cyclohexanol has been researched along with dronabinol in 175 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.14) | 18.7374 |
| 1990's | 60 (34.29) | 18.2507 |
| 2000's | 60 (34.29) | 29.6817 |
| 2010's | 51 (29.14) | 24.3611 |
| 2020's | 2 (1.14) | 2.80 |
| Authors | Studies |
|---|---|
| Abood, ME; Kaminski, NE; Kessler, FK; Martin, BR; Schatz, AR | 1 |
| Compton, DR; Johnson, MR; Martin, BR; Melvin, LS | 1 |
| Balster, RL; Barrett, RL; Britt, DT; Gold, LH; Martin, BR | 1 |
| Brown, DA; Caulfield, MP | 1 |
| Briley, EM; Felder, CC; Matsuda, LA; Veluz, JS; Williams, HL | 1 |
| Martin, BR; Thomas, BF; Wei, X | 1 |
| Ali, SF; Howlett, AC; Paule, MG; Scallet, AC; Slikker, W; Westlake, TM | 1 |
| Lichtman, AH; Martin, BR | 1 |
| Compton, DR; Johnson, MR; Little, PJ; Martin, BR; Mechoulam, R; Melvin, LS; Prescott, WR; Razdan, RK; Thomas, BF; Ward, SJ | 1 |
| Banijamali, A; Charalambous, A; Compton, DR; Friend, FL; Lin, S; Makriyannis, A; Marciniak, G; Martin, BR | 1 |
| Champion, TM; Howlett, AC; Mechoulam, R; Wilken, GH | 1 |
| Howlett, AC; Johnson, MR; Melvin, LS | 1 |
| Devane, WA; Dysarz, FA; Howlett, AC; Johnson, MR; Melvin, LS | 1 |
| Melvin, LS; Milne, GM; Weissman, A | 1 |
| Casellas, P; Derocq, JM; Le Fur, G; Marchand, J; Ségui, M | 1 |
| Balster, RL; Barrett, RL; Lowe, J; Martin, BR; Wiley, JL | 1 |
| Cebeira, M; Fernández-Ruiz, JJ; García, L; Ramos, JA; Romero, J | 1 |
| Dimen, KR; Lichtman, AH; Martin, BR | 1 |
| Fournier, DJ; Grzybowska, J; Li, X; Makriyannis, A; Morse, KL | 1 |
| Dai, D; Duncan, SG; Huffman, JW; Jordan, RD; Lainton, JA | 1 |
| Cook, SA; Lichtman, AH; Martin, BR; Welch, SP | 1 |
| Balster, R; Martin, B; Wiley, J | 1 |
| Dunlow, LD; Patrick, GS; Razdan, RK; Welch, SP | 1 |
| Bass, PP; Pugh, G; Welch, SP | 1 |
| Compton, DR; Fan, F; Martin, BR; Melvin, L; Ward, S | 1 |
| Compton, DR; Martin, BR; Mechoulam, R; Razdan, RK; Smith, PB; Welch, SP | 1 |
| Fernández-Ruiz, JJ; Gorriti, MA; Palomo, T; Ramos, JA; Rodríguez de Fonseca, F | 1 |
| Kaminski, NE | 1 |
| Charalambous, A; Compton, DR; Grzybowska, J; Lin, S; Makriyannis, A; Marciniak, G; Martin, BR; Semus, SF | 1 |
| Abood, ME; Fan, F; Martin, BR; Sauss, C; Tilton, CL | 1 |
| Cebeira, M; Fernández-Ruiz, JJ; Martín, M; Ramos, JA; Rodríguez de Fonseca, F | 1 |
| Berkery, D; Chang, MC; Laychock, SG; Schuel, H; Schuel, R; Zimmerman, AM; Zimmerman, S | 1 |
| Griffin, G; Pertwee, RG; Stevenson, LA | 1 |
| Glowa, J; Herkenham, M; Oviedo, A | 1 |
| Cook, SA; Lichtman, AH; Martin, BR | 1 |
| Lowe, JA; Mansbach, RS; Rovetti, CC; Winston, EN | 1 |
| Compton, DR; Fernando, SR; Griffin, G; Martin, BR; Pertwee, RG; Razdan, RK; Ryan, W | 1 |
| Friedman, H; Klein, T; Newton, C; Smith, MS; Yamamoto, Y | 1 |
| Balster, RL; Compton, DR; Dutta, A; Gordon, PM; Lichtman, AH; Martin, BR; Razdan, RK; Siegel, C; Singer, M; Wiley, JL | 1 |
| Bloom, AS; Edgemond, WS; Moldvan, JC | 1 |
| Welch, SP | 1 |
| Burkey, RT; Nation, JR | 1 |
| Burkey, TH; Consroe, P; Ehlert, FJ; Hosohata, Y; Quock, RM; Roeske, WR; Yamamura, HI | 1 |
| Cardounel, A; Kalimi, M; Qureshi, J; Saady, M | 1 |
| Aberman, J; Carriero, D; Hill, A; Lin, SY; Makriyannis, A; Salamone, JD | 1 |
| Corchero, J; Fernandez-Ruiz, JJ; Fuentes, JA; Manzanares, J; Ramos, JA; Romero, J | 1 |
| Dubroeucq, MC; Imperato, A; Jeantaud, B; Petitet, F; Reibaud, M | 1 |
| Berrendero, F; Cebeira, M; de Miguel, R; Fernández-Ruiz, JJ; García-Gil, L; Hernández, ML; Ramos, JA; Romero, J | 1 |
| Hiley, CR; White, R | 1 |
| Brockie, HC; Fernando, SR; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B | 1 |
| Bonhaus, DW; Chang, LK; Kwan, J; Martin, GR | 1 |
| Huffman, JW; Liddle, J; Martin, BR; Wiley, JL | 1 |
| Baba, N; Ishima, Y; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Seki, C; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Cadogan, AK; Cheer, JF; Fone, KC; Kendall, DA; Marsden, CA | 1 |
| Bonner, TI; Herkenham, M; Hohmann, AG; Zimmer, A; Zimmer, AM | 1 |
| Cabral, GA; Carlisle, SJ; Matveyeva, M; McCoy, KL | 1 |
| DiCamelli, R; Greenberg, MJ; Hillard, CJ; Kearn, CS; Kurzawa, K | 1 |
| Brown, S; Derleth, C; Hsieh, C; Mackie, K | 1 |
| Berrendero, F; Bisogno, T; Corchero, J; Di Marzo, V; Fernández-Ruiz, J; Fuentes, JA; González, S; Manzanares, J; Ramos, JA; Romero, J; Wenger, T | 1 |
| Lowe, J; Mason, DJ; Welch, SP | 1 |
| Göthert, M; Likungu, J; Molderings, GJ | 1 |
| Crocker, P; Gibson, TM; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B; Stevenson, LA | 1 |
| Eads, M; Embrey, JP; Houser, SJ; Welch, SP | 1 |
| Angus, JA; Lay, L; Wright, CE | 1 |
| Banner, WK; Gibson, TM; Martin, BR; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B; Stevenson, LA | 1 |
| Bonner, T; Buckley, NE; Felder, CC; Glass, M; McCoy, KL; Mezey, E; Zimmer, A | 1 |
| Abood, ME; Aung, MM; Griffin, G; Martin, BR; Razdan, RK; Williams, S | 1 |
| Bradbury, R; Copolov, D; Dean, B; Scarr, E; Sundram, S | 1 |
| Fox, A; Gentry, C; James, I; Kesingland, A; McNair, K; Patel, S; Urban, L | 1 |
| Darmani, NA | 1 |
| Jan, TR; Kaminski, NE; Rao, GK | 1 |
| Guaza, C; Molina-Holgado, E; Molina-Holgado, F; Rothwell, NJ | 1 |
| Christopoulos, A; Devlin, MG | 1 |
| Breivogel, CS; Crim, JL; Darmani, NA; Janoyan, JJ; Martin, BR; Parekh, B; Sim-Selley, LJ | 1 |
| Carai, MA; Casu, MA; Gessa, GL; Marchese, G; Pani, L; Porcella, A; Reali, R; Ruiu, S; Saba, P | 1 |
| Del Giudice, E; Facchinetti, F; Furegato, S; Leon, A; Passarotto, M | 1 |
| Rhee, MH | 1 |
| Hart, R; Huffman, JW; Hurst, DP; Lu, J; Mabon, R; Martin, BR; Reggio, PH; Wiley, JL; Wu, MJ | 1 |
| Ihenetu, K; Molleman, A; Parsons, M; Whelan, C | 1 |
| Huffman, JW; Liddle, J; Martin, BR; Miller, JR; Thomas, BF; Wiley, JL; Yu, S | 1 |
| Niederhoffer, N; Schmid, K; Szabo, B | 1 |
| De Vry, J; Jentzsch, KR | 3 |
| Engler, C; Feuerstein, TJ; Steffens, M; Zentner, J | 1 |
| De Vry, J; Eckel, G; Jentzsch, KR; Kuhl, E | 1 |
| Battista, N; Bernardi, G; Calabresi, P; Centonze, D; Finazzi-Agrò, A; Maccarrone, M; Mercuri, NB; Rossi, S | 1 |
| Kraft, B; Kress, HG; Wintersberger, W | 1 |
| Duncan, M; Kendall, DA; Ralevic, V | 1 |
| Cravatt, BF; Hillard, CJ; Patel, S | 1 |
