cycloheximide has been researched along with leupeptins in 146 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (10.96) | 18.7374 |
| 1990's | 25 (17.12) | 18.2507 |
| 2000's | 56 (38.36) | 29.6817 |
| 2010's | 42 (28.77) | 24.3611 |
| 2020's | 7 (4.79) | 2.80 |
| Authors | Studies |
|---|---|
| Ballard, FJ; Knowles, SE | 1 |
| Bang, YJ; Danielpour, D; Kim, KY; Kim, SJ; Myers, CE; O'Reilly, MA; Trepel, JB | 1 |
| Bianchi, CP; Booz, GW | 1 |
| Homma, S; Oppenheim, RW; Prevette, D; Tytell, M | 1 |
| Collins, AR; Grubb, A | 1 |
| Knutson, VP | 1 |
| Brostrom, CO; Brostrom, MA; Gmitter-Yellen, D; Grandison, LJ; Kuznetsov, G; Prostko, CR; Wong, WL | 1 |
| Edwards, RH; MacLennan, PA; McArdle, A | 1 |
| Mercer, JR; Silva, SV | 1 |
| Dagenhardt, K; Di Stefano, JF; Hagag, N; Kirchner, M | 1 |
| Kovács, AL; Kovács, J; László, L | 2 |
| Hoppe, W; Kresse, H; Rauch, U | 1 |
| Blau, HM; Kaplan, ID | 1 |
| Ballard, FJ | 1 |
| Beertsen, W; Everts, V; Tigchelaar-Gutter, W | 1 |
| Khairallah, EA | 1 |
| Grinde, B; Jahnsen, R | 1 |
| Kovács, J | 1 |
| Hashida, S; Katunuma, N; Khairallah, EA; Kominami, E | 1 |
| Berg, T; Carlander, B; Drevon, CA; Tolleshaug, H | 1 |
| Dunn, WA; Hubbard, AL | 1 |
| Curtis, AS; Forrester, JV; Lawrie, F; McInnes, C | 1 |
| Amenta, JS; Mayer, RJ; Russell, SM | 1 |
| Ettienne, EM; Singer, RH; Swartz, K | 1 |
| Beatini, N; Maxfield, FR; Schissel, SL; Tabas, I; Zha, X | 1 |
| Delaissé, JM; Kishore, BK; Montenez, JP; Tulkens, PM | 1 |
| Lodish, HF; Neumann, D; Watowich, SS; Wikström, L | 1 |
| Davis, EC; Mecham, RP | 1 |
| Lu, Q; Mellgren, RL | 1 |
| Baldwin, AS; Mayo, MW; Wang, CY | 1 |
| An, WG; Blagosklonny, MV; Neckers, L; Schulte, T; Sutphin, P; Whitesell, L | 1 |
| Chang, YC; Heintz, NH; Illenye, S; Magae, J; Mitsui, Y; Omura, S; Tanaka, K; Tejima, T | 1 |
| Biber, J; Lederer, E; Murer, H; Pfister, MF; Ruf, I; Stange, G; Ziegler, U | 1 |
| Kawazoe, Y; Nagata, K; Nakai, A; Tanabe, M | 1 |
| MacDonald, PN; Masuyama, H | 1 |
| Harney, J; Larsen, PR; Steinsapir, J | 1 |
| Gebert, CA; Park, SH; Waxman, DJ | 2 |
| Haines, DS; Pan, Y | 1 |
| Boulaire, J; Cannella, D; Fitzgerald, P; Fotedar, A; Fotedar, R; Rousseau, D | 1 |
| Devin, A; Lewis, J; Lin, Y; Liu, ZG; Miller, A; Neckers, L; Rodriguez, Y | 1 |
| Boudjelal, M; Fisher, GJ; Voorhees, JJ; Wang, Z | 1 |
| Avner, R; Doolman, R; Harats, D; Ravid, T; Roitelman, J | 1 |
| Groscurth, P; Hermisson, M; Krammer, PH; Liston, P; Wagenknecht, B; Weller, M | 1 |
| Kreuz, S; Scheurich, P; Siegmund, D; Wajant, H | 1 |
| Fong, WF; Lam, W; Leung, CH; Wong, NS; Yang, MS; Zhuang, WJ | 1 |
| Kimura, G; Ohtsu, M; Okuda, A | 1 |
| Akin, D; Cohen, RJ; Feldherr, CM | 1 |
| Beaulieu, JF; Bennett, MW; Lentze, MJ; O'Connell, J; Ruemmele, FM; Seidman, EG | 1 |
| Gilbert, DM; Keezer, SM | 1 |
| Harthill, JE; MacKintosh, C; Milne, FC; Pozuelo Rubio, M | 1 |
| Dai, W; Darzynkiewicz, Z; Jhanwar-Uniyal, M; Liu, T; Luo, L; Ruan, Q; Traganos, F; Wang, Q; Xie, S | 1 |
| Bessho, Y; Harada, T; Hirata, H; Kageyama, R; Ohtsuka, T; Yoshikawa, K; Yoshiura, S | 1 |
| Kim, HA; Kim, YH; Song, YW | 1 |
| Hattori, T; Hayashi, H; Inoue, Y; Ohoka, N; Onozaki, K | 1 |
| Jing, Y; Lu, M; Waxman, S; Xia, L | 1 |
| Blasi, F; Longobardi, E | 1 |
| Bagui, TK; Haura, E; Mohapatra, S; Pledger, WJ | 1 |
| Beyer, K; Görner, K; Haass, C; Holtorf, E; Kahle, PJ; Nuscher, B; Odoy, S; Regula, JT; Yamamoto, A | 1 |
| Hagen, T; Lam, F; Moncada, S; Taylor, CT | 1 |
| Arulpragasam, A; Butcher, NJ; Minchin, RF | 1 |
| Cross, A; Derouet, M; Edwards, SW; Moots, RJ; Thomas, L | 1 |
| Elliott, AA; Joiakim, A; Mathieu, PA; Reiners, JJ | 1 |
| Body, JJ; Journé, F; Laurent, G; Leclercq, G; Nonclercq, D | 1 |
| Journé, F; Laïos, I; Laurent, G; Leclercq, G; Nonclercq, D; Toillon, RA; Vidal, DS | 1 |
| Maeda, M; Miura, H; Yamamoto, N; Yamaoka, S | 1 |
| Beck, JA; Gens, JS; Kempson, SA; Lammers, PE; Montrose, MH | 1 |
| Kawatani, Y; Minegishi, N; Shimizu, R; Suzuki, N; Yamamoto, M | 1 |
| Peng, A; Sun, QY; Tan, X; Wang, Y; Wang, YC | 1 |
| El-Kadi, AO; Korashy, HM | 1 |
| Baltzis, D; Koromilas, AE; Pluquet, O; Qu, LK | 1 |
| Chik, CL; Ho, AK; McNeil, L; Price, DM; Terriff, D | 1 |
| Fridman, R; Kim, HR; Liu, XW; Taube, ME | 1 |
| Bremer, E; George, D; Li, H; Monroe, J; Yang, W; Zhang, Y | 1 |
| Alao, JP; Coombes, RC; Gamble, SC; Lam, EW; Pomeranz, KM; Stavropoulou, AV; Vigushin, DM | 1 |
| Chen, Y; Magnuson, T; Yee, D | 1 |
| Chiao, JW; Liu, XM; Wang, LG | 1 |
| Baydoun, AR; Molleman, A; Mormina, ME; Thakur, S; Whelan, CJ | 1 |
| Fried, SK; Lee, MJ | 1 |
| Godbole, D; Mojamdar, M; Pal, JK | 1 |
| Boeckers, T; Dresbach, T; Garner, CC; Geva, R; Gundelfinger, ED; Tsuriel, S; Zamorano, P; Ziv, NE | 1 |
| Barberà, A; Fernández-Novell, JM; Guinovart, JJ; Rodríguez-Gil, JE | 1 |
| Chiasson, S; Girard, D; Pelletier, M; Ratthé, C | 1 |
| Bronk, SF; Gores, GJ; Ustundag, Y | 1 |
| Li, JP; Yang, JL | 1 |
| Ben-Izhak, O; Egozi, D; Hershko, DD; Paor, G; Shapira, M; Skorecki, K | 1 |
| Ding, WX; Ni, HM; Yin, XM | 1 |
| Espina, B; Hulley, PA; Liang, M; Russell, RG | 1 |
| Boyer, ME; Bresnick, EH; Grass, JA; Lurie, LJ | 1 |
| Harada, M; Omary, MB; Strnad, P; Toivola, DM | 1 |
| Chang, CC; Chen, HY; Chu, CY; Kuo, IH; Kuo, ML; Lin, BR; Lin, MT; Shih, HJ; Sureshbabu, M | 1 |
| Campos, EI; Garate, M; Li, G; Wang, Y; Wong, RP | 1 |
| Cebotaru, L; Ciobanu, I; Flotte, T; Guggino, WB; Vij, N; Wright, J | 1 |
| Chen, G; Fröhlich, O; Huang, H; Klein, JD; Price, SR; Sands, JM; Yang, Y | 1 |
| Adeli, K; Kohen-Avramoglu, R; Nemat-Gorgani, N; Qiu, W; Rutledge, AC; Zhang, R | 1 |
| Choe, J; Choi, C; Jang, D; Lee, J; Lim, C | 1 |
