cycloheximide and h 89

Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Bucladesine; Cells, Cultured; Corticosterone; Cyclic AMP; Cycloheximide; Gene Expression; Genes, fos; Isoquinolines; Kinetics; Male; Potassium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Binding Sites; Blotting, Northern; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Gene Expression; Isoquinolines; Kinetics; Molecular Sequence Data; Naphthalenes; Nerve Growth Factors; Neuropeptide Y; Oligodeoxyribonucleotides; PC12 Cells; Piperazines; Polycyclic Compounds; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic

Topics: Alkaloids; Carrier Proteins; Cholera Toxin; Choriocarcinoma; Cocaine; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Female; Humans; Isoquinolines; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Pregnancy; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cells, Cultured; Chemotactic Factors; Culture Media, Conditioned; Cycloheximide; Depression, Chemical; Dexamethasone; Genistein; Hypersensitivity; Indole Alkaloids; Inflammation; Isoelectric Focusing; Isoflavones; Isoquinolines; Leukocytes; Male; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sulfonamides

Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Insulin; Isoquinolines; Leucine; Lipase; Liver; Male; Protein Kinase Inhibitors; Rats; Rats, Wistar; Sulfonamides; Vanadates

Topics: Alkaline Phosphatase; Alkaloids; Animals; Bucladesine; Calcimycin; Cyclic AMP; Cycloheximide; Dinoprostone; Isoquinolines; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cycloheximide; Ethers, Cyclic; Isoquinolines; Mice; Nicotine; Okadaic Acid; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Receptors, Cholinergic; Sulfonamides

Topics: Animals; Apoptosis; Bucladesine; Cell Differentiation; Cell Division; Cell Line; Central Nervous System Neoplasms; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; DNA, Neoplasm; Enzyme Inhibitors; Isoquinolines; Kinetics; Neurites; Neuroblastoma; Neurons; Rats; Sulfonamides; Time Factors; Tumor Cells, Cultured

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Isoenzymes; Isoquinolines; Lactams, Macrocyclic; Male; Mice; Mice, Inbred BALB C; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA; Sulfonamides; T-Lymphocytes; Thymus Gland

Topics: Animals; Bucladesine; Cells, Cultured; Cycloheximide; Enzyme Inhibitors; Gene Expression; Isoquinolines; Liver; Male; Plasminogen Activator Inhibitor 1; Protein Synthesis Inhibitors; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Tissue Plasminogen Activator

Topics: Acetylcholine; Animals; Arachidonic Acid; Brain Chemistry; Chick Embryo; Cycloheximide; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Indomethacin; Ion Channel Gating; Isoquinolines; Maleimides; Masoprocol; Membrane Potentials; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Receptors, Nicotinic; Sulfonamides; Torpedo; Xenopus

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dinoprostone; Enkephalins; Enzyme Inhibitors; Flavonoids; Imidazoles; Isoquinolines; Kinetics; Nimodipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Transcription Factor AP-1; Transcription, Genetic

Topics: Adrenal Medulla; Animals; Anticonvulsants; Bucladesine; Carbachol; Carbamazepine; Catecholamines; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Ion Channel Gating; Ion Transport; Isoquinolines; Potassium; Sodium Channel Agonists; Sulfonamides; Up-Regulation; Veratridine

Topics: Animals; Arylamine N-Acetyltransferase; Chick Embryo; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Drug Synergism; Enzyme Inhibitors; Isoquinolines; Photoreceptor Cells; Protein Synthesis Inhibitors; Retina; RNA, Messenger; Sulfonamides

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Isoquinolines; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Rats; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate

Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Division; Cell Line; Cell Survival; Chromones; Colforsin; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Cysteine Proteinase Inhibitors; Cytochrome c Group; Cytosol; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Activation; Enzyme Inhibitors; Epithelium; Fibroblasts; Flavonoids; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Intestinal Mucosa; Isoquinolines; Microscopy, Fluorescence; Mitochondria; Morpholines; Peptides; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Receptors, Cell Surface; Receptors, Glucagon; Signal Transduction; Sulfonamides; Time Factors; Transfection

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Biological Transport; Cells, Cultured; Cholesterol; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Isoquinolines; Mitochondria; Nucleic Acid Synthesis Inhibitors; Phosphoproteins; Protein Isoforms; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Sulfonamides

Topics: Animals; Biological Transport; Cell Nucleus; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Cytoplasm; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeodomain Proteins; Insulin; Insulin Secretion; Isoquinolines; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; RNA, Messenger; Sulfonamides; Trans-Activators; Tumor Cells, Cultured

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1

Topics: Animals; Aromatase Inhibitors; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Culture Media, Serum-Free; Cycloheximide; Egtazic Acid; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Estradiol; Fadrozole; Female; Fulvestrant; Gene Expression Regulation; Isoquinolines; Male; Mesencephalon; Mice; Mice, Inbred BALB C; Nerve Growth Factors; Neurons; Receptor, trkB; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Thapsigargin

Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Benzamides; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Indoles; Isoquinolines; Kainic Acid; Long-Term Potentiation; Maleimides; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nootropic Agents; Oocytes; Patch-Clamp Techniques; Perforant Pathway; Piperazines; Protein Synthesis Inhibitors; Rats; Receptors, Glutamate; Recombinant Fusion Proteins; Signal Transduction; Sulfonamides; Synaptic Transmission; Xenopus laevis

Topics: Calcium; Cell Nucleus; Chelating Agents; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Cytosol; Dactinomycin; DNA-Binding Proteins; Egtazic Acid; Enzyme Inhibitors; Guanidines; Heat Shock Transcription Factors; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Indoles; Intestinal Mucosa; Intestines; Isoquinolines; Maleimides; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Protein Kinase C; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Transcription Factors; Tumor Cells, Cultured

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Animals; Calcium Signaling; Cell Cycle Proteins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Immediate-Early Proteins; Isoquinolines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; RNA, Messenger; Sulfonamides; Transcriptional Activation; Tumor Cells, Cultured

Topics: Adenocarcinoma; Anticarcinogenic Agents; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Endometrial Neoplasms; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Flavonoids; Fulvestrant; Humans; Indoles; Isoquinolines; Ligands; MAP Kinase Signaling System; Phosphoprotein Phosphatases; Phosphorylation; Point Mutation; Sulfonamides; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured

Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Bilirubin; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Immunoblotting; Immunohistochemistry; Isoquinolines; Membrane Proteins; Metalloporphyrins; Mice; Pregnenolone; Protoporphyrins; RNA, Messenger; Stimulation, Chemical; Sulfonamides; Thiobarbituric Acid Reactive Substances; Time Factors; Tumor Cells, Cultured

Topics: Animals; Animals, Newborn; Astrocytes; Brain; Cell Differentiation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Drug Interactions; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; Isoquinolines; Models, Biological; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Rats; Sulfonamides; Thyroid Hormones; Time Factors

Topics: Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Female; Follicle Stimulating Hormone; Gonadotropins, Equine; Granulosa Cells; Immunoblotting; Immunohistochemistry; Isoquinolines; Luteinizing Hormone; Ovary; Phosphorylation; PPAR gamma; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Sulfonamides

Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Benzylamines; Butadienes; Calcium Signaling; Carbazoles; Cell Hypoxia; Cell Line; Cycloheximide; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Ionomycin; Isoquinolines; Kidney; Nitriles; PC12 Cells; Polyribosomes; Protein Biosynthesis; Protein Kinase C-alpha; Protein Kinases; Protein Synthesis Inhibitors; Rats; RNA Caps; RNA, Messenger; RNA, Small Interfering; Sirolimus; Sulfonamides; TOR Serine-Threonine Kinases

Topics: Animals; Cells, Cultured; Chromatin Immunoprecipitation; Colforsin; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dactinomycin; Gene Expression Regulation; Isoquinolines; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Models, Biological; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Messenger; Sulfonamides; Up-Regulation

Topics: Amygdala; Animals; Anisomycin; Cocaine; Conditioning, Classical; Cycloheximide; Dopamine Uptake Inhibitors; Extracellular Signal-Regulated MAP Kinases; Isoquinolines; Male; Memory; Mice; Mice, Inbred C57BL; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Signal Transduction; Space Perception; Sulfonamides

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Benzamides; Cell Differentiation; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoquinolines; Leptin; Methionine; Mevalonic Acid; Mice; Morpholines; Polyisoprenyl Phosphates; Protein Prenylation; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Sulfonamides; Wortmannin

Topics: Blotting, Western; Cell Line; Cell Line, Tumor; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Estradiol; Estrogen Receptor alpha; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Isoquinolines; Luciferases; Protein Kinase Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sulfonamides

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Antibodies, Monoclonal; Cell Differentiation; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Colforsin; Cyclic AMP; Cycloheximide; Female; Gene Expression; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Glycoprotein Hormones, alpha Subunit; Humans; Hydrocortisone; Isoquinolines; Placenta; Pregnancy; Promoter Regions, Genetic; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Trophoblasts

Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Humans; Hydrogen Peroxide; Isoquinolines; Neoplasm Proteins; Oncogene Proteins, Viral; Proteasome Endopeptidase Complex; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA, Small Interfering; Sulfonamides; Ubiquitin; Uterine Cervical Neoplasms; Wortmannin; Xanthones

Topics: Animals; Biopterins; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Cysteine Proteinase Inhibitors; Dopamine; Gene Expression Regulation; Isoquinolines; Leupeptins; Mesencephalon; Neurons; PC12 Cells; Phosphorylation; Primary Cell Culture; Proteasome Endopeptidase Complex; Proteolysis; Rats; Receptors, Dopamine D2; Serine; Signal Transduction; Sulfonamides; Tyrosine 3-Monooxygenase; Ubiquitin; Ubiquitination