cyclohexanol has been researched along with sr141716 in 171 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 49 (28.65) | 18.2507 |
| 2000's | 87 (50.88) | 29.6817 |
| 2010's | 32 (18.71) | 24.3611 |
| 2020's | 3 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Casellas, P; Derocq, JM; Le Fur, G; Marchand, J; Ségui, M | 1 |
| Balster, RL; Barrett, RL; Lowe, J; Martin, BR; Wiley, JL | 1 |
| Le Fur, G; Poncelet, M; Rinaldi-Carmona, M; Soubrié, P; Souilhac, J | 1 |
| Barth, F; Calandra, B; Caput, D; Congy, C; Héaulme, M; Martinez, S; Maruani, J; Néliat, G; Rinaldi-Carmona, M; Shire, D | 1 |
| Bouaboula, M; Bourrié, B; Calandra, B; Canat, X; Casellas, P; Le Fur, G; Poinot-Chazel, C; Rinaldi-Carmona, M | 1 |
| Griffin, G; Huffman, JW; Lainton, JA; Pertwee, RG | 1 |
| Anderson, JJ; Chase, TN; Kask, AM | 1 |
| Lowe, JA; Mansbach, RS; Rovetti, CC; Winston, EN | 1 |
| Hawksworth, GM; Joe-Adigwe, G; Pertwee, RG | 1 |
| Coutts, AA; Fernando, SR; Nash, JE; Pertwee, RG | 1 |
| Dey, SK; Paria, BC; Yang, ZM | 1 |
| Rosenberg, HC; Tersigni, TJ | 1 |
| Brown, RE; Dastur, FN; McGregor, IS; McLellan, RA | 1 |
| Ashby, CR; Gatley, SJ; Gifford, AN; Samiian, L | 1 |
| Berrendero, F; Fernández-Ruiz, JJ; Garcia-Gil, L; Garcia-Palomero, E; Hernandez, ML; Ramos, JA; Romero, J | 1 |
| Carta, G; Casu, MA; Gessa, GL; Mascia, MS | 1 |
| Barth, F; Bouaboula, M; Calandra, B; Canat, X; Casellas, P; Le Fur, G; Lupker, J; Maffrand, JP; Milligan, L; Pecceu, F; Perrachon, S; Portier, M; Rinaldi-Carmona, M | 1 |
| Alexander, SP; Boyd, EA; Cadogan, AK; Kendall, DA | 1 |
| Coutts, AA; Pertwee, RG | 1 |
| Burkey, TH; Consroe, P; Ehlert, FJ; Hosohata, Y; Quock, RM; Roeske, WR; Yamamura, HI | 1 |
| Aanonsen, L; Hargreaves, KM; Richardson, JD | 1 |
| Fuzio, D; Manfredi, B; Parolaro, D; Patrini, G; Sacerdote, P | 1 |
| Adams, IB; Compton, DR; Martin, BR | 1 |
| Burch, DF; Gilliam, AF; Roche, MJ; Seltzman, HH; Thomas, BF | 1 |
| Bouaboula, M; Casellas, P; Derocq, JM; Marchand, J; Rinaldi-Carmona, M; Ségui, M | 1 |
| Miller, AS; Sañudo-Peña, MC; Walker, JM | 1 |
| Crépel, F; Daniel, H; Lévénés, C; Soubrié, P | 1 |
| Dubroeucq, MC; Imperato, A; Jeantaud, B; Petitet, F; Reibaud, M | 1 |
| Bord, A; Bouaboula, M; Carayon, P; Casellas, P; Defrance, T; Derocq, JM; Dussossoy, D; Fur, GL; Galiègue, S; Jbilo, O; Marchand, J; Mondière, P; Pénarier, G | 1 |
| Järvinen, K; Järvinen, T; Mahadevan, V; Pate, DW; Urtti, A | 1 |
| Brockie, HC; Fernando, SR; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B | 1 |
| Barth, F; Bouaboula, M; Carayon, P; Casellas, P; Le Duigou, A; Le Fur, G; Oustric, D; Rinaldi-Carmona, M | 1 |
| Baba, N; Ishima, Y; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Seki, C; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Sañudo-Peña, MC; Walker, JM | 1 |
| Basavarajappa, BS; Hungund, BL | 2 |
| Cabral, GA; Carlisle, SJ; Olson, JM; Waksman, Y | 1 |
| Hohmann, AG; Tsou, K; Walker, JM | 1 |
| Niederhoffer, N; Szabo, B | 2 |
| Abadji, V; Chin, C; Kendall, DA; Lucas-Lenard, JM | 1 |
| Bianchini, L; Bouaboula, M; Casellas, P; McKenzie, FR; Pouyssegur, J | 1 |
| Gallate, JE; Mallet, PE; McGregor, IS; Saharov, T | 1 |
| DiCamelli, R; Greenberg, MJ; Hillard, CJ; Kearn, CS; Kurzawa, K | 1 |
| Bertrand, P; Imperato, A; Jeantaud, B; Petitet, F | 1 |
| Calandra, B; Carillon, C; Delpech, M; Ferrara, P; Kernéis, A; Le Fur, G; Portier, M; Shire, D | 1 |
| Brown, S; Derleth, C; Hsieh, C; Mackie, K | 1 |
| Bauer, U; Göthert, M; Kathmann, M; Schlicker, E | 1 |
| Lowe, J; Mason, DJ; Welch, SP | 1 |
| Bueb, J; Delzenne, NM; DiPaolo, FG; Govaerts, SJ; Hermans, E; Kanyonyo, M; Lambert, DM; Sonveaux, P; Tschirhart, EJ | 1 |
| Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Pinto, L | 1 |
| Kishimoto, S; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Capasso, F; Izzo, AA; Mascolo, N; Tonini, M | 1 |
| Angus, JA; Lay, L; Wright, CE | 1 |
| Bouaboula, M; Casellas, P; Dornand, J; Gross, A; Liautard, JP; Marchant, J; Ouahrani-Bettache, S; Terraza, A | 1 |
| Braida, D; Sala, M | 2 |
| Massi, P; Panerai, AE; Parolaro, D; Sacerdote, P | 1 |
| Freund, TF; Hájos, N; Katona, I; Ledent, C; MacKie, K; Mody, I; Naiem, SS | 1 |
| Massi, P; Parolaro, D; Rubino, T; Viganò, D | 1 |
| Braida, D; Pozzi, M; Sala, M | 1 |
| Kathmann, M; Schlicker, E; Weber, B | 1 |
| Braida, D; Parolaro, D; Pozzi, M; Sala, M | 1 |
| Angus, JA; Christopoulos, A; Coles, P; Lay, L; Lew, MJ | 1 |
| Hillard, CJ; Patel, S | 1 |
| Andersson, M; Disney, G; Fowler, CJ; Jacobsson, SO; Nilsson, O; Tiger, G | 1 |
| Fox, A; Gentry, C; James, I; Kesingland, A; McNair, K; Patel, S; Urban, L | 1 |
| Braida, D; Cavallini, R; Pozzi, M; Sala, M | 1 |
| Craib, SJ; Ellington, HC; Pertwee, RG; Ross, RA | 1 |
| Erbelding, D; Kilbinger, H; Mang, CF | 1 |
| Arévalo, C; de Miguel, R; Hernández-Tristán, R | 1 |
| Bardotti, M; Parolaro, D; Poli, G; Ponti, W; Rubino, T | 1 |
| Bisogno, T; Capasso, F; Capasso, R; Di Marzo, V; Esposito, G; Fezza, F; Iuvone, T; Izzo, AA; Mascolo, N; Pinto, L | 1 |
| Fernandez-Ruiz, JJ; Hansen, HH; Niederhoffer, N; Szabo, B | 1 |
| Cabral, GA; Carlisle, SJ; Harmon, KN | 1 |
| Felder, CC; Golightly, SF; Hosohata, Y; Noecker, RJ; Porter, AC; Ryan, EP; Stamer, WD; Varga, E; Yamamura, HI | 1 |
| Darmani, NA | 1 |
| Arnold, JC; Hunt, GE; McGregor, IS | 1 |
| Guaza, C; Molina-Holgado, E; Molina-Holgado, F; Rothwell, NJ | 1 |
| De Miguel, R; Fernández, B; Gomez, N; Guaza, C; Ramos, JA; Romero, EM; Sagredo, O; Urigüen, L; Viveros, MP | 1 |
| Croci, T; Landi, M; Le Fur, G; Maffrand, JP; Manara, L; Rinaldi-Carmona, M | 1 |
| Bass, CE; Grier, M; Griffin, G; Mahadevan, A; Martin, BR; Razdan, RK | 1 |
| Bonhaus, DW; Hedley, LR; Lemaire, M; Lowe, DA; Martin, RS; Secchi, RL; Sung, E | 1 |
| Ihenetu, K; Molleman, A; Parsons, ME; Whelan, CJ | 1 |
| Breivogel, CS; Crim, JL; Darmani, NA; Janoyan, JJ; Martin, BR; Parekh, B; Sim-Selley, LJ | 1 |
| Carai, MA; Casu, MA; Gessa, GL; Marchese, G; Pani, L; Porcella, A; Reali, R; Ruiu, S; Saba, P | 1 |
| Barda, L; Blau, H; Cohen, V; Faigenboim, M; Foox, A; Fride, E; Mechoulam, R; Rosenberg, E | 1 |
| de Miguel, R; De Petrocellis, L; Di Marzo, V; Fernández-Ruiz, J; Lastres-Becker, I; Makriyannis, A | 1 |
| Ihenetu, K; Molleman, A; Parsons, M; Whelan, C | 1 |
| Cornish, JL; Mallet, PE; McGregor, IS; Norwood, CS | 1 |
| Niederhoffer, N; Schmid, K; Szabo, B | 1 |
| Kendall, DA; Murphy, JW | 1 |
| Barnes, PJ; Belvisi, MG; Birrell, MA; Crispino, N; Hele, DJ; Patel, HJ; Venkatesan, P; Yacoub, MH | 1 |
| Abood, ME; Anavi-Goffer, S; Barnett-Norris, J; Hurst, DP; Lynch, DL; McAllister, SD; Reggio, PH; Rizvi, G | 1 |
| Köfalvi, A; Ledent, C; Sperlágh, B; Vizi, ES | 1 |
| De Vry, J; Jentzsch, KR | 1 |
| Hunt, GE; Li, KM; Mallet, PE; McGregor, IS; Morley, KC | 1 |
| Angus, JA; Scott, DA; Wright, CE | 1 |
| Mendiguren, A; Pineda, J | 2 |
| Duncan, M; Kendall, DA; Ralevic, V | 1 |
| Adolfs, TJ; Borst, AJ; Coolen, HK; de Looff, W; Keizer, HG; Kruse, CG; Lange, JH; McCreary, AC; van Stuivenberg, HH; Veerman, W; Verveer, PC; Wals, HC | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 1 |
| Khodayar, MJ; Naderi, N; Shafaghi, B; Zarindast, MR | 1 |
| Boon, A; Bridges, D; Deadwyler, SA; Grigorenko, E; Hampson, RE; McCloud, S; Zhuang, SY | 1 |
| Cossu, G; Deiana, S; Fadda, P; Fattore, L; Fratta, W; Spano, S | 1 |
| Fix, SE; Francisco, ME; Gilliam, AF; Pertwee, RG; Schulz, AK; Seltzman, HH; Stevenson, LA; Thomas, BF; Thomas, JB | 1 |
| Baillie, GL; Christopoulos, A; Cowley, P; Easson, M; Goodwin, G; Goodwin, R; Marrs, J; McIntosh, L; McLean, A; Pertwee, RG; Price, MR; Ross, RA; Stevenson, LA; Thomas, A; Thomson, F; Walker, G; Westwood, P | 1 |
| Dykstra, LA; Ward, SJ | 1 |
| Khodayar, MJ; Naderi, N; Shafaghi, B; Zarrindast, MR | 1 |
| Alkorta, I; Alsasua, A; Cuberes, MR; Dannert, MT; Dordal, A; Frigola, J; Goya, P; Hernandez-Folgado, L; Holenz, J; Jagerovic, N; Martín, MI | 1 |
| Hille, B; Lauckner, JE; Mackie, K | 1 |
| Andersen, MB; Madsen, MV; Peacock, L; Werge, T | 1 |
| Cassidy, MP; He, H; Milstien, S; Paugh, SW; Selley, DE; Sim-Selley, LJ; Spiegel, S | 1 |
| Abellán, G; Bilbao, A; Cippitelli, A; Gómez, R; Goya, P; Hernández-Folgado, L; Jagerovic, N; Macias, M; Navarro, M; Pavon, FJ; Rodríguez de Fonseca, F; Rodríguez-Franco, MA; Serrano, A | 1 |
| Berger, C; Kuhnert, K; Müller, HD; Schäbitz, WR; Schomacher, M; Schwab, S; Sommer, C | 1 |
| Ahn, KH; D'Antona, AM; Kendall, DA; Lucas-Lenard, J; Mierke, DF; Wang, L | 1 |
| McMahon, LR | 2 |
| Baillie, GL; Pertwee, RG; Phillips, AM; Razdan, RK; Ross, RA; Thomas, A | 1 |
| Hillard, CJ; Rademacher, DJ | 1 |
| Howlett, AC; McCollum, L; Mukhopadhyay, S | 1 |
| Shivachar, AC | 1 |
| Dekkers, BG; Dröge, MJ; Elzinga, CR; Gkoumassi, E; Meurs, H; Nelemans, SA; Schmidt, M; Zaagsma, J | 1 |
| Babbs, AJ; Bali, U; Horswill, JG; Jeevaratnam, P; Keily, JF; Reynet, C; Shaaban, S; Wong Kai In, P | 1 |
| Ginsburg, BC; Lamb, RJ; McMahon, LR | 1 |
| Baker, D; Bennett, T; Gardiner, SM; Hiley, CR; Hoi, PM; Kaup, SS; Okuyama, M; Selwood, DL; Visintin, C | 1 |
| Glass, M; Keelan, JA; Mitchell, MD; Ponnampalam, AP; Sato, TA; Wang, A | 1 |
| Agudelo, M; Friedman, H; Klein, TW; Newton, C; Nong, L; Sherwood, T; Widen, R | 1 |
| Buckley, NE; Cabral, GA; Marciano-Cabral, F; Martin, BR; Raborn, ES | 1 |
| Cooper, TB; Hungund, BL; Thanos, PK; Vadasz, C; Vinod, KY; Volkow, ND; Yalamanchili, R | 1 |
| Lichtman, AH; Thorpe, AJ; Wise, LE | 1 |
| Bevins, RA; Lyford, GD; Murray, JE; Wells, NR | 1 |
| Dodd, GT; Luckman, SM; McKie, S; Stark, JA; Williams, SR | 1 |
| Booker, L; Lichtman, AH; Mahadevan, A; Naidu, PS; Razdan, RK | 1 |
| Abood, ME; Bai, Y; Barak, LS; Caron, MG; Kapur, A; Sharir, H; Zhao, P | 1 |
| Berrendero, F; Burokas, A; Gispert, JD; Heyne, A; Kiesselbach, C; Maldonado, R; Martín, M; Martín-García, E; Millán, O; Rubí, B | 1 |
| Clapper, JR; Eisenstein, SA; Hohmann, AG; Holmes, PV; Piomelli, D | 1 |
| Amigou, E; Cohen-Salmon, M; Ezan, P; Froger, N; Giaume, C; Orellana, JA; Sáez, JC | 1 |
| Amrutkar, D; Gandhi, M; Gullapalli, S; Gupta, S; Kandadi, MR; Karande, V; Kumar, H; Narayanan, S | 1 |
| McMahon, LR; Stewart, JL | 1 |
| Dodd, GT; Luckman, SM; Lutz, B; Mancini, G | 1 |
| Burston, JJ; Craig, AA; Selley, DE; Sim-Selley, LJ; Wiley, JL | 1 |
| Avigliano, L; Baldassarri, S; Bertoni, A; Catani, MV; Catanzaro, G; Gasperi, V; Maccarrone, M; Sinigaglia, F | 1 |
| Milligan, G; Pediani, JD; Ward, RJ | 1 |
| Baskfield, CY; Matthew Walentiny, D; Vann, RE; Wiley, JL | 1 |
| Bisset, KM; Dhopeshwarkar, AS; Liao, C; Nicholson, RA | 1 |
| Gadthula, S; Kottani, R; Mahadeven, A; Selley, DE; Wang, P; Wiley, JL | 1 |
| Craft, RM; Laggart, JD; Tsutsui, KT; Wakley, AA | 1 |
| Baxter, P; Benfenati, F; Cerovic, M; Greco, B; Nazzaro, C; Parolaro, D; Pedarzani, P; Rubino, T; Tkatch, T; Tonini, R; Trusel, M | 1 |
| Ahn, KH; Kendall, DA; Mahmoud, MM | 1 |
| Avdesh, A; Hoe, Y; Martin-Iverson, MT; Martins, RN | 1 |
| Abdullah, R; Cravatt, BF; Kinsey, SG; Lichtman, AH; Ramesh, D; Selley, DE; Wise, LE | 1 |
| Abood, ME; Kapur, A; Makriyannis, A; Marcu, J; Reggio, PH; Shore, DM; Trznadel, M | 1 |
| Giuffrida, A; Martinez, AA; Seillier, A | 1 |
| Halikhedkar, A; Järbe, TU; LeMay, BJ; Makriyannis, A; Vadivel, SK; Wood, J; Zvonok, A | 1 |
| Dhopeshwarkar, AS; Nicholson, RA | 1 |
| Hruba, L; McMahon, LR | 1 |
| Abdelrahman, M; Gamage, TF; Greig, IR; Ignatowska-Jankowska, BM; Lichtman, AH; Pertwee, RG; Poklis, J; Ross, RA; Thakur, GA; Tichkule, R; Trembleau, L; Wiley, JL | 1 |
| McMahon, LR; Rodriguez, JS | 1 |
| Bauer, R; Brodhun, M; Brust, P; Deuther-Conrad, W; Donat, CK; Fischer, F; Walter, B | 1 |
| Bass, CE; Blume, LC; Eldeeb, K; Howlett, AC; Selley, DE | 1 |
| Grim, TW; Lichtman, AH; Morales, AJ; Negus, SS; Wiebelhaus, JM | 1 |
| Breivogel, CS; Vaghela, MS | 1 |
| Christopoulos, A; Glass, M; Khajehali, E; Leach, K; Malone, DT; Sexton, PM | 1 |
| Farrens, DL; Fay, JF | 1 |
| Bass, CE; Blume, LC; Chen, R; Howlett, AC; Leone-Kabler, S; Luessen, DJ; Lyons, E; Marrs, GS; Selley, DE | 1 |
| Farquhar, CE; Gamage, TF; Lefever, TW; Nguyen, T; Thomas, BF; Wiley, JL; Zhang, Y | 1 |
| Dopart, R; Kendall, DA | 1 |
| Ahmad, A; Daneva, Z; Dempsey, SK; Li, N; Li, PL; Lyall, V; Mummalaneni, S; Ritter, JK | 1 |
| Cinar, R; Gao, B; Godlewski, G; Gunduz-Cinar, O; Herrerias, A; Iyer, MR; Kunos, G; Lin, Y; Santos-Molina, L; Wood, CM; Zawatsky, CN | 1 |
171 other study(ies) available for cyclohexanol and sr141716
| Article | Year |
|---|---|
Cannabinoids enhance human B-cell growth at low nanomolar concentrations.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Base Sequence; Benzoxazines; Cannabinoids; CD40 Antigens; Cell Division; Cyclohexanols; DNA; Dronabinol; Humans; Ligands; Lymphocyte Activation; Molecular Sequence Data; Morpholines; Naphthalenes; Palatine Tonsil; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Antigen, B-Cell; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Virulence Factors, Bordetella | 1995 |
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraperitoneal; Male; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1995 |
Intrastriatal injection of cannabinoid receptor agonists induced turning behavior in mice.
Topics: Analgesics; Animals; Benzoxazines; Cannabis; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Female; Injections; Mice; Morpholines; Naphthalenes; Neurons; Oxidopamine; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Neurokinin-2; Rimonabant; Stereoisomerism; Stereotyped Behavior | 1995 |
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor.
Topics: Animals; Benzoxazines; Binding, Competitive; Biological Assay; Brain; Cannabinoids; Cell Membrane; Cyclohexanols; In Vitro Techniques; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1994 |
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Analgesics; Animals; Benzoquinones; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; Cell Line; CHO Cells; Cricetinae; Cyclohexanols; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Immediate-Early Proteins; Kinetics; Lactams, Macrocyclic; Pertussis Toxin; Piperidines; Pyrazoles; Quinones; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Rifabutin; Rimonabant; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Virulence Factors, Bordetella | 1995 |
Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens.
Topics: Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vas Deferens | 1995 |
Effects of cannabinoid receptor stimulation and blockade on catalepsy produced by dopamine receptor antagonists.
Topics: Animals; Benzazepines; Brain; Catalepsy; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Piperidines; Pyrazoles; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Salicylamides | 1996 |
Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats.
Topics: Animals; Columbidae; Cyclohexanols; Discrimination Learning; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reflex, Startle; Rimonabant | 1996 |
Further evidence for the presence of cannabinoid CB1 receptors in mouse vas deferens.
Topics: Animals; Cannabinoids; Colforsin; Cyclic AMP; Cyclohexanols; In Vitro Techniques; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Vas Deferens | 1996 |
Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine.
Topics: Acetylcholine; Analgesics; Animals; Cyclohexanols; Dose-Response Relationship, Drug; Guinea Pigs; Intestine, Small; Male; Muscle Contraction; Myenteric Plexus; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Blastocyst; Blotting, Western; Cannabinoids; Cyclohexanols; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Female; Immunohistochemistry; Male; Mice; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1996 |
Local pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABA.
Topics: Action Potentials; Analgesics; Analysis of Variance; Animals; Benzoxazines; Bicuculline; Cannabinoids; Cyclohexanols; gamma-Aminobutyric Acid; Iontophoresis; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pressure; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substantia Nigra | 1996 |
Cannabinoid modulation of rat pup ultrasonic vocalizations.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Body Temperature; Cannabinoids; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Hypothermia; Motor Activity; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rimonabant; Vocalization, Animal | 1996 |
Examination of the effect of the cannabinoid receptor agonist, CP 55,940, on electrically evoked transmitter release from rat brain slices.
Topics: Acetylcholine; Analgesics; Animals; Benzoxazines; Cannabinoids; Corpus Striatum; Cyclohexanols; Hippocampus; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Atypical location of cannabinoid receptors in white matter areas during rat brain development.
Topics: Animals; Animals, Newborn; Autoradiography; Benzoxazines; Brain; Brain Chemistry; Cannabinoids; Cyclohexanols; Female; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A.
Topics: Acetylcholine; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1997 |
A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions.
Topics: Adenylate Cyclase Toxin; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Enzyme Activation; Humans; Insulin; Insulin-Like Growth Factor I; Pertussis Toxin; Piperidines; Pyrazoles; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Virulence Factors, Bordetella | 1997 |
Influence of cannabinoids on electrically evoked dopamine release and cyclic AMP generation in the rat striatum.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Arachidonic Acids; Cannabinoids; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclohexanols; Dopamine; Electric Stimulation; Endocannabinoids; In Vitro Techniques; Kinetics; Male; Phosphatidylinositols; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Second Messenger Systems | 1997 |
Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus.
Topics: Acetylcholine; Benzoxazines; Child, Preschool; Cyclohexanols; Histamine; Humans; In Vitro Techniques; Male; Morpholines; Myenteric Plexus; Naloxone; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism | 1997 |
Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Male; Mice; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Receptors, N-Methyl-D-Aspartate; Rimonabant; Spinal Cord; Tritium | 1998 |
Regulation of immune functions in rat splenocytes after acute and chronic in vivo treatment with CP-55,940, a synthetic cannabinoid compound.
Topics: Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Cytotoxicity, Immunologic; Drug Administration Schedule; Immunosuppressive Agents; Injections, Intraperitoneal; Killer Cells, Natural; Lymphocyte Activation; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen | 1997 |
Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain.
Topics: Animals; Arachidonic Acids; Autoradiography; Brain; Cannabinoids; Cyclohexanols; Endocannabinoids; Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Comparative receptor binding analyses of cannabinoid agonists and antagonists.
Topics: Analgesics; Animals; Binding, Competitive; Cannabinoids; Cyclohexanols; Male; Models, Molecular; Piperidines; Pyrazoles; Rats; Rats, Inbred F344; Rimonabant | 1998 |
The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinoids; Cell Division; CHO Cells; Cricetinae; Cyclohexanols; Endocannabinoids; Enzyme Activation; Gene Expression Regulation; Mice; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Signal Transduction; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1998 |
Ipsilateral turning behavior induced by unilateral microinjections of a cannabinoid into the rat subthalamic nucleus.
Topics: Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Functional Laterality; Globus Pallidus; Injections, Intraventricular; Male; Mesencephalon; Microinjections; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Thalamic Nuclei | 1998 |
Cannabinoids decrease excitatory synaptic transmission and impair long-term depression in rat cerebellar Purkinje cells.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebellar Cortex; Cyclohexanols; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Morpholines; Naphthalenes; Nerve Fibers; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Synaptic Transmission | 1998 |
Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Cannabidiol; Cell Membrane; Cerebellar Cortex; Cyclohexanols; Dronabinol; Guanosine Triphosphate; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation.
Topics: Animals; B-Lymphocyte Subsets; Camphanes; CD40 Antigens; Cell Differentiation; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Germinal Center; Humans; Microscopy, Confocal; Palatine Tonsil; Peptide Fragments; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Rimonabant; Transfection | 1998 |
Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Endocannabinoids; Female; Intraocular Pressure; Male; Ocular Hypotension; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine.
Topics: Analgesics; Animals; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; Cyclohexanols; Dronabinol; Guinea Pigs; Intestine, Small; Kinetics; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Neuromuscular Junction; Piperidines; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1998 |
Modulation of CB1 cannabinoid receptor functions after a long-term exposure to agonist or inverse agonist in the Chinese hamster ovary cell expression system.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Transfection | 1998 |
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cell Line; Cyclohexanols; Dronabinol; Endocannabinoids; Models, Chemical; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 1999 |
A novel neurotransmitter system involved in the control of motor behavior by the basal ganglia.
Topics: Action Potentials; Analgesics; Animals; Basal Ganglia; Benzoxazines; Bicuculline; Cannabinoids; Cyclohexanols; Dopamine; Dopamine Agonists; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Morpholines; Motor Neurons; Naphthalenes; Nerve Degeneration; Neurotransmitter Agents; Oxidopamine; Piperidines; Pyrazoles; Quinpirole; Rats; Rimonabant; Sympatholytics; Thalamic Nuclei | 1998 |
Down-regulation of cannabinoid receptor agonist-stimulated [35S]GTP gamma S binding in synaptic plasma membrane from chronic ethanol exposed mouse.
Topics: Analgesics; Animals; Binding, Competitive; Brain Chemistry; Central Nervous System Depressants; Chronic Disease; Cyclohexanols; Dose-Response Relationship, Drug; Down-Regulation; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes; Synaptic Membranes | 1999 |
The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells.
Topics: Animals; Animals, Newborn; Cannabinoids; Cells, Cultured; Cyclohexanols; Immunohistochemistry; Microglia; Nitric Oxide; Nitric Oxide Synthase; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger | 1999 |
Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat.
Topics: Analgesics; Animals; Axotomy; Benzoxazines; Cannabinoids; Cyclohexanols; Hot Temperature; Injections, Intravenous; Injections, Intraventricular; Lumbosacral Region; Male; Mechanoreceptors; Microinjections; Morpholines; Naphthalenes; Neurons; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Spinal Cord | 1999 |
Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation.
Topics: Analgesics; Animals; Benzoxazines; Blood Pressure; Bradycardia; Cannabinoids; Cardiovascular Physiological Phenomena; Cisterna Magna; Consciousness; Cyclohexanols; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Rate; Infusions, Intravenous; Injections; Injections, Intravenous; Kidney; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Sympathetic Nervous System; Sympathomimetics | 1999 |
Involvement of the carboxyl terminus of the third intracellular loop of the cannabinoid CB1 receptor in constitutive activation of Gs.
Topics: Animals; CHO Cells; Cholera Toxin; Cricetinae; Cyclic AMP; Cyclohexanols; GTP-Binding Proteins; Humans; Mutation; Peptide Fragments; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Virulence Factors, Bordetella | 1999 |
Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Hydrogen-Ion Concentration; Piperidines; Protein Isoforms; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Sodium-Hydrogen Exchangers | 1999 |
Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist.
Topics: Animals; Beer; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Ethanol; Male; Motor Activity; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant; Self Administration; Sucrose | 1999 |
Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange.
Topics: Animals; Binding, Competitive; Cannabinoids; Cell Membrane; Cerebellum; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Ligands; Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1999 |
Cannabinoid penetration into mouse brain as determined by ex vivo binding.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Male; Mice; Morpholines; Naphthalenes; Perfusion; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Drug; Rimonabant; Tritium | 1999 |
Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor.
Topics: Animals; Binding Sites; Cannabinoids; CHO Cells; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclohexanols; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Gene Expression; Genes, Reporter; GTP-Binding Proteins; Humans; Isoquinolines; Luciferases; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Receptors, Cannabinoid; Receptors, Corticotropin-Releasing Hormone; Receptors, Drug; Recombinant Fusion Proteins; Rimonabant; Signal Transduction; Sulfonamides | 1999 |
Internalization and recycling of the CB1 cannabinoid receptor.
Topics: Acids; Ammonium Chloride; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cells, Cultured; Clathrin; Coated Vesicles; Cyclohexanols; Dronabinol; Drug Tolerance; Endocytosis; Endosomes; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Immunosuppressive Agents; Morpholines; Mutagenesis; Naphthalenes; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Tertiary; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Transfection; Up-Regulation; Virulence Factors, Bordetella | 1999 |
Cannabinoid CB1 receptor-mediated inhibition of NMDA- and kainate-stimulated noradrenaline and dopamine release in the brain.
Topics: Animals; Benzoxazines; Binding, Competitive; Brain Chemistry; Cannabinoids; Cerebral Cortex; Cyclohexanols; Dopamine; Excitatory Amino Acid Agonists; Guinea Pigs; Kainic Acid; Male; Membranes; Morpholines; N-Methylaspartate; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical | 1999 |
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dimethyl Sulfoxide; Dronabinol; Dynorphins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1999 |
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors.
Topics: Animals; Benzoxazines; Binding, Competitive; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Ethanolamines; Humans; Molecular Structure; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen; Transfection; Tumor Cells, Cultured | 1999 |
The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats.
Topics: Analgesics; Animals; Antidiarrheals; Benzoxazines; Castor Oil; Cyclohexanols; Defecation; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gastrointestinal Transit; Loperamide; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
Topics: Amides; Arachidonic Acids; Calcium Signaling; Camphanes; Cannabinoids; Cyclohexanols; Cyclooxygenase Inhibitors; Drug Interactions; Endocannabinoids; Ethanolamines; Glycerides; HL-60 Cells; Humans; Ligands; Lipoxygenase Inhibitors; Molecular Mimicry; Palmitic Acids; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Structure-Activity Relationship; Virulence Factors, Bordetella | 2000 |
Modulation of peristalsis by cannabinoid CB(1) ligands in the isolated guinea-pig ileum.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; Compliance; Cyclohexanols; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Morpholines; Muscle Contraction; Naphthalenes; Peristalsis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Heart Atria; In Vitro Techniques; Male; Mesenteric Artery, Inferior; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Vascular Resistance | 2000 |
A beneficial aspect of a CB1 cannabinoid receptor antagonist: SR141716A is a potent inhibitor of macrophage infection by the intracellular pathogen Brucella suis.
Topics: Animals; Anti-Bacterial Agents; Antigens, CD; Benzoxazines; Brucella; Calcitriol; Camphanes; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Intercellular Adhesion Molecule-1; Macrophage Activation; Macrophages; Mice; Monocytes; Morpholines; Naphthalenes; Phagocytosis; Piperidines; Pyrazoles; Reactive Oxygen Species; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoid-induced working memory impairment is reversed by a second generation cholinesterase inhibitor in rats.
Topics: Animals; Behavior, Animal; Cannabinoids; Cholinesterase Inhibitors; Cyclohexanols; Male; Maze Learning; Memory; Memory Disorders; Motor Activity; Physostigmine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2000 |
Cannabinoids cause central sympathoexcitation and bradycardia in rabbits.
Topics: Animals; Benzoxazines; Blood Pressure; Bradycardia; Cannabinoids; Cyclohexanols; Drug Interactions; Female; Heart Rate; Injections, Intraventricular; Kidney; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Sympathetic Nervous System | 2000 |
In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors.
Topics: Animals; Camphanes; Cannabinoids; Cell Movement; Cells, Cultured; Cyclohexanols; Dose-Response Relationship, Drug; Immunosuppressive Agents; In Vitro Techniques; Macrophages, Peritoneal; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations.
Topics: Action Potentials; Analgesics; Animals; Antibodies; Benzoxazines; Cannabinoids; Cyclohexanols; Electrophysiology; Epitopes; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Microscopy, Electron; Morpholines; Naphthalenes; Neural Inhibition; Neural Pathways; Periodicity; Piperidines; Presynaptic Terminals; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission | 2000 |
Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55,940.
Topics: Animals; Behavior, Animal; Brain; Cannabinoids; Cerebellum; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclohexanols; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Drug Tolerance; GTP-Binding Proteins; Hippocampus; Injections, Intraperitoneal; Male; Marijuana Abuse; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction | 2000 |
CP 55,940 protects against ischemia-induced electroencephalographic flattening and hyperlocomotion in Mongolian gerbils.
Topics: Analgesics; Animals; Brain; Brain Ischemia; Cyclohexanols; Electroencephalography; Gerbillinae; Hyperkinesis; Male; Neuroprotective Agents; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoid CB1 receptor-mediated inhibition of acetylcholine release in the brain of NMRI, CD-1 and C57BL/6J mice.
Topics: Acetylcholine; Animals; Benzoxazines; Brain; Calcium; Choline; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Morpholines; Naphthalenes; Oxotremorine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 2001 |
Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzimidazoles; Conditioning, Operant; Cyclohexanols; Heroin; Male; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reinforcement Schedule; Rimonabant; Self Administration | 2001 |
Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens.
Topics: Animals; Benzofurans; Benzoxazines; Calcium Channel Blockers; Cyclohexanols; Electric Stimulation; In Vitro Techniques; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vas Deferens | 2001 |
Cannabinoid CB(1) receptor agonists produce cerebellar dysfunction in mice.
Topics: Animals; Behavior, Animal; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebellar Diseases; Cyclohexanols; Dopamine Agonists; Gait; Male; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Pharmacological properties of cannabinoid receptors in the avian brain: similarity of rat and chicken cannabinoid1 receptor recognition sites and expression of cannabinoid2 receptor-like immunoreactivity in the embryonic chick brain.
Topics: Amidohydrolases; Animals; Benzoxazines; Blotting, Western; Brain; Cell Membrane; Chick Embryo; Cyclohexanols; Drug Interactions; Ligands; Morpholines; Naphthalenes; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Species Specificity | 2001 |
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dronabinol; Hyperalgesia; Morpholines; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sciatica | 2001 |
Cannabinoid receptor agonist-stimulated [35S]guanosine triphosphate gammaS binding in the brain of C57BL/6 and DBA/2 mice.
Topics: Analgesics; Animals; Brain; Cannabinoids; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Species Specificity | 2001 |
Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system.
Topics: Analgesics; Analgesics, Opioid; Animals; Brain; Conditioning, Psychological; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Heroin; Male; Naloxone; Narcotic Antagonists; Opioid Peptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant | 2001 |
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Bronchi; Calcium Channel Blockers; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; In Vitro Techniques; Indomethacin; Lipoxygenase; Muscle Contraction; Oxazepines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Thiorphan | 2001 |
Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Camphanes; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Guinea Pigs; Ileum; In Vitro Techniques; Male; Methacholine Chloride; Muscle Contraction; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters.
Topics: Analgesics; Animals; Anxiety; Cannabinoids; Cyclohexanols; Drug Therapy, Combination; Exploratory Behavior; Hypothalamus; Male; Motor Activity; Neurotransmitter Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2001 |
Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages.
Topics: Animals; Bone Marrow Cells; Camphanes; Cannabinoids; Cats; Cyclohexanols; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome; Histocytochemistry; Immunosuppressive Agents; Macrophages; Nitric Oxide; Phagocytosis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation.
Topics: Analgesics; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Cannabinol; Croton Oil; Cyclohexanols; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Motility; Inflammatory Bowel Diseases; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Effects of cannabinoids on adrenaline release from adrenal medullary cells.
Topics: Adrenal Glands; Adrenal Medulla; Analgesics; Animals; Benzoxazines; Blood Pressure; Cannabinoids; Chromaffin Cells; Cyclohexanols; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Epinephrine; Heart Rate; In Vitro Techniques; Injections, Intravenous; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation.