| Ausserlechner, MJ; Pereira-Smith, OM; Tominaga, E; Tominaga, K | 1 |
| Aplin, AE; Hu, R | 1 |
| Bathina, M; Bisanz, K; Koss, B; Opferman, JT; Perciavalle, RM; Stewart, DP | 1 |
| Guo, M; Jiang, W; Liu, Y; Ma, D; Wu, H; Zhang, Y; Zhang, Z; Zhao, Z | 1 |
| Kim, SY; Park, JW | 1 |
| De Jong, S; De Vries, EG; Ek, WB; Le, PT; Pennarun, B; Spierings, DC; Van Geelen, CM | 1 |
| Arawaka, S; Fukushima, S; Hara, S; Kato, T; Koyama, S; Machiya, Y; Sakamoto, M; Sato, H | 1 |
| Chen, D; Dong, X; Dou, QP; Guo, H; Huang, H; Li, S; Li, X; Liu, J; Liu, N; Liu, S; Lu, X; Yang, C; Zhang, C; Zhao, C; Zhao, K; Zhou, P | 1 |
| Baek, KH; Cha, BH; Kim, KS; Lee, SH; Lim, KH; Ramakrishna, S; Suresh, B | 1 |
| Alvarez-Velilla, R; Balaña-Fouce, R; Estrada, CG; Pérez-Pertejo, Y; Reguera, RM | 1 |
| Boyd, MT; Rubbi, CP; Vlatkovic, N | 1 |
| Bauer, P; Lingam, S; Meiser, J | 1 |
| Chung, KC; Han, KA; Im, E; Lee, K; Oh, Y; Um, JW | 1 |
| Březinová, D; Castorálová, M; Knejzlík, Z; Lipov, J; Ruml, T; Svéda, M | 1 |
| Chang, PA; Chen, YY; Long, DX; Mou, XL; Qin, WZ | 1 |
| Chua, NH; Deng, S; Jang, IC; Niu, QW; Zhao, P | 1 |
| Abazyan, B; Abazyan, S; Ma, TM; Nomura, J; Pletnikov, MV; Sawa, A; Seshadri, S; Snyder, SH; Yang, C | 1 |
| Ahmad, F; Blaesse, P; Kaila, K; Puskarjov, M | 1 |
| Muratsubaki, H; Yamaki, A | 1 |
| Chudinova, EM; Ivanov, PA; Nadezhdina, ES | 1 |
| Bednarek, SY; Chen, Q; Fu, W; Jiang, N; Li, C; Liu, J; Ma, B; Pan, J; Wang, C; Yan, X | 1 |
| Ginzberg, MB; Kafri, R; Kirschner, MW; Lahav, G; Levy, J; Oh, S | 1 |
| Abbas, T; Dutta, A; Keaton, M; Mueller, AC; Rossi, M; Shibata, E | 1 |
| Baltrusch, S; Hofmeister-Brix, A; Lenzen, S | 1 |
| Edvinsson, L; Wang, SW; Xie, YH; Xu, CB; Zhang, Y | 1 |
| Hamajima, N; Johmura, Y; Nakanishi, M; Saitoh, S; Suzuki, S | 1 |
| Heikkila, JJ; Khan, S | 1 |
| Cebotaru, L; Cebotaru, V; Guggino, WB; Rapino, D | 1 |
| Lozano, G; Pant, V | 1 |
| Chen, S; Dai, Y; Grant, S; Jones, R; Leng, Y; Lin, H; Orlowski, RZ; Pei, XY; Zhang, Y; Zhou, L | 1 |
| Fujiwara, H; Ichikawa, D; Kitagawa, M; Komatsu, S; Konishi, H; Kosuga, T; Nakashima, S; Okamoto, K; Otsuji, E; Shiozaki, A | 1 |
| Ichinose, H; Kawahata, I; Ohtaku, S; Tomioka, Y; Yamakuni, T | 1 |
| Mayinger, P; Vallejo, MC | 1 |
| Fujita-Yamaguchi, Y; Hirose-Yotsuya, L; Itakura, K; Okamoto, F; Whitson, RH; Yamakawa, T | 1 |
| Dong, M; Fan, D; Geng, P; Hou, P; Huang, B; Li, H; Li, Y; Li, Z; Liu, D; Lu, J; Ma, M; Mihretab, A; Wang, G; Yao, R; Zhang, Y | 1 |
| Chang, PT; Fang, YC; Gan, YL; Hsu, PH; Huang, JJ; Jeng, CJ; Jow, GM; Ma, YT; Tang, CY | 1 |
| Chen, RJ; Chung, LC; Day, CH; Hsieh, YL; Huang, CY; Kuo, WW; Lin, KH; Shibu, MA; Viswanadha, VP; Wen, SY | 1 |
| Cao, H; Ren, SN; Tian, XF; Zang, HL | 1 |
| Iaria, J; Liu, S; Simpson, RJ; Zhu, HJ | 1 |
| Hirata, Y; Oh-Hashi, K; Takahashi, K | 1 |
| Deng, L; Fan, S; Lesinski, GB; Owonikoko, TK; Qian, G; Ramalingam, SS; Sun, SY; Zhang, S; Zheng, H | 1 |
| Jiang, C; Liu, J; Liu, Y; Nie, Z; Qiu, J; Sheng, Q; Yang, F; Zhu, B | 1 |
| Chen, BB; Evankovich, JW; Larsen, MB; Lear, TB; Lin, B; Liu, Y; Lockwood, KC; Ouyang, Y | 1 |
| Cuicui, L; Fei, X; Hongjia, F; Huan, F; Jialun, L; Jianpeng, X; Jie, W; Jiemin, W; Jing, F; Jing, L; Lin, Y; Lulu, W; Qiuju, W; Sha, L; Weiwei, Z; Ying, L; You, P; Zhaolin, M | 1 |
| Becker, S; Berkholz, J; Karle, W; Liem, CH; Munz, B; Muralikumar, S; Roos, K; Steinemann, G; Volkamer, A; Zakrzewicz, A | 1 |
| Aryal, N; Boiko, S; Cidado, J; Drew, L; Fawell, SE; Gregory, GP; Hattersley, M; Johnstone, RW; Proia, T; Saeh, JC; San Martin, M; Shao, W; Wu, MM | 1 |
| Cheung, ALM; Cheung, PY; Liu, J; Lv, L; Tsao, SW; Yang, H | 1 |
| Hirata, Y; Murase, R; Oh-Hashi, K; Yamamoto, A | 1 |
| Churchman, LS; Tye, BW | 1 |
146 other study(ies) available for cycloheximide and leupeptins
| Article | Year |
|---|---|
Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells.
Topics: Amino Acids; Arginine; Canavanine; Carcinoma, Hepatocellular; Cells, Cultured; Cycloheximide; Fetal Blood; Insulin; Leucine; Leupeptins; Liver Neoplasms; Neoplasm Proteins; Neoplasms, Experimental; Pepstatins; Phenylmethylsulfonyl Fluoride; Phosphoenolpyruvate Carboxykinase (GTP); Puromycin | 1976 |
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.
Topics: 1-Methyl-3-isobutylxanthine; Aprotinin; Blotting, Northern; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; DNA Replication; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Leupeptins; Male; Pentoxifylline; Phenylmethylsulfonyl Fluoride; Prostatic Neoplasms; RNA, Neoplasm; Theophylline; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Stimulation-enhanced 3-O-methylglucose efflux from the frog sartorius: kinetics and properties of the system.
Topics: 3-O-Methylglucose; Animals; Calcium; Cycloheximide; Dipeptides; Electric Stimulation; Humans; Kinetics; Leupeptins; Male; Methylglucosides; Muscles; Phloretin; Rana pipiens; Tetradecanoylphorbol Acetate | 1992 |
Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes.
Topics: Animals; Cell Survival; Chick Embryo; Chloroquine; Curare; Cycloheximide; Dactinomycin; Ganglia, Spinal; Gene Expression; Genotype; Leupeptins; Microscopy, Electron; Motor Neurons; Protein Biosynthesis; Puromycin; RNA; Spinal Cord | 1990 |
Inhibitory effects of recombinant human cystatin C on human coronaviruses.
Topics: Antiviral Agents; Cathepsin B; Cells, Cultured; Coronaviridae; Cycloheximide; Cystatin C; Cystatins; Escherichia coli; Humans; Leupeptins; Papain; Recombinant Proteins; Virus Replication | 1991 |
Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation.
Topics: Animals; Blotting, Western; Cells, Cultured; Chloroquine; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Insulin; Insulin Antagonists; Leucine; Leupeptins; Mice; Peptide Fragments; Receptor, Insulin | 1991 |
Inhibition of translational initiation by metalloendoprotease antagonists. Evidence for involvement of sequestered Ca2+ stores.
Topics: Amino Acid Sequence; Animals; Calcimycin; Calcium; Carrier Proteins; Cell Line; Cycloheximide; Dactinomycin; Dipeptides; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Immunoglobulin Heavy Chains; Inositol Phosphates; Kinetics; Leucine; Leupeptins; Metalloendopeptidases; Molecular Chaperones; Molecular Sequence Data; Oligopeptides; Peptide Chain Initiation, Translational; Phorbol 12,13-Dibutyrate; RNA, Messenger; Serine Endopeptidases; Tetradecanoylphorbol Acetate | 1991 |
Effects of calcium on protein turnover of incubated muscles from mdx mice.
Topics: Animals; Calcium; Cycloheximide; Kinetics; Leupeptins; Methylamines; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscles; Muscular Dystrophy, Animal; Proteins; Tyrosine | 1991 |
The effect of lysosomal inhibitors on protein degradation in cat hepatocyte monolayers.
Topics: Ammonium Chloride; Animals; Cats; Cells, Cultured; Cycloheximide; Insulin; Leucine; Leupeptins; Liver; Lysosomes; Proteins | 1991 |
Activation of cancer cell proteases and cytotoxicity by EGF and PDGF growth factors.
Topics: Amiloride; Animals; Cell Line; Cell Survival; Cells, Cultured; Cycloheximide; Enzyme Activation; Epidermal Growth Factor; Hemolysis; Humans; Leupeptins; Mice; Peptide Hydrolases; Platelet-Derived Growth Factor; Tosyllysine Chloromethyl Ketone; Tumor Cells, Cultured | 1990 |
Regression of autophagic vacuoles in pancreatic acinar, seminal vesicle epithelial, and liver parenchymal cells: a comparative morphometric study of the effect of vinblastine and leupeptin followed by cycloheximide treatment.
Topics: Animals; Cycloheximide; Epithelium; Leupeptins; Liver; Male; Mice; Mice, Inbred Strains; Oligopeptides; Organ Specificity; Organoids; Pancreas; Seminal Vesicles; Vacuoles; Vinblastine | 1988 |
Degradation of endocytosed dermatan sulfate proteoglycan in human fibroblasts.
Topics: Ammonium Chloride; Biological Transport; Cells, Cultured; Chondroitin; Chondroitin Sulfate Proteoglycans; Cycloheximide; Dermatan Sulfate; Diazomethane; Endocytosis; Fibroblasts; Half-Life; Humans; Kinetics; Leucine; Leupeptins; Lysosomes; Molecular Weight; Protease Inhibitors; Proteoglycans; Sulfates | 1988 |
Metabolic properties of human acetylcholine receptors can be characterized on cultured human muscle.
Topics: Cell Differentiation; Cell Division; Cells, Cultured; Cycloheximide; Humans; Kinetics; Leupeptins; Lysosomes; Muscles; Receptors, Cholinergic | 1986 |
Regulation of protein breakdown by epidermal growth factor in A431 cells.
Topics: Adenine; Ammonium Chloride; Autolysis; Carcinoma, Squamous Cell; Cell Line; Cycloheximide; Epidermal Growth Factor; Fibroblasts; Humans; Hydrogen-Ion Concentration; Insulin; Leupeptins; Lung; Proteins; Time Factors; Vinblastine | 1985 |
Effect of amino acids and cycloheximide on changes caused by vinblastine, leupeptin and methylamine in the autophagic/lysosomal system of mouse hepatocytes in vivo.
Topics: Amino Acids; Animals; Autophagy; Cycloheximide; Leupeptins; Liver; Lysosomes; Male; Methylamines; Mice; Organoids; Phagocytosis; Proteins; Vacuoles; Vinblastine | 1985 |
The digestion of phagocytosed collagen is inhibited by the proteinase inhibitors leupeptin and E-64.
Topics: 2,2'-Dipyridyl; Animals; Ascorbic Acid; Bone and Bones; Collagen; Culture Techniques; Cycloheximide; Cytochalasin B; Fibroblasts; Leucine; Leupeptins; Mice; Microscopy, Electron; Oligopeptides; Phagocytosis; Vacuoles | 1985 |
Quantitative assessment of the contribution of autophagy to intracellular protein breakdown.
Topics: Animals; Autolysis; Cathepsins; Cycloheximide; Cytoplasm; Drug Administration Schedule; Fasting; Homeostasis; Leupeptins; Liver; Lysosomes; Microtubules; Protein Conformation; Proteins; Rats | 1985 |
Effects of protein-degradation inhibitors on the inactivation of tyrosine aminotransferase, tryptophan oxygenase and benzopyrene hydroxylase in isolated rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cell Separation; Cycloheximide; In Vitro Techniques; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leupeptins; Liver; Male; Methylamines; Oligopeptides; Rats; Rats, Inbred Strains; Tryptophan Oxygenase; Tyrosine Transaminase | 1982 |
Morphometric study of the effect of leupeptin, vinblastine, estron acetate and cycloheximide on the autophagic vacuole-lysosomal compartments in mouse seminal vesicle cells.
Topics: Animals; Autophagy; Cycloheximide; Depression, Chemical; Estrone; Leupeptins; Lysosomes; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Oligopeptides; Phagocytosis; Seminal Vesicles; Vacuoles; Vinblastine | 1983 |
Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin.
Topics: Acid Phosphatase; Aminopeptidases; Animals; Autophagy; Cathepsin D; Cathepsin H; Cathepsins; Centrifugation, Density Gradient; Cycloheximide; Cysteine Endopeptidases; Cytoplasm; Dexamethasone; Fructose-Bisphosphate Aldolase; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Male; Oligopeptides; Organoids; Phagocytosis; Rats; Rats, Inbred Strains; Tyrosine Transaminase; Vacuoles | 1983 |
Metabolism of asialoglycoproteins in cultured rat hepatocytes: evidence for receptor mediated uptake and degradation which is not feed-back regulated.
Topics: alpha-Fetoproteins; Ammonium Chloride; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Cells, Cultured; Chloroquine; Cycloheximide; Fetuins; Leupeptins; Liver; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface | 1983 |
Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.
Topics: Animals; Cycloheximide; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Horseradish Peroxidase; In Vitro Techniques; Kinetics; Leupeptins; Ligands; Liver; Male; Microscopy, Electron; Rats; Receptors, Cell Surface; Subcellular Fractions | 1984 |
Adhesion of cells to polystyrene surfaces.
Topics: Animals; Bacteriological Techniques; Cell Adhesion; Cricetinae; Culture Media; Cycloheximide; Kidney; Leupeptins; Oxidation-Reduction; Polystyrenes; Trypsin | 1983 |
Degradation of proteins in rat liver mitochondrial outer membrane transplanted into different cell types. Evidence for alternative processing.
Topics: Ammonium Chloride; Animals; Cell Line; Cricetinae; Cycloheximide; Half-Life; Humans; Intracellular Membranes; Leucine; Leupeptins; Liver Neoplasms, Experimental; Membrane Proteins; Mice; Microscopy, Fluorescence; Mitochondria, Liver; Rats | 1984 |
Increased turnover of proteins from the sarcoplasmic reticulum of dystrophic chicken muscle cells in tissue culture.
Topics: Animals; Cells, Cultured; Chick Embryo; Cycloheximide; Kinetics; Leupeptins; Methionine; Muscle Proteins; Muscles; Muscular Dystrophy, Animal; Sarcoplasmic Reticulum | 1981 |
Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Cholesterol Esters; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Esterification; Female; Hydroxycholesterols; Leucine; Leupeptins; Lipoproteins, VLDL; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Microscopy, Fluorescence; Sphingomyelin Phosphodiesterase | 1995 |
Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of cysteine proteinases inhibitors.
Topics: Animals; Bone Resorption; Cathepsin B; Cells, Cultured; Culture Techniques; Cycloheximide; Fibroblasts; Hydrolases; Leupeptins; Mice; Parathyroid Hormone; Protein Biosynthesis; Proteins; Rats; Rats, Wistar; Skull; Time Factors | 1994 |
Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes.
Topics: 3T3 Cells; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Cycloheximide; Endoplasmic Reticulum; Golgi Apparatus; Hexosaminidases; Leupeptins; Lysosomes; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Peptide Fragments; Receptors, Erythropoietin | 1993 |
Selective degradation of accumulated secretory proteins in the endoplasmic reticulum. A possible clearance pathway for abnormal tropoelastin.
Topics: Ammonium Chloride; Animals; Blotting, Northern; Brefeldin A; Cattle; Cells, Cultured; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum; Leucine; Leupeptins; Ligaments; Microscopy, Electron; Nocodazole; Organelles; Protein Synthesis Inhibitors; RNA, Messenger; Serine Proteinase Inhibitors; Transcription, Genetic; Tropoelastin | 1996 |
Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells.
Topics: Apoptosis; Calpain; Coumarins; Cycloheximide; Cysteine Proteinase Inhibitors; Diazomethane; HL-60 Cells; Humans; Isocoumarins; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Serine Proteinase Inhibitors | 1996 |
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Nucleus; Cycloheximide; Daunorubicin; DNA-Binding Proteins; Humans; I-kappa B Proteins; Interleukin-1; Leupeptins; Neoplasms; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Synthesis Inhibitors; Radiation, Ionizing; Staurosporine; Transcription Factor RelA; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Topics: Acetylcysteine; Animals; Benzoquinones; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Enzyme Inhibitors; Half-Life; Humans; Lactams, Macrocyclic; Leupeptins; Mice; Multienzyme Complexes; Mutation; Octoxynol; Polyethylene Glycols; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Quinones; Rats; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin.
Topics: Acetylcysteine; Animals; beta-Galactosidase; Blotting, Northern; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Compartmentation; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kidney; Leupeptins; Lysosomes; Microscopy, Confocal; Multienzyme Complexes; Opossums; Parathyroid Hormone; Phosphates; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters | 1998 |
Proteasome inhibition leads to the activation of all members of the heat-shock-factor family.
Topics: Animals; Avian Proteins; Cell Nucleus; Chickens; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Erythroblasts; Heat Shock Transcription Factors; Heat-Shock Proteins; Kinetics; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Trans-Activators; Transcription Factors; Tunicamycin | 1998 |
Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Animals; ATPases Associated with Diverse Cellular Activities; Calcitriol; Carrier Proteins; Cloning, Molecular; Cycloheximide; Cysteine Endopeptidases; Gene Expression Regulation; Half-Life; Intracellular Signaling Peptides and Proteins; Lactones; Leupeptins; Ligands; LIM Domain Proteins; Mice; Multienzyme Complexes; Osteosarcoma; Peptide Fragments; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Structure, Secondary; Receptors, Calcitriol; Transcription Factors; Transfection; Tumor Cells, Cultured | 1998 |
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes.
Topics: Adenosine Triphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chloroquine; Cycloheximide; Cysteine Endopeptidases; Cytochalasin B; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Isoenzymes; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Pituitary Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Rats; Thyroxine; Triiodothyronine, Reverse; Tumor Cells, Cultured; Ubiquitins | 1998 |
Termination of growth hormone pulse-induced STAT5b signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cycloheximide; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Growth Hormone; Janus Kinase 2; Leupeptins; Liver; Milk Proteins; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Somatotropin; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Vanadates | 1999 |
Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; Electrophoresis; Female; Genistein; Growth Hormone; Growth Inhibitors; Janus Kinase 2; Leupeptins; Liver; Male; Milk Proteins; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Vanadates | 1999 |
The pathway regulating MDM2 protein degradation can be altered in human leukemic cells.
Topics: Burkitt Lymphoma; Cell Division; Cycloheximide; Cysteine Endopeptidases; Genes, p53; Half-Life; Humans; Jurkat Cells; Leukemia-Lymphoma, Adult T-Cell; Leukocytes, Mononuclear; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Nuclear Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway.
Topics: 3T3 Cells; Acetylcysteine; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Hemagglutinins; Humans; Leupeptins; Mice; Models, Genetic; Multienzyme Complexes; Mutagenesis; Osteosarcoma; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Time Factors; Transfection; Tumor Cells, Cultured; Ubiquitins | 1999 |
Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation.
Topics: Apoptosis; Benzoquinones; Cell Survival; Cycloheximide; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Genes, Reporter; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; I-kappa B Kinase; Kinetics; Lactams, Macrocyclic; Leupeptins; Luciferases; NF-kappa B; Protein Serine-Threonine Kinases; Proteins; Quinones; Receptor-Interacting Protein Serine-Threonine Kinases; Recombinant Proteins; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Ubiquitin/proteasome pathway regulates levels of retinoic acid receptor gamma and retinoid X receptor alpha in human keratinocytes.
Topics: Amino Acid Motifs; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation; HeLa Cells; Humans; Keratinocytes; Kinetics; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Receptors, Retinoic Acid; Retinoic Acid Receptor gamma; Retinoid X Receptors; RNA, Messenger; Sequence Deletion; Transcription Factors; Transfection; Ubiquitins; Ultraviolet Rays | 2000 |
The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Animals; beta-Galactosidase; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cholesterol; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Leupeptins; Lovastatin; Oligopeptides; Peptide Hydrolases; Precipitin Tests; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Tricarboxylic Acids; Ubiquitins | 2000 |
Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Caspases; Cell Survival; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Glioma; Humans; Lactams; Leupeptins; Membrane Glycoproteins; Mice; Mitochondria; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Transgenes; Tumor Cells, Cultured | 2000 |
NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling.
Topics: Antibodies, Monoclonal; Apoptosis; Benzoquinones; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; CD40 Antigens; Cell Line; Cycloheximide; DNA-Binding Proteins; HeLa Cells; Humans; I-kappa B Proteins; Interleukin-1; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Lactams, Macrocyclic; Leupeptins; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Quinones; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 2001 |
PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.
Topics: Acetophenones; Benzopyrans; Cell Division; Cycloheximide; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; GADD45 Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Leupeptins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Proteins; Pyridines; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitins | 2001 |
Reversion of temperature-sensitive mutation by inhibition of proteasome-mediated degradation of mutated D123 protein.
Topics: Acetylcysteine; Animals; Antigens, Polyomavirus Transforming; Base Sequence; Cell Cycle Proteins; Cell Division; Cell Line, Transformed; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genetic Complementation Test; Hybrid Cells; Leupeptins; Multienzyme Complexes; Point Mutation; Proteasome Endopeptidase Complex; Proteins; Rats; Temperature; Ubiquitin | 2001 |
Regulation of functional nuclear pore size in fibroblasts.
Topics: 3T3 Cells; Active Transport, Cell Nucleus; Animals; Benzothiazoles; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diffusion; Fibroblasts; Gold Colloid; Leupeptins; Mice; Multienzyme Complexes; Nuclear Localization Signals; Nuclear Pore; Proteasome Endopeptidase Complex; Thiazoles; Toluene; Tumor Suppressor Protein p53 | 2001 |
The susceptibility to Fas-induced apoptosis in normal enterocytes is regulated on the level of cIAP1 and 2.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Line; Cycloheximide; Down-Regulation; Enterocytes; fas Receptor; Fas-Associated Death Domain Protein; Humans; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Leupeptins; NF-kappa B; Proteins; RNA, Messenger; Ubiquitin-Protein Ligases; Up-Regulation | 2002 |
Evidence for a pre-restriction point Cdk3 activity.
Topics: Animals; Cells, Cultured; CHO Cells; Cricetinae; Cyclin-Dependent Kinases; Cycloheximide; Cysteine Endopeptidases; Enzyme Inhibitors; G1 Phase; Leupeptins; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Kinases; Protein Synthesis Inhibitors; Purines; Replication Origin; Roscovitine | 2002 |
Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells.
Topics: 14-3-3 Proteins; Amino Acids; Animals; Carrier Proteins; Cell Extracts; Chromones; Cycloheximide; Enzyme Inhibitors; Epidermal Growth Factor; Glucose; Growth Substances; Intracellular Signaling Peptides and Proteins; Leupeptins; Morpholines; Nerve Growth Factor; PC12 Cells; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Tyrosine 3-Monooxygenase | 2002 |
Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.
Topics: Acetylcysteine; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Cysteine Endopeptidases; Doxorubicin; Fibroblasts; HeLa Cells; Humans; Hydrogen Peroxide; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Oxidative Stress; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Reactive Oxygen Species | 2002 |
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.
Topics: Acetylcysteine; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Blood; Cell Line; Cycloheximide; Cysteine Endopeptidases; Feedback, Physiological; Gene Expression Regulation; Glycosyltransferases; Half-Life; Homeodomain Proteins; Leupeptins; Mesoderm; Mice; Multienzyme Complexes; PC12 Cells; Periodicity; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Transcription Factor HES-1; Transcription, Genetic; Transfection; Ubiquitin | 2002 |
Facilitation of fas mediated apoptosis of human chondrocytes by the proteasome inhibitor and actinomycin D.
Topics: Antibodies, Monoclonal; Apoptosis; Cartilage, Articular; Caspase Inhibitors; Cells, Cultured; Chondrocytes; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Inhibitors; fas Receptor; Humans; Imidazoles; Indoles; Leupeptins; Maleimides; MAP Kinase Signaling System; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Pyridines | 2003 |
C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.
Topics: Carcinoma, Squamous Cell; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins; Cell Line; Cycloheximide; Cysteine Endopeptidases; Dimerization; Humans; Kidney; Leucine Zippers; Leupeptins; Melanoma; Methyl Methanesulfonate; Multienzyme Complexes; Neoplasm Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Sequence Deletion; Transcription Factor CHOP; Transcription Factors; Tumor Cells, Cultured; Ubiquitin | 2003 |
The cleavage product deltaPML-RARalpha contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Arsenic; Blotting, Western; Cell Differentiation; Cell Line; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Leukemia, Promyelocytic, Acute; Leupeptins; Luciferases; Multienzyme Complexes; Neoplasm Proteins; Oncogene Proteins, Fusion; Plasmids; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Transcriptional Activation; Transfection; Tretinoin; Tumor Cells, Cultured | 2003 |
Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation.
Topics: Amino Acid Sequence; Blotting, Northern; Cell Differentiation; Cell Nucleus; Cycloheximide; Cysteine Endopeptidases; Cytoplasm; Dimerization; DNA; Homeodomain Proteins; Immunoblotting; Kinetics; Leupeptins; Models, Biological; Molecular Sequence Data; Multienzyme Complexes; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Proteasome Endopeptidase Complex; Protein Binding; Protein Biosynthesis; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Teratocarcinoma; Time Factors; Transfection; Tretinoin; Tumor Cells, Cultured | 2003 |
P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Cycle Proteins; Cells, Cultured; Cyclin D; Cyclin D3; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leupeptins; Mice; Models, Biological; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; RNA, Messenger; Time Factors; Tumor Suppressor Proteins | 2003 |
Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1.
Topics: Cell Line; Circular Dichroism; Cycloheximide; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Escherichia coli; Gene Deletion; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Mass Spectrometry; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation; Neurons; Oncogene Proteins; Parkinson Disease; Point Mutation; Proteasome Endopeptidase Complex; Protein Conformation; Protein Deglycase DJ-1; Protein Folding; Protein Structure, Secondary; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Temperature; Time Factors | 2004 |
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha.
Topics: Antioxidants; Cell Hypoxia; Cell Line; Cell Respiration; Cycloheximide; Cysteine Proteinase Inhibitors; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Luciferases; Methacrylates; Mitochondria; Nitric Oxide; Nitric Oxide Donors; Oxygen; Procollagen-Proline Dioxygenase; Protein Synthesis Inhibitors; Reactive Oxygen Species; Recombinant Fusion Proteins; Signal Transduction; Thiazoles; Transcription Factors; Transfection; Triazenes | 2003 |
Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation.
Topics: 4-Aminobenzoic Acid; Alleles; Arylamine N-Acetyltransferase; Binding Sites; Blotting, Western; Cell Line, Tumor; Cloning, Molecular; Cycloheximide; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Complementary; Down-Regulation; Escherichia coli; Genotype; Glutathione Transferase; Humans; Isoenzymes; Leukocytes, Mononuclear; Leupeptins; Models, Biological; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation; Oxidative Stress; Peptide Hydrolases; Phenotype; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Synthesis Inhibitors; Recombinant Proteins; Time Factors; Ubiquitin | 2004 |
Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1.
Topics: Apoptosis; Calpain; Caspases; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leupeptins; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2004 |
Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome.
Topics: Anisomycin; Cycloheximide; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA; Enzyme Induction; Fatty Acids, Unsaturated; Humans; Leucine; Leupeptins; Polychlorinated Dibenzodioxins; Proteasome Endopeptidase Complex; Protein Biosynthesis; Puromycin; Receptors, Aryl Hydrocarbon; Tritium; Tumor Cells, Cultured | 2004 |
Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways.
Topics: Breast Neoplasms; Cycloheximide; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Immunoenzyme Techniques; Lactones; Leupeptins; Ligands; Macrolides; Molecular Chaperones; Proteasome Inhibitors; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Pyrrolidines; Signal Transduction; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 2004 |
Role of the proteasome in the regulation of estrogen receptor alpha turnover and function in MCF-7 breast carcinoma cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cycloheximide; Down-Regulation; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Genes, Reporter; Humans; Leupeptins; Ligands; Luciferases; Methionine; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Sulfur Radioisotopes; Tamoxifen; Transcription, Genetic; Tritium | 2005 |
Distinct IkappaB kinase regulation in adult T cell leukemia and HTLV-I-transformed cells.
Topics: Arsenites; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cycloheximide; Enzyme Inhibitors; Human T-lymphotropic virus 1; Humans; I-kappa B Kinase; Leukemia-Lymphoma, Adult T-Cell; Leupeptins; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; T-Lymphocytes | 2005 |
Membrane insertion of betaine/GABA transporter during hypertonic stress correlates with nuclear accumulation of TonEBP.
Topics: Animals; Betaine; Biological Transport; Biotinylation; Blotting, Western; Carrier Proteins; Cell Line; Cell Membrane; Cell Nucleus; Cycloheximide; Cytoplasm; Dogs; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; Gastrointestinal Agents; Green Fluorescent Proteins; Kidney; Leupeptins; Membrane Transport Proteins; Microscopy, Confocal; Protein Synthesis Inhibitors; Regression Analysis; Sodium; Time Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 2005 |
Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; GATA2 Transcription Factor; Gene Deletion; Gene Expression Regulation; Half-Life; Humans; Leukemia, Experimental; Leupeptins; Mice; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcriptional Activation; Ubiquitins; Ultraviolet Rays | 2005 |
Participation of the ubiquitin-proteasome pathway in rat oocyte activation.
Topics: Animals; Cell Nucleus Structures; Cells, Cultured; Colchicine; Cycloheximide; Cysteine Proteinase Inhibitors; Cytochalasin B; Female; Leupeptins; Meiosis; Oocytes; Parthenogenesis; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Ubiquitin | 2005 |
Regulatory mechanisms modulating the expression of cytochrome P450 1A1 gene by heavy metals.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cycloheximide; Cytochrome P-450 CYP1A1; Dactinomycin; Drug Interactions; Enzyme Induction; Gene Expression Regulation, Neoplastic; Hepatocytes; Leupeptins; Metals, Heavy; Mice; Polychlorinated Dibenzodioxins; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Response Elements; RNA, Messenger | 2005 |
Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta.
Topics: Animals; Cell Line; Cycloheximide; Doxorubicin; Endoplasmic Reticulum; Fatty Acids, Unsaturated; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Leupeptins; Mice; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Protein Transport; Serine; Signal Transduction; Thapsigargin; Tumor Suppressor Protein p53; Tunicamycin; Ubiquitin; Ubiquitin-Protein Ligases | 2005 |
Role of protein turnover in the activation of p38 mitogen-activated protein kinase in rat pinealocytes.
Topics: Animals; Cycloheximide; Dactinomycin; Enzyme Activation; Leupeptins; Male; MAP Kinase Kinase 3; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Norepinephrine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pineal Gland; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley | 2005 |
TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27(KIP1) protein.
Topics: Breast; Cell Adhesion; Cell Cycle; Cell Line; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Cycloheximide; Epithelial Cells; Female; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Retinoblastoma Protein; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2006 |
Proteasome inhibition induces both pro- and anti-cell death pathways in prostate cancer cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Autophagy; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Cytokines; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Humans; Intercellular Signaling Peptides and Proteins; Leupeptins; Male; Microscopy, Electron; Molecular Chaperones; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Synthesis Inhibitors; Signal Transduction | 2006 |
The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines.
Topics: Active Transport, Cell Nucleus; Animals; Cell Cycle; Cell Nucleus; Cyclin D1; Cycloheximide; Cytoplasm; Enzyme Inhibitors; Exportin 1 Protein; Fatty Acids, Unsaturated; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Karyopherins; Leupeptins; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Mas; Receptors, Cytoplasmic and Nuclear; Transfection | 2006 |
A novel mouse Smad4 mutation reduces protein stability and wild-type protein levels.
Topics: Alleles; Animals; Cycloheximide; Cysteine Proteinase Inhibitors; Embryo, Mammalian; Genes, Dominant; Heterozygote; Leupeptins; Mice; Mice, Knockout; Mutation; Neoplasms; Phenotype; Protein Synthesis Inhibitors; Signal Transduction; Smad4 Protein; Stem Cells | 2006 |
Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate.
Topics: Androgen Receptor Antagonists; Anticarcinogenic Agents; Cell Line, Tumor; Cycloheximide; Humans; Isothiocyanates; Leupeptins; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Sp1 Transcription Factor; Transcription, Genetic | 2006 |
Cannabinoid signalling in TNF-alpha induced IL-8 release.
Topics: Benzoxazines; Blotting, Western; Cannabinoid Receptor Agonists; Cannabinoids; Cycloheximide; Cysteine Proteinase Inhibitors; Dactinomycin; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; HT29 Cells; Humans; I-kappa B Proteins; Interleukin-8; Leupeptins; Morpholines; Naphthalenes; NF-kappa B; Protein Synthesis Inhibitors; Receptors, Cannabinoid; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 2006 |
Multilevel regulation of leptin storage, turnover, and secretion by feeding and insulin in rat adipose tissue.
Topics: Adipocytes; Adipose Tissue; Animals; Blotting, Northern; Body Weight; Chloroquine; Cycloheximide; Insulin; Iodine Isotopes; Leptin; Leupeptins; Lysosomes; Male; Rats; Rats, Wistar; RNA, Messenger; Starvation; Sulfur Isotopes | 2006 |
Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.
Topics: Animals; Cycloheximide; Enzyme Stability; Leupeptins; Melanins; Melanoma, Amelanotic; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Oxidoreductases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Protein Subunits; Protein Transport | 2006 |
Local sharing as a predominant determinant of synaptic matrix molecular dynamics.
Topics: Animals; Animals, Newborn; Biological Transport; Carrier Proteins; Cell Communication; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; Dendritic Cells; Green Fluorescent Proteins; Leupeptins; Nerve Tissue Proteins; Neuronal Plasticity; Presynaptic Terminals; Protein Denaturation; Protein Synthesis Inhibitors; Protein Transport; Rats; Rats, Wistar; Synapses; Synapsins; Synaptic Transmission; Synaptic Vesicles; Tissue Distribution | 2006 |
Lithium ions increase hepatic glycogen synthase stability through a proteasome-related mechanism.
Topics: Animals; Calpain; Cations, Monovalent; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Activation; Glycogen Synthase; Glycogen Synthase Kinase 3; Hepatocytes; Leupeptins; Lithium Chloride; Liver Glycogen; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2007 |
Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.
Topics: Apoptosis; Cycloheximide; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Profiling; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-4; Leupeptins; Neutrophils; Pyridines; Receptors, Interleukin-4, Type I; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship; Suppressor of Cytokine Signaling Proteins; Tyrphostins | 2007 |
Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells.
Topics: Animals; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Caspases; Cell Line; Cell Line, Tumor; Cholangiocarcinoma; Cycloheximide; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Humans; Leupeptins; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Synthesis Inhibitors; Rats | 2007 |
Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite.
Topics: Anaphase-Promoting Complex-Cyclosome; Apoptosis; Arsenites; Carcinogens, Environmental; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Cell Survival; Cyclin B; Cyclin B1; Cycloheximide; Enzyme Activation; G2 Phase; Humans; Imidazoles; Leupeptins; MAP Kinase Signaling System; Micronuclei, Chromosome-Defective; Mitogen-Activated Protein Kinase 14; Mitosis; Peptide Hydrolases; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Pyridines; Sodium Compounds; Ubiquitin; Ubiquitin-Protein Ligase Complexes | 2007 |
Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells.
Topics: Cell Cycle; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cycloheximide; Cysteine Proteinase Inhibitors; Embryonic Stem Cells; Flow Cytometry; G1 Phase; G2 Phase; Humans; Immunoblotting; Leupeptins; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; S Phase; S-Phase Kinase-Associated Proteins; Ubiquitin | 2007 |
Absence of Bax switched MG132-induced apoptosis to non-apoptotic cell death that could be suppressed by transcriptional or translational inhibition.
Topics: Adenosine Triphosphate; Apoptosis; bcl-2-Associated X Protein; Cycloheximide; Dactinomycin; Endoplasmic Reticulum; HCT116 Cells; Humans; Leupeptins; Necrosis; Polyubiquitin; Proteasome Inhibitors; Protein Biosynthesis; Protein Folding; Protein Structure, Quaternary; Transcription, Genetic; Vacuoles | 2007 |
Regulation of bim in glucocorticoid-mediated osteoblast apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Bone Marrow Cells; Cells, Cultured; Culture Media, Serum-Free; Cycloheximide; Cysteine Proteinase Inhibitors; Dexamethasone; Dose-Response Relationship, Drug; Extracellular Matrix; Glucocorticoids; Humans; Leupeptins; Membrane Proteins; Mifepristone; Osteoblasts; Proto-Oncogene Proteins; Receptors, Glucocorticoid; RNA, Messenger; RNA, Small Interfering; Stromal Cells; Time Factors; Up-Regulation | 2008 |
Differential GATA factor stabilities: implications for chromatin occupancy by structurally similar transcription factors.
Topics: Animals; Cell Line, Tumor; Cell Nucleus; Chromatin; Chromatin Immunoprecipitation; Cycloheximide; Cysteine Proteinase Inhibitors; GATA1 Transcription Factor; GATA2 Transcription Factor; Gene Expression; Humans; K562 Cells; Leupeptins; Mice; Mutation; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Tamoxifen; Transcription Factors; Transfection | 2008 |
Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion.
Topics: Apoptosis; Autophagy; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Inclusion Bodies; Keratins; Leupeptins; Organelles; Proteasome Inhibitors; Protein Synthesis Inhibitors | 2008 |
Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cobalt; Cycloheximide; Cysteine-Rich Protein 61; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kinetics; Leupeptins; MAP Kinase Signaling System; Neoplasm Invasiveness; Neoplasm Proteins; Plasminogen Activator Inhibitor 1; Protein Biosynthesis; Protein Synthesis Inhibitors; Recombinant Proteins; RNA, Messenger; Stomach Neoplasms; Up-Regulation | 2008 |
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
Topics: Acetylcysteine; Animals; Cell Cycle; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Leupeptins; NAD(P)H Dehydrogenase (Quinone); Nuclear Proteins; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Serine; Tumor Suppressor Proteins; Ultraviolet Rays | 2008 |
Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cycloheximide; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expression Regulation; Leupeptins; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Sequence Deletion | 2008 |
MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.
Topics: Animals; Binding Sites; Cell Line; Cell Membrane; Cycloheximide; Dogs; Enzyme Inhibitors; Humans; Imidazoles; Kidney Medulla; Leupeptins; Male; Membrane Transport Proteins; Mice; Piperazines; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Sequence Deletion; Ubiquitin-Protein Ligases; Ubiquitination; Urea; Urea Transporters | 2008 |
Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus.
Topics: Adenosine Triphosphatases; Animals; Apolipoprotein B-100; Binding Sites; Cell Cycle Proteins; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Cycloheximide; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Leupeptins; Membrane Proteins; Molecular Chaperones; Mutation; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Selenoproteins; Transduction, Genetic; Transfection; Ubiquitin-Protein Ligases; Valosin Containing Protein | 2009 |
The DOUBLETIME protein kinase regulates phosphorylation of the Drosophila PDP1epsilon.
Topics: Animals; Animals, Genetically Modified; Casein Kinase 1 epsilon; Cell Line, Transformed; Cell Nucleus; Circadian Rhythm; Cycloheximide; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drosophila; Drosophila Proteins; Gene Expression Regulation; Green Fluorescent Proteins; Immunoprecipitation; Leupeptins; Phosphorylation; Protein Synthesis Inhibitors; RNA Interference; Transfection; Ubiquitin-Protein Ligases | 2009 |
The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway.
Topics: Benzoates; Cell Nucleus; Cell Proliferation; Cycloheximide; Cysteine Proteinase Inhibitors; Cytoplasm; Doxycycline; Enzyme Inhibitors; Furans; Gene Expression Regulation; HeLa Cells; Humans; Leupeptins; Oligopeptides; Peptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyrazoles; Recombinant Fusion Proteins; Transcription Factors; Transfection; Ubiquitin; Ubiquitin-Activating Enzymes | 2010 |
alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells.
Topics: alpha-Crystallin B Chain; Bleomycin; Butadienes; Cells, Cultured; Cyclin D1; Cycloheximide; DNA Damage; Etoposide; Humans; Leupeptins; Melanocytes; Melanoma; Mutant Proteins; Mutation; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; Tetracycline | 2010 |
Ubiquitin-independent degradation of antiapoptotic MCL-1.
Topics: Alleles; Animals; Apoptosis; Cell Line; Cycloheximide; Embryo, Mammalian; Fibroblasts; Half-Life; Hematopoietic System; Humans; Leupeptins; Mice; Mutant Proteins; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Stability; Proto-Oncogene Proteins c-bcl-2; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination | 2010 |
Regulation of intracellular decorin via proteasome degradation in rat mesangial cells.
Topics: Animals; Cell Proliferation; Collagen Type IV; Cycloheximide; Decorin; Flow Cytometry; Gene Expression Regulation; Glycosylation; Half-Life; Intracellular Space; Leupeptins; Lysosomes; Male; Mesangial Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta1; Tunicamycin; Ubiquitination | 2010 |
Modulation of hypoxia-inducible factor-1α expression by mitochondrial NADP+-dependent isocitrate dehydrogenase.
Topics: Acetylcysteine; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Isocitrate Dehydrogenase; Leupeptins; Mitochondrial Proteins; Phosphatidylinositol 3-Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Sp1 Transcription Factor | 2010 |
Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cycloheximide; Cysteine Proteinase Inhibitors; DNA Mismatch Repair; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Inhibitory Concentration 50; Leupeptins; Phenotype; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Synthesis Inhibitors; Recombinant Proteins; RNA Interference; Time Factors; TNF-Related Apoptosis-Inducing Ligand | 2010 |
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Cell Line, Tumor; Cerebral Cortex; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lewy Bodies; Neurons; Okadaic Acid; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Phosphatase 1; Protein Phosphatase 2; Protein Synthesis Inhibitors; Rabbits; Ubiquitin | 2010 |
Gambogic acid enhances proteasome inhibitor-induced anticancer activity.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Boronic Acids; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Survival; Cycloheximide; Cysteine Proteinase Inhibitors; Drug Synergism; Humans; K562 Cells; Leupeptins; Male; Mice; Neoplasms, Experimental; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Synthesis Inhibitors; Signal Transduction; Transplantation, Homologous; Tumor Burden; Xanthones | 2011 |
PEST motif sequence regulating human NANOG for proteasomal degradation.
Topics: Amino Acid Motifs; Amino Acid Sequence; Cell Line; Cycloheximide; Embryonic Stem Cells; Gene Expression; Half-Life; Homeodomain Proteins; Humans; Leupeptins; Molecular Sequence Data; Nanog Homeobox Protein; Polyubiquitin; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proteolysis; Recombinant Fusion Proteins; Ubiquitination; Up-Regulation | 2011 |
Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.
Topics: Acetylcysteine; Cell Culture Techniques; Cloning, Molecular; Cycloheximide; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Gene Expression; Immunoprecipitation; Kinetics; Leishmania donovani; Leishmaniasis, Visceral; Leupeptins; Methionine Adenosyltransferase; Oligopeptides; Plasmids; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; S-Adenosylmethionine; Transfection; Ubiquitin | 2011 |
The nucleolus directly regulates p53 export and degradation.
Topics: 3T3 Cells; Active Transport, Cell Nucleus; Animals; Cell Fusion; Cell Line, Tumor; Cell Nucleolus; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; Cycloheximide; Cytoplasm; Demecolcine; DNA Damage; Fatty Acids, Unsaturated; Green Fluorescent Proteins; Humans; Intranuclear Space; Leupeptins; Mice; Models, Biological; Nucleolus Organizer Region; Photobleaching; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-mdm2; Recombinant Fusion Proteins; Ribosomal Proteins; Subcellular Fractions; Tumor Suppressor Protein p53; Ubiquitin; Ubiquitination | 2011 |
Posttranslational regulation of the iron deficiency basic helix-loop-helix transcription factor FIT is affected by iron and nitric oxide.
Topics: Animals; Arabidopsis; Arabidopsis Proteins; Basic Helix-Loop-Helix Transcription Factors; Cycloheximide; Cysteine Proteinase Inhibitors; Gene Expression Regulation, Plant; Iron; Leupeptins; Mice; Models, Biological; Nitric Oxide; Plant Leaves; Plant Roots; Plants, Genetically Modified; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Seedlings | 2011 |
Neddylation positively regulates the ubiquitin E3 ligase activity of parkin.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cells, Cultured; Cycloheximide; Embryo, Mammalian; Gene Expression Regulation; Hippocampus; Humans; Immunoprecipitation; Leupeptins; Mutation; NEDD8 Protein; Neuroblastoma; Neurotoxins; Protein Binding; Protein Synthesis Inhibitors; Rats; RNA, Small Interfering; Sincalide; Stem Cells; Subcellular Fractions; Time Factors; Transfection; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitins | 2012 |
SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis.
Topics: Benzoquinones; Cycloheximide; Heat-Shock Response; HEK293 Cells; HeLa Cells; Humans; Lactams, Macrocyclic; Leupeptins; Models, Biological; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Protein Synthesis Inhibitors; Puromycin; Small Ubiquitin-Related Modifier Proteins; Sumoylation; Ubiquitins | 2012 |
Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.
Topics: Adenine; Animals; Autophagy; Carboxylic Ester Hydrolases; Cycloheximide; Green Fluorescent Proteins; HEK293 Cells; Humans; Leupeptins; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Protein Structure, Tertiary; Proteolysis; Recombinant Fusion Proteins | 2012 |
Enhancing protein stability with retained biological function in transgenic plants.
Topics: Acetates; Arabidopsis; Arabidopsis Proteins; Basic Helix-Loop-Helix Transcription Factors; Cycloheximide; Cyclopentanes; DNA-Binding Proteins; Gene Expression Regulation, Plant; Half-Life; Leupeptins; Nuclear Proteins; Oxylipins; Phenotype; Plant Growth Regulators; Plants, Genetically Modified; Protein Isoforms; Protein Stability; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Seedlings; Transcription Factors | 2012 |
Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.
Topics: Acoustic Stimulation; Amphetamine; Analysis of Variance; Animals; Astrocytes; Brain; Cell Line, Transformed; Cycloheximide; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Glial Fibrillary Acidic Protein; Humans; Inhibition, Psychological; Leupeptins; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neuroprotective Agents; Protein Binding; Racemases and Epimerases; Reflex, Startle; Schizophrenia; Serine; Transfection | 2013 |
Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Calcium; Calcium Ionophores; Calpain; Cycloheximide; Cysteine Proteinase Inhibitors; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Emetine; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Ionomycin; K Cl- Cotransporters; Leupeptins; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Protein Synthesis Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Statistics, Nonparametric; Symporters; Valine | 2012 |
Phenazine methosulfate decreases HIF-1α accumulation during the exposure of cells to hypoxia.
Topics: Calcium-Binding Proteins; Cell Hypoxia; Cycloheximide; Cysteine Proteinase Inhibitors; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Methylphenazonium Methosulfate; Oxidants; Oxygen; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Stability; Protein Synthesis Inhibitors; Proteolysis; Signal Transduction | 2012 |
Cellular acidosis inhibits assembly, disassembly, and motility of stress granules.
Topics: Cycloheximide; Cytoplasmic Granules; Eukaryotic Initiation Factor-2; Fluorescence Recovery After Photobleaching; HeLa Cells; Humans; Hydrogen-Ion Concentration; Leupeptins; Microtubules; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Ribonucleoproteins | 2012 |
Clathrin light chains regulate clathrin-mediated trafficking, auxin signaling, and development in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Membrane; Clathrin Heavy Chains; Clathrin Light Chains; Cycloheximide; Endosomes; F-Box Proteins; Gravitropism; Indoleacetic Acids; Leupeptins; Mutation; Plant Proteins; Plants, Genetically Modified; Receptors, Cell Surface; Signal Transduction; trans-Golgi Network | 2013 |
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.
Topics: Cell Count; Cell Cycle; Cell Line; Cell Proliferation; Cell Size; Cycloheximide; Dimethyl Sulfoxide; Feedback, Physiological; G1 Phase; HeLa Cells; Humans; Leupeptins; Phosphoproteins; S Phase; Single-Cell Analysis; Sirolimus | 2013 |
CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.
Topics: Amino Acid Sequence; Cell Line; Cell Movement; Conserved Sequence; Cullin Proteins; Cycloheximide; F-Box Proteins; Gene Expression Regulation; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Humans; Leupeptins; Molecular Sequence Data; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Synthesis Inhibitors; Protein-Arginine N-Methyltransferases; Proteolysis; RNA, Small Interfering; Smad2 Protein; Transforming Growth Factor beta; Ubiquitin-Protein Ligases; Ubiquitination | 2013 |
The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.
Topics: Acetylcysteine; Animals; Chlorocebus aethiops; COS Cells; Cycloheximide; Glucokinase; Glucose; Hepatocytes; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Leupeptins; Mice; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proteolysis; Single-Cell Analysis; Ubiquitin; Ubiquitination | 2013 |
Nuclear Factor-kappaB-Mediated Endothelin Receptor Up-Regulation Increases Renal Artery Contractility in Rats.
Topics: Animals; Cycloheximide; Dactinomycin; Imidazoles; Leupeptins; Male; Muscle, Smooth, Vascular; NF-kappa B; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Endothelin A; Receptor, Endothelin B; Renal Artery; Signal Transduction; Up-Regulation; Vasoconstriction; Viper Venoms | 2013 |
Increased protein stability of CDKN1C causes a gain-of-function phenotype in patients with IMAGe syndrome.
Topics: Adrenal Insufficiency; Base Sequence; Blotting, Western; Cyclin-Dependent Kinase Inhibitor p57; Cycloheximide; Exome; Female; Fetal Growth Retardation; Flow Cytometry; Gene Components; Humans; Leupeptins; Male; Molecular Sequence Data; Mutation, Missense; Osteochondrodysplasias; Pedigree; Phenotype; Proliferating Cell Nuclear Antigen; Protein Stability; Sequence Analysis, DNA; Siblings; Urogenital Abnormalities | 2013 |
Distinct patterns of HSP30 and HSP70 degradation in Xenopus laevis A6 cells recovering from thermal stress.
Topics: Animals; Cell Line; Cycloheximide; Epithelial Cells; Heat-Shock Response; HSP30 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Stability; Protein Synthesis Inhibitors; Proteolysis; RNA Stability; Xenopus laevis | 2014 |
Correcting the cystic fibrosis disease mutant, A455E CFTR.
Topics: Anilides; Animals; Boronic Acids; Bortezomib; Chlorocebus aethiops; COS Cells; Cycloheximide; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expression; Genetic Complementation Test; Half-Life; Humans; Hydroxamic Acids; Leupeptins; Mutation; Plasmids; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrazines; Small Molecule Libraries; Transfection | 2014 |
Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; DNA Damage; Doxorubicin; Feedback, Physiological; Fibroblasts; Gene Expression Regulation; Genotype; Leupeptins; Mice; Point Mutation; Promoter Regions, Genetic; Proteolysis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Radiation Tolerance; Signal Transduction; Stress, Physiological; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2014 |
Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Boronic Acids; Bortezomib; Cell Line, Tumor; Cells, Cultured; Cyclin T; Cyclin-Dependent Kinase 9; Cycloheximide; Flavonoids; Gene Expression Regulation; Heat-Shock Proteins; Humans; Indoles; Leupeptins; Membrane Proteins; Mice; Mice, Knockout; Mitochondrial Proteins; Piperidines; Protein Transport; Pyrazines; Pyrroles; RNA, Small Interfering; Sequestosome-1 Protein | 2014 |
Tumor necrosis factor-α-induced apoptosis of gastric cancer MKN28 cells: accelerated degradation of the inhibitor of apoptosis family members.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Caspase 3; Caspase 8; Cell Line, Tumor; Cycloheximide; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Inhibitor of Apoptosis Proteins; Leupeptins; NF-kappa B; Oligopeptides; Proteolysis; Quinoxalines; Signal Transduction; Survivin; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein | 2015 |
Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system.
Topics: Animals; Biopterins; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Cysteine Proteinase Inhibitors; Dopamine; Gene Expression Regulation; Isoquinolines; Leupeptins; Mesencephalon; Neurons; PC12 Cells; Phosphorylation; Primary Cell Culture; Proteasome Endopeptidase Complex; Proteolysis; Rats; Receptors, Dopamine D2; Serine; Signal Transduction; Sulfonamides; Tyrosine 3-Monooxygenase; Ubiquitin; Ubiquitination | 2015 |
Delayed Turnover of Unphosphorylated Ssk1 during Carbon Stress Activates the Yeast Hog1 Map Kinase Pathway.
Topics: Cycloheximide; Gene Expression Regulation, Fungal; Glucose; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Proteins; Mitogen-Activated Protein Kinases; Osmotic Pressure; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinases; Protein Synthesis Inhibitors; Proteolysis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sodium Chloride; Stress, Physiological; Ubiquitination | 2015 |
Knockdown of AT-rich interaction domain (ARID) 5B gene expression induced AMPKα2 activation in cardiac myocytes.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Cycloheximide; DNA-Binding Proteins; Fatty Acids; Gene Knockdown Techniques; Glucose; Leupeptins; Male; Mice; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Phosphorylation; RNA, Messenger; Signal Transduction; Transcription Factors | 2015 |
The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer.
Topics: Animals; Breast Neoplasms; Cadherins; CDC2 Protein Kinase; Cell Line, Tumor; Cell Movement; Cycloheximide; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Lung Neoplasms; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Proteasome Endopeptidase Complex; Protein Binding; RNA, Long Noncoding; Ubiquitin | 2017 |
Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels.
Topics: Animals; Cell Membrane; Cullin Proteins; Cycloheximide; Endoplasmic Reticulum; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Leupeptins; Lysosomes; Neurons; Proteasome Endopeptidase Complex; Protein Binding; Protein Stability; Proteolysis; Rats | 2017 |
E2/ER β Enhances Calcineurin Protein Degradation and PI3K/Akt/MDM2 Signal Transduction to Inhibit ISO-Induced Myocardial Cell Apoptosis.
Topics: Animals; Apoptosis; Calcineurin; Cell Line; Cycloheximide; Cytochromes c; Estradiol; Estrogen Receptor beta; Isoproterenol; Leupeptins; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Pyrazoles; Pyrimidines; Rats; Signal Transduction | 2017 |
The ubiquitin ligase TRIM25 inhibits hepatocellular carcinoma progression by targeting metastasis associated 1 protein.
Topics: Atlases as Topic; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Movement; Cycloheximide; Disease Progression; Gene Expression Regulation, Neoplastic; Half-Life; Hepatocytes; Histone Deacetylases; Humans; Leupeptins; Liver Neoplasms; Protein Binding; Protein Stability; Proteolysis; Repressor Proteins; RNA, Small Interfering; Signal Transduction; Trans-Activators; Transcription Factors; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Ubiquitination | 2017 |
Ras enhances TGF-β signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1.
Topics: Animals; B30.2-SPRY Domain; Cell Movement; Cycloheximide; Dogs; Down-Regulation; HEK293 Cells; Humans; Leupeptins; Madin Darby Canine Kidney Cells; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; ras Proteins; Receptor, Transforming Growth Factor-beta Type II; Signal Transduction; Smad2 Protein; Suppressor of Cytokine Signaling Proteins; Transforming Growth Factor beta; Ubiquitination | 2018 |
Regulation of the ER-bound transcription factor Luman/CREB3 in HEK293 cells.
Topics: Brefeldin A; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; HEK293 Cells; Humans; Leupeptins; Membrane Proteins; Nigericin; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Proteins; Tunicamycin | 2019 |
Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation.
Topics: A549 Cells; B7-H1 Antigen; Benzoxazoles; beta-Transducin Repeat-Containing Proteins; Cycloheximide; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; Humans; Leupeptins; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Morpholines; Naphthyridines; Neoplasms; Protein Stability; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2019 |
The effect of acetylation on the protein stability of BmApoLp-III in the silkworm, Bombyx mori.
Topics: Acetylation; Animals; Apolipoproteins; Benzoates; Bombyx; Cell Line; Cycloheximide; Insect Proteins; Leupeptins; Nitrobenzenes; Panobinostat; Protein Stability; Pyrazoles; Pyrazolones | 2020 |
The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing.
Topics: Amino Acid Motifs; Cell Line; Culture Media; Cycloheximide; Humans; Leupeptins; Mechanistic Target of Rapamycin Complex 1; Nuclear Proteins; Protein Binding; Protein Stability; Proteolysis; RNA Interference; RNA, Small Interfering; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination | 2019 |
SETDB2 promoted breast cancer stem cell maintenance by interaction with and stabilization of ΔNp63α protein.
Topics: Breast Neoplasms; Cell Line, Tumor; Cycloheximide; Female; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Histone-Lysine N-Methyltransferase; Humans; Leupeptins; Neoplastic Stem Cells; Transcription Factors; Tumor Suppressor Proteins | 2020 |
Stability of Smyd1 in endothelial cells is controlled by PML-dependent SUMOylation upon cytokine stimulation.
Topics: Cell Nucleus; Cycloheximide; Cytokines; DNA-Binding Proteins; Endothelial Cells; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Interferon-gamma; Leupeptins; Muscle Proteins; Promyelocytic Leukemia Protein; Proteasome Inhibitors; Protein Processing, Post-Translational; RNA, Small Interfering; SUMO-1 Protein; Sumoylation; Transcription Factors; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation | 2021 |
Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas.
Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Cycloheximide; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Lymphoma, Large B-Cell, Diffuse; Macrocyclic Compounds; Mice; Mice, Inbred NOD; Mice, SCID; Minor Histocompatibility Antigens; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Peptide Fragments; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Sulfonamides; Xenograft Model Antitumor Assays | 2021 |
FBX4 mediates rapid cyclin D1 proteolysis upon DNA damage in immortalized esophageal epithelial cells.
Topics: Cell Cycle; Cyclin D1; Cycloheximide; DNA Damage; Down-Regulation; Epithelial Cells; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagus; F-Box Proteins; Gamma Rays; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteolysis; Tumor Suppressor Protein p53 | 2021 |
Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells.
Topics: Alkaloids; Basic-Leucine Zipper Transcription Factors; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Gene Expression Regulation; HEK293 Cells; Humans; Leupeptins; Proteins | 2021 |
Hsf1 activation by proteotoxic stress requires concurrent protein synthesis.
Topics: Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Ethanol; Gene Expression Regulation, Fungal; Heat-Shock Proteins; Heat-Shock Response; Leupeptins; Oxidative Stress; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Protein Transport; Proteostasis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 2021 |