| Mallet, PE; McGregor, IS; O'Shea, M; Singh, ME | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 1 |
| Forlani, G; Parolaro, D; Rubino, T; Viganò, D; Zippel, R | 1 |
| Brain, C; Chen, A; Courade, JP; Dyson, A; Fox, A; Groarke, A; Loong, Y; Peacock, M; Yaqoob, M | 1 |
| Llorente, R; Marco, EM; Moreno, E; Viveros, MP | 1 |
| Hille, B; Lauckner, JE; Mackie, K | 1 |
| Carchenilla, MS; Jacobsson, SO; Johansson, M; Persson, E; Svensson, AC | 1 |
| Fowler, CJ; Jacobsson, SO; Nilsson, O | 1 |
| McMahon, LR | 3 |
| Buzsaki, G; McNaughton, BL; Montgomery, SM; Robbe, D; Rueda-Orozco, PE; Thome, A | 1 |
| Marron Fernandez de Velasco, E; Rodriguez, RE; Rodriguez-Martin, I | 1 |
| Lichtman, AH; Martin, BR; Pertwee, RG; Razdan, RK; Ross, RA; Stevenson, LA; Thomas, A; Varvel, SA | 1 |
| Battistin, L; Carbonare, MD; D'Arrigo, A; Facchinetti, F; Giudice, ED; Guiotto, A; Leon, A; Passarotto, M; Rinaldi, L | 1 |
| Crim, J; Darmani, NA; Janoyan, JJ; Ramirez, J | 1 |
| Bosier, B; Hermans, E; Lambert, DM; Najimi, M; Tilleux, S | 1 |
| Abood, ME; Anavi-Goffer, S; Barnett-Norris, J; Fleischer, D; Howlett, AC; Hurst, DP; Lewis, DL; Lynch, DL; Mukhopadhyay, S; Reggio, PH; Shi, S | 1 |
| Deno, G; Fan, X; Gonsiorek, W; Hipkin, RW; Kozlowski, J; Lunn, CA | 1 |
| Ginsburg, BC; Lamb, RJ; McMahon, LR | 1 |
| Buckley, NE; Cabral, GA; Marciano-Cabral, F; Martin, BR; Raborn, ES | 1 |
| Araújo, JR; Azevedo, I; Gonçalves, P; Martel, F | 1 |
| Bosier, B; Hermans, E; Lambert, D | 1 |
| Breivogel, CS; Gerfin, S; Huffman, JW; Lambert, JM; Razdan, RK | 1 |
| Bosier, B; Hermans, E; Lambert, DM | 2 |
| Araújo, JR; Gonçalves, P; Martel, F | 1 |
| Izenwasser, S; Reed, SC; Wade, D; Werling, LL | 1 |
| Dalton, VS; Wang, H; Zavitsanou, K | 1 |
| Díaz, A; Pazos, A; Rodríguez-Gaztelumendi, A; Rojo, ML | 1 |
| Dekkers, BG; Dröge, MJ; Elzinga, CR; Gkoumassi, E; Hasenbosch, RE; Meurs, H; Nelemans, SA; Schmidt, M; Zaagsma, J | 1 |
| Lichtman, AH; Thorpe, AJ; Wise, LE | 1 |
| Booker, L; Lichtman, AH; Mahadevan, A; Naidu, PS; Razdan, RK | 1 |
| Cabral, GA; Raborn, ES | 1 |
| Makwana, R; Molleman, A; Parsons, ME | 1 |
| McMahon, LR; Stewart, JL | 1 |
| Dodd, GT; Luckman, SM; Lutz, B; Mancini, G | 1 |
| Bosier, B; Hermans, E; Lambert, DM; Michotte, Y; Sarre, S; Smolders, I | 1 |
| Arnold, JC; Boucher, AA; Huang, X; Hunt, GE; Karl, T; McGregor, IS; Micheau, J | 1 |
| Burston, JJ; Craig, AA; Selley, DE; Sim-Selley, LJ; Wiley, JL | 1 |
| Dalton, VS; Zavitsanou, K | 1 |
| Fernández-Ruiz, J; García, C; García-Arencibia, M; Palomo-Garo, C; Pertwee, R; Ramos, J | 1 |
| Bolognini, D; Cascio, MG; Parolaro, D; Pertwee, RG | 1 |
| Baskfield, CY; Matthew Walentiny, D; Vann, RE; Wiley, JL | 1 |
| Bertalovitz, AC; Kendall, DA; Shim, JY | 1 |
| Ahmad, S; Groblewski, T; Ndong, C; O'Donnell, D | 1 |
| Bogacz, R; Jones, MW; Kucewicz, MT; Tricklebank, MD | 1 |
| Gadthula, S; Kottani, R; Mahadeven, A; Selley, DE; Wang, P; Wiley, JL | 1 |
| Craft, RM; Laggart, JD; Tsutsui, KT; Wakley, AA | 1 |
| Baxter, P; Benfenati, F; Cerovic, M; Greco, B; Nazzaro, C; Parolaro, D; Pedarzani, P; Rubino, T; Tkatch, T; Tonini, R; Trusel, M | 1 |
| Bosier, B; Hermans, E; Lambert, DM; Mertens, B; Michotte, Y; Muccioli, GG; Sarre, S | 1 |
| Ginsburg, BC; Hruba, L; McMahon, LR | 1 |
| Kwilasz, AJ; Negus, SS | 1 |
| Funada, M; Tomiyama, K | 1 |
| Agosti, V; Bisaga, A; Brooks, DJ; Carpenter, KM; Levin, FR; Mariani, J; Nunes, EV; Pavlicova, M; Sullivan, MA | 1 |
| Abdullah, R; Cravatt, BF; Kinsey, SG; Lichtman, AH; Ramesh, D; Selley, DE; Wise, LE | 1 |
| France, CP; Maguire, DR; Yang, W | 1 |
| Kumar, P; Song, ZH | 1 |
| Akhtar, MT; Ali, S; Rashidi, H; Richardson, MK; van der Kooy, F; Verpoorte, R | 1 |
| Feliszek, M; Ilayan, E; Malinowska, B; Schlicker, E | 1 |
| Grabenauer, M; Lefever, TW; Marusich, JA; Moore, KN; Thomas, BF; Wiley, JL | 1 |
| Halikhedkar, A; Järbe, TU; LeMay, BJ; Makriyannis, A; Vadivel, SK; Wood, J; Zvonok, A | 1 |
| Hruba, L; McMahon, LR | 1 |
| Abdelrahman, M; Gamage, TF; Greig, IR; Ignatowska-Jankowska, BM; Lichtman, AH; Pertwee, RG; Poklis, J; Ross, RA; Thakur, GA; Tichkule, R; Trembleau, L; Wiley, JL | 1 |
| Cabral, GA; Jamerson, M; Marciano-Cabral, F; Raborn, ES | 1 |
| McMahon, LR; Rodriguez, JS | 1 |
| Bagher, AM; Denovan-Wright, EM; Dupré, DJ; Kelly, ME; Laprairie, RB | 1 |
| Di Marzo, V; Ligresti, A; Melis, M; Parolaro, D; Piscitelli, F; Prini, P; Rubino, T; Sagheddu, C; Tonini, R; Trusel, M; Zamberletti, E | 1 |
| Forster, MJ; Gatch, MB | 1 |
| Breivogel, CS; Vaghela, MS | 1 |
| Christopoulos, A; Glass, M; Khajehali, E; Leach, K; Malone, DT; Sexton, PM | 1 |
| Dow-Edwards, D; Frank, A; Harte-Hargrove, L; Izenwasser, S; Silva, L; Wade, D | 1 |
| Bonsi, P; Fezza, F; Maccarrone, M; Madeo, G; Maltese, M; Martella, G; Mastrangelo, N; Pisani, A; Rapino, C; Schirinzi, T | 1 |
| France, CP; Gerak, LR | 1 |
| Eldeeb, K; Howlett, AC; Leone-Kabler, S | 1 |
| France, CP; Maguire, DR | 3 |
| John, WS; Martin, TJ; Nader, MA | 1 |
| Craft, RM; Lefever, TW; Marusich, JA; Wiley, JL | 1 |
| Bedse, G; Gaulden, AD; Hartley, ND; Kingsley, PJ; Marnett, LJ; Neale, E; Patel, S; Patrick, TA; Plath, N; Uddin, MJ | 1 |
| Farquhar, CE; Gamage, TF; Lefever, TW; Nguyen, T; Thomas, BF; Wiley, JL; Zhang, Y | 1 |
| Henderson-Redmond, AN; LaFleur, RA; Morgan, DJ; Wilson, RP | 1 |
| Delcroix, V; Makarenkova, HP; Murataeva, N; Straiker, A; Thayer, A; Wager-Miller, J | 1 |
| Budde, H; Coronado-Álvarez, A; Imperatori, C; Machado, S; Macías-Triana, L; Murillo-Rodríguez, E; Romero-Cordero, K; Tatum-Kuri, A; Vera-Barrón, A; Yamamoto, T | 1 |
4 review(s) available for cyclohexanol and dronabinol
| Article | Year |
|---|---|
Classical and nonclassical cannabinoids: mechanism of action--brain binding.
Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Brain; Cannabinoids; Cyclohexanols; Dronabinol; Structure-Activity Relationship | 1990 |
Behavioural and neuroendocrine effects of cannabinoids in critical developmental periods.
Topics: Animals; Behavior, Animal; Benzoxazines; Brain; Cannabinoids; Critical Period, Psychological; Cyclohexanols; Dronabinol; Morpholines; Naphthalenes; Neurosecretory Systems | 2005 |
