cyclohexanol has been researched along with 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol in 693 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (0.43) | 18.7374 |
| 1990's | 198 (28.57) | 18.2507 |
| 2000's | 294 (42.42) | 29.6817 |
| 2010's | 180 (25.97) | 24.3611 |
| 2020's | 18 (2.60) | 2.80 |
| Authors | Studies |
|---|---|
| Abood, ME; Kaminski, NE; Kessler, FK; Martin, BR; Schatz, AR | 1 |
| Mailleux, P; Vanderhaeghen, JJ | 3 |
| Compton, DR; Johnson, MR; Martin, BR; Melvin, LS | 1 |
| Balster, RL; Barrett, RL; Britt, DT; Gold, LH; Martin, BR | 1 |
| Brown, DA; Caulfield, MP | 1 |
| Briley, EM; Felder, CC; Matsuda, LA; Veluz, JS; Williams, HL | 1 |
| Martin, BR; Thomas, BF; Wei, X | 1 |
| Herkenham, M | 2 |
| Mailleux, P; Vanderhaeghen, JJ; Verslijpe, M | 1 |
| Houston, DB; Howlett, AC | 2 |
| Ali, SF; Howlett, AC; Paule, MG; Scallet, AC; Slikker, W; Westlake, TM | 1 |
| Lichtman, AH; Martin, BR | 2 |
| Compton, DR; Johnson, MR; Little, PJ; Martin, BR; Mechoulam, R; Melvin, LS; Prescott, WR; Razdan, RK; Thomas, BF; Ward, SJ | 1 |
| Banijamali, A; Charalambous, A; Compton, DR; Friend, FL; Lin, S; Makriyannis, A; Marciniak, G; Martin, BR | 1 |
| Gérard, CM; Mollereau, C; Parmentier, M; Vassart, G | 1 |
| Evans, DM; Howlett, AC; Johnson, MR | 1 |
| Baizman, E; Bell, M; Childers, S; D'Ambra, T; Eissenstat, M; Estep, K; Haycock, D; Howlett, A; Luttinger, D; Ward, SJ | 1 |
| De Costa, BR; Groen, BG; Herkenham, M; Lynn, AB; Richfield, EK | 1 |
| de Costa, BR; Herkenham, M; Johnson, MR; Lynn, AB; Melvin, LS; Rice, KC | 1 |
| Champion, TM; Howlett, AC; Mechoulam, R; Wilken, GH | 1 |
| Howlett, AC; Johnson, MR; Melvin, LS | 1 |
| de Costa, BR; Herkenham, M; Johnson, MR; Little, MD; Lynn, AB; Melvin, LS; Rice, KC | 1 |
| Martin, BR; Thomas, BF | 1 |
| Devane, WA; Dysarz, FA; Howlett, AC; Johnson, MR; Melvin, LS | 1 |
| Fouda, HG; Lukaszewicz, J; Luther, EW | 1 |
| Casellas, P; Derocq, JM; Le Fur, G; Marchand, J; Ségui, M | 1 |
| Balster, RL; Barrett, RL; Lowe, J; Martin, BR; Wiley, JL | 1 |
| Itoh, K; Kondo, S; Nakane, S; Shinoda, A; Sugiura, T; Sukagawa, A; Waku, K; Yamashita, A | 1 |
| Le Fur, G; Poncelet, M; Rinaldi-Carmona, M; Soubrié, P; Souilhac, J | 1 |
| Giaume, C; Glowinski, J; Piomelli, D; Venance, L | 1 |
| Briley, EM; Devane, WA; Felder, CC; Mackie, K; Mansouri, J; Priller, J | 1 |
| Cebeira, M; Fernández-Ruiz, JJ; García, L; Ramos, JA; Romero, J | 1 |
| Dimen, KR; Lichtman, AH; Martin, BR | 1 |
| Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Venier, I | 1 |
| Abadji, V; Fernando, SR; Griffin, G; Makriyannis, A; Pertwee, RG | 1 |
| Dragunow, M; Glass, M | 1 |
| Fan, P | 1 |
| Bouaboula, M; Bourrié, B; Casellas, P; Le Fur, G; Rinaldi-Carmona, M; Shire, D | 1 |
| Fernando, S; Griffin, G; Hill, A; Li, X; Makriyannis, A; Pertwee, R | 1 |
| Fournier, DJ; Grzybowska, J; Li, X; Makriyannis, A; Morse, KL | 1 |
| Abadji, V; Busch-Petersen, J; Drake, DJ; Fernandez-Garcia, MC; Hill, WA; Kawakami, JK; Makriyannis, A; Tius, MA; Zou, XL | 1 |
| Dai, D; Duncan, SG; Huffman, JW; Jordan, RD; Lainton, JA | 1 |
| Adams, IB; Compton, DR; Martin, BR; Razdan, RK; Ryan, W; Singer, M | 1 |
| Cook, SA; Lichtman, AH; Martin, BR; Welch, SP | 1 |
| Coffin, PO; Martin, WJ; Patrick, SL; Tsou, K; Walker, JM | 1 |
| Balster, R; Martin, B; Wiley, J | 1 |
| Adams, IB; Compton, DR; Martin, BR; Razdan, RK; Ryan, W; Singer, M; Thomas, BF | 1 |
| Dunlow, LD; Patrick, GS; Razdan, RK; Welch, SP | 1 |
| Campbell, WB; Edgemond, WS; Hillard, CJ | 1 |
| Bass, PP; Pugh, G; Welch, SP | 1 |
| Welch, SP | 2 |
| Bonner, TI; Herkenham, M; Howlett, AC; Matsuda, LA; Westlake, TM | 1 |
| Abood, ME; Compton, DR; Martin, BR; McLaughlin, CR | 1 |
| Compton, DR; Fan, F; Martin, BR; Melvin, L; Ward, S | 1 |
| Compton, DR; Martin, BR; Mechoulam, R; Razdan, RK; Smith, PB; Welch, SP | 1 |
| Barth, F; Calandra, B; Caput, D; Congy, C; Héaulme, M; Martinez, S; Maruani, J; Néliat, G; Rinaldi-Carmona, M; Shire, D | 1 |
| Bennett, BA; Childers, SR; Deadwyler, SA; Edwards, TA; Hampson, RE; Mu, J; Pacheco, MA; Ward, SJ | 1 |
| Akhavan, N; Chin, SA; Deutsch, DG; Howlett, AC; Koutek, B; Prestwich, GD; Salehani, D | 1 |
| Lai, NK; Martin, WJ; Patrick, SL; Tsou, K; Walker, JM | 1 |
| Fernández-Ruiz, JJ; Gorriti, MA; Palomo, T; Ramos, JA; Rodríguez de Fonseca, F | 1 |
| Evans, DM; Howlett, AC; Johnson, MR; Lake, JT | 1 |
| Herkenham, M; Lynn, AB | 1 |
| Childers, SR; Pacheco, MA; Ward, SJ | 1 |
| Kaminski, NE | 1 |
| Howlett, AC; Johnson, MR; Melvin, LS; Milne, GM; Subramaniam, B; Wilken, GH | 1 |
| Dragunow, M; Faull, RL; Glass, M | 1 |
| Charalambous, A; Compton, DR; Grzybowska, J; Lin, S; Makriyannis, A; Marciniak, G; Martin, BR; Semus, SF | 1 |
| Abood, ME; Fan, F; Martin, BR; Sauss, C; Tilton, CL | 1 |
| Belluzzi, JD; Stein, L; Xue, BG | 1 |
| Cebeira, M; Fernández-Ruiz, JJ; Martín, M; Ramos, JA; Rodríguez de Fonseca, F | 1 |
| Berkery, D; Chang, MC; Laychock, SG; Schuel, H; Schuel, R; Zimmerman, AM; Zimmerman, S | 1 |
| Griffin, G; Pertwee, RG; Stevenson, LA | 1 |
| Hubbard, JR; Kalimi, MY; Lu, R; Martin, BR | 1 |
| Axelrod, J; Briley, EM; Devane, WA; Felder, CC; Mackie, K; Simpson, JT | 1 |
| Glowa, J; Herkenham, M; Oviedo, A | 1 |
| D'Ambra, TE; Haycock, DA; Kuster, JE; Stevenson, JI; Ward, SJ | 1 |
| Bonnin, A; Fernández-Ruiz, JJ; Ramos, JA; Rodríguez de Fonseca, F | 1 |
| Compton, DR; De Costa, BR; Johnson, MR; Martin, BR; Melvin, LS; Razdan, RK; Rice, KC | 1 |
| Bouaboula, M; Bourrié, B; Calandra, B; Canat, X; Casellas, P; Le Fur, G; Poinot-Chazel, C; Rinaldi-Carmona, M | 1 |
| Anderson, JJ; Anderson, LA; Chase, TN; Walters, JR | 1 |
| Ikeda, SR; Lewis, DL; Pan, X | 1 |
| Makriyannis, A; Melvin, LS; Xie, XQ | 1 |
| Cook, SA; Lichtman, AH; Martin, BR | 1 |
| Eissenstat, MA; Flippen-Anderson, JL; Howlett, AC; Johnson, MR; Rice, KC; Ward, SJ; Yamada, K | 1 |
| Griffin, G; Huffman, JW; Lainton, JA; Pertwee, RG | 1 |
| Goligorsky, MS; Liu, Y; Stefano, GB | 1 |
| Abood, M; Fan, F; Martin, BR; Tao, Q | 1 |
| Anderson, JJ; Chase, TN; Kask, AM | 1 |
| Consroe, P; Edsall, SA; Knapp, RJ; Roeske, WR; Vanderah, TW; Yamamura, HI | 1 |
| Lowe, JA; Mansbach, RS; Rovetti, CC; Winston, EN | 1 |
| Barth, F; Bouaboula, M; Calandra, B; Casellas, P; Ferrara, P; Le Fur, G; Oustric, D; Rinaldi-Carmona, M; Shire, D | 1 |
| Abood, ME; Compton, DR; Martin, BR; Showalter, VM | 1 |
| Hawksworth, GM; Joe-Adigwe, G; Pertwee, RG | 1 |
| Patrick, RL; Patrick, SL; Sañudo-Peña, MC; Walker, JM | 1 |
| Coutts, AA; Fernando, SR; Nash, JE; Pertwee, RG | 1 |
| Issakidis, CN; McGregor, IS; Prior, G | 1 |
| Dey, SK; Paria, BC; Yang, ZM | 1 |
| Rosenberg, HC; Tersigni, TJ | 1 |
| Abadji, V; Abouzid, K; Fan, P; Hill, WA; Khanolkar, AD; Lin, S; Makriyannis, A; Meng, Z; Taha, G | 1 |
| Colleoni, M; Costa, B; Parolaro, D | 1 |
| Brown, RE; Dastur, FN; McGregor, IS; McLellan, RA | 1 |
| Compton, DR; Fernando, SR; Griffin, G; Martin, BR; Pertwee, RG; Razdan, RK; Ryan, W | 1 |
| Göthert, M; Schlicker, E; Timm, J | 1 |
| Friedman, H; Klein, T; Newton, C; Smith, MS; Yamamoto, Y | 1 |
| Arreaza, G; Deutsch, DG; Howlett, A; Huang, Z; Omeir, R; Prestwich, GD; Salehani, D | 1 |
| Massi, P; Parenti, M; Parolaro, D; Patrini, G; Rubino, T | 1 |
| Balster, RL; Compton, DR; Dutta, A; Gordon, PM; Lichtman, AH; Martin, BR; Razdan, RK; Siegel, C; Singer, M; Wiley, JL | 1 |
| Bloom, AS; Edgemond, WS; Moldvan, JC | 1 |
| Ashby, CR; Gatley, SJ; Gifford, AN; Samiian, L | 1 |
| Combs, V; Mason, DJ; Pugh, G; Welch, SP | 1 |
| Berrendero, F; Fernández-Ruiz, JJ; Garcia-Gil, L; Garcia-Palomero, E; Hernandez, ML; Ramos, JA; Romero, J | 1 |
| Carta, G; Casu, MA; Gessa, GL; Mascia, MS | 1 |
| Brown, S; Mackie, K; Twitchell, W | 1 |
| Burkey, RT; Nation, JR | 1 |
| Fuzio, D; Massi, P; Parolaro, D; Patrini, G; Rubino, T | 1 |
| Barth, F; Bouaboula, M; Calandra, B; Canat, X; Casellas, P; Le Fur, G; Lupker, J; Maffrand, JP; Milligan, L; Pecceu, F; Perrachon, S; Portier, M; Rinaldi-Carmona, M | 1 |
| Bucher, B; Godlewski, G; Malinowska, B; Schlicker, E | 1 |
| Alexander, SP; Boyd, EA; Cadogan, AK; Kendall, DA | 1 |
| Coutts, AA; Pertwee, RG | 1 |
| Compton, DR; Dutta, AK; Martin, BR; Razdan, RK; Ryan, W; Singer, M; Thomas, BF | 1 |
| Gatley, SJ; Gifford, AN; Lan, R; Makriyannis, A; Pyatt, B; Volkow, ND | 1 |
| Pertwee, RG | 1 |
| Childers, SR; Pacheco, MA; Stark, S | 1 |
| Bagetta, G; Finazzi Agrò, A; Maccarrone, M; Nieuwenhuizen, WF; Paoletti, AM; van der Stelt, M; Veldink, GA; Vliegenthart, JF | 1 |
| Burkey, TH; Consroe, P; Ehlert, FJ; Hosohata, Y; Quock, RM; Roeske, WR; Yamamura, HI | 1 |
| Aanonsen, L; Hargreaves, KM; Richardson, JD | 2 |
| Fuzio, D; Manfredi, B; Parolaro, D; Patrini, G; Sacerdote, P | 1 |
| Abadji, V; Chin, CN; Kendall, DA; Lucas-Lenard, J | 1 |
| Barth, F; Bouaboula, M; Brelière, JC; Calandra, B; Casellas, P; Congy, C; Derocq, JM; Le Fur, GL; Millan, J; Oustric, D; Portier, M; Rinaldi-Carmona, M; Sarran, M; Shire, D | 1 |
| Adams, IB; Compton, DR; Martin, BR | 1 |
| Burch, DF; Gilliam, AF; Roche, MJ; Seltzman, HH; Thomas, BF | 1 |
| Gerwick, W; Ketchum, S; Milligan, K; Murray, TF; Ortega, MJ; Salva, J; Soderstrom, K; Yoo, HD | 1 |
| Cardounel, A; Kalimi, M; Qureshi, J; Saady, M | 1 |
| Bouaboula, M; Casellas, P; Derocq, JM; Marchand, J; Rinaldi-Carmona, M; Ségui, M | 1 |
| Aberman, J; Carriero, D; Hill, A; Lin, SY; Makriyannis, A; Salamone, JD | 1 |
| Miller, AS; Sañudo-Peña, MC; Walker, JM | 1 |
| Basavarajappa, BS; Cooper, TB; Hungund, BL | 1 |
| Corchero, J; Fernandez-Ruiz, JJ; Fuentes, JA; Manzanares, J; Ramos, JA; Romero, J | 1 |
| Darlington, CL; Newsham-West, D; Smith, PF | 1 |
| Khen, S; Patrick, RL; Patrick, SL; Sañudo-Peña, MC; Tsou, K; Walker, JM | 1 |
| Campbell, WB; Edgemond, WS; Greenberg, MJ; Hillard, CJ; McGinley, PJ; Muthian, S | 1 |
| Crépel, F; Daniel, H; Lévénés, C; Soubrié, P | 1 |
| Dubroeucq, MC; Imperato, A; Jeantaud, B; Petitet, F; Reibaud, M | 1 |
| Berrendero, F; Cebeira, M; de Miguel, R; Fernández-Ruiz, JJ; García-Gil, L; Hernández, ML; Ramos, JA; Romero, J | 1 |
| Abood, ME; Cabral, GA; Cabral, WA; Nowell, KW; Pettit, DA; Zimmerman, HW | 1 |
| de Miguel, R; Fernández-Ruiz, JJ; Ramos, JA; Romero, J; Wenger, T | 1 |
| Miller, AS; Walker, JM | 1 |
| Force, M; Miller, AS; Sañudo-Peña, MC; Tsou, K; Walker, JM | 1 |
| Arnold, JC; Hunt, GE; McGregor, IS; Topple, AN | 1 |
| Shen, M; Thayer, SA | 1 |
| Herkenham, M; Hohmann, AG | 2 |
| Collantes, ER; Eissenstat, MA; Howlett, AC; Shim, JY; Subramaniam, B; Ward, SJ; Welsh, WJ | 1 |
| Hiley, CR; White, R | 1 |
| Bord, A; Bouaboula, M; Carayon, P; Casellas, P; Defrance, T; Derocq, JM; Dussossoy, D; Fur, GL; Galiègue, S; Jbilo, O; Marchand, J; Mondière, P; Pénarier, G | 1 |
| Järvinen, K; Järvinen, T; Mahadevan, V; Pate, DW; Urtti, A | 1 |
| Brockie, HC; Fernando, SR; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B | 1 |
| Bonhaus, DW; Chang, LK; Kwan, J; Martin, GR | 1 |
| Barth, F; Bouaboula, M; Carayon, P; Casellas, P; Le Duigou, A; Le Fur, G; Oustric, D; Rinaldi-Carmona, M | 1 |
| Huffman, JW; Liddle, J; Martin, BR; Wiley, JL | 1 |
| Baba, N; Ishima, Y; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Seki, C; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Sañudo-Peña, MC; Walker, JM | 1 |
| Basavarajappa, BS; Hungund, BL | 2 |
| Cabral, GA; Carlisle, SJ; Olson, JM; Waksman, Y | 1 |
| Hohmann, AG; Tsou, K; Walker, JM | 2 |
| Abood, ME; Andreassi, J; Bachtel, K; Cabral, GA; Ekman, MC; Hurst, DP; McAllister, SD; Nowell, KW; Reggio, PH; Tao, Q | 1 |
| Niederhoffer, N; Szabo, B | 2 |
| Howlett, AC; Meschler, JP | 1 |
| Briley, EM; Herkenham, M; Hohmann, AG | 1 |
| Brockie, HC; Makriyannis, A; Murphy, VL; Pertwee, RG; Ross, RA; Stevenson, LA; Templeton, F | 1 |
| Corchero, J; Fuentes, JA; Manzanares, J | 1 |
| Abadji, V; Chin, C; Kendall, DA; Lucas-Lenard, JM | 1 |
| Casellas, P; Derocq, JM; Jbilo, O; Le Fur, G; Segui, M | 1 |
| Cadogan, AK; Cheer, JF; Fone, KC; Kendall, DA; Marsden, CA | 1 |
| Bianchini, L; Bouaboula, M; Casellas, P; McKenzie, FR; Pouyssegur, J | 1 |
| Bonner, TI; Herkenham, M; Hohmann, AG; Zimmer, A; Zimmer, AM | 1 |
| Gallate, JE; Mallet, PE; McGregor, IS; Saharov, T | 1 |
| Campbell, WB; DiCamelli, R; Greenberg, MJ; Hillard, CJ; Manna, S; Murphy, V; Pertwee, RG; Ross, RA; Stevenson, LA | 1 |
| Cabral, GA; Carlisle, SJ; Matveyeva, M; McCoy, KL | 1 |
| DiCamelli, R; Greenberg, MJ; Hillard, CJ; Kearn, CS; Kurzawa, K | 1 |
| Bertrand, P; Imperato, A; Jeantaud, B; Petitet, F | 1 |
| Calandra, B; Carillon, C; Delpech, M; Ferrara, P; Kernéis, A; Le Fur, G; Portier, M; Shire, D | 1 |
| Brown, S; Derleth, C; Hsieh, C; Mackie, K | 1 |
| Bauer, U; Göthert, M; Kathmann, M; Schlicker, E | 1 |
| Berrendero, F; Bisogno, T; Corchero, J; Di Marzo, V; Fernández-Ruiz, J; Fuentes, JA; González, S; Manzanares, J; Ramos, JA; Romero, J; Wenger, T | 1 |
| Koch, H; Müller, T; Szabo, B | 1 |
| Lowe, J; Mason, DJ; Welch, SP | 1 |
| Göthert, M; Likungu, J; Molderings, GJ | 1 |
| Crocker, P; Gibson, TM; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B; Stevenson, LA | 1 |
| Bueb, J; Delzenne, NM; DiPaolo, FG; Govaerts, SJ; Hermans, E; Kanyonyo, M; Lambert, DM; Sonveaux, P; Tschirhart, EJ | 1 |
| Abood, ME; Griffin, G; McAllister, SD; Satin, LS | 1 |
| Bruneus, M; Gatley, SJ; Gifford, AN; Goutopoulos, A; Lin, S; Makriyannis, A; Volkow, ND | 1 |
| Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Pinto, L | 1 |
| Kishimoto, S; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Mackie, K; Romero, J; Sañudo-Peña, MC; Tsou, K; Walker, JM | 1 |
| Besret, L; Dunnett, SB; Everitt, BJ; Jain, M; Monaghan, EM; Page, KJ | 1 |
| Abood, ME; Griffin, G; Tao, Q | 1 |
| Capasso, F; Izzo, AA; Mascolo, N; Tonini, M | 1 |
| Eads, M; Embrey, JP; Houser, SJ; Welch, SP | 1 |
| Angus, JA; Lay, L; Wright, CE | 1 |
| Bouaboula, M; Casellas, P; Dornand, J; Gross, A; Liautard, JP; Marchant, J; Ouahrani-Bettache, S; Terraza, A | 1 |
| Campbell, WB; Hillard, CJ; Muthian, S; Nithipatikom, K | 1 |
| Fan, X; Gonsiorek, W; Hipkin, RW; Lundell, D; Lunn, C; Narula, S | 1 |
| Banner, WK; Gibson, TM; Martin, BR; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B; Stevenson, LA | 1 |
| Houston, DB; Howlett, AC; Lan, R; Liu, Q; Makriyannis, A; Pigg, JJ; Wilken, GH | 1 |
| Campbell, WB; Edgemond, WS; Hillard, CJ; Jarrahian, A; Manna, S | 1 |
| Bouaboula, M; Casellas, P; Clère, C; Derocq, JM; Jbilo, O; Ségui, M | 1 |
| Bonner, T; Buckley, NE; Felder, CC; Glass, M; McCoy, KL; Mezey, E; Zimmer, A | 1 |
| Auclair, N; Crepel, F; Otani, S; Soubrie, P | 1 |
| Braida, D; Sala, M | 2 |
| Barth, F; Calandra, B; Ferrara, P; Gouldson, P; Kernéis, A; Le Fur, G; Legoux, P; Rinaldi-Carmona, M; Shire, D | 1 |
| Barnes, PJ; Belvisi, MG; Birrell, M; Clarke, D; Haddad, EB; Ling, A; Spicuzza, L; Venkatesan, P | 1 |
| Massi, P; Panerai, AE; Parolaro, D; Sacerdote, P | 1 |
| Freund, TF; Hájos, N; Katona, I; Ledent, C; MacKie, K; Mody, I; Naiem, SS | 1 |
| Massi, P; Parolaro, D; Rubino, T; Viganò, D | 1 |
| Braida, D; Pozzi, M; Sala, M | 1 |
| Abood, ME; Aung, MM; Griffin, G; Martin, BR; Razdan, RK; Williams, S | 1 |
| Conley, TJ; Howlett, AC; Meschler, JP | 1 |
| Bockaert, J; Manzoni, OJ | 1 |
| Baydoun, A; Begg, M; Molleman, A; Parsons, ME | 1 |
| Bisogno, T; Brandi, I; Dasse, O; Davis, JB; De Petrocellis, L; Di Marzo, V; Jefferson, RG; Mahadevan, A; Martin, BR; Razdan, RK; Winckler, RL | 1 |
| Kathmann, M; Schlicker, E; Weber, B | 1 |
| Braida, D; Parolaro, D; Pozzi, M; Sala, M | 1 |
| Angus, JA; Christopoulos, A; Coles, P; Lay, L; Lew, MJ | 1 |
| Johnson, F; Soderstrom, K | 1 |
| Hillard, CJ; Patel, S | 2 |
| Niederhoffer, N; Nordheim, U; Szabo, B | 1 |
| Bradbury, R; Copolov, D; Dean, B; Scarr, E; Sundram, S | 1 |
| Andersson, M; Disney, G; Fowler, CJ; Jacobsson, SO; Nilsson, O; Tiger, G | 1 |
| Fox, A; Gentry, C; James, I; Kesingland, A; McNair, K; Patel, S; Urban, L | 1 |
| Grimaldi, M; Hampson, AJ | 1 |
| Theobald, RJ | 1 |
| Dar, MS; DeSanty, KP | 1 |
| Massi, P; Parolaro, D; Romorini, S; Vaccani, A | 1 |
| Braida, D; Cavallini, R; Pozzi, M; Sala, M | 1 |
| Hryniewicz, A; Koneczny, B; Malinowska, B; Piszcz, J; Schlicker, E | 1 |
| Craib, SJ; Ellington, HC; Pertwee, RG; Ross, RA | 1 |
| Erbelding, D; Kilbinger, H; Mang, CF | 1 |
| Cheng, JS; Chou, KJ; Fang, HC; Jan, CR; Law, YP; Lee, KC; Su, W; Tseng, LL; Wang, JL | 1 |
| Bari, M; De Petrocellis, L; Di Marzo, V; Fezza, F; Finazzi-Agrò, A; Maccarrone, M; Salvati, S | 1 |
| Arévalo, C; de Miguel, R; Hernández-Tristán, R | 1 |
| Bardotti, M; Parolaro, D; Poli, G; Ponti, W; Rubino, T | 1 |
| Bisogno, T; Capasso, F; Capasso, R; Di Marzo, V; Esposito, G; Fezza, F; Iuvone, T; Izzo, AA; Mascolo, N; Pinto, L | 1 |
| Fernandez-Ruiz, JJ; Hansen, HH; Niederhoffer, N; Szabo, B | 1 |
| Biegon, A; Kerman, IA | 1 |
| Acsady, L; Freund, TF; Hajos, N; Katona, I; Ledent, C; Mackie, K; Rancz, EA | 1 |
| Arnold, JC; Hunt, GE; Mallet, PE; McGregor, IS; Topple, AN | 1 |
| Cabral, GA; Carlisle, SJ; Harmon, KN | 1 |
| Felder, CC; Golightly, SF; Hosohata, Y; Noecker, RJ; Porter, AC; Ryan, EP; Stamer, WD; Varga, E; Yamamura, HI | 1 |
| Hayase, T; Yamamoto, K; Yamamoto, Y | 3 |
| Bönisch, H; Brüss, M; Göthert, M; Hammermann, R; Molderings, GJ | 1 |
| Darmani, NA | 1 |
| Begg, M; Molleman, A; Parsons, M | 1 |
| Arnold, JC; Hunt, GE; McGregor, IS | 1 |
| Jan, TR; Kaminski, NE; Rao, GK | 1 |
| Brunetti, G; Carai, MM; Colombo, G; Gessa, L; Gomez, R; Melis, S; Serra, S; Vacca, G | 1 |
| Guaza, C; Molina-Holgado, E; Molina-Holgado, F; Rothwell, NJ | 1 |
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| Jay, TM; Krebs, MO; Le Pen, G; Lenkei, Z; Rame, M; Renard, J; Vitalis, T | 1 |
| Crestani, AP; de Freitas Cassini, L; de Oliveira Alvares, L; Duran, JM; Haubrich, J; Quillfeldt, JA; Santana, F; Sierra, RO | 1 |
| Giuffrida, A; Seillier, A | 1 |
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| Banister, SD; Connor, M; Glass, M; Kassiou, M; Kevin, R; Longworth, M; Mack, JB; McGregor, IS; Sachdev, S; Santiago, M; Stuart, J | 1 |
| Bass, CE; Blume, LC; Chen, R; Howlett, AC; Leone-Kabler, S; Luessen, DJ; Lyons, E; Marrs, GS; Selley, DE | 1 |
| Hind, WH; O'Sullivan, SE; Stanley, CP; Tufarelli, C | 1 |
| Dahal, S; France, CP; Minervini, V | 1 |
| Ford, BM; Franks, LN; Prather, PL; Radominska-Pandya, A | 1 |
| John, WS; Martin, TJ; Nader, MA | 1 |
| Baranowska-Kuczko, M; Harasim-Symbor, E; Kasacka, I; Malinowska, B; Pędzińska-Betiuk, A; Toczek, M; Weresa, J | 1 |
| Bedse, G; Gaulden, AD; Hartley, ND; Kingsley, PJ; Marnett, LJ; Neale, E; Patel, S; Patrick, TA; Plath, N; Uddin, MJ | 1 |
| Fingerle, J; Grether, U; Hartung, T; Heitman, LH; IJzerman, AP; Martella, A; Rufer, AC; Sijben, H; Ullmer, C; van der Stelt, M | 1 |
| Farquhar, CE; Gamage, TF; Lefever, TW; Nguyen, T; Thomas, BF; Wiley, JL; Zhang, Y | 1 |
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| France, CP; Minervini, V | 2 |
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| Henderson-Redmond, AN; LaFleur, RA; Morgan, DJ; Wilson, RP | 1 |
| Giménez-Llort, L; Giralt, MT; Ledent, C; Llorente-Ovejero, A; Lombardero, L; Manuel, I; Rodríguez-Puertas, R | 1 |
| Alshehri, FS; Hakami, AY; Sari, Y | 1 |
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| Budde, H; Coronado-Álvarez, A; Imperatori, C; Machado, S; Macías-Triana, L; Murillo-Rodríguez, E; Romero-Cordero, K; Tatum-Kuri, A; Vera-Barrón, A; Yamamoto, T | 1 |
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| Cinar, R; Gao, B; Godlewski, G; Gunduz-Cinar, O; Herrerias, A; Iyer, MR; Kunos, G; Lin, Y; Santos-Molina, L; Wood, CM; Zawatsky, CN | 1 |
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6 review(s) available for cyclohexanol and 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
| Article | Year |
|---|---|
Classical and nonclassical cannabinoids: mechanism of action--brain binding.
Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Brain; Cannabinoids; Cyclohexanols; Dronabinol; Structure-Activity Relationship | 1990 |
Pharmacology of cannabinoid CB1 and CB2 receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Calcium; Cannabinoids; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclohexanols; Humans; Leukocytes; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Spleen; Structure-Activity Relationship | 1997 |
Behavioural and neuroendocrine effects of cannabinoids in critical developmental periods.
Topics: Animals; Behavior, Animal; Benzoxazines; Brain; Cannabinoids; Critical Period, Psychological; Cyclohexanols; Dronabinol; Morpholines; Naphthalenes; Neurosecretory Systems | 2005 |
Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Endocannabinoids; Humans; Ligands; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2008 |
[Drug discrimination properties and cytotoxicity of the cannabinoid receptor ligands].
Topics: Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dronabinol; Humans; Ligands; Morpholines; Naphthalenes; Receptor, Cannabinoid, CB1; Substrate Specificity | 2012 |
The synthetic CB
Topics: Analgesics; Animals; Anti-Anxiety Agents; Cannabinoid Receptor Agonists; Cannabinoids; Controlled Substances; Cyclohexanols; Dronabinol; Humans; Mental Disorders; Pain; Phenanthridines; Receptor, Cannabinoid, CB1 | 2021 |
687 other study(ies) available for cyclohexanol and 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
| Article | Year |
|---|---|
Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation.
Topics: Animals; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Electrophoresis, Agar Gel; Female; Immunosuppressive Agents; Mice; Polymerase Chain Reaction; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; RNA; Spleen; Stereoisomerism | 1992 |
Localization of cannabinoid receptor in the human developing and adult basal ganglia. Higher levels in the striatonigral neurons.
Topics: Aged; Aged, 80 and over; Aging; Autoradiography; Basal Ganglia; Brain; Cannabinoids; Corpus Striatum; Cyclohexanols; Humans; In Vitro Techniques; Infant; Infant, Newborn; Neurons; Organ Specificity; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Substantia Nigra; Tritium | 1992 |
Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents.
Topics: Adenylyl Cyclases; Analgesics; Animals; Bridged Bicyclo Compounds; Cannabinoids; Cyclohexanols; Dronabinol; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Structure-Activity Relationship; Tritium | 1992 |
A comparison of the discriminative stimulus properties of delta 9-tetrahydrocannabinol and CP 55,940 in rats and rhesus monkeys.
Topics: Analgesics; Animals; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Macaca mulatta; Male; Rats; Rats, Inbred Strains | 1992 |
Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism.
Topics: Analgesics; Calcium Channel Blockers; Cannabinoids; Cyclohexanols; Dronabinol; GTP-Binding Proteins; Humans; Neuroblastoma; omega-Conotoxins; Peptides, Cyclic; Pertussis Toxin; Receptors, Cannabinoid; Receptors, Drug; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones.
Topics: Animals; Arachidonic Acid; Calcium; Cannabinoids; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Cyclohexanols; DNA; Dronabinol; Humans; Inositol Phosphates; L Cells; Mice; Phospholipases A; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transfection; Type C Phospholipases | 1992 |
Characterization and autoradiographic localization of the cannabinoid binding site in rat brain using [3H]11-OH-delta 9-THC-DMH.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Cyclohexanols; Dronabinol; Male; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 1992 |
Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry.
Topics: Animals; Autoradiography; Blotting, Northern; Brain; Brain Stem; Cyclohexanols; DNA; Female; Histocytochemistry; Neurons; Nucleic Acid Hybridization; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Spinal Cord; Staining and Labeling | 1992 |
Cannabinoid receptor localization in brain: relationship to motor and reward systems.
Topics: Animals; Autoradiography; Brain; Cannabinoids; Corpus Striatum; Cyclohexanols; Dopamine; Guinea Pigs; Humans; Macaca mulatta; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Drug; Reward; Tritium | 1992 |
Initial observations on the distribution of cannabinoid receptor binding sites in the human adult basal ganglia using autoradiography.
Topics: Adult; Aged; Autoradiography; Basal Ganglia; Brain Chemistry; Cyclohexanols; Female; Humans; Male; Middle Aged; Receptors, Cannabinoid; Receptors, Drug | 1992 |
Age-related loss of cannabinoid receptor binding sites and mRNA in the rat striatum.
Topics: Aging; Analgesics; Animals; Autoradiography; Corpus Striatum; Cyclohexanols; DNA Probes; In Situ Hybridization; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger | 1992 |
Solubilization of the cannabinoid receptor from rat brain membranes.
Topics: Analgesics; Animals; Binding, Competitive; Cannabinoids; Cell Membrane; Chromatography, Gel; Cyclohexanols; Kinetics; Phenanthridines; Prosencephalon; Rats; Receptors, Cannabinoid; Receptors, Drug | 1992 |
Chronic exposure to delta 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors.
Topics: Analgesics; Animals; Brain; Cannabinoids; Cerebellum; Cerebral Cortex; Cyclohexanols; Dronabinol; Hippocampus; Kinetics; Macaca mulatta; Male; Organ Specificity; Phenanthridines; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug | 1991 |
Spinal and supraspinal components of cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dronabinol; Injections, Intravenous; Injections, Spinal; Male; Rats; Rats, Inbred Strains; Spinal Cord | 1991 |
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Body Temperature; Brain; Cannabinoids; Cyclohexanols; Dronabinol; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Conformation; Morpholines; Motor Activity; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Drug; Structure-Activity Relationship | 1991 |
Pharmacological evaluation of halogenated delta 8-THC analogs.
Topics: Analgesics; Animals; Binding, Competitive; Body Temperature; Catalepsy; Cyclohexanols; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Receptors, Cannabinoid; Receptors, Drug | 1991 |
Molecular cloning of a human cannabinoid receptor which is also expressed in testis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain Stem; Cannabinoids; Cell Line; Cloning, Molecular; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; DNA; Gene Expression; Humans; Male; Molecular Sequence Data; Receptors, Cannabinoid; Receptors, Drug; RNA; Testis; Transcription, Genetic | 1991 |
Ca(2+)-dependent release from rat brain of cannabinoid receptor binding activity.
Topics: Animals; Brain; Calcimycin; Calcium; Cannabinoids; Cyclohexanols; In Vitro Techniques; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug | 1992 |
Characterization and localization of cannabinoid receptors in brain: an in vitro technique using slide-mounted tissue sections.
Topics: Animals; Autoradiography; Brain Chemistry; Cyclohexanols; Rats; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1991 |
Spinal action of cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Injections; Male; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord | 1990 |
Aminoalkylindoles (AAIs): a new route to the cannabinoid receptor?
Topics: Amines; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; GTP-Binding Proteins; Indoles; Morpholines; Naphthalenes; Rats; Receptors, Cannabinoid; Receptors, Drug | 1990 |
Neuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellum.
Topics: Adenylyl Cyclases; Animals; Autoradiography; Cannabinoids; Cerebellum; Colforsin; Cyclohexanols; Heterozygote; Homozygote; Mice; Mice, Neurologic Mutants; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Cannabinoid; Receptors, Drug; Second Messenger Systems; Tritium | 1991 |
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study.
Topics: Animals; Autoradiography; Brain; Buffers; Cannabinoids; Cyclohexanols; Male; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug; Serum Albumin, Bovine; Temperature; Time Factors; Tissue Distribution | 1991 |
Stereochemical effects of 11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cells, Cultured; Cyclic AMP; Cyclohexanols; Dronabinol; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug | 1990 |
Cannabinoid receptor localization in brain.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Humans; Kinetics; Mice; Organ Specificity; Receptors, Cannabinoid; Receptors, Drug; Species Specificity; Tritium | 1990 |
Identification of metabolites of CP-55,940 formed in-vitro by mouse livers.
Topics: Animals; Cannabinoids; Cyclohexanols; Inactivation, Metabolic; Liver; Mice; Mixed Function Oxygenases; Structure-Activity Relationship | 1989 |
Determination and characterization of a cannabinoid receptor in rat brain.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain Chemistry; Cyclohexanols; Dronabinol; Guanylyl Imidodiphosphate; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug; Sodium | 1988 |
Selected ion monitoring analysis of CP-55,940, a cannabinoid derived analgetic agent.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dogs; Female; Gas Chromatography-Mass Spectrometry | 1987 |
Cannabinoids enhance human B-cell growth at low nanomolar concentrations.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Base Sequence; Benzoxazines; Cannabinoids; CD40 Antigens; Cell Division; Cyclohexanols; DNA; Dronabinol; Humans; Ligands; Lymphocyte Activation; Molecular Sequence Data; Morpholines; Naphthalenes; Palatine Tonsil; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Antigen, B-Cell; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Virulence Factors, Bordetella | 1995 |
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraperitoneal; Male; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1995 |
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain.
Topics: Animals; Arachidonic Acids; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Lipase; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Synaptic Membranes; Tritium | 1995 |
Intrastriatal injection of cannabinoid receptor agonists induced turning behavior in mice.
Topics: Analgesics; Animals; Benzoxazines; Cannabis; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Female; Injections; Mice; Morpholines; Naphthalenes; Neurons; Oxidopamine; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Neurokinin-2; Rimonabant; Stereoisomerism; Stereotyped Behavior | 1995 |
Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes.
Topics: Animals; Arachidonic Acids; Astrocytes; Benzoxazines; Calcium; Cannabinoids; Cell Membrane Permeability; Cells, Cultured; Corpus Striatum; Cyclohexanols; Endocannabinoids; Gap Junctions; Glutamic Acid; Isoquinolines; Mice; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Rats; Signal Transduction | 1995 |
Mead ethanolamide, a novel eicosanoid, is an agonist for the central (CB1) and peripheral (CB2) cannabinoid receptors.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Endocannabinoids; Humans; L Cells; Mice; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug | 1995 |
Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to delta 9-tetrahydrocannabinol.
Topics: Analgesics; Animals; Arachidonic Acids; Brain Chemistry; Calcium Channel Blockers; Cannabinoids; Cannabis; Cyclohexanols; Dronabinol; Endocannabinoids; In Vitro Techniques; Kinetics; Male; Membranes; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug | 1995 |
Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Memory; Rats; Rats, Sprague-Dawley; Spatial Behavior; Temperature | 1995 |
Chronic CP-55,940 alters cannabinoid receptor mRNA in the rat brain: an in situ hybridization study.
Topics: Animals; Brain; Cannabinoids; Cyclohexanols; In Situ Hybridization; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Time Factors | 1994 |
Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Cannabis; Cyclohexanols; Electric Stimulation; Endocannabinoids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Ligands; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Phenylmethylsulfonyl Fluoride; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Stereoisomerism; Vas Deferens | 1995 |
Induction of the Krox 24 transcription factor in striosomes by a cannabinoid agonist.
Topics: Animals; Cannabinoids; Corpus Striatum; Cyclohexanols; Gene Expression Regulation; Genes, Immediate-Early; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; Transcription Factors; Zinc Fingers | 1995 |
Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Endocannabinoids; Morpholines; Naphthalenes; Neurons; Nodose Ganglion; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Serotonin | 1995 |
Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells.
Topics: Animals; Astrocytes; Astrocytoma; Base Sequence; CHO Cells; Cricetinae; Cyclohexanols; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; GTP-Binding Proteins; Humans; Immediate-Early Proteins; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transcription Factors; Tumor Cells, Cultured | 1995 |
AM630, a competitive cannabinoid receptor antagonist.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Cannabinoids; Cyclohexanols; Endocannabinoids; In Vitro Techniques; Indoles; Male; Mice; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 1995 |
A novel electrophilic high affinity irreversible probe for the cannabinoid receptor.
Topics: Affinity Labels; Animals; Binding, Competitive; Cannabinoids; Cyclohexanols; Dronabinol; In Vitro Techniques; Ligands; Protein Binding; Rats; Receptors, Cannabinoid; Receptors, Drug; Synaptosomes | 1995 |
Classical/non-classical cannabinoid hybrids; stereochemical requirements for the southern hydroxyalkyl chain.
Topics: Animals; Binding, Competitive; Cannabinoids; Cyclohexanols; In Vitro Techniques; Prosencephalon; Rats; Receptors, Cannabinoid; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship | 1995 |
Variation of the alkyl side chain in delta 8-THC.
Topics: Analgesics; Animals; Binding, Competitive; Catalepsy; Cyclohexanols; Dronabinol; Hypothermia; Mice; Motor Activity; Structure-Activity Relationship | 1995 |
Pharmacological and behavioral evaluation of alkylated anandamide analogs.
Topics: Alkylation; Analgesics; Animals; Arachidonic Acids; Binding, Competitive; Cannabinoids; Cyclohexanols; Endocannabinoids; Male; Motor Activity; Polyunsaturated Alkamides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship; Swine | 1995 |
Evaluation of cAMP involvement in cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Colforsin; Cyclic AMP; Cyclohexanols; Dronabinol; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley | 1995 |
An examination of the central sites of action of cannabinoid-induced antinociception in the rat.
Topics: Analgesics; Animals; Autoradiography; Benzoxazines; Binding Sites; Brain; Cannabinoids; Cyclohexanols; Injections, Intraventricular; Male; Morpholines; Naphthalenes; Rats; Rats, Sprague-Dawley; Tritium | 1995 |
Discriminative stimulus effects of anandamide in rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 1995 |
Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoids; Cyclohexanols; Endocannabinoids; Kinetics; Male; Mice; Mice, Inbred ICR; Models, Molecular; Phenylmethylsulfonyl Fluoride; Polyunsaturated Alkamides; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1995 |
Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to delta 9-THC after intrathecal administration to mice: blockade of delta 9-THC-induced antinociception.
Topics: Analgesics; Animals; Arachidonic Acids; Binding Sites; Calcium Channel Blockers; Cyclohexanols; Dronabinol; Drug Tolerance; Endocannabinoids; Injections, Spinal; Mice; Narcotic Antagonists; Pertussis Toxin; Polyunsaturated Alkamides; Potassium Channel Blockers; Rats; Spinal Cord; Synaptosomes; Virulence Factors, Bordetella | 1995 |
Characterization of ligand binding to the cannabinoid receptor of rat brain membranes using a novel method: application to anandamide.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cyclohexanols; Endocannabinoids; Filtration; Ligands; Male; Membranes; Neurochemistry; Phenylmethylsulfonyl Fluoride; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Time Factors | 1995 |
Modulation of free intracellular calcium and cAMP by morphine and cannabinoids, alone and in combination in mouse brain and spinal cord synaptosomes.
Topics: Animals; Brain Chemistry; Calcium; Cannabinoids; Cyclic AMP; Cyclohexanols; Dronabinol; Drug Interactions; In Vitro Techniques; Mice; Morphine; Spinal Cord; Synaptosomes | 1994 |
Blockade of cannabinoid-induced antinociception by naloxone benzoylhydrazone (NalBZH).
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Injections, Intraventricular; Injections, Spinal; Mice; Naloxone; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Cannabinoid receptor binding and messenger RNA expression in human brain: an in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Autoradiography; Brain Chemistry; Cannabinoids; Cyclohexanols; Female; Hippocampus; Humans; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Memory; Middle Aged; Nerve Degeneration; Receptors, Cannabinoid; Receptors, Drug; RNA Probes; RNA, Messenger; Silver Staining | 1994 |
Cannabinoid receptors in developing rats: detection of mRNA and receptor binding.
Topics: Aging; Animals; Animals, Newborn; Brain; Cannabinoids; Cyclohexanols; Female; Gene Expression Regulation; Male; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger | 1994 |
Development of cross-tolerance between delta 9-tetrahydrocannabinol, CP 55,940 and WIN 55,212.
Topics: Analgesics; Animals; Benzoxazines; Body Temperature; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Male; Mice; Mice, Inbred ICR; Morpholines; Motor Activity; Naphthalenes | 1994 |
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.
Topics: Analgesics; Animals; Arachidonic Acids; Binding, Competitive; Brain; Calcium Channel Blockers; Cyclohexanols; Dronabinol; Drug Administration Routes; Drug Interactions; Endocannabinoids; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Polyunsaturated Alkamides; Receptors, Purinergic P2; Tritium | 1994 |
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor.
Topics: Animals; Benzoxazines; Binding, Competitive; Biological Assay; Brain; Cannabinoids; Cell Membrane; Cyclohexanols; In Vitro Techniques; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1994 |
Cannabinoids modulate potassium current in cultured hippocampal neurons.
Topics: Action Potentials; Animals; Benzoxazines; Cannabinoids; Cells, Cultured; Cyclohexanols; GTP Phosphohydrolases; GTP-Binding Proteins; Hippocampus; Membrane Potentials; Morpholines; Naphthalenes; Neurons; Phenanthridines; Potassium; Rats; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-B | 1993 |
Inhibitors of arachidonoyl ethanolamide hydrolysis.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Binding, Competitive; Cannabinoids; Cyclohexanols; Endocannabinoids; Esters; Fatty Acids; Hydrolysis; Ketones; Polyunsaturated Alkamides; Rats; Tumor Cells, Cultured | 1994 |
Antinociceptive actions of cannabinoids following intraventricular administration in rats.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Microinjections; Morpholines; Naphthalenes; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reflex; Tissue Distribution | 1993 |
Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment.
Topics: Animals; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Down-Regulation; Dronabinol; Drug Tolerance; Exploratory Behavior; Kinetics; Limbic System; Male; Membranes; Mesencephalon; Motor Activity; Neostriatum; Prosencephalon; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug | 1994 |
Endogenous cannabinoid receptor binding activity released from rat brain slices by depolarization.
Topics: Animals; Benzoxazines; Binding Sites; Brain; Calcimycin; Calcium; Calcium Channel Blockers; Cyclohexanols; Drug Antagonism; In Vitro Techniques; Male; Membrane Potentials; Morpholines; Naphthalenes; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 1994 |
Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: implications for receptor-mediated immune modulation by cannabinoids.
Topics: Adjuvants, Immunologic; Animals; Binding Sites; Cannabinoids; Cyclohexanols; Female; Immune System; Male; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Tissue Distribution | 1994 |
Differential requirements of sodium for coupling of cannabinoid receptors to adenylyl cyclase in rat brain membranes.
Topics: Adenylyl Cyclases; Analgesics; Animals; Baclofen; Benzoxazines; Brain; Cannabinoids; Cerebellum; Corpus Striatum; Cyclohexanols; GTP-Binding Proteins; Kinetics; Male; Morpholines; Naphthalenes; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-B; Sodium; Sodium Chloride | 1994 |
Evidence for a cannabinoid receptor in immunomodulation by cannabinoid compounds.
Topics: Adenylyl Cyclases; Animals; Cannabinoids; Cells, Cultured; Colforsin; Cyclohexanols; Dronabinol; Female; Immunity; Immunoglobulin M; Mice; Receptors, Cannabinoid; Receptors, Drug; Spleen; Stereoisomerism | 1993 |
Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs.
Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Cannabinoids; Cyclohexanols; In Vitro Techniques; Male; Mice; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship; Tumor Cells, Cultured | 1993 |
Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.
Topics: Aged; Aged, 80 and over; Autoradiography; Cannabinoids; Cyclohexanols; Humans; Huntington Disease; In Vitro Techniques; Male; Middle Aged; Presynaptic Terminals; Receptors, Cannabinoid; Receptors, Drug; Substantia Nigra | 1993 |
Pharmacological evaluation of iodo and nitro analogs of delta 8-THC and delta 9-THC.
Topics: Analgesics; Animals; Body Temperature; Cannabidiol; Cannabinoids; Cyclohexanols; Dronabinol; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Conformation; Motor Activity; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1993 |
Development of behavioral tolerance to delta 9-THC without alteration of cannabinoid receptor binding or mRNA levels in whole brain.
Topics: Animals; Behavior, Animal; Blotting, Northern; Brain Chemistry; Cyclohexanols; DNA Probes; Dronabinol; Drug Tolerance; Electrophoresis, Polyacrylamide Gel; In Situ Hybridization; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger | 1993 |
In vitro reinforcement of hippocampal bursting by the cannabinoid receptor agonist (-)-CP-55,940.
Topics: Action Potentials; Animals; Cannabinoids; Cyclohexanols; Hippocampus; In Vitro Techniques; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Stereoisomerism | 1993 |
Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement.
Topics: Animals; Brain; Cannabinoids; Cyclohexanols; Dopamine; Dronabinol; Estradiol; Estrus; Female; Kinetics; Male; Neurons; Orchiectomy; Ovariectomy; Ovary; Progesterone; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Sex Characteristics; Testis; Testosterone; Tritium | 1994 |
Evidence for a cannabinoid receptor in sea urchin sperm and its role in blockade of the acrosome reaction.
Topics: Acrosome; Animals; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Dronabinol; Female; Humans; In Vitro Techniques; Kinetics; Male; Mice; Rats; Receptors, Cannabinoid; Receptors, Drug; Sea Urchins; Sperm-Ovum Interactions; Spermatozoa; Stereoisomerism | 1993 |
Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.
Topics: Amides; Animals; Arachidonic Acids; Benzoxazines; Body Temperature; Cannabinoids; Cyclohexanols; Dronabinol; Drug Tolerance; Electric Stimulation; Endocannabinoids; Fatty Acids, Unsaturated; Male; Mice; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Vas Deferens | 1993 |
Roles of sulfhydryl and disulfide groups in the binding of CP-55,940 to rat brain cannabinoid receptor.
Topics: Animals; Brain; Cannabinoids; Cyclohexanols; Disulfides; Dithiothreitol; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Sulfhydryl Compounds; Sulfhydryl Reagents | 1993 |
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.
Topics: Amides; Animals; Arachidonic Acids; Binding, Competitive; Calcium Channels; Cannabinoids; Cell Membrane; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Endocannabinoids; Fatty Acids, Unsaturated; Humans; Kinetics; Pertussis Toxin; Polyunsaturated Alkamides; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Structure-Activity Relationship; Transfection; Tritium; Virulence Factors, Bordetella | 1993 |
Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Kinetics; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Time Factors; Tritium | 1993 |
Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins.
Topics: Animals; Brain Chemistry; Cholic Acids; Cyclohexanols; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Phenanthridines; Rats; Receptors, Cannabinoid; Receptors, Drug; Solubility | 1993 |
Aminoalkylindole binding in rat cerebellum: selective displacement by natural and synthetic cannabinoids.
Topics: Analgesics; Animals; Benzoxazines; Binding, Competitive; Cannabinoids; Cerebellum; Cyclohexanols; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Magnesium; Male; Morpholines; Naphthalenes; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Stereoisomerism | 1993 |
Presence of cannabinoid binding sites in the brain from early postnatal ages.
Topics: Aging; Animals; Animals, Newborn; Brain; Cannabinoids; Cyclohexanols; Female; Kinetics; Male; Prosencephalon; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Sex Characteristics; Tritium | 1993 |
Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.
Topics: Animals; Binding, Competitive; Cannabinoids; Cyclohexanols; Male; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1993 |
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Analgesics; Animals; Benzoquinones; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; Cell Line; CHO Cells; Cricetinae; Cyclohexanols; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Immediate-Early Proteins; Kinetics; Lactams, Macrocyclic; Pertussis Toxin; Piperidines; Pyrazoles; Quinones; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Rifabutin; Rimonabant; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Virulence Factors, Bordetella | 1995 |
The cannabinoid agonists WIN 55,212-2 and CP 55,940 attenuate rotational behavior induced by a dopamine D1 but not a D2 agonist in rats with unilateral lesions of the nigrostriatal pathway.
Topics: Animals; Benzoxazines; Cannabinoids; Corpus Striatum; Cyclohexanols; Functional Laterality; Male; Morpholines; Motor Activity; Naphthalenes; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Drug; Rotation; Substantia Nigra | 1995 |
Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression system.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Calcium Channels; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Morpholines; Naphthalenes; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Superior Cervical Ganglion; Virulence Factors, Bordetella | 1996 |
The conformational properties of the highly selective cannabinoid receptor ligand CP-55,940.
Topics: Cannabinoids; Cyclohexanols; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Conformation; Receptors, Cannabinoid; Receptors, Drug | 1996 |
Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement.
Topics: Analgesics; Animