Compounds > cyclohexanol
Page last updated: 2024-08-18

cyclohexanol and sr 144528

cyclohexanol has been researched along with sr 144528 in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (13.64)18.2507
2000's29 (65.91)29.6817
2010's8 (18.18)24.3611
2020's1 (2.27)2.80

Authors

AuthorsStudies
Barth, F; Bouaboula, M; Brelière, JC; Calandra, B; Casellas, P; Congy, C; Derocq, JM; Le Fur, GL; Millan, J; Oustric, D; Portier, M; Rinaldi-Carmona, M; Sarran, M; Shire, D1
Bouaboula, M; Casellas, P; Derocq, JM; Marchand, J; Rinaldi-Carmona, M; Ségui, M1
Bord, A; Bouaboula, M; Carayon, P; Casellas, P; Defrance, T; Derocq, JM; Dussossoy, D; Fur, GL; Galiègue, S; Jbilo, O; Marchand, J; Mondière, P; Pénarier, G1
Brockie, HC; Fernando, SR; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B1
Brockie, HC; Makriyannis, A; Murphy, VL; Pertwee, RG; Ross, RA; Stevenson, LA; Templeton, F1
Casellas, P; Derocq, JM; Jbilo, O; Le Fur, G; Segui, M1
Kishimoto, S; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Sugiura, T; Suhara, Y; Takayama, H; Waku, K1
Capasso, F; Izzo, AA; Mascolo, N; Tonini, M1
Angus, JA; Lay, L; Wright, CE1
Bouaboula, M; Casellas, P; Dornand, J; Gross, A; Liautard, JP; Marchant, J; Ouahrani-Bettache, S; Terraza, A1
Bouaboula, M; Casellas, P; Clère, C; Derocq, JM; Jbilo, O; Ségui, M1
Barth, F; Calandra, B; Ferrara, P; Gouldson, P; Kernéis, A; Le Fur, G; Legoux, P; Rinaldi-Carmona, M; Shire, D1
Massi, P; Panerai, AE; Parolaro, D; Sacerdote, P1
Erbelding, D; Kilbinger, H; Mang, CF1
Bardotti, M; Parolaro, D; Poli, G; Ponti, W; Rubino, T1
Jan, TR; Kaminski, NE; Rao, GK1
Guaza, C; Molina-Holgado, E; Molina-Holgado, F; Rothwell, NJ1
Mannaioni, PF; Marzocca, C; Masini, E; Passani, MB; Pierpaoli, S; Vannacci, A; Zagli, G1
Ihenetu, K; Molleman, A; Parsons, ME; Whelan, CJ1
Ihenetu, K; Molleman, A; Parsons, M; Whelan, C1
Barnes, PJ; Belvisi, MG; Birrell, MA; Crispino, N; Hele, DJ; Patel, HJ; Venkatesan, P; Yacoub, MH1
Angus, JA; Scott, DA; Wright, CE1
Gokoh, M; Kishimoto, S; Kobayashi, Y; Oka, S; Sugiura, T; Waku, K1
Duncan, M; Kendall, DA; Ralevic, V1
Filip, M; McCreary, AC; Przegaliński, E; Zaniewska, M1
McMahon, LR1
Baillie, GL; Pertwee, RG; Phillips, AM; Razdan, RK; Ross, RA; Thomas, A1
Howlett, AC; McCollum, L; Mukhopadhyay, S1
Bingham, B; Chlenov, M; Cummons, TA; Harrison, JE; He, Y; Jones, PG; Kennedy, JD; Kotnis, S; Lu, P; Piesla, MJ; Resnick, L; Smith, VA; Strassle, BW; Sun, SC; Uveges, AJ; Whiteside, GT1
Dekkers, BG; Dröge, MJ; Elzinga, CR; Gkoumassi, E; Meurs, H; Nelemans, SA; Schmidt, M; Zaagsma, J1
Dunn, WR; Pakdeechote, P; Ralevic, V1
Agudelo, M; Friedman, H; Klein, TW; Newton, C; Nong, L; Sherwood, T; Widen, R1
Buckley, NE; Cabral, GA; Marciano-Cabral, F; Martin, BR; Raborn, ES1
Bani, D; Cinci, L; Giannini, L; Mannaioni, PF; Mariottini, C; Masini, E; Mastroianni, R; Nistri, S; Passani, MB; Vannacci, A1
Booker, L; Lichtman, AH; Mahadevan, A; Naidu, PS; Razdan, RK1
Avigliano, L; Baldassarri, S; Bertoni, A; Catani, MV; Catanzaro, G; Gasperi, V; Maccarrone, M; Sinigaglia, F1
Gertsch, J; Lazo, JS; Schreiter, B; Wang, L; Xie, XQ; Xie, Z; Zhang, Y1
Bolognini, D; Cascio, MG; Parolaro, D; Pertwee, RG1
Ahmad, S; Groblewski, T; Ndong, C; O'Donnell, D1
Gadthula, S; Kottani, R; Mahadeven, A; Selley, DE; Wang, P; Wiley, JL1
Craft, RM; Laggart, JD; Tsutsui, KT; Wakley, AA1
Dykstra, H; Fan, S; Haskó, J; Krizbai, I; Mahadevan, A; McCormick, R; Persidsky, Y; Ramirez, SH; Reichenbach, N; Skuba, A; Son, YJ; Tuma, R; Zhang, M1
Alqarni, M; Bartlow, P; Feng, R; Myint, KZ; Tong, Q; Wang, L; Xie, XQ; Yang, P1
Gawrisch, K; Hines, KG; Hooper, L; Teague, W; Yeliseev, AA; Zoretich, K; Zoubak, L1

Other Studies

44 other study(ies) available for cyclohexanol and sr 144528

ArticleYear
SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2

    Topics: Adenylyl Cyclases; Administration, Oral; Animals; B-Lymphocytes; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinoids; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; Humans; Lymphocyte Activation; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins

1998
The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines.
    FEBS letters, 1998, Apr-03, Volume: 425, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinoids; Cell Division; CHO Cells; Cricetinae; Cyclohexanols; Endocannabinoids; Enzyme Activation; Gene Expression Regulation; Mice; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Signal Transduction; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella

1998
Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation.
    Blood, 1998, Nov-15, Volume: 92, Issue:10

    Topics: Animals; B-Lymphocyte Subsets; Camphanes; CD40 Antigens; Cell Differentiation; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Germinal Center; Humans; Microscopy, Confocal; Palatine Tonsil; Peptide Fragments; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Rimonabant; Transfection

1998
Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine.
    British journal of pharmacology, 1998, Volume: 125, Issue:6

    Topics: Analgesics; Animals; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; Cyclohexanols; Dronabinol; Guinea Pigs; Intestine, Small; Kinetics; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Neuromuscular Junction; Piperidines; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium

1998
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630.
    British journal of pharmacology, 1999, Volume: 126, Issue:3

    Topics: Animals; Benzoxazines; Binding, Competitive; Camphanes; Cannabinoids; CHO Cells; Chromans; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Morpholines; Naphthalenes; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Tritium

1999
Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60.
    FEBS letters, 1999, Apr-09, Volume: 448, Issue:2-3

    Topics: Analgesics; Blotting, Northern; Camphanes; Chemokine CCL2; Chemokine CCL4; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Cyclohexanols; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Growth Substances; HL-60 Cells; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8; Macrophage Inflammatory Proteins; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Time Factors; Transfection

1999
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
    The Journal of biological chemistry, 2000, Jan-07, Volume: 275, Issue:1

    Topics: Amides; Arachidonic Acids; Calcium Signaling; Camphanes; Cannabinoids; Cyclohexanols; Cyclooxygenase Inhibitors; Drug Interactions; Endocannabinoids; Ethanolamines; Glycerides; HL-60 Cells; Humans; Ligands; Lipoxygenase Inhibitors; Molecular Mimicry; Palmitic Acids; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Structure-Activity Relationship; Virulence Factors, Bordetella

2000
Modulation of peristalsis by cannabinoid CB(1) ligands in the isolated guinea-pig ileum.
    British journal of pharmacology, 2000, Volume: 129, Issue:5

    Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; Compliance; Cyclohexanols; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Morpholines; Muscle Contraction; Naphthalenes; Peristalsis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant

2000
Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse.
    European journal of pharmacology, 2000, Mar-10, Volume: 391, Issue:1-2

    Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Heart Atria; In Vitro Techniques; Male; Mesenteric Artery, Inferior; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Vascular Resistance

2000
A beneficial aspect of a CB1 cannabinoid receptor antagonist: SR141716A is a potent inhibitor of macrophage infection by the intracellular pathogen Brucella suis.
    Journal of leukocyte biology, 2000, Volume: 67, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Antigens, CD; Benzoxazines; Brucella; Calcitriol; Camphanes; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Intercellular Adhesion Molecule-1; Macrophage Activation; Macrophages; Mice; Monocytes; Morpholines; Naphthalenes; Phagocytosis; Piperidines; Pyrazoles; Reactive Oxygen Species; Receptors, Cannabinoid; Receptors, Drug; Rimonabant

2000
Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation.
    The Journal of biological chemistry, 2000, May-26, Volume: 275, Issue:21

    Topics: Camphanes; Cannabinoids; Cell Differentiation; Cell Movement; Cyclohexanols; Cytokines; Gene Expression Regulation; HL-60 Cells; Humans; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotide Array Sequence Analysis; Phosphorylation; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Transfection

2000
Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor.
    European journal of pharmacology, 2000, Jul-28, Volume: 401, Issue:1

    Topics: Amino Acid Sequence; Animals; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; COS Cells; Cyclohexanols; Humans; Luciferases; Models, Molecular; Molecular Sequence Data; Morpholines; Mutagenesis, Site-Directed; Mutation; Naphthalenes; Protein Structure, Tertiary; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins

2000
In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors.
    Journal of neuroimmunology, 2000, Sep-22, Volume: 109, Issue:2

    Topics: Animals; Camphanes; Cannabinoids; Cell Movement; Cells, Cultured; Cyclohexanols; Dose-Response Relationship, Drug; Immunosuppressive Agents; In Vitro Techniques; Macrophages, Peritoneal; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant

2000
Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: Acetylcholine; Animals; Arachidonic Acids; Camphanes; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Guinea Pigs; Ileum; In Vitro Techniques; Male; Methacholine Chloride; Muscle Contraction; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant

2001
Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages.
    Veterinary immunology and immunopathology, 2001, Volume: 82, Issue:3-4

    Topics: Animals; Bone Marrow Cells; Camphanes; Cannabinoids; Cats; Cyclohexanols; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome; Histocytochemistry; Immunosuppressive Agents; Macrophages; Nitric Oxide; Phagocytosis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant

2001
Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity.
    Molecular pharmacology, 2002, Volume: 61, Issue:2

    Topics: Amino Acid Motifs; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinol; Cyclohexanols; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Dronabinol; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Nuclear Proteins; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; T-Lymphocytes; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transfection

2002
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
    Journal of neuroscience research, 2002, Mar-15, Volume: 67, Issue:6

    Topics: Analgesics; Animals; Arachidonic Acids; Astrocytes; Calcium Channel Blockers; Camphanes; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Gene Expression; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant

2002
Down-regulation by cannabinoids of the immunological activation of human basophils and guinea pig mast cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51 Suppl 1

    Topics: Animals; Antigens, CD; Arachidonic Acids; Basophils; Camphanes; Cannabinoids; Cyclohexanols; Down-Regulation; Endocannabinoids; Glycerides; Guinea Pigs; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Macrophage Activation; Mast Cells; Platelet Membrane Glycoproteins; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Tetraspanin 30

2002
Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids.
    European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2

    Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cannabinoids; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; HT29 Cells; Humans; Immunoblotting; Indoles; Interleukin-8; Kinetics; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Necrosis Factor-alpha

2003
Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells.
    European journal of pharmacology, 2003, Mar-19, Volume: 464, Issue:2-3

    Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Humans; Indoles; Interleukin-2; Leukocytes, Mononuclear; Morpholines; Naphthalenes; Phytohemagglutinins; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant

2003
Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.
    British journal of pharmacology, 2003, Volume: 140, Issue:2

    Topics: Animals; Camphanes; Cannabinoids; Capsaicin; Consciousness; Cough; Cyclohexanols; Dinoprost; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Hypertonic Solutions; In Vitro Techniques; Male; Middle Aged; Neurons, Afferent; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Rimonabant; Vagus Nerve

2003
Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat.
    Pain, 2004, Volume: 109, Issue:1-2

    Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Ligation; Male; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Nerves; Time Factors

2004
2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells.
    Journal of biochemistry, 2004, Volume: 135, Issue:4

    Topics: Arachidonic Acid; Arachidonic Acids; Blotting, Northern; Calcitriol; Camphanes; Cell Differentiation; Chemokine CCL2; Chemokines; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Gene Expression; Glycerides; HL-60 Cells; Humans; Interleukin-8; Lipopolysaccharides; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB2; RNA, Messenger; Time Factors

2004
Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:1

    Topics: Animals; Benzofurans; Benzoxazines; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Cyclohexanols; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Vasodilation

2004
Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.
    European journal of pharmacology, 2006, Jul-01, Volume: 540, Issue:1-3

    Topics: Aconitine; Animals; Arachidonic Acids; Azetidines; Benzamides; Benzoxazines; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Male; Mecamylamine; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Nicotinic

2006
Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:3

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; Animals; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cocaine; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Ketamine; Macaca mulatta; Male; Midazolam; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2006
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
    British journal of pharmacology, 2007, Volume: 150, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Brain; Camphanes; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Phenols; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Rimonabant; Transfection

2007
Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Animals; Arachidonic Acids; Benzofurans; Benzoxazines; Camphanes; Cannabinoid Receptor Modulators; Cells, Cultured; Chromones; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Endothelial Cells; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Morpholines; Naphthalenes; Nitric Oxide; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Pyrazoles; Rabbits; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Rimonabant; Signal Transduction

2007
Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers.
    British journal of pharmacology, 2007, Volume: 151, Issue:7

    Topics: Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Camphanes; Cannabinoids; Carrageenan; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Indoles; Mice; Morpholines; Naphthalenes; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB2; Species Specificity; Stereoisomerism; Tritium

2007
Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.
    British journal of pharmacology, 2007, Volume: 151, Issue:7

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Arachidonic Acids; Blotting, Western; Bronchi; Camphanes; Cannabinoids; Cell Line; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Drug Antagonism; Epithelial Cells; Humans; Immunosuppressive Agents; Interleukin-8; Pertussis Toxin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Tumor Necrosis Factor-alpha

2007
Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed.
    British journal of pharmacology, 2007, Volume: 152, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Adrenergic Fibers; Animals; Arachidonic Acids; Benzofurans; Benzoxazines; Camphanes; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; In Vitro Techniques; Male; Mesenteric Arteries; Morpholines; Muscle Tonus; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Perfusion; Polyunsaturated Alkamides; Prazosin; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Purinergic P2

2007
Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2008, Volume: 3, Issue:1

    Topics: Animals; B-Lymphocytes; Camphanes; Cannabinoids; Cyclohexanols; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunoglobulin Class Switching; Immunoglobulin E; Immunoglobulin M; In Vitro Techniques; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Rimonabant; Th2 Cells

2008
The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2008, Volume: 3, Issue:2

    Topics: Animals; Arachidonic Acids; Camphanes; Chemokine CCL5; Chemotaxis; Cyclohexanols; Dronabinol; Female; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, CCR1; Receptors, CCR5; Receptors, G-Protein-Coupled; Rimonabant; RNA, Messenger; Signal Transduction

2008
Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.
    Journal of cellular and molecular medicine, 2008, Volume: 12, Issue:6A

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antigens; Asthma; Camphanes; Cyclic AMP; Cyclohexanols; Deoxyguanosine; DNA Damage; Guinea Pigs; Humans; Leukocytes; Lung; Male; Mast Cells; Models, Biological; Ovalbumin; Piperidines; Prostaglandin D2; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha

2008
Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.
    Drug and alcohol dependence, 2009, Nov-01, Volume: 105, Issue:1-2

    Topics: Acetic Acid; Analgesics; Animals; Anti-Obesity Agents; Camphanes; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger

2009
Human platelets express authentic CB₁ and CB₂ receptors.
    Current neurovascular research, 2010, Volume: 7, Issue:4

    Topics: Adult; Binding, Competitive; Blood Platelets; Calcium; Camphanes; Cyclic AMP; Cyclohexanols; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Integrin beta3; Male; Piperidines; Platelet Count; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tritium; Young Adult

2010
Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor.
    International immunopharmacology, 2011, Volume: 11, Issue:9

    Topics: Adenylyl Cyclases; Amino Acid Substitution; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; Cell Line, Transformed; Cell Membrane; Colforsin; Computer Simulation; Cyclic AMP; Cyclohexanols; HEK293 Cells; Humans; Ligands; Models, Molecular; Morpholines; Mutagenesis, Site-Directed; Naphthalenes; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction

2011
AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
    British journal of pharmacology, 2012, Volume: 165, Issue:8

    Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Dronabinol; Humans; Indoles; Ligands; Morpholines; Naphthalenes; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB2

2012
Cloning and pharmacological characterization of the dog cannabinoid CB₂receptor.
    European journal of pharmacology, 2011, Nov-01, Volume: 669, Issue:1-3

    Topics: Amino Acid Sequence; Animals; Arachidonic Acids; Base Sequence; Benzoxazines; Binding, Competitive; Camphanes; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dogs; Dronabinol; Endocannabinoids; Humans; Mice; Molecular Sequence Data; Morpholines; Naphthalenes; Pan troglodytes; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Sequence Alignment

2011
3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2

    Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Drug Inverse Agonism; Female; Freezing Reaction, Cataleptic; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship; Transfection

2012
Sex differences in cannabinoid 1 vs. cannabinoid 2 receptor-selective antagonism of antinociception produced by delta9-tetrahydrocannabinol and CP55,940 in the rat.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:3

    Topics: Analgesics; Animals; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Morphine; Motor Activity; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sex Characteristics

2012
Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Mar-21, Volume: 32, Issue:12

    Topics: Animals; Anisoles; Blood-Brain Barrier; Camphanes; Cannabinoids; Capillary Permeability; Cell Adhesion; Cells, Cultured; Cyclohexanols; Dextrans; Disease Models, Animal; Electric Impedance; Encephalitis; Endothelial Cells; Endothelium; Flow Cytometry; Fluorescein-5-isothiocyanate; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Lipopolysaccharides; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoproteins; Platelet Endothelial Cell Adhesion Molecule-1; Pyrazoles; Receptor, Cannabinoid, CB2; Statistics, Nonparametric; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Zonula Occludens-1 Protein

2012
Examining the critical roles of human CB2 receptor residues Valine 3.32 (113) and Leucine 5.41 (192) in ligand recognition and downstream signaling activities.
    Biochemical and biophysical research communications, 2014, Sep-26, Volume: 452, Issue:3

    Topics: Animals; Binding Sites; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; CHO Cells; Cricetulus; Cyclic AMP; Cyclohexanols; Escherichia coli; Humans; Hydrophobic and Hydrophilic Interactions; Leucine; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB2; Recombinant Proteins; Signal Transduction; Valine

2014
Site-selective labeling and electron paramagnetic resonance studies of human cannabinoid receptor CB
    Biochimica et biophysica acta. Biomembranes, 2021, 08-01, Volume: 1863, Issue:8

    Topics: Camphanes; Cyclohexanols; Cysteine; Electron Spin Resonance Spectroscopy; Humans; Mutagenesis, Site-Directed; Protein Conformation; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Spin Labels

2021