Topics: Animals; Cannabinoids; Cyclohexanols; Gene Expression; Microglia; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger | 2001 |
Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cattle; Cell Separation; Ciliary Body; Cyclic AMP; Cyclohexanols; Endocannabinoids; Fluorescent Antibody Technique; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intraocular Pressure; Ligands; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Trabecular Meshwork | 2001 |
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Emetics; Endocannabinoids; Female; Glycerides; Humans; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews | 2002 |
Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats.
Topics: Animals; Benzazepines; Brain; Cannabinoids; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant; Self Stimulation | 2001 |
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
Topics: Analgesics; Animals; Arachidonic Acids; Astrocytes; Calcium Channel Blockers; Camphanes; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Gene Expression; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Antinociceptive, behavioural and neuroendocrine effects of CP 55,940 in young rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Corticosterone; Cyclohexanols; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Female; Grooming; Male; Marijuana Abuse; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Neostriatum; Neurosecretory Systems; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sex Characteristics | 2002 |
Role of the endocannabinoid system in MDMA intracerebral self-administration in rats.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acids, Unsaturated; Hallucinogens; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reinforcement, Psychology; Rimonabant; Self Administration | 2002 |
Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB(1) receptors.
Topics: Administration, Oral; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Transit; Injections, Intraventricular; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
SR-141716A-induced stimulation of locomotor activity. A structure-activity relationship study.
Topics: Animals; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical; Structure-Activity Relationship | 2002 |
Effects of cannabinoid receptor ligands on psychosis-relevant behavior models in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Arousal; Attention; Behavior, Animal; Cyclohexanols; Dextroamphetamine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hallucinogens; Male; Motor Activity; Piperidines; Psychoses, Substance-Induced; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reflex, Startle; Rimonabant; Stereotyped Behavior | 2003 |
Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids.
Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cannabinoids; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; HT29 Cells; Humans; Immunoblotting; Indoles; Interleukin-8; Kinetics; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Necrosis Factor-alpha | 2003 |
Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation.
Topics: Animals; Antiemetics; Benzoxazines; Binding, Competitive; Brain; Cisplatin; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Sulfur Radioisotopes; Tritium; Vomiting | 2003 |
Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract.
Topics: Animals; Antiemetics; Binding, Competitive; Blotting, Western; Cyclohexanols; Digestive System; Dose-Response Relationship, Drug; Dronabinol; Gastric Mucosa; Gastrointestinal Transit; Immunohistochemistry; Intestine, Large; Intestine, Small; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stomach; Tritium | 2003 |
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor.
Topics: Animals; Animals, Newborn; Animals, Suckling; Arachidonic Acids; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Modulators; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Endocannabinoids; Female; Glycerides; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Milk; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Survival Rate; Time Factors | 2003 |
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids, Neutral; Animals; Arachidonic Acids; Basal Ganglia; Cannabinoid Receptor Modulators; Capsaicin; Corpus Striatum; Cyclohexanols; Disease Models, Animal; Dopamine; Endocannabinoids; gamma-Aminobutyric Acid; Huntington Disease; Hyperkinesis; Male; Motor Activity; Nitro Compounds; Palmitates; Piperidines; Propionates; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells.
Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Humans; Indoles; Interleukin-2; Leukocytes, Mononuclear; Morpholines; Naphthalenes; Phytohemagglutinins; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Pre-exposure to the cannabinoid receptor agonist CP 55940 enhances morphine behavioral sensitization and alters morphine self-administration in Lewis rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Drug Synergism; Male; Morphine; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Self Administration; Time Factors | 2003 |
The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression.
Topics: Animals; Atropine Derivatives; Benzoxazines; Bradycardia; Cannabinoids; Cardiovascular System; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Hypotension; Male; Medulla Oblongata; Microinjections; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sympathetic Fibers, Postganglionic; Sympathetic Nervous System | 2003 |
Integrity of extracellular loop 1 of the human cannabinoid receptor 1 is critical for high-affinity binding of the ligand CP 55,940 but not SR 141716A.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Molecular Sequence Data; Piperidines; Protein Conformation; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.
Topics: Animals; Camphanes; Cannabinoids; Capsaicin; Consciousness; Cough; Cyclohexanols; Dinoprost; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Hypertonic Solutions; In Vitro Techniques; Male; Middle Aged; Neurons, Afferent; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Rimonabant; Vagus Nerve | 2003 |
An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.
Topics: Benzoxazines; Binding Sites; Cyclohexanols; Humans; Immunochemistry; Ligands; Models, Molecular; Morpholines; Naphthalenes; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2003 |
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioactivity; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synaptosomes; Tritium | 2003 |
Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm.
Topics: Animals; Appetitive Behavior; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Morpholines; Motivation; Naphthalenes; Piperidines; Premedication; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2004 |
Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats.
Topics: Animals; Cannabinoids; Cyclohexanols; Fever; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin | 2004 |
Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Ligation; Male; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Nerves; Time Factors | 2004 |
Cannabinoids enhance N-methyl-D-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cyclohexanols; Drug Interactions; Electrophysiology; Endocannabinoids; Excitatory Amino Acid Agonists; In Vitro Techniques; Locus Coeruleus; Male; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.
Topics: Animals; Benzofurans; Benzoxazines; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Cyclohexanols; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Vasodilation | 2004 |
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.
Topics: Administration, Oral; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Hypotension; Hypothermia; Imidazoles; Mice; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat.
Topics: Analysis of Variance; Animals; Baclofen; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Injections, Spinal; Male; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-B; Rimonabant; Signal Transduction; Spinal Cord | 2005 |
Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores.
Topics: Animals; Benzoxazines; Calcium; Cell Culture Techniques; Cell Death; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclohexanols; Dantrolene; Drug Interactions; Estrenes; Fetus; Hippocampus; Macrocyclic Compounds; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Okadaic Acid; Oxazoles; Piperidines; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Thionucleotides | 2005 |
Cannabinoid CB(1) antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats.
Topics: Animals; Behavior, Addictive; Benzoxazines; Conditioning, Operant; Cyclohexanols; Drug Interactions; Extinction, Psychological; Heroin; Heroin Dependence; Male; Morpholines; Naloxone; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration | 2005 |
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities.
Topics: Amides; Animals; Binding Sites; Brain; Cell Membrane; Cyclohexanols; Humans; Mice; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Allosteric modulation of the cannabinoid CB1 receptor.
Topics: Allosteric Regulation; Animals; Binding Sites; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Vas Deferens | 2005 |
The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940).
Topics: Animals; Conditioning, Operant; Corn Oil; Cyclohexanols; Dietary Fats; Dietary Sucrose; Feeding Behavior; Female; Food, Formulated; Gene Deletion; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Taste; Time Factors | 2005 |
Antinociceptive effect of spinally administered cannabinergic and 2-adrenoceptor drugs on the formalin test in rat: possible interactions.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Cyclohexanols; Formaldehyde; Injections, Spinal; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, alpha-2; Receptors, Cannabinoid; Rimonabant; Spinal Cord; Yohimbine | 2006 |
Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides.
Topics: Animals; Binding Sites; Cyclohexanols; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Triazoles; Vas Deferens | 2006 |
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Cytoplasm; DNA, Complementary; Dronabinol; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Glycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Humans; Immunosuppressive Agents; Morpholines; Naphthalenes; Neurons; Pertussis Toxin; Piperidines; Protein Binding; Protein Conformation; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Time Factors; Type C Phospholipases | 2005 |
Systemic effect of cannabinoids on the spontaneous firing rate of locus coeruleus neurons in rats.
Topics: Action Potentials; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; In Vitro Techniques; Injections, Intravenous; Injections, Intraventricular; Kinetics; Locus Coeruleus; Male; Morpholines; Naphthalenes; Neurons; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Effects of the cannabinoid CB1 receptor agonist CP55,940 and antagonist SR141716A on d-amphetamine-induced behaviours in Cebus monkeys.
Topics: Animals; Anti-Anxiety Agents; Arousal; Behavior, Animal; Cebus; Central Nervous System Stimulants; Cyclohexanols; Dextroamphetamine; Drug Interactions; Female; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stereotyped Behavior | 2006 |
Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
Topics: Animals; Benzoxazines; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Endocytosis; Enzyme Activation; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Naphthalenes; Phenols; Piperidines; Propylene Glycols; Proto-Oncogene Proteins c-akt; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sphingosine | 2006 |
Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.
Topics: Animals; Anti-Obesity Agents; Blood-Brain Barrier; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Cyclohexanols; Eating; Ethanol; Feeding Behavior; Male; Maze Learning; Membranes, Artificial; Motor Activity; Permeability; Phenols; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rats, Zucker; Rimonabant; Self Administration; Triazoles | 2006 |
Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Ischemia; Cyclohexanols; Dizocilpine Maleate; Down-Regulation; Excitatory Amino Acid Antagonists; Male; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rimonabant | 2006 |
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acids; Binding, Competitive; Cannabinoids; Cell Line; Cyclic AMP; Cyclohexanes; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Mutation; Phenols; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Hallucinogens; Humans; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Macaca mulatta; Male; Midazolam; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Brain; Camphanes; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Phenols; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Rimonabant; Transfection | 2007 |
Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Body Weight; Cannabinoid Receptor Modulators; Carbamates; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Endocannabinoids; Food Deprivation; Food Preferences; Male; Mice; Mice, Inbred ICR; Phenols; Piperidines; Pyrazoles; Restraint, Physical; Reward; Rimonabant; Stress, Psychological; Sucrose; Time Factors; Water Deprivation | 2007 |
Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells.
Topics: Animals; Arachidonic Acids; Benzofurans; Benzoxazines; Camphanes; Cannabinoid Receptor Modulators; Cells, Cultured; Chromones; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Endothelial Cells; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Morpholines; Naphthalenes; Nitric Oxide; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Pyrazoles; Rabbits; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Rimonabant; Signal Transduction | 2007 |
Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Aspartic Acid; Astrocytes; Benzoxazines; Biological Transport; Biomarkers; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cannabinoids; Cells, Cultured; Cerebral Cortex; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acids; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kinetics; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Proteins; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sodium; Time Factors | 2007 |
Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Arachidonic Acids; Blotting, Western; Bronchi; Camphanes; Cannabinoids; Cell Line; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Drug Antagonism; Epithelial Cells; Humans; Immunosuppressive Agents; Interleukin-8; Pertussis Toxin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Tumor Necrosis Factor-alpha | 2007 |
PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats.
Topics: Allosteric Regulation; Animals; Appetite Depressants; Cell Line; Cell Membrane; Cerebral Cortex; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Eating; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Molecular Structure; Phenylurea Compounds; Piperidines; Pyrazoles; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Saccharomyces cerevisiae; Silicone Elastomers; Sulfur Radioisotopes; Weight Gain | 2007 |
Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2008 |
Vascular pharmacology of a novel cannabinoid-like compound, 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide (VSN16) in the rat.
Topics: Animals; Apamin; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cerebellum; Charybdotoxin; Cyclohexanols; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Molecular Structure; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cannabinoid; Resorcinols; Rimonabant; Tritium; TRPV Cation Channels; Vascular Resistance; Vasodilation | 2007 |
Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue- and CB1-receptor-specific mechanism.
Topics: Adult; Amnion; Blotting, Western; Cannabinoid Receptor Modulators; Chorion; Cyclohexanols; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Decidua; Dinoprostone; Female; Humans; In Vitro Techniques; Nitrobenzenes; Piperidines; Placenta; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant; Sulfonamides | 2008 |
Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes.
Topics: Animals; B-Lymphocytes; Camphanes; Cannabinoids; Cyclohexanols; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunoglobulin Class Switching; Immunoglobulin E; Immunoglobulin M; In Vitro Techniques; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Rimonabant; Th2 Cells | 2008 |
The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.
Topics: Animals; Arachidonic Acids; Camphanes; Chemokine CCL5; Chemotaxis; Cyclohexanols; Dronabinol; Female; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, CCR1; Receptors, CCR5; Receptors, G-Protein-Coupled; Rimonabant; RNA, Messenger; Signal Transduction | 2008 |
Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Analgesics; Animals; Binding, Competitive; Brain; Cyclohexanols; Disease Models, Animal; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant; Species Specificity | 2008 |
Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol.
Topics: Analysis of Variance; Animals; Catheterization; Central Nervous System Agents; Cyclohexanols; Dronabinol; Hippocampus; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Microinjections; Piperidines; Psychotropic Drugs; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Investigation of endocannabinoid modulation of conditioned responding evoked by a nicotine CS and the Pavlovian stimulus effects of CP 55,940 in adult male rats.
Topics: Animals; Conditioning, Classical; Cyclohexanols; Discrimination Learning; Drug Interactions; Male; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Central cannabinoid signaling mediating food intake: a pharmacological-challenge magnetic resonance imaging and functional histology study in rat.
Topics: Animals; Brain; Brain Mapping; Cannabinoids; Central Nervous System Agents; Cyclohexanols; Drug Interactions; Eating; Genes, Immediate-Early; Hyperphagia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Oxygen; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.
Topics: Acetic Acid; Analgesics; Animals; Anti-Obesity Agents; Camphanes; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger | 2009 |
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
Topics: Analgesics; Arrestins; beta-Arrestins; Cannabinoid Receptor Agonists; Cannabinoids; Cell Line; Cyclohexanols; Humans; Ligands; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Obesity; Phosphorylation; Piperidines; Protein Kinase C; Protein Kinase C beta; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant | 2009 |
Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant.
Topics: Amides; Analysis of Variance; Animals; Autoradiography; Benzoxazines; Body Weight; Brain; Cyclohexanols; Diet Fads; Disease Models, Animal; Eating; Female; Guanosine 5'-O-(3-Thiotriphosphate); International Cooperation; Morpholines; Naphthalenes; Obesity; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Isotopes; Time Factors; Tomography Scanners, X-Ray Computed; Tritium; Whole Body Imaging | 2010 |
A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.
Topics: Animals; Arachidonic Acids; Autoradiography; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Cyclohexanols; Densitometry; Dopamine; Endocannabinoids; Environment; Glycerides; Limbic System; Lipid Metabolism; Male; Mass Spectrometry; Motor Activity; Olfactory Bulb; Piperidines; Pyrazoles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments.
Topics: Analgesics; Animals; Animals, Newborn; Arachidonic Acids; Astrocytes; Benzoxazines; Cannabinoids; Cells, Cultured; Cerebral Cortex; Connexin 43; Connexins; Culture Media, Conditioned; Cyclohexanols; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Ethidium; Gene Expression Regulation; Interleukin-1beta; Lipopolysaccharides; Maximum Tolerated Dose; Mice; Microglia; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Tumor Necrosis Factor-alpha | 2009 |
Characterization of active and inactive states of CB1 receptor and the differential binding state modulation by cannabinoid agonists, antagonists and inverse agonists.
Topics: Animals; Binding, Competitive; Brain; Cyclohexanols; Dogs; Drug Inverse Agonism; In Vitro Techniques; Ligands; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs.
Topics: Adrenergic Agonists; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Clonidine; Cyclohexanols; Discrimination, Psychological; Dronabinol; Female; Heart Rate; Macaca mulatta; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2010 |
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhythm; COS Cells; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Drug Administration Routes; Eating; Food Deprivation; Green Fluorescent Proteins; Hemoglobins; Hyperphagia; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Peptide Fragments; Piperidines; Protein Transport; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Transfection | 2010 |
Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure.
Topics: Age Distribution; Animals; Brain; Cyclohexanols; Dronabinol; Drug Administration Schedule; Drug Tolerance; Female; Male; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Sexual Maturation | 2010 |
Human platelets express authentic CB₁ and CB₂ receptors.
Topics: Adult; Binding, Competitive; Blood Platelets; Calcium; Camphanes; Cyclic AMP; Cyclohexanols; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Integrin beta3; Male; Piperidines; Platelet Count; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tritium; Young Adult | 2010 |
Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.
Topics: Alkyl and Aryl Transferases; Benzoxazoles; Cell Line; Cell Membrane; Cloning, Molecular; Cyclohexanols; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Phenylurea Compounds; Phosphorylation; Piperidines; Plasmids; Pyrazoles; Pyrrolidines; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Rimonabant; Thiazoles; Urea | 2011 |
Dissimilar cannabinoid substitution patterns in mice trained to discriminate Δ(9)-tetrahydrocannabinol or methanandamide from vehicle.
Topics: Animals; Arachidonic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Generalization, Stimulus; Male; Mice; Mice, Inbred C57BL; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors | 2011 |
The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro.
Topics: Animals; Benzoxazines; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Mice; Morpholines; Naphthalenes; Phthalic Acids; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant | 2011 |
3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism.
Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Drug Inverse Agonism; Female; Freezing Reaction, Cataleptic; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship; Transfection | 2012 |
Sex differences in cannabinoid 1 vs. cannabinoid 2 receptor-selective antagonism of antinociception produced by delta9-tetrahydrocannabinol and CP55,940 in the rat.
Topics: Analgesics; Animals; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Morphine; Motor Activity; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sex Characteristics | 2012 |
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium | 2012 |
Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation.
Topics: Allosteric Regulation; Animals; Cyclohexanols; Drug Synergism; Endocytosis; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Hippocampus; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neurons; Pertussis Toxin; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Secondary; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
Pharmacological effects of cannabinoids on the reference and working memory functions in mice.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Male; Maze Learning; Memory; Memory, Short-Term; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity | 2013 |
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Benzodioxoles; Brain Chemistry; Cyclohexanols; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders | 2013 |
Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.
Topics: Amino Acid Sequence; Benzoxazines; Binding, Competitive; Cell Line; Cyclohexanols; Energy Metabolism; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Models, Chemical; Molecular Sequence Data; Morpholines; Mutagenesis, Site-Directed; Naphthalenes; Piperidines; Protein Conformation; Protein Structure, Secondary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2013 |
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Male; Phencyclidine; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Quinazolinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Schizophrenia; Social Behavior | 2013 |
Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cyclic AMP; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Indoles; Isomerism; Male; Molecular Structure; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Benzophenanthridine alkaloid, piperonyl butoxide and (S)-methoprene action at the cannabinoid-1 receptor (CB1-receptor) pathway of mouse brain: Interference with [(3)H]CP55940 and [(3)H]SR141716A binding and modification of WIN55212-2-dependent inhibition
Topics: Animals; Benzophenanthridines; Benzoxazines; Binding Sites; Brain; Cyclohexanols; Glutamic Acid; Isoquinolines; Male; Methoprene; Mice; Morpholines; Naphthalenes; Piperidines; Piperonyl Butoxide; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spleen; Synaptosomes | 2014 |
The cannabinoid agonist HU-210: pseudo-irreversible discriminative stimulus effects in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Time Factors | 2014 |
In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.
Topics: Allosteric Regulation; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Catalepsy; Cyclohexanols; Dronabinol; Drug Evaluation; Eating; Endocannabinoids; Female; Hypothermia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nociception; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
JWH-018 in rhesus monkeys: differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects.
Topics: Animals; Benzoxazines; Body Temperature; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dronabinol; Hypothermia; Indoles; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Brain Injuries; Cannabinoid Receptor Modulators; Cyclohexanols; Disease Models, Animal; Female; Isoquinolines; Piperidines; Protein Binding; Pyrazoles; Radionuclide Imaging; Receptors, Cannabinoid; Receptors, GABA; Rimonabant; Swine; Time Factors; Tritium | 2014 |
Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells.
Topics: Animals; Carrier Proteins; Cell Line, Tumor; Cyclic AMP; Cyclohexanols; GTP-Binding Protein alpha Subunits, Gi-Go; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction | 2015 |
Effects of acute and repeated dosing of the synthetic cannabinoid CP55,940 on intracranial self-stimulation in mice.
Topics: Animals; Brain; Catalepsy; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Drug Tolerance; Male; Medial Forebrain Bundle; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation | 2015 |
The effects of beta-arrestin1 deletion on acute cannabinoid activity, brain cannabinoid receptors and tolerance to cannabinoids in mice.
Topics: Animals; Arrestins; beta-Arrestins; Brain; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Dronabinol; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sequence Deletion | 2015 |
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.
Topics: Allosteric Regulation; Animals; Benzoxazines; Cannabinoid Receptor Agonists; CHO Cells; Cricetulus; Cyclohexanols; Dronabinol; Humans; Indoles; MAP Kinase Signaling System; Morpholines; Naphthalenes; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2015 |
Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1.
Topics: Algorithms; Animals; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Chlorocebus aethiops; COS Cells; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Kinetics; Models, Biological; Models, Molecular; Mutation; Piperidines; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Cannabinoid receptor interacting protein suppresses agonist-driven CB
Topics: Animals; Benzoxazines; Carrier Proteins; Cell Line; Cell Membrane; Cyclohexanols; Endocannabinoids; Gene Dosage; Gene Knockdown Techniques; Mice; Morpholines; Naphthalenes; Piperidines; Protein Transport; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cell Surface; Rimonabant; RNA, Small Interfering; Signal Transduction | 2016 |
The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB
Topics: Allosteric Regulation; Animals; Cannabinoid Receptor Modulators; Cerebellum; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Phenylurea Compounds; Piperidines; Pregnenolone; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant | 2017 |
Allosteric modulators restore orthosteric agonist binding to mutated CB
Topics: Binding Sites; Cannabinoid Receptor Agonists; Cyclohexanols; HEK293 Cells; Humans; Indoles; Ligands; Mutation; Phenylurea Compounds; Piperidines; Protein Binding; Protein Conformation; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2020 |
Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Diuresis; Endocannabinoids; Loop of Henle; Male; Mice; Mice, Inbred C57BL; Natriuresis; Ouabain; Piperidines; Polyunsaturated Alkamides; Pyridines; Rimonabant; Sodium; Sodium-Potassium-Exchanging ATPase | 2021 |
Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia.
Topics: Alcohol Drinking; Animals; Anxiety; Behavior, Animal; Cannabinoid Receptor Antagonists; Catalepsy; Cyclohexanols; Elevated Plus Maze Test; Endotoxemia; Endotoxins; Ethanol; Gastrointestinal Tract; Hypothermia, Induced; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stereoisomerism; Sulfonamides | 2021 |