Labels; Animals; Biological Transport; Cycloheximide; Dose-Response Relationship, Drug; Folic Acid; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Succinimides | 1987 |
Fidelity of DNA replication in isolated L-cell nuclei.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Cell Nucleus; Centrifugation, Density Gradient; Chemical Precipitation; Cycloheximide; Cytoplasm; Dactinomycin; Deoxyribonucleases; DNA; DNA Replication; Drug Stability; Hot Temperature; Hydroxyapatites; Isotope Labeling; L Cells; Methotrexate; Mice; Nucleic Acid Denaturation; Thymidine; Thymine Nucleotides; Time Factors; Tritium | 1972 |
Increase of dihydrofolate reductase activity in cultured mammalian cells after exposure to methotrexate.
Topics: Culture Techniques; Cycloheximide; Dactinomycin; Floxuridine; Humans; Leucine; Leukemia, Myeloid; Lymphocytes; Methotrexate; Neoplasm Proteins; Nucleosides; Puromycin; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase; Tritium | 1967 |
Stabilization of dihydrofolate reductase by inhibitors in vivo and in vitro.
Topics: Animals; Biodegradation, Environmental; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Chromatography, Gel; Cycloheximide; Drug Stability; Electrophoresis; Enzyme Activation; Folic Acid Antagonists; Humans; Leucovorin; Leukemia L1210; Liver Neoplasms; Methotrexate; Mice; Rats; Tetrahydrofolate Dehydrogenase; Triamterene; Trimethoprim | 1971 |
Enzyme increase by folate and methotrexate in cultured mammalian cells.
Topics: Biological Transport; Cell Line; Cycloheximide; Folic Acid; Glucosephosphate Dehydrogenase; Hybrid Cells; Kinetics; Ligases; Methotrexate; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Time Factors; Transferases | 1974 |
Toxicity, clearance and distribution of endotoxin in mice as influenced by actinomycin D, cycloheximide, -amanitin and lead acetate.
Topics: Acetates; Animals; Azathioprine; Chromium Isotopes; Cycloheximide; Cyclophosphamide; Dactinomycin; Endotoxins; Escherichia coli; Fluorouracil; Injections, Intraperitoneal; Injections, Intravenous; Lead; Lethal Dose 50; Male; Methotrexate; Mice; Mycotoxins; Protein Biosynthesis; RNA; Salmonella; Time Factors | 1972 |
Studies on nucleoside deaminase. Increase in activity in HeLa cell cultures caused by cytosine arabinoside.
Topics: Alkaline Phosphatase; Aminohydrolases; Antimetabolites; Carbon Isotopes; Cell Fractionation; Culture Media; Cycloheximide; Cytarabine; Cytidine; Deamination; DNA; DNA Nucleotidyltransferases; Glucosephosphate Dehydrogenase; HeLa Cells; L-Lactate Dehydrogenase; Leucine; Methotrexate; Nucleosides; Protein Biosynthesis; Thymidine; Time Factors; Tritium; Uridine | 1973 |
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria; Male; Methotrexate; Mice; Mice, Inbred Strains; Phenobarbital; Phenytoin; Plasmodium; Primidone; Pyrimethamine; Thalidomide; Triamterene | 1973 |
Vriation of dihydrofolate reductase activity in mammalian cells in vitro.
Topics: Blood Cells; Cell Line; Culture Media; Culture Techniques; Cycloheximide; Folic Acid Antagonists; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase | 1969 |
Specific binding of cortisol in subcellular fractions of HeLa cells: temperature dependence and effects of inhibitors.
Topics: 17-Hydroxycorticosteroids; Arsenicals; Azides; Binding Sites; Cell Nucleus; Chloramphenicol; Cyanides; Cycloheximide; Cytoplasm; Dactinomycin; Depression, Chemical; Dinitrophenols; Female; Fluorouracil; HeLa Cells; Hexoses; Humans; Hydrocortisone; In Vitro Techniques; Iodoacetates; Methotrexate; Microsomes; Mitochondria; Ouabain; Prednisolone; Puromycin; Temperature; Tritium | 1971 |
Levels of ribonucleotide reductase activity during the division cycle of the L cell.
Topics: Cell Division; Culture Techniques; Cycloheximide; Cytosine Nucleotides; DNA; DNA Replication; L Cells; Methotrexate; Nucleotides; Oxidoreductases; Time Factors; Tritium | 1968 |
The effect of methotrexate on enzymes induced following partial hepatectomy.
Topics: Aminohydrolases; Animals; Carbon Isotopes; Cycloheximide; Dactinomycin; DNA Nucleotidyltransferases; Enzyme Induction; Hepatectomy; Ligases; Liver; Methotrexate; Phosphotransferases; Puromycin; Rats; RNA, Messenger; Stimulation, Chemical; Thymidine; Thymidine Kinase; Time Factors | 1969 |
Effects of some metabolic inhibitors on x-ray dose-response curves for the survival of mammalian cells in vitro, and on early recovery between fractionated x-ray doses.
Topics: Anti-Bacterial Agents; Culture Techniques; Cycloheximide; Dinitrophenols; Fluorouracil; HeLa Cells; Humans; Methotrexate; Puromycin; Radiation Effects; Radiometry | 1966 |
Methotrexate stimulation of asparagine synthetase activity in rat liver.
Topics: Animals; Aspartate-Ammonia Ligase; Cycloheximide; Glycine; Glycine Hydroxymethyltransferase; L-Lactate Dehydrogenase; Ligases; Liver; Male; Methotrexate; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1982 |
Effect of serum concentration and metabolic inhibitors on the attachment of Treponema pallidum to rabbit cells.
Topics: Adhesiveness; Animals; Blood; Cell Division; Cells, Cultured; Culture Media; Cycloheximide; DNA; Genitalia; Methotrexate; Oxygen; Protein Biosynthesis; Rabbits; Treponema pallidum | 1983 |
Relationship between chromatin structure and replication in mouse L-cells.
Topics: Animals; Chromatin; Cycloheximide; Cytarabine; DNA Replication; Floxuridine; Hydroxyurea; Isoleucine; L Cells; Methotrexate; Mice; Mitomycin; Mitomycins; Protein Biosynthesis; Structure-Activity Relationship | 1980 |
Oxytocin stimulates glucose oxidation in rat thymocytes.
Topics: Adenine; Animals; Cycloheximide; Glucose; In Vitro Techniques; Inosine; Kinetics; Male; Methotrexate; Oxidation-Reduction; Oxytocin; Rats; Rats, Inbred Strains; Thymus Gland | 1984 |
Enhancement of actinomycin D- and cis-diamminedichloroplatinum(II)-induced killing of human fibroblasts by human beta-interferon.
Topics: Cell Survival; Cisplatin; Cycloheximide; Cyclophosphamide; Dactinomycin; Fibroblasts; Humans; Interferon Type I; Kinetics; Methotrexate; Vincristine | 1983 |
Carcinogen-induced drug resistance in rat hepatocytes.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Cell Cycle; Cell Survival; Cells, Cultured; Cycloheximide; Doxorubicin; Drug Resistance; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Methotrexate; Rats | 1981 |
Triiodothyronine induces a transferable factor which suppresses TSH secretion in cultured mouse thyrotropic tumor cells.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Female; In Vitro Techniques; Methotrexate; Mice; Neoplasms, Experimental; Thyroid Neoplasms; Thyrotropin; Thyrotropin-Releasing Hormone; Triiodothyronine | 1981 |
In vitro and in vivo interactions of methotrexate and other antimetabolites with the oestrogen high affinity receptors of the rat uterus.
Topics: Animals; Antimetabolites; Cycloheximide; Dactinomycin; Doxorubicin; Estradiol; Female; Methotrexate; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Uterus | 1983 |
Diminished toxicity of methotrexate in CD2F1 mice pretreated with cycloheximide.
Topics: Animals; Cycloheximide; Injections, Intraperitoneal; Lethal Dose 50; Leukemia P388; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred Strains; Protein Biosynthesis; Time Factors | 1982 |
Effects of methotrexate on ribonucleotide pools in growing and in growth-arrested tumor cells and antagonism by RNA synthesis inhibitors.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Cycloheximide; Cytarabine; Dactinomycin; Doxorubicin; Glycine; Kinetics; Methotrexate; Mice; Ribonucleotides; Transcription, Genetic | 1982 |
Flow cytometric characterization of proliferation-associated nuclear antigen (p105) during the cell cycle in normal lymphocytes and promyelocytic leukemia cells (HL-60).
Topics: Camptothecin; Cell Cycle; Cycloheximide; DNA Damage; DNA, Neoplasm; Flow Cytometry; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Lymphocyte Activation; Lymphocytes; Methotrexate; Phytohemagglutinins; Proliferating Cell Nuclear Antigen; Teniposide; Vinblastine | 1995 |
Posttranslational mitochondrial protein import in a homologous yeast in vitro system.
Topics: Animals; Antimetabolites, Antineoplastic; Cycloheximide; Fungal Proteins; HSP70 Heat-Shock Proteins; Methotrexate; Mice; Mitochondria; Neurospora crassa; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rabbits; Saccharomyces cerevisiae; Yeasts | 1995 |
Targeted and non-targeted actions of anti-cancer drugs.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Cycloheximide; Deoxycytidine Kinase; Fluorouracil; Hypoxanthine Phosphoribosyltransferase; Isoxazoles; Methotrexate; Neoplasms, Experimental; Pyrimidines; Rats; Rats, Inbred Strains; Ribavirin; Thymidine Kinase; Thymidylate Synthase | 1994 |
Coupling of cytosolic protein synthesis and mitochondrial protein import in yeast. Evidence for cotranslational import in vivo.
Topics: Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cycloheximide; Cytosol; Electron Transport Complex IV; Fungal Proteins; Immunosorbent Techniques; Methotrexate; Mice; Mitochondria; Protein Biosynthesis; Protein Processing, Post-Translational; Proton-Translocating ATPases; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Tetrahydrofolate Dehydrogenase | 1993 |
Effects of Taxol on choriocarcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Choriocarcinoma; Chorionic Gonadotropin; Cycloheximide; Etoposide; Female; Humans; Methotrexate; Paclitaxel; Pregnancy; Tumor Cells, Cultured; Uterine Neoplasms | 1995 |
Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Cycloheximide; Cyclosporine; Dose-Response Relationship, Drug; Doxorubicin; Fas Ligand Protein; fas Receptor; Humans; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Methotrexate; Protein Synthesis Inhibitors; Tumor Cells, Cultured | 1996 |
FLR1 gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiae and its benomyl-induced expression is dependent on pdr3 transcriptional regulator.
Topics: 4-Nitroquinoline-1-oxide; Antifungal Agents; Antimetabolites, Antineoplastic; Benomyl; Carcinogens; Carrier Proteins; Cycloheximide; DNA Primers; DNA-Binding Proteins; DNA, Fungal; Drug Resistance, Microbial; Electrophoresis, Agar Gel; Fluconazole; Fungicides, Industrial; Gene Expression Regulation, Fungal; Membrane Transport Proteins; Methotrexate; Mutagenesis, Insertional; Organic Anion Transporters; Plasmids; Polymerase Chain Reaction; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 1999 |
Methotrexate induces interleukin-8 production by human bronchial and alveolar epithelial cells.
Topics: Acetylcysteine; Bronchi; Cell Line; Cycloheximide; Epithelial Cells; Folic Acid Antagonists; Free Radical Scavengers; Glucose; Humans; Hypoglycemia; Interleukin-1; Interleukin-8; Lipopolysaccharides; Methotrexate; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Pulmonary Alveoli; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Proteasomes begin ornithine decarboxylase digestion at the C terminus.
Topics: Animals; Cycloheximide; Cysteine Endopeptidases; Genetic Vectors; Methotrexate; Mice; Multienzyme Complexes; Mutagenesis, Insertional; Ornithine Decarboxylase; Peptide Fragments; Plasmids; Polymerase Chain Reaction; Proteasome Endopeptidase Complex; Protein Denaturation; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Substrate Specificity | 2004 |
Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts.
Topics: Animals; Anthracenes; Blotting, Northern; Cells, Cultured; Cycloheximide; Dactinomycin; DNA; DNA-Binding Proteins; Enzyme Activation; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Inositol Phosphates; Methotrexate; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; Phosphorylation; Prostaglandin D2; Protein Binding; Protein Kinase C; Protein Kinase Inhibitors; Response Elements; RNA, Messenger; Transcription Factors | 2004 |
Elucidating the germination transcriptional program using small molecules.
Topics: 2,4-Dinitrophenol; Abscisic Acid; Arabidopsis; Cell Nucleus; Computational Biology; Cycloheximide; Gene Expression Profiling; Germination; Methotrexate; Plastids; Seeds; Transcription, Genetic | 2008 |
Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals.
Topics: Anisomycin; Antifungal Agents; Biological Transport; Candida albicans; Curcumin; Cycloheximide; Drug Synergism; Enzyme Inhibitors; Fluconazole; Itraconazole; Ketoconazole; Methotrexate; Miconazole; Multidrug Resistance-Associated Proteins; Pyrimidines; Rhodamines; Saccharomyces cerevisiae; Triazoles; Voriconazole | 2009 |