Compounds > cyclohexanol
Page last updated: 2024-08-18

cyclohexanol and guanosine 5'-o-(3-thiotriphosphate)

cyclohexanol has been researched along with guanosine 5'-o-(3-thiotriphosphate) in 68 studies

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (13.24)18.2507
2000's37 (54.41)29.6817
2010's22 (32.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berrendero, F; Fernández-Ruiz, JJ; Garcia-Gil, L; Garcia-Palomero, E; Hernandez, ML; Ramos, JA; Romero, J1
Childers, SR; Pacheco, MA; Stark, S1
Burkey, TH; Consroe, P; Ehlert, FJ; Hosohata, Y; Quock, RM; Roeske, WR; Yamamura, HI1
Berrendero, F; Cebeira, M; de Miguel, R; Fernández-Ruiz, JJ; García-Gil, L; Hernández, ML; Ramos, JA; Romero, J1
Basavarajappa, BS; Hungund, BL2
Howlett, AC; Meschler, JP1
Brockie, HC; Makriyannis, A; Murphy, VL; Pertwee, RG; Ross, RA; Stevenson, LA; Templeton, F1
Campbell, WB; DiCamelli, R; Greenberg, MJ; Hillard, CJ; Manna, S; Murphy, V; Pertwee, RG; Ross, RA; Stevenson, LA1
DiCamelli, R; Greenberg, MJ; Hillard, CJ; Kearn, CS; Kurzawa, K1
Abood, ME; Griffin, G; Tao, Q1
Fan, X; Gonsiorek, W; Hipkin, RW; Lundell, D; Lunn, C; Narula, S1
Houston, DB; Howlett, AC; Lan, R; Liu, Q; Makriyannis, A; Pigg, JJ; Wilken, GH1
Abood, ME; Aung, MM; Griffin, G; Martin, BR; Razdan, RK; Williams, S1
Felder, CC; Golightly, SF; Hosohata, Y; Noecker, RJ; Porter, AC; Ryan, EP; Stamer, WD; Varga, E; Yamamura, HI1
De Vry, J; Horváth, E; Mauler, F; Mittendorf, J1
Bonhaus, DW; Calixto, JJ; Chang, TK; Dietrich, PS; MacLennan, SJ; Martin, RS; Reyes, CL; Reynen, PH1
Bass, CE; Grier, M; Griffin, G; Mahadevan, A; Martin, BR; Razdan, RK1
Breivogel, CS; Crim, JL; Darmani, NA; Janoyan, JJ; Martin, BR; Parekh, B; Sim-Selley, LJ1
Gafni, M; Sarne, Y; Shapira, M1
Manzanares, J; Oliva, JM; Ortiz, S; Palomo, T1
Arango, V; Basavarajappa, BS; Cooper, TB; Hungund, BL; Kassir, SA; Mann, JJ; Vinod, KY; Yalamanchili, R1
Arango, V; Cooper, TB; Hungund, BL; Kassir, SA; Mann, JJ; Vinod, KY; Xie, S1
Järvinen, T; Kokkola, T; Laitinen, JT; Poso, A; Salo, OM; Savinainen, JR1
Forlani, G; Parolaro, D; Rubino, T; Viganò, D; Zippel, R1
Joseph, BK; Mayeux, PR; Prather, PL; Ruckle, MB; Shoemaker, JL1
Brain, C; Chen, A; Courade, JP; Dyson, A; Fox, A; Groarke, A; Loong, Y; Peacock, M; Yaqoob, M1
Bianchessi, S; Castiglioni, C; Marmorato, P; Parolaro, D; Rubino, T; Vaccani, A; Viganò, D1
Baillie, GL; Christopoulos, A; Cowley, P; Easson, M; Goodwin, G; Goodwin, R; Marrs, J; McIntosh, L; McLean, A; Pertwee, RG; Price, MR; Ross, RA; Stevenson, LA; Thomas, A; Thomson, F; Walker, G; Westwood, P1
Andersson, M; Fuxe, K; Strömberg, I; Terasmaa, A1
Cassidy, MP; He, H; Milstien, S; Paugh, SW; Selley, DE; Sim-Selley, LJ; Spiegel, S1
Alonso-Ferrero, ME; Díez-Alarcia, R; Fernández-López, A; Mostany, R; Paniagua, MA; Pazos, A; Pilar-Cuéllar, F1
Cooper, TB; Hungund, BL; Vinod, KY; Xie, S; Yalamanchili, R1
Ahn, KH; D'Antona, AM; Kendall, DA; Lucas-Lenard, J; Mierke, DF; Wang, L1
Marron Fernandez de Velasco, E; Rodriguez, RE; Rodriguez-Martin, I1
Baillie, GL; Pertwee, RG; Phillips, AM; Razdan, RK; Ross, RA; Thomas, A1
Lichtman, AH; Martin, BR; Pertwee, RG; Razdan, RK; Ross, RA; Stevenson, LA; Thomas, A; Varvel, SA1
Fadda, P; Fattore, L; Fratta, W; Parolaro, D; Rubino, T; Viganò, D1
Babbs, AJ; Bali, U; Horswill, JG; Jeevaratnam, P; Keily, JF; Reynet, C; Shaaban, S; Wong Kai In, P1
Deno, G; Fan, X; Gonsiorek, W; Hipkin, RW; Kozlowski, J; Lunn, CA1
Castelli, MP; D'Agostino, A; Gessa, GL; Maccarrone, M; Paola Piras, A; Perra, S; Pibiri, F; Pistis, M1
Drmota, T; Elebring, T; Greasley, PJ; Hermansson, NO; Hjorth, S; Larsson, N; Leonova, J; Nilsson, K; Ryberg, E; Sjögren, S1
Devanathan, S; Georgieva, T; Hruby, VJ; Park, CK; Roeske, WR; Salamon, Z; Stropova, D; Tollin, G; Varga, E; Yamamura, HI1
Ambrosio, E; Biscaia, M; Fernández, B; García-Lecumberri, C; Higuera-Matas, A; Miguéns, M; Viveros, MP1
Gardner, EE; Geiger, S; Heilmann, J; Nickl, K; Seifert, R1
Díaz, A; Pazos, A; Rodríguez-Gaztelumendi, A; Rojo, ML1
Advani, T; Cassano, T; Giuffrida, A; Hensler, JG; Seillier, A1
Bolognini, D; Cascio, MG; Corelli, F; Di Marzo, V; Maione, S; Palazzo, E; Pasquini, S; Pertwee, RG1
Berrendero, F; Burokas, A; Gispert, JD; Heyne, A; Kiesselbach, C; Maldonado, R; Martín, M; Martín-García, E; Millán, O; Rubí, B1
Becker, A; Höllt, V; Schröder, H1
Fowler, CJ; Rojo, ML; Söderström, I1
Bisset, KM; Dhopeshwarkar, AS; Liao, C; Nicholson, RA1
Gadthula, S; Kottani, R; Mahadeven, A; Selley, DE; Wang, P; Wiley, JL1
Baxter, P; Benfenati, F; Cerovic, M; Greco, B; Nazzaro, C; Parolaro, D; Pedarzani, P; Rubino, T; Tkatch, T; Tonini, R; Trusel, M1
Ahn, KH; Kendall, DA; Mahmoud, MM1
Ferlazzo, F; Fowler, CJ; Laricchiuta, D; Petrosini, L; Rodriguez-Gaztelumendi, A; Rojo, ML1
Abood, ME; Anavi-Goffer, S; Baillie, GL; Bolognini, D; Horswill, JG; McAllister, S; Pertwee, RG; Reggio, PH; Ross, RA; Stephens, GJ; Strange, PG1
Abdullah, R; Cravatt, BF; Kinsey, SG; Lichtman, AH; Ramesh, D; Selley, DE; Wise, LE1
Abood, ME; Kapur, A; Makriyannis, A; Marcu, J; Reggio, PH; Shore, DM; Trznadel, M1
Grabenauer, M; Lefever, TW; Marusich, JA; Moore, KN; Thomas, BF; Wiley, JL1
Cipriano, M; Fowler, CJ; Olsson, T; Rojo, ML; Simonytė, K; Söderström, I1
Ferrer, I; Giralt, MT; González de San Román, E; Manuel, I; Rodríguez-Puertas, R1
Farrens, DL; Fay, JF1
Cascio, MG; Denovan-Wright, EM; Janero, DR; Korde, A; Kulkarni, AR; Kulkarni, PM; Laprairie, RB; Makriyannis, A; Pertwee, RG; Thakur, GA; Tichkule, RB; Zhou, H; Zvonok, N1
Kendall, DA; Khurana, L; Shim, JY1
Ford, BM; Franks, LN; Prather, PL; Radominska-Pandya, A1
Farquhar, CE; Gamage, TF; Lefever, TW; Nguyen, T; Thomas, BF; Wiley, JL; Zhang, Y1
Giménez-Llort, L; Giralt, MT; Ledent, C; Llorente-Ovejero, A; Lombardero, L; Manuel, I; Rodríguez-Puertas, R1

Other Studies

68 other study(ies) available for cyclohexanol and guanosine 5'-o-(3-thiotriphosphate)

ArticleYear
Atypical location of cannabinoid receptors in white matter areas during rat brain development.
    Synapse (New York, N.Y.), 1997, Volume: 26, Issue:3

    Topics: Animals; Animals, Newborn; Autoradiography; Benzoxazines; Brain; Brain Chemistry; Cannabinoids; Cyclohexanols; Female; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant

1997
Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells.
    Cellular and molecular neurobiology, 1997, Volume: 17, Issue:5

    Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Calcium Channel Blockers; Cannabinoids; Cerebellum; Cyclohexanols; Endocannabinoids; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Hybrid Cells; Male; Membrane Proteins; Morpholines; Naphthalenes; Neuroblastoma; Polyunsaturated Alkamides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Sensitivity and Specificity; Tritium

1997
Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.
    European journal of pharmacology, 1997, Oct-08, Volume: 336, Issue:2-3

    Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant

1997
Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development.
    Development (Cambridge, England), 1998, Volume: 125, Issue:16

    Topics: Animals; Autoradiography; Benzoxazines; Brain; Colforsin; Cyclic AMP; Cyclohexanols; Dronabinol; Gene Expression Regulation, Developmental; Gestational Age; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Morpholines; Naphthalenes; Neuroglia; Protein Binding; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Signal Transduction

1998
Down-regulation of cannabinoid receptor agonist-stimulated [35S]GTP gamma S binding in synaptic plasma membrane from chronic ethanol exposed mouse.
    Brain research, 1999, Jan-02, Volume: 815, Issue:1

    Topics: Analgesics; Animals; Binding, Competitive; Brain Chemistry; Central Nervous System Depressants; Chronic Disease; Cyclohexanols; Dose-Response Relationship, Drug; Down-Regulation; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes; Synaptic Membranes

1999
Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Artemisia; Behavior, Animal; Bicyclic Monoterpenes; Binding, Competitive; Brain Chemistry; Cannabinoids; Colforsin; Cyclohexanols; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Male; Monoterpenes; Palatine Tonsil; Plants, Medicinal; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Terpenes

1999
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630.
    British journal of pharmacology, 1999, Volume: 126, Issue:3

    Topics: Animals; Benzoxazines; Binding, Competitive; Camphanes; Cannabinoids; CHO Cells; Chromans; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Morpholines; Naphthalenes; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Tritium

1999
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3

    Topics: Adenylyl Cyclases; Animals; Arachidonic Acids; Binding, Competitive; Body Temperature; Cannabinoids; Cerebellum; CHO Cells; Cricetinae; Cyclohexanols; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Neurons; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Transfection; Vas Deferens

1999
Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange.
    Journal of neurochemistry, 1999, Volume: 72, Issue:6

    Topics: Animals; Binding, Competitive; Cannabinoids; Cell Membrane; Cerebellum; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Ligands; Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium

1999
Cloning and pharmacological characterization of the rat CB(2) cannabinoid receptor.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:3

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug

2000
Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.
    Molecular pharmacology, 2000, Volume: 57, Issue:5

    Topics: Animals; Arachidonic Acids; Binding, Competitive; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Drug Antagonism; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Insecta; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Sulfur Radioisotopes; Transfection

2000
Azido- and isothiocyanato-substituted aryl pyrazoles bind covalently to the CB1 cannabinoid receptor and impair signal transduction.
    Journal of neurochemistry, 2000, Volume: 74, Issue:5

    Topics: Adenylyl Cyclases; Animals; Cyclohexanols; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Phenanthridines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction

2000
Separation of cannabinoid receptor affinity and efficacy in delta-8-tetrahydrocannabinol side-chain analogues.
    British journal of pharmacology, 2001, Volume: 132, Issue:2

    Topics: Animals; Carboxylic Acids; Cell Membrane; Cerebellum; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship

2001
Cannabinoid receptor agonist-stimulated [35S]guanosine triphosphate gammaS binding in the brain of C57BL/6 and DBA/2 mice.
    Journal of neuroscience research, 2001, May-15, Volume: 64, Issue:4

    Topics: Analgesics; Animals; Brain; Cannabinoids; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Species Specificity

2001
Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.
    European journal of pharmacology, 2001, Nov-23, Volume: 431, Issue:3

    Topics: Animals; Arachidonic Acids; Cannabinoids; Cattle; Cell Separation; Ciliary Body; Cyclic AMP; Cyclohexanols; Endocannabinoids; Fluorescent Antibody Technique; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intraocular Pressure; Ligands; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Trabecular Meshwork

2001
Characterization of the diarylether sulfonylester (-)-(R)-3-(2-hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:1

    Topics: Animals; Binding, Competitive; Body Temperature; Brain Injuries; Brain Ischemia; Cyclohexanols; Discrimination, Psychological; Guanosine 5'-O-(3-Thiotriphosphate); Hematoma, Subdural; Indans; Male; Middle Cerebral Artery; Neuroprotective Agents; Rats; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Succinate Dehydrogenase; Sulfonic Acids

2002
Pharmacological comparison of a recombinant CB1 cannabinoid receptor with its G(alpha 16) fusion product.
    Journal of biomolecular screening, 2002, Volume: 7, Issue:3

    Topics: Calcium; Cyclic AMP; Cyclohexanols; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Sulfur Radioisotopes; Tritium

2002
SR-141716A-induced stimulation of locomotor activity. A structure-activity relationship study.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 74, Issue:1

    Topics: Animals; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical; Structure-Activity Relationship

2002
Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation.
    European journal of pharmacology, 2003, Jan-10, Volume: 459, Issue:1

    Topics: Animals; Antiemetics; Benzoxazines; Binding, Competitive; Brain; Cisplatin; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Sulfur Radioisotopes; Tritium; Vomiting

2003
Long-term interactions between opioid and cannabinoid agonists at the cellular level: cross-desensitization and downregulation.
    Brain research, 2003, Jan-17, Volume: 960, Issue:1-2

    Topics: Animals; Cell Line; Cell Membrane; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclohexanols; Diprenorphine; Down-Regulation; Drug Interactions; Etorphine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Narcotic Antagonists; Rats; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Receptors, Opioid, delta; Signal Transduction; Transfection

2003
Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice.
    Journal of neurochemistry, 2003, Volume: 85, Issue:1

    Topics: Animals; Autoradiography; Behavior, Animal; Benzoxazines; Binding, Competitive; Body Temperature; Brain; Cannabinoids; Corticosterone; Cyclohexanols; Disease Models, Animal; Drug Tolerance; Enkephalins; Exploratory Behavior; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morpholines; Motor Activity; Naphthalenes; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger; Substance Withdrawal Syndrome; Transcription, Genetic; Tyrosine 3-Monooxygenase

2003
Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims.
    Molecular psychiatry, 2004, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Aged; Analgesics; Cyclohexanols; Depressive Disorder; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Prefrontal Cortex; Receptor, Cannabinoid, CB1; Suicide; Sulfur Radioisotopes; Tritium; Up-Regulation

2004
Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims.
    Biological psychiatry, 2005, Mar-01, Volume: 57, Issue:5

    Topics: Adolescent; Adult; Aged; Alcoholism; Binding, Competitive; Blotting, Western; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mass Spectrometry; Middle Aged; Prefrontal Cortex; Radioligand Assay; Receptor, Cannabinoid, CB1; Suicide; Sulfur Isotopes; Tritium

2005
Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.
    British journal of pharmacology, 2005, Volume: 145, Issue:5

    Topics: Animals; Benzoxazines; Blotting, Western; Cell Line; Cerebellum; CHO Cells; Cricetinae; Cyclohexanols; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isomerism; Ligands; Models, Molecular; Morpholines; Naphthalenes; Rats; Receptor, Cannabinoid, CB2; Receptor, Muscarinic M4; Receptors, G-Protein-Coupled; Receptors, Melatonin; Transfection

2005
Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects.
    Journal of neurochemistry, 2005, Volume: 93, Issue:4

    Topics: Aminoacetonitrile; Analgesics; Animals; Autoradiography; Behavior, Animal; Blotting, Western; Brain; Cyclohexanols; Diagnostic Imaging; Dronabinol; Drug Administration Schedule; Drug Tolerance; Extracellular Signal-Regulated MAP Kinases; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Knockout; Motor Activity; Protease Inhibitors; Protein Binding; ras-GRF1; Receptor, Cannabinoid, CB1; Signal Transduction; Sulfur Isotopes; Tritium

2005
The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Arachidonic Acids; Binding, Competitive; Biotransformation; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; Down-Regulation; Endocannabinoids; Enzyme Inhibitors; Glycerides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; In Vitro Techniques; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, G-Protein-Coupled; Transfection

2005
Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat.
    Pain, 2005, Volume: 116, Issue:1-2

    Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Catalepsy; Cell Line; Chromatography; Cricetinae; Cricetulus; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypothermia; Inflammation; Ligation; Male; Morpholines; Motor Activity; Naphthalenes; Pain; Pain Measurement; Pain Threshold; Radioligand Assay; Rats; Rats, Wistar; Rotarod Performance Test; Sciatic Neuropathy; Sulfur Isotopes; Time Factors; Tritium

2005
Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems.
    Psychopharmacology, 2005, Volume: 182, Issue:4

    Topics: Animals; Area Under Curve; Behavior, Animal; Brain; Brain Chemistry; Cannabinoids; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Male; Narcotics; Pain Measurement; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Opioid; Sulfur Isotopes; Tritium

2005
Allosteric modulation of the cannabinoid CB1 receptor.
    Molecular pharmacology, 2005, Volume: 68, Issue:5

    Topics: Allosteric Regulation; Animals; Binding Sites; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Vas Deferens

2005
Subchronic haloperidol increases CB(1) receptor binding and G protein coupling in discrete regions of the basal ganglia.
    Journal of neuroscience research, 2005, Oct-15, Volume: 82, Issue:2

    Topics: Analgesics; Animals; Basal Ganglia; Binding, Competitive; Cyclohexanols; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Receptors, G-Protein-Coupled; Up-Regulation

2005
Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
    Molecular pharmacology, 2006, Volume: 70, Issue:1

    Topics: Animals; Benzoxazines; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Endocytosis; Enzyme Activation; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Naphthalenes; Phenols; Piperidines; Propylene Glycols; Proto-Oncogene Proteins c-akt; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sphingosine

2006
Cannabinoid system in the budgerigar brain.
    Brain research, 2006, May-04, Volume: 1087, Issue:1

    Topics: Animals; Autoradiography; Benzoxazines; Brain; Brain Mapping; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Melopsittacus; Morpholines; Naphthalenes; Phenols; Protein Binding; Radioligand Assay; Receptors, Cannabinoid; Sulfur Isotopes; Tritium

2006
Effect of chronic ethanol exposure and its withdrawal on the endocannabinoid system.
    Neurochemistry international, 2006, Volume: 49, Issue:6

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Central Nervous System Depressants; Chromatography, Liquid; Cyclohexanols; Endocannabinoids; Ethanol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mass Spectrometry; Mice; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Sulfur Radioisotopes

2006
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation.
    Brain research, 2006, Sep-07, Volume: 1108, Issue:1

    Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acids; Binding, Competitive; Cannabinoids; Cell Line; Cyclic AMP; Cyclohexanes; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Mutation; Phenols; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant

2006
Characterization of cannabinoid-binding sites in zebrafish brain.
    Neuroscience letters, 2007, Feb-21, Volume: 413, Issue:3

    Topics: Animals; Benzoxazines; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Protein Binding; Radioligand Assay; Tritium; Zebrafish

2007
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
    British journal of pharmacology, 2007, Volume: 150, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Brain; Camphanes; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Phenols; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Rimonabant; Transfection

2007
The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.
    British journal of pharmacology, 2007, Volume: 150, Issue:5

    Topics: Analgesics, Non-Narcotic; Animals; Benzoxazines; Binding, Competitive; Body Temperature; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Locomotion; Male; Mice; Mice, Inbred ICR; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Pain Measurement; Pain Threshold; Phenols; Protein Binding; Psychotropic Drugs; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Vas Deferens

2007
Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2.
    The European journal of neuroscience, 2007, Volume: 25, Issue:7

    Topics: Analgesics, Opioid; Animals; Benzoxazines; Brain; Cannabinoids; Cyclohexanols; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; Humans; Male; Morpholines; Naphthalenes; Rats; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Self Administration

2007
PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats.
    British journal of pharmacology, 2007, Volume: 152, Issue:5

    Topics: Allosteric Regulation; Animals; Appetite Depressants; Cell Line; Cell Membrane; Cerebral Cortex; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Eating; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Molecular Structure; Phenylurea Compounds; Piperidines; Pyrazoles; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Saccharomyces cerevisiae; Silicone Elastomers; Sulfur Radioisotopes; Weight Gain

2007
Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB2) in rodents and primates.
    British journal of pharmacology, 2007, Volume: 151, Issue:8

    Topics: Animals; Binding, Competitive; Cell Membrane; Chemotaxis; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Macaca fascicularis; Mice; Quinolizines; Rats; Receptor, Cannabinoid, CB2; Species Specificity

2007
Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Binding, Competitive; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Female; Guanosine 5'-O-(3-Thiotriphosphate); Litter Size; Male; Morpholines; Motor Activity; Naphthalenes; Phospholipase D; Polyunsaturated Alkamides; Pregnancy; Prenatal Exposure Delayed Effects; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Sulfur Radioisotopes; Weight Gain

2007
The orphan receptor GPR55 is a novel cannabinoid receptor.
    British journal of pharmacology, 2007, Volume: 152, Issue:7

    Topics: Amino Acid Sequence; Animals; Arachidonic Acids; Binding Sites; Binding, Competitive; Cannabidiol; Cannabinoids; Cell Line; Cloning, Molecular; Cyclohexanols; Down-Regulation; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mice; Molecular Sequence Data; Organ Specificity; Polymerase Chain Reaction; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Structure-Activity Relationship

2007
Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.
    European journal of pharmacology, 2008, Feb-26, Volume: 581, Issue:1-2

    Topics: Animals; Benzoxazines; Cells, Cultured; Cyclohexanols; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morpholines; Naphthalenes; Protein Conformation; Receptor, Cannabinoid, CB1; Signal Transduction; Spodoptera

2008
Sex-dependent effects of periadolescent exposure to the cannabinoid agonist CP-55,940 on morphine self-administration behaviour and the endogenous opioid system.
    Neuropharmacology, 2008, Volume: 54, Issue:5

    Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Brain; Conditioning, Operant; Cyclohexanols; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Guanosine 5'-O-(3-Thiotriphosphate); Male; Morphine; Protein Binding; Rats; Rats, Wistar; Receptors, Opioid, mu; Reinforcement Schedule; Self Administration; Sex Characteristics; Statistics, Nonparametric; Sulfur Isotopes

2008
Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein G(alpha)i2beta1gamma2.
    Neuroscience letters, 2008, Dec-05, Volume: 447, Issue:1

    Topics: Animals; Cell Line, Transformed; Cyclohexanols; Dose-Response Relationship, Drug; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein gamma Subunits; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Insecta; Protein Binding; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Time Factors

2008
Altered CB receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine.
    Journal of neurochemistry, 2009, Volume: 108, Issue:6

    Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Cyclohexanols; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Exploratory Behavior; Fluoxetine; Guanosine 5'-O-(3-Thiotriphosphate); Immunosuppressive Agents; Isotopes; Male; Olfactory Bulb; Prefrontal Cortex; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Time Factors

2009
Inhibition of fatty-acid amide hydrolase and CB1 receptor antagonism differentially affect behavioural responses in normal and PCP-treated rats.
    The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:3

    Topics: Amidohydrolases; Amphetamine; Animals; Autoradiography; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Cyclohexanols; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Hallucinogens; Interpersonal Relations; Male; Memory, Short-Term; Motor Activity; Neuropsychological Tests; Phencyclidine; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Sulfur Isotopes; Time Factors

2010
In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists.
    Pharmacological research, 2010, Volume: 61, Issue:4

    Topics: Analgesics; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Drug Inverse Agonism; Formaldehyde; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Molecular Structure; Pain; Quinolones; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship

2010
Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant.
    Journal of neurochemistry, 2010, Volume: 112, Issue:5

    Topics: Amides; Analysis of Variance; Animals; Autoradiography; Benzoxazines; Body Weight; Brain; Cyclohexanols; Diet Fads; Disease Models, Animal; Eating; Female; Guanosine 5'-O-(3-Thiotriphosphate); International Cooperation; Morpholines; Naphthalenes; Obesity; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Isotopes; Time Factors; Tomography Scanners, X-Ray Computed; Tritium; Whole Body Imaging

2010
Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue.
    Neurochemistry international, 2011, Volume: 58, Issue:1

    Topics: Amino Acids; Animals; Binding, Competitive; Brain Chemistry; Cyclic AMP; Cyclohexanols; Cyclooxygenase 2 Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Isoxazoles; Male; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sulfonamides; Transfection

2011
Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats.
    Brain research, 2011, Feb-10, Volume: 1373

    Topics: Animals; Autoradiography; Brain; Brain Ischemia; Cyclohexanols; Disease Models, Animal; Estradiol; Estrogens; Female; Functional Laterality; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Infarction, Middle Cerebral Artery; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sulfur Isotopes; Time Factors; Tritium

2011
The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro.
    Neurochemistry international, 2011, Volume: 59, Issue:5

    Topics: Animals; Benzoxazines; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Mice; Morpholines; Naphthalenes; Phthalic Acids; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant

2011
3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2

    Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Drug Inverse Agonism; Female; Freezing Reaction, Cataleptic; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship; Transfection

2012
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
    Nature neuroscience, 2012, Jan-08, Volume: 15, Issue:2

    Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium

2012
Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation.
    The Journal of biological chemistry, 2012, Apr-06, Volume: 287, Issue:15

    Topics: Allosteric Regulation; Animals; Cyclohexanols; Drug Synergism; Endocytosis; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Hippocampus; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neurons; Pertussis Toxin; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Secondary; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant

2012
CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Amidohydrolases; Animals; Autoradiography; Avoidance Learning; Brain; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Male; Maze Learning; Mice; Mice, Inbred C57BL; Motivation; Receptor, Cannabinoid, CB1

2012
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.
    Molecular pharmacology, 2013, Volume: 83, Issue:2

    Topics: Allosteric Regulation; Animals; Arrestins; Benzoxazines; beta-Arrestins; Brain; Cell Line; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Indoles; Kinetics; Ligands; Male; MAP Kinase Signaling System; Mice; Morpholines; Naphthalenes; Phosphorylation; Piperidines; Protein Binding; Receptor, Cannabinoid, CB1; Signal Transduction

2013
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Benzodioxoles; Brain Chemistry; Cyclohexanols; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders

2013
Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:2

    Topics: Amino Acid Sequence; Benzoxazines; Binding, Competitive; Cell Line; Cyclohexanols; Energy Metabolism; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Models, Chemical; Molecular Sequence Data; Morpholines; Mutagenesis, Site-Directed; Naphthalenes; Piperidines; Protein Conformation; Protein Structure, Secondary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction

2013
Cannabinoids in disguise: Δ9-tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles.
    Neuropharmacology, 2013, Volume: 75

    Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Protein Binding; Receptor, Cannabinoid, CB1; Sulfur Isotopes; Transfection; Tritium

2013
Effects of dietary glucose and fructose upon cannabinoid CB1 receptor functionality in the rat brain: a pilot study.
    Life sciences, 2014, Jul-17, Volume: 108, Issue:2

    Topics: Adiponectin; Analysis of Variance; Animals; Autoradiography; Brain; Cyclohexanols; Dietary Carbohydrates; Fructose; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); Leptin; Male; Pilot Projects; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Statistics, Nonparametric

2014
Type-1 cannabinoid receptor activity during Alzheimer's disease progression.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 42, Issue:3

    Topics: Alzheimer Disease; Analgesics; Benzoxazines; Brain; Cyclohexanols; Diagnosis; Disease Progression; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isotopes; Male; Morpholines; Naphthalenes; Radionuclide Imaging; Receptor, Cannabinoid, CB1; Statistics, Nonparametric

2014
Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Jul-07, Volume: 112, Issue:27

    Topics: Algorithms; Animals; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Chlorocebus aethiops; COS Cells; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Kinetics; Models, Biological; Models, Molecular; Mutation; Piperidines; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant

2015
Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s).
    Journal of medicinal chemistry, 2016, Jan-14, Volume: 59, Issue:1

    Topics: Affinity Labels; Allosteric Site; Animals; Arrestins; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Drug Discovery; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Ligands; Models, Molecular; Phenylurea Compounds; Piperidines; Pyridines; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Structure-Activity Relationship

2016
Computational analysis of the CB1 carboxyl-terminus in the receptor-G protein complex.
    Proteins, 2016, Volume: 84, Issue:4

    Topics: Amino Acid Sequence; Analgesics; Binding Sites; Cell Membrane; Cyclohexanols; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Domains; Protein Structure, Secondary; Protein Subunits; Receptor, Cannabinoid, CB1; Recombinant Proteins

2016
Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Breast Neoplasms; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Isomerism; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Selective Estrogen Receptor Modulators; Tamoxifen

2016
The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB
    Neuropharmacology, 2017, Volume: 125

    Topics: Allosteric Regulation; Animals; Cannabinoid Receptor Modulators; Cerebellum; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Phenylurea Compounds; Piperidines; Pregnenolone; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant

2017
Endocannabinoid and Muscarinic Signaling Crosstalk in the 3xTg-AD Mouse Model of Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 64, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Brain; Cannabinoids; Cholinergic Agents; Cyclohexanols; Disease Models, Animal; Endocannabinoids; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Oxazines; Presenilin-1; Radioisotopes; Signal Transduction; tau Proteins

2018