[Drug discrimination properties and cytotoxicity of the cannabinoid receptor ligands].
Topics: Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dronabinol; Humans; Ligands; Morpholines; Naphthalenes; Receptor, Cannabinoid, CB1; Substrate Specificity | 2012 |
The synthetic CB
Topics: Analgesics; Animals; Anti-Anxiety Agents; Cannabinoid Receptor Agonists; Cannabinoids; Controlled Substances; Cyclohexanols; Dronabinol; Humans; Mental Disorders; Pain; Phenanthridines; Receptor, Cannabinoid, CB1 | 2021 |
1 trial(s) available for cyclohexanol and dronabinol
| Article | Year |
|---|---|
A randomized double-blind, placebo-controlled trial of venlafaxine-extended release for co-occurring cannabis dependence and depressive disorders.
Topics: Adult; Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Combined Modality Therapy; Cyclohexanols; Delayed-Action Preparations; Depressive Disorder, Major; Double-Blind Method; Dronabinol; Female; Humans; Male; Marijuana Abuse; Medication Adherence; Recurrence; Selective Serotonin Reuptake Inhibitors; Treatment Failure; Venlafaxine Hydrochloride | 2013 |
170 other study(ies) available for cyclohexanol and dronabinol
| Article | Year |
|---|---|
Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation.
Topics: Animals; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Electrophoresis, Agar Gel; Female; Immunosuppressive Agents; Mice; Polymerase Chain Reaction; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; RNA; Spleen; Stereoisomerism | 1992 |
Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents.
Topics: Adenylyl Cyclases; Analgesics; Animals; Bridged Bicyclo Compounds; Cannabinoids; Cyclohexanols; Dronabinol; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Structure-Activity Relationship; Tritium | 1992 |
A comparison of the discriminative stimulus properties of delta 9-tetrahydrocannabinol and CP 55,940 in rats and rhesus monkeys.
Topics: Analgesics; Animals; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Macaca mulatta; Male; Rats; Rats, Inbred Strains | 1992 |
Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism.
Topics: Analgesics; Calcium Channel Blockers; Cannabinoids; Cyclohexanols; Dronabinol; GTP-Binding Proteins; Humans; Neuroblastoma; omega-Conotoxins; Peptides, Cyclic; Pertussis Toxin; Receptors, Cannabinoid; Receptors, Drug; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones.
Topics: Animals; Arachidonic Acid; Calcium; Cannabinoids; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Cyclohexanols; DNA; Dronabinol; Humans; Inositol Phosphates; L Cells; Mice; Phospholipases A; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transfection; Type C Phospholipases | 1992 |
Characterization and autoradiographic localization of the cannabinoid binding site in rat brain using [3H]11-OH-delta 9-THC-DMH.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Cyclohexanols; Dronabinol; Male; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 1992 |
Chronic exposure to delta 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors.
Topics: Analgesics; Animals; Brain; Cannabinoids; Cerebellum; Cerebral Cortex; Cyclohexanols; Dronabinol; Hippocampus; Kinetics; Macaca mulatta; Male; Organ Specificity; Phenanthridines; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug | 1991 |
Spinal and supraspinal components of cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dronabinol; Injections, Intravenous; Injections, Spinal; Male; Rats; Rats, Inbred Strains; Spinal Cord | 1991 |
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Body Temperature; Brain; Cannabinoids; Cyclohexanols; Dronabinol; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Conformation; Morpholines; Motor Activity; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Drug; Structure-Activity Relationship | 1991 |
Pharmacological evaluation of halogenated delta 8-THC analogs.
Topics: Analgesics; Animals; Binding, Competitive; Body Temperature; Catalepsy; Cyclohexanols; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Receptors, Cannabinoid; Receptors, Drug | 1991 |
Stereochemical effects of 11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cells, Cultured; Cyclic AMP; Cyclohexanols; Dronabinol; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug | 1990 |
Determination and characterization of a cannabinoid receptor in rat brain.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain Chemistry; Cyclohexanols; Dronabinol; Guanylyl Imidodiphosphate; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug; Sodium | 1988 |
Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol.
Topics: Amphetamine; Analgesia; Animals; Anticonvulsants; Apomorphine; Behavior, Animal; Body Temperature; Cyclohexanols; Dogs; Dronabinol; Drug Interactions; Male; Mice; Motor Activity; Pain; Tetrabenazine; Vocalization, Animal | 1982 |
Cannabinoids enhance human B-cell growth at low nanomolar concentrations.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Base Sequence; Benzoxazines; Cannabinoids; CD40 Antigens; Cell Division; Cyclohexanols; DNA; Dronabinol; Humans; Ligands; Lymphocyte Activation; Molecular Sequence Data; Morpholines; Naphthalenes; Palatine Tonsil; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Antigen, B-Cell; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Virulence Factors, Bordetella | 1995 |
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraperitoneal; Male; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1995 |
Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to delta 9-tetrahydrocannabinol.
Topics: Analgesics; Animals; Arachidonic Acids; Brain Chemistry; Calcium Channel Blockers; Cannabinoids; Cannabis; Cyclohexanols; Dronabinol; Endocannabinoids; In Vitro Techniques; Kinetics; Male; Membranes; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug | 1995 |
Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Memory; Rats; Rats, Sprague-Dawley; Spatial Behavior; Temperature | 1995 |
A novel electrophilic high affinity irreversible probe for the cannabinoid receptor.
Topics: Affinity Labels; Animals; Binding, Competitive; Cannabinoids; Cyclohexanols; Dronabinol; In Vitro Techniques; Ligands; Protein Binding; Rats; Receptors, Cannabinoid; Receptors, Drug; Synaptosomes | 1995 |
Variation of the alkyl side chain in delta 8-THC.
Topics: Analgesics; Animals; Binding, Competitive; Catalepsy; Cyclohexanols; Dronabinol; Hypothermia; Mice; Motor Activity; Structure-Activity Relationship | 1995 |
Evaluation of cAMP involvement in cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Colforsin; Cyclic AMP; Cyclohexanols; Dronabinol; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley | 1995 |
Discriminative stimulus effects of anandamide in rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 1995 |
Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to delta 9-THC after intrathecal administration to mice: blockade of delta 9-THC-induced antinociception.
Topics: Analgesics; Animals; Arachidonic Acids; Binding Sites; Calcium Channel Blockers; Cyclohexanols; Dronabinol; Drug Tolerance; Endocannabinoids; Injections, Spinal; Mice; Narcotic Antagonists; Pertussis Toxin; Polyunsaturated Alkamides; Potassium Channel Blockers; Rats; Spinal Cord; Synaptosomes; Virulence Factors, Bordetella | 1995 |
Modulation of free intracellular calcium and cAMP by morphine and cannabinoids, alone and in combination in mouse brain and spinal cord synaptosomes.
Topics: Animals; Brain Chemistry; Calcium; Cannabinoids; Cyclic AMP; Cyclohexanols; Dronabinol; Drug Interactions; In Vitro Techniques; Mice; Morphine; Spinal Cord; Synaptosomes | 1994 |
Development of cross-tolerance between delta 9-tetrahydrocannabinol, CP 55,940 and WIN 55,212.
Topics: Analgesics; Animals; Benzoxazines; Body Temperature; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Male; Mice; Mice, Inbred ICR; Morpholines; Motor Activity; Naphthalenes | 1994 |
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.
Topics: Analgesics; Animals; Arachidonic Acids; Binding, Competitive; Brain; Calcium Channel Blockers; Cyclohexanols; Dronabinol; Drug Administration Routes; Drug Interactions; Endocannabinoids; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Polyunsaturated Alkamides; Receptors, Purinergic P2; Tritium | 1994 |
Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment.
Topics: Animals; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Down-Regulation; Dronabinol; Drug Tolerance; Exploratory Behavior; Kinetics; Limbic System; Male; Membranes; Mesencephalon; Motor Activity; Neostriatum; Prosencephalon; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug | 1994 |
Evidence for a cannabinoid receptor in immunomodulation by cannabinoid compounds.
Topics: Adenylyl Cyclases; Animals; Cannabinoids; Cells, Cultured; Colforsin; Cyclohexanols; Dronabinol; Female; Immunity; Immunoglobulin M; Mice; Receptors, Cannabinoid; Receptors, Drug; Spleen; Stereoisomerism | 1993 |
Pharmacological evaluation of iodo and nitro analogs of delta 8-THC and delta 9-THC.
Topics: Analgesics; Animals; Body Temperature; Cannabidiol; Cannabinoids; Cyclohexanols; Dronabinol; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Conformation; Motor Activity; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1993 |
Development of behavioral tolerance to delta 9-THC without alteration of cannabinoid receptor binding or mRNA levels in whole brain.
Topics: Animals; Behavior, Animal; Blotting, Northern; Brain Chemistry; Cyclohexanols; DNA Probes; Dronabinol; Drug Tolerance; Electrophoresis, Polyacrylamide Gel; In Situ Hybridization; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger | 1993 |
Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement.
Topics: Animals; Brain; Cannabinoids; Cyclohexanols; Dopamine; Dronabinol; Estradiol; Estrus; Female; Kinetics; Male; Neurons; Orchiectomy; Ovariectomy; Ovary; Progesterone; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Sex Characteristics; Testis; Testosterone; Tritium | 1994 |
Evidence for a cannabinoid receptor in sea urchin sperm and its role in blockade of the acrosome reaction.
Topics: Acrosome; Animals; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Dronabinol; Female; Humans; In Vitro Techniques; Kinetics; Male; Mice; Rats; Receptors, Cannabinoid; Receptors, Drug; Sea Urchins; Sperm-Ovum Interactions; Spermatozoa; Stereoisomerism | 1993 |
Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.
Topics: Amides; Animals; Arachidonic Acids; Benzoxazines; Body Temperature; Cannabinoids; Cyclohexanols; Dronabinol; Drug Tolerance; Electric Stimulation; Endocannabinoids; Fatty Acids, Unsaturated; Male; Mice; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Vas Deferens | 1993 |
Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Kinetics; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Time Factors; Tritium | 1993 |
Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement.
Topics: Analgesics; Animals; Bucladesine; Cannabinoids; Caudate Nucleus; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraventricular; Male; Periaqueductal Gray; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Stereoisomerism; Virulence Factors, Bordetella | 1996 |
Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats.
Topics: Animals; Columbidae; Cyclohexanols; Discrimination Learning; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reflex, Startle; Rimonabant | 1996 |
Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations.
Topics: Analgesics; Animals; Benzoxazines; Binding, Competitive; Cyclohexanols; Dronabinol; Guinea Pigs; Injections, Intraperitoneal; Intestine, Small; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Receptors, Cannabinoid; Receptors, Drug; Vas Deferens | 1996 |
Psychoactive cannabinoids increase mortality and alter acute phase cytokine responses in mice sublethally infected with Legionella pneumophila.
Topics: Acute-Phase Proteins; Animals; Cannabinol; Cyclohexanols; Cytokines; Dronabinol; Female; Legionnaires' Disease; Mice; Mice, Inbred BALB C; RNA, Messenger | 1997 |
Evaluation of agonist-antagonist properties of nitrogen mustard and cyano derivatives of delta 8-tetrahydrocannabinol.
Topics: Animals; Body Temperature Regulation; Cannabinoids; Catalepsy; Cyclohexanols; Dronabinol; Male; Maze Learning; Mice; Mice, Inbred ICR; Motor Activity; Nitrogen Mustard Compounds; Pain; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1996 |
Nonclassical and endogenous cannabinoids: effects on the ordering of brain membranes.
Topics: Analgesics; Animals; Arachidonic Acid; Arachidonic Acids; Benzoxazines; Brain; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Male; Membrane Lipids; Morpholines; Naphthalenes; Phenanthridines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Synaptic Membranes | 1997 |
Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Dynorphins; Endocannabinoids; Injections, Intraperitoneal; Injections, Spinal; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 1997 |
(R)-methanandamide, but not anandamide, substitutes for delta 9-THC in a drug-discrimination procedure.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Generalization, Stimulus; Hallucinogens; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 1997 |
Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Identification and characterization of a novel synthetic cannabinoid CP 55,940 binder in rat brain cytosol.
Topics: Animals; Arachidonic Acids; Binding, Competitive; Cannabinoids; Cerebral Cortex; Cyclohexanols; Cytosol; Dithiothreitol; Dronabinol; Endocannabinoids; Kinetics; Male; Nucleotides; Organ Specificity; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Cytoplasmic and Nuclear; Receptors, Drug; Salts; Sulfhydryl Reagents; Temperature | 1998 |
A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing.
Topics: Animals; Arachidonic Acids; Benzoxazines; Conditioning, Operant; Cyclohexanols; Dronabinol; Male; Morpholines; Naphthalenes; Rats | 1998 |
Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain.
Topics: Animals; Arachidonic Acids; Brain Chemistry; Corpus Striatum; Cyclohexanols; Dronabinol; Drug Tolerance; Enkephalins; In Situ Hybridization; Male; Mammillary Bodies; Nucleus Accumbens; Organ Specificity; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Ventromedial Hypothalamic Nucleus | 1998 |
Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Cannabidiol; Cell Membrane; Cerebellar Cortex; Cyclohexanols; Dronabinol; Guanosine Triphosphate; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development.
Topics: Animals; Autoradiography; Benzoxazines; Brain; Colforsin; Cyclic AMP; Cyclohexanols; Dronabinol; Gene Expression Regulation, Developmental; Gestational Age; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Morpholines; Naphthalenes; Neuroglia; Protein Binding; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Signal Transduction | 1998 |
The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery.
Topics: Amides; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Endothelium, Vascular; Ethanolamines; In Vitro Techniques; Ligands; Male; Mesenteric Arteries; Methoxamine; Morpholines; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Palmitic Acids; Polyunsaturated Alkamides; Rats; Rats, Wistar | 1998 |
Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine.
Topics: Analgesics; Animals; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; Cyclohexanols; Dronabinol; Guinea Pigs; Intestine, Small; Kinetics; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Neuromuscular Junction; Piperidines; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1998 |
Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arachidonic Acids; Benzoxazines; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; Humans; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transfection | 1998 |
Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.
Topics: Animals; Binding, Competitive; Brain; Cannabinoids; Cell Membrane; Cyclohexanols; Dronabinol; Indicators and Reagents; Kinetics; Mice; Molecular Structure; Receptors, Cannabinoid; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship | 1998 |
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cell Line; Cyclohexanols; Dronabinol; Endocannabinoids; Models, Chemical; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 1999 |
Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors.
Topics: Amphetamines; Animals; Behavior, Animal; Cannabinoids; Cerebral Cortex; Cyclohexanols; Dronabinol; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Male; Motor Activity; Muscle Contraction; Oleic Acids; Phosphatidylinositols; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Cannabinoid; Receptors, Drug; Receptors, Serotonin; Reflex; Serotonin; Serotonin Receptor Agonists | 1999 |
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Central Nervous System; Cyclohexanols; Dronabinol; Gene Targeting; Mice; Mice, Knockout; Molecular Structure; Motor Activity; Receptors, Cannabinoid; Receptors, Drug | 1999 |
Cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for CB2 receptor participation.
Topics: Animals; Cannabinoids; Cyclohexanols; Dronabinol; Hybridomas; Interleukin-2; Lymphocyte Activation; Macrophages; Mice; Muramidase; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Transcription, Genetic | 1999 |
Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange.
Topics: Animals; Binding, Competitive; Cannabinoids; Cell Membrane; Cerebellum; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Ligands; Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1999 |
Internalization and recycling of the CB1 cannabinoid receptor.
Topics: Acids; Ammonium Chloride; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cells, Cultured; Clathrin; Coated Vesicles; Cyclohexanols; Dronabinol; Drug Tolerance; Endocytosis; Endosomes; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Immunosuppressive Agents; Morpholines; Mutagenesis; Naphthalenes; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Tertiary; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Transfection; Up-Regulation; Virulence Factors, Bordetella | 1999 |
Identification of endocannabinoids and cannabinoid CB(1) receptor mRNA in the pituitary gland.
Topics: Animals; Autoradiography; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Gas Chromatography-Mass Spectrometry; In Situ Hybridization; Male; Pituitary Gland; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger | 1999 |
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dimethyl Sulfoxide; Dronabinol; Dynorphins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1999 |
Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship.
Topics: Adrenergic Uptake Inhibitors; Arachidonic Acids; Atrial Function; Corticosterone; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Electrophysiology; Endocannabinoids; Excitatory Amino Acid Agonists; Female; Guanidine; Humans; Imidazoles; Imidazoline Receptors; Ligands; Male; Norepinephrine; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Receptors, Presynaptic; Sympathetic Nervous System; Sympathomimetics | 1999 |
Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Dronabinol; Electric Stimulation; In Vitro Techniques; Male; Mice; Muscle Contraction; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship; Vas Deferens | 1999 |
Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Delta(9)-THC and anandamide.
Topics: Analgesia; Analgesics; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dronabinol; Dynorphins; Endocannabinoids; Endorphins; Male; Pain; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Spinal Cord | 2000 |
Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Heart Atria; In Vitro Techniques; Male; Mesenteric Artery, Inferior; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Vascular Resistance | 2000 |
O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Binding, Competitive; Cannabinoids; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Dronabinol; Drug Interactions; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Solubility; Tritium; Vas Deferens; Water | 2000 |
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.
Topics: Animals; Body Temperature; Catalepsy; Cyclohexanols; Dronabinol; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cannabinoid; Receptors, Drug; T-Lymphocytes | 2000 |
Separation of cannabinoid receptor affinity and efficacy in delta-8-tetrahydrocannabinol side-chain analogues.
Topics: Animals; Carboxylic Acids; Cell Membrane; Cerebellum; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 2001 |
Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use.
Topics: Brain; Cannabinoids; Cannabis; Cyclohexanols; Dronabinol; Humans; In Vitro Techniques; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Schizophrenia; Substance-Related Disorders | 2001 |
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dronabinol; Hyperalgesia; Morpholines; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sciatica | 2001 |
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Emetics; Endocannabinoids; Female; Glycerides; Humans; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews | 2002 |
Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity.
Topics: Amino Acid Motifs; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinol; Cyclohexanols; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Dronabinol; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Nuclear Proteins; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; T-Lymphocytes; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transfection | 2002 |
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
Topics: Analgesics; Animals; Arachidonic Acids; Astrocytes; Calcium Channel Blockers; Camphanes; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Gene Expression; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Modulation of cannabinoid agonist binding by 5-HT in the rat cerebellum.
Topics: Animals; Benzoxazines; Binding, Competitive; Cannabinoids; Cell Membrane; Cerebellum; Cyclohexanols; Dronabinol; GTP-Binding Proteins; Male; Morpholines; Naphthalenes; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Cannabinoid; Receptors, Drug; Receptors, Serotonin; Serotonin | 2002 |
Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation.
Topics: Animals; Antiemetics; Benzoxazines; Binding, Competitive; Brain; Cisplatin; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Sulfur Radioisotopes; Tritium; Vomiting | 2003 |
Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract.
Topics: Animals; Antiemetics; Binding, Competitive; Blotting, Western; Cyclohexanols; Digestive System; Dose-Response Relationship, Drug; Dronabinol; Gastric Mucosa; Gastrointestinal Transit; Immunohistochemistry; Intestine, Large; Intestine, Small; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stomach; Tritium | 2003 |
Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Arachidonic Acids; Benzoxazines; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Encephalitis; Endocannabinoids; Glycerides; Inflammation Mediators; Microglia; Morpholines; Naphthalenes; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Tumor Necrosis Factor-alpha | 2003 |
Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Blotting, Western; Cannabinoids; Chlorocebus aethiops; COS Cells; Cyclohexanols; Dronabinol; Excitatory Amino Acid Antagonists; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Tertiary; Receptors, Cannabinoid; Receptors, Drug; Serine; Signal Transduction; Transfection | 2002 |
3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor.
Topics: Cannabinoids; Cyclohexanols; Dronabinol; Hydrogen Bonding; Indicators and Reagents; Indoles; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Naphthalenes; Receptors, Cannabinoid; Receptors, Drug; Spectrophotometry, Infrared; Stereoisomerism; Structure-Activity Relationship | 2003 |
Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells.
Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Humans; Indoles; Interleukin-2; Leukocytes, Mononuclear; Morpholines; Naphthalenes; Phytohemagglutinins; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Structure-activity relationships for 1',1'-dimethylalkyl-Delta8-tetrahydrocannabinols.
Topics: Animals; Binding, Competitive; Body Temperature; Cyclohexanols; Dronabinol; In Vitro Techniques; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Conformation; Motor Activity; Pain Measurement; Quantitative Structure-Activity Relationship; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Spectrophotometry, Infrared | 2003 |
Analysis of the respiratory effects of cannabinoids in rats.
Topics: Anesthesia; Animals; Atropine Derivatives; Benzoxazines; Blood Pressure; Cannabinoids; Cyclohexanols; Depression, Chemical; Dronabinol; Heart Rate; Hemodynamics; Morpholines; Muscarinic Agonists; Naphthalenes; Norepinephrine; Oxygen Consumption; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Respiration, Artificial; Respiratory Mechanics | 2003 |
Intrinsic activity estimation of cannabinoid CB1 receptor ligands in a drug discrimination paradigm.
Topics: Analgesics; Animals; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dronabinol; Hallucinogens; Male; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2003 |
Cannabinoid CB1 receptor-mediated modulation of evoked dopamine release and of adenylyl cyclase activity in the human neocortex.
Topics: Adenylyl Cyclases; Amygdala; Animals; Arachidonic Acids; Benzoxazines; Binding Sites; Colforsin; Cyclic AMP; Cyclohexanols; Dopamine; Dronabinol; Electric Stimulation; Endocannabinoids; Female; Humans; Ligands; Male; Morpholines; Naphthalenes; Neocortex; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Synaptosomes; Tetrodotoxin; Tritium | 2004 |
Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development.
Topics: Analgesics; Animals; Benzoxazines; Body Temperature; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Morpholines; Naphthalenes; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1 | 2004 |
Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm.
Topics: Animals; Appetitive Behavior; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Morpholines; Motivation; Naphthalenes; Piperidines; Premedication; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2004 |
A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amidohydrolases; Animals; Arachidonic Acids; Cerebral Cortex; Cocaine; Cyclohexanols; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neostriatum; Patch-Clamp Techniques; Polyunsaturated Alkamides; Quinpirole; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Synaptic Transmission; Synaptosomes | 2004 |
Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide.
Topics: Adult; Arachidonic Acids; Cyclohexanols; Dronabinol; Endocannabinoids; Female; Humans; Male; Neutrophils; Polyunsaturated Alkamides; Receptors, Cannabinoid; Superoxides | 2004 |
Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.
Topics: Animals; Benzofurans; Benzoxazines; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Cyclohexanols; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Vasodilation | 2004 |
Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala.
Topics: Amygdala; Analgesics; Animals; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dronabinol; Genes, fos; Male; Mice; Mice, Inbred ICR; Restraint, Physical; Stress, Psychological | 2005 |
Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat.
Topics: Alkanesulfonates; Amines; Amitriptyline; Animals; Baclofen; Behavior, Animal; Benzoxazines; Carbamazepine; Cyclohexanecarboxylic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Gabapentin; gamma-Aminobutyric Acid; Indans; Male; Molecular Structure; Morphine; Morpholines; Naphthalenes; Nitriles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sulfonic Acids | 2004 |
Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Cannabinoids; Cognition; Conditioning, Operant; Cyclohexanols; Dronabinol; Exploratory Behavior; Female; Hallucinogens; Interpersonal Relations; Learning; Memory Disorders; Memory, Short-Term; Motor Activity; Psychomotor Performance; Rats; Rats, Wistar | 2004 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects.
Topics: Aminoacetonitrile; Analgesics; Animals; Autoradiography; Behavior, Animal; Blotting, Western; Brain; Cyclohexanols; Diagnostic Imaging; Dronabinol; Drug Administration Schedule; Drug Tolerance; Extracellular Signal-Regulated MAP Kinases; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Knockout; Motor Activity; Protease Inhibitors; Protein Binding; ras-GRF1; Receptor, Cannabinoid, CB1; Signal Transduction; Sulfur Isotopes; Tritium | 2005 |
Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Catalepsy; Cell Line; Chromatography; Cricetinae; Cricetulus; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypothermia; Inflammation; Ligation; Male; Morpholines; Motor Activity; Naphthalenes; Pain; Pain Measurement; Pain Threshold; Radioligand Assay; Rats; Rats, Wistar; Rotarod Performance Test; Sciatic Neuropathy; Sulfur Isotopes; Time Factors; Tritium | 2005 |
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Cytoplasm; DNA, Complementary; Dronabinol; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Glycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Humans; Immunosuppressive Agents; Morpholines; Naphthalenes; Neurons; Pertussis Toxin; Piperidines; Protein Binding; Protein Conformation; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Time Factors; Type C Phospholipases | 2005 |
Expression of functional CB1 cannabinoid receptors in retinoic acid-differentiated P19 embryonal carcinoma cells.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Benzoxazines; Blotting, Western; Calcium; Carcinoma; Cell Differentiation; Cell Line, Tumor; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; gamma-Aminobutyric Acid; Gene Expression; Mice; Morpholines; Naphthalenes; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temperature; Tretinoin; Tritium | 2006 |
The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells.
Topics: Analysis of Variance; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line; Cell Movement; Chemotaxis; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Endothelial Cells; Flow Cytometry; Humans; Indoles; Interleukin-8; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Thapsigargin; Tumor Necrosis Factor-alpha | 2006 |
Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; Animals; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cocaine; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Ketamine; Macaca mulatta; Male; Midazolam; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2006 |
Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Hallucinogens; Humans; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Macaca mulatta; Male; Midazolam; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
Cannabinoids reveal importance of spike timing coordination in hippocampal function.
Topics: Action Potentials; Animals; Cannabinoids; Cortical Synchronization; Cyclohexanes; Cyclohexanols; Dronabinol; Hippocampus; Periodicity; Phenols; Rats; Receptors, Cannabinoid; Theta Rhythm | 2006 |
Characterization of cannabinoid-binding sites in zebrafish brain.
Topics: Animals; Benzoxazines; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Protein Binding; Radioligand Assay; Tritium; Zebrafish | 2007 |
The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.
Topics: Analgesics, Non-Narcotic; Animals; Benzoxazines; Binding, Competitive; Body Temperature; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Locomotion; Male; Mice; Mice, Inbred ICR; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Pain Measurement; Pain Threshold; Phenols; Protein Binding; Psychotropic Drugs; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Vas Deferens | 2007 |
Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells.
Topics: Animals; Benzoxazines; beta-N-Acetylhexosaminidases; Calcium; Cannabidiol; Cannabinoids; Capsaicin; Cell Degranulation; Cell Line; Cyclohexanols; Dronabinol; Intracellular Fluid; Mast Cells; Morpholines; Naphthalenes; Rats; TRPV Cation Channels | 2007 |
Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew.
Topics: Animals; Antiemetics; Benzoxazines; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Dronabinol; Gamma Rays; Locomotion; Morpholines; Naphthalenes; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Shrews; Vomiting | 2007 |
Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Catecholamines; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Dronabinol; Gene Expression Regulation, Enzymologic; Ligands; Mice; Models, Biological; Neuroblastoma; Neurons; Neuroprotective Agents; Promoter Regions, Genetic; Protein Transport; Receptor, Cannabinoid, CB1; Signal Transduction; Tyrosine 3-Monooxygenase | 2007 |
Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.
Topics: Amino Acid Sequence; Analgesics; Benzoxazines; Cyclohexanols; Dronabinol; Humans; Leucine; Lipid Bilayers; Molecular Sequence Data; Morpholines; Mutagenesis; Naphthalenes; Pertussis Toxin; Protein Structure, Secondary; Protein Structure, Tertiary; Receptor, Cannabinoid, CB1; Signal Transduction | 2007 |
Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB2) in rodents and primates.
Topics: Animals; Binding, Competitive; Cell Membrane; Chemotaxis; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Macaca fascicularis; Mice; Quinolizines; Rats; Receptor, Cannabinoid, CB2; Species Specificity | 2007 |
Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2008 |
The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.
Topics: Animals; Arachidonic Acids; Camphanes; Chemokine CCL5; Chemotaxis; Cyclohexanols; Dronabinol; Female; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, CCR1; Receptors, CCR5; Receptors, G-Protein-Coupled; Rimonabant; RNA, Messenger; Signal Transduction | 2008 |
Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells.
Topics: Arachidonic Acids; Caco-2 Cells; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Deoxyglucose; Dronabinol; Endocannabinoids; Humans; Indoles; Intestinal Absorption; Piperidines; Polyunsaturated Alkamides; Pyrazoles | 2008 |
Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor.
Topics: Animals; Cell Line, Tumor; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Enhancer Elements, Genetic; Genes, Reporter; GTP-Binding Protein alpha Subunits, Gi-Go; Luciferases, Renilla; Mice; Protein Kinase Inhibitors; Receptor, Cannabinoid, CB1; Signal Transduction; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2008 |
Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice.
Topics: Animals; Arachidonic Acids; Arrestins; beta-Arrestins; Body Temperature; Brain; Cyclohexanols; Dronabinol; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Pain Threshold; Radioligand Assay; Receptor, Cannabinoid, CB1 | 2008 |
Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells.
Topics: Animals; Cell Line, Tumor; Cyclohexanols; Dronabinol; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptor, Cannabinoid, CB1; Signal Transduction | 2008 |
Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression.
Topics: Adenylyl Cyclases; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Cell Line, Tumor; Colforsin; Cyclohexanols; DNA Primers; Dronabinol; Enzyme Activation; Excitatory Amino Acid Antagonists; Genes, Reporter; Luciferases; Mice; Neuroblastoma; Pertussis Toxin; Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tyrosine 3-Monooxygenase | 2009 |
Effect of cannabinoids upon the uptake of folic acid by BeWo cells.
Topics: Arachidonic Acids; Carrier Proteins; Cell Culture Techniques; Cell Line, Tumor; Cyclohexanols; Dronabinol; Drug Administration Schedule; Endocannabinoids; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Hydrogen-Ion Concentration; Indoles; Membrane Transport Proteins; Piperidines; Placenta; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cell Surface | 2009 |
Chronic nicotine alters cannabinoid-mediated locomotor activity and receptor density in periadolescent but not adult male rats.
Topics: Adolescent; Aging; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dronabinol; Female; Humans; Male; Motor Activity; Nicotine; Nicotinic Agonists; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid | 2009 |
HU210-induced downregulation in cannabinoid CB1 receptor binding strongly correlates with body weight loss in the adult rat.
Topics: Animals; Autoradiography; Basal Ganglia; Brain; Cerebral Cortex; Cyclohexanols; Down-Regulation; Dronabinol; Male; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Weight Loss | 2009 |
Altered CB receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Cyclohexanols; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Exploratory Behavior; Fluoxetine; Guanosine 5'-O-(3-Thiotriphosphate); Immunosuppressive Agents; Isotopes; Male; Olfactory Bulb; Prefrontal Cortex; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Time Factors | 2009 |
(Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bronchi; Calcium; Cannabinoid Receptor Modulators; Cannabinoids; Cell Line; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Epithelial Cells; Humans; RNA, Messenger; TRPC Cation Channels | 2009 |
Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol.
Topics: Analysis of Variance; Animals; Catheterization; Central Nervous System Agents; Cyclohexanols; Dronabinol; Hippocampus; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Microinjections; Piperidines; Psychotropic Drugs; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.
Topics: Acetic Acid; Analgesics; Animals; Anti-Obesity Agents; Camphanes; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger | 2009 |
Cannabinoid inhibition of macrophage migration to the trans-activating (Tat) protein of HIV-1 is linked to the CB(2) cannabinoid receptor.
Topics: Cannabinoids; Chemotaxis; Cyclohexanols; Dronabinol; Gene Knockdown Techniques; HIV-1; Humans; Macrophages; Receptor, Cannabinoid, CB2; RNA, Small Interfering; tat Gene Products, Human Immunodeficiency Virus; U937 Cells | 2010 |
Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cyclohexanols; Dronabinol; Electric Stimulation; Endocannabinoids; Female; Ileum; In Vitro Techniques; Male; Morpholines; Myenteric Plexus; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid | 2010 |
Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs.
Topics: Adrenergic Agonists; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Clonidine; Cyclohexanols; Discrimination, Psychological; Dronabinol; Female; Heart Rate; Macaca mulatta; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2010 |
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhythm; COS Cells; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Drug Administration Routes; Eating; Food Deprivation; Green Fluorescent Proteins; Hemoglobins; Hyperphagia; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Peptide Fragments; Piperidines; Protein Transport; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Transfection | 2010 |
Revisiting the complex influences of cannabinoids on motor functions unravels pharmacodynamic differences between cannabinoid agonists.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoids; Catalepsy; Cyclohexanols; Dronabinol; Male; Motor Activity; Rats; Rats, Wistar; Time Factors | 2010 |
The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dronabinol; Drug Tolerance; Exploratory Behavior; Genotype; Heterozygote; Male; Mice; Mice, Mutant Strains; Motor Activity; Neuregulin-1; Proto-Oncogene Proteins c-fos; Psychotropic Drugs; Reflex, Startle; Schizophrenia | 2011 |
Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure.
Topics: Age Distribution; Animals; Brain; Cyclohexanols; Dronabinol; Drug Administration Schedule; Drug Tolerance; Female; Male; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Sexual Maturation | 2010 |
Cannabinoid effects on CB1 receptor density in the adolescent brain: an autoradiographic study using the synthetic cannabinoid HU210.
Topics: Age Factors; Analgesics; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Brain; Brain Mapping; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Male; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Tissue Distribution; Tritium | 2010 |
Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's disease.
Topics: Animals; Antioxidants; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dopamine; Dronabinol; Glutamic Acid; Lipopolysaccharides; Male; Mice; Motor Activity; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Substantia Nigra; Tyrosine 3-Monooxygenase | 2011 |
AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Dronabinol; Humans; Indoles; Ligands; Morpholines; Naphthalenes; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB2 | 2012 |
Dissimilar cannabinoid substitution patterns in mice trained to discriminate Δ(9)-tetrahydrocannabinol or methanandamide from vehicle.
Topics: Animals; Arachidonic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Generalization, Stimulus; Male; Mice; Mice, Inbred C57BL; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors | 2011 |
Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activation.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Cannabinoids; Cyclohexanols; Dronabinol; HEK293 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Receptor, Cannabinoid, CB1; Structure-Activity Relationship | 2011 |
Cloning and pharmacological characterization of the dog cannabinoid CB₂receptor.
Topics: Amino Acid Sequence; Animals; Arachidonic Acids; Base Sequence; Benzoxazines; Binding, Competitive; Camphanes; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dogs; Dronabinol; Endocannabinoids; Humans; Mice; Molecular Sequence Data; Morpholines; Naphthalenes; Pan troglodytes; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Sequence Alignment | 2011 |
Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation.
Topics: Action Potentials; Analysis of Variance; Animals; Biological Clocks; Brain Waves; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Confidence Intervals; Cyclohexanols; Dronabinol; Electric Stimulation; Evoked Potentials; Hippocampus; Immunosuppressive Agents; Male; Maze Learning; Memory, Short-Term; Mental Disorders; Nerve Net; Neurons; Prefrontal Cortex; Rats; Rats, Long-Evans; Reaction Time; Receptors, Cannabinoid; Statistics, Nonparametric; Time Factors | 2011 |
3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism.
Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Drug Inverse Agonism; Female; Freezing Reaction, Cataleptic; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship; Transfection | 2012 |
Sex differences in cannabinoid 1 vs. cannabinoid 2 receptor-selective antagonism of antinociception produced by delta9-tetrahydrocannabinol and CP55,940 in the rat.
Topics: Analgesics; Animals; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Morphine; Motor Activity; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sex Characteristics | 2012 |
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium | 2012 |
Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.
Topics: Animals; Cannabinoids; Corpus Striatum; Cyclohexanols; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Male; Protein Binding; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Tyrosine 3-Monooxygenase | 2012 |
Apparent inverse relationship between cannabinoid agonist efficacy and tolerance/cross-tolerance produced by Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys.
Topics: Animals; Cannabinoids; Cannabis; Cyclohexanols; Dronabinol; Drug Tolerance; Female; Indoles; Macaca mulatta; Male; Naphthalenes; Receptor, Cannabinoid, CB1 | 2012 |
Dissociable effects of the cannabinoid receptor agonists Δ9-tetrahydrocannabinol and CP55940 on pain-stimulated versus pain-depressed behavior in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain; Cannabinoid Receptor Agonists; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Eating; Electrodes, Implanted; Ketoprofen; Lactic Acid; Male; Pain; Rats; Rats, Sprague-Dawley; Self Stimulation | 2012 |
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Benzodioxoles; Brain Chemistry; Cyclohexanols; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders | 2013 |
Interactions between μ-opioid receptor agonists and cannabinoid receptor agonists in rhesus monkeys: antinociception, drug discrimination, and drug self-administration.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cyclohexanols; Data Interpretation, Statistical; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Heroin Dependence; Hot Temperature; Macaca mulatta; Morphine; Morpholines; Naphthalenes; Pain Measurement; Receptors, Cannabinoid; Receptors, Opioid, mu; Self Administration | 2013 |
Identification of raloxifene as a novel CB2 inverse agonist.
Topics: Benzoxazines; Binding, Competitive; Bone Density Conservation Agents; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Approval; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Morpholines; Naphthalenes; Raloxifene Hydrochloride; Receptor, Cannabinoid, CB2; Transfection; Tritium; United States; United States Food and Drug Administration | 2013 |
Developmental effects of cannabinoids on zebrafish larvae.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cyclohexanols; Dronabinol; Embryo, Nonmammalian; Female; Larva; Lethal Dose 50; Locomotion; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Toxicity Tests, Acute; Toxicity Tests, Chronic; Zebrafish | 2013 |
Do cannabinoids exhibit a tyramine-like effect?
Topics: Adrenergic Uptake Inhibitors; Animals; Arachidonic Acids; Benzoxazines; Cannabidiol; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Glycerides; Kidney Cortex; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Time Factors; Tyramine | 2013 |
Cannabinoids in disguise: Δ9-tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Protein Binding; Receptor, Cannabinoid, CB1; Sulfur Isotopes; Transfection; Tritium | 2013 |
Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cyclic AMP; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Indoles; Isomerism; Male; Molecular Structure; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
The cannabinoid agonist HU-210: pseudo-irreversible discriminative stimulus effects in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Time Factors | 2014 |
In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.
Topics: Allosteric Regulation; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Catalepsy; Cyclohexanols; Dronabinol; Drug Evaluation; Eating; Endocannabinoids; Female; Hypothermia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nociception; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.
Topics: Blood-Brain Barrier; Cannabinoid Receptor Agonists; Cell Adhesion; Collagen Type IV; Cyclohexanols; Dronabinol; Extracellular Matrix; Extracellular Matrix Proteins; HIV-1; Humans; Inflammation; Laminin; Monocytes; Receptor, Cannabinoid, CB2; Recombinant Proteins; tat Gene Products, Human Immunodeficiency Virus; U937 Cells | 2014 |
JWH-018 in rhesus monkeys: differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects.
Topics: Animals; Benzoxazines; Body Temperature; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dronabinol; Hypothermia; Indoles; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons.
Topics: Animals; Arachidonic Acids; Arrestin; Benzoxazines; Blotting, Western; Cannabinoid Receptor Agonists; Cannabinoids; Cells, Cultured; Corpus Striatum; Cyclohexanols; Dendritic Spines; Dronabinol; Endocannabinoids; Fluorescence Resonance Energy Transfer; Glycerides; GTP-Binding Proteins; Ligands; Luminescent Proteins; Mice; Models, Biological; Morpholines; Naphthalenes; Neurons; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Signal Transduction | 2014 |
Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex.
Topics: Age Factors; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Developmental Disabilities; Dizocilpine Maleate; Dronabinol; Estradiol; Estrous Cycle; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Neurites; Piperidines; Prefrontal Cortex; Pyrazoles; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptic Potentials; Tritium | 2015 |
Δ9-Tetrahydrocannabinol-like discriminative stimulus effects of compounds commonly found in K2/Spice.
Topics: Animals; Cannabinoid Receptor Agonists; Conditioning, Operant; Cyclohexanols; Discrimination, Psychological; Dronabinol; Indoles; Male; Motor Activity; Naphthalenes; Rats; Rats, Sprague-Dawley; Spices; Time Factors | 2014 |
The effects of beta-arrestin1 deletion on acute cannabinoid activity, brain cannabinoid receptors and tolerance to cannabinoids in mice.
Topics: Animals; Arrestins; beta-Arrestins; Brain; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Dronabinol; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sequence Deletion | 2015 |
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.
Topics: Allosteric Regulation; Animals; Benzoxazines; Cannabinoid Receptor Agonists; CHO Cells; Cricetulus; Cyclohexanols; Dronabinol; Humans; Indoles; MAP Kinase Signaling System; Morpholines; Naphthalenes; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2015 |
Sex-specific alterations in hippocampal cannabinoid 1 receptor expression following adolescent delta-9-tetrahydrocannabinol treatment in the rat.
Topics: Age Factors; Animals; Autoradiography; Cyclohexanols; Dronabinol; Female; Hippocampus; Male; Psychotropic Drugs; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Factors | 2015 |
Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cerebral Cortex; Corpus Striatum; Cyclohexanols; Dopamine; Dopamine Agents; Dronabinol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Mice; Mice, Transgenic; Morpholines; Naphthalenes; Protein Binding; Protein Kinases; Receptor, Cannabinoid, CB1; Synapses; Time Factors; Tritium | 2016 |
Combined Treatment with Morphine and Δ9-Tetrahydrocannabinol in Rhesus Monkeys: Antinociceptive Tolerance and Withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Heart Rate; Macaca mulatta; Morphine; Morpholines; Naphthalenes; Opioid-Related Disorders; Pain Measurement; Substance Withdrawal Syndrome | 2016 |
CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function.
Topics: Animals; Cannabinoids; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dronabinol; GTP-Binding Proteins; Humans; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Signal Transduction | 2016 |
Interactions between cannabinoid receptor agonists and mu opioid receptor agonists in rhesus monkeys discriminating fentanyl.
Topics: Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Discrimination, Psychological; Dronabinol; Drug Interactions; Female; Fentanyl; Macaca mulatta; Nalbuphine; Receptors, Opioid, mu | 2016 |
Behavioral Determinants of Cannabinoid Self-Administration in Old World Monkeys.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Cercopithecidae; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Macaca fascicularis; Macaca mulatta; Male; Reaction Time; Receptors, Cannabinoid; Reinforcement, Psychology; Self Administration | 2017 |
Comparison of the discriminative stimulus and response rate effects of
Topics: Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Indoles; Male; Morpholines; Naphthalenes; Rats; Sex Characteristics | 2017 |
Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.
Topics: Adaptation, Ocular; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Agonists; Cyclohexanols; Disease Models, Animal; Dronabinol; Endocannabinoids; Excitatory Postsynaptic Potentials; Glycerides; Heterocyclic Compounds, 1-Ring; Locomotion; Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyridines; Signal Transduction | 2017 |
The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB
Topics: Allosteric Regulation; Animals; Cannabinoid Receptor Modulators; Cerebellum; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Phenylurea Compounds; Piperidines; Pregnenolone; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant | 2017 |
Antinociceptive effects of mixtures of mu opioid receptor agonists and cannabinoid receptor agonists in rats: Impact of drug and fixed-dose ratio.
Topics: Analgesics; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2018 |
Sex differences in antinociceptive response to Δ-9-tetrahydrocannabinol and CP 55,940 in the mouse formalin test.
Topics: Analgesics; Analysis of Variance; Animals; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Female; Formaldehyde; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Pain; Pain Measurement; Receptor, Cannabinoid, CB1; Sex Characteristics; Time Factors; Treatment Outcome | 2018 |
Reinforcing effects of opioid/cannabinoid mixtures in rhesus monkeys responding under a food/drug choice procedure.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Choice Behavior; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Eating; Female; Macaca mulatta; Male; Reaction Time; Reinforcement, Psychology; Self Administration | 2018 |
THC Regulates Tearing via Cannabinoid CB1 Receptors.
Topics: Animals; Blotting, Western; Cyclohexanols; Dronabinol; Dry Eye Syndromes; Female; Lacrimal Apparatus; Male; Mice; Mice, Knockout; Receptor, Cannabinoid, CB1; Sex Factors; Tears | 2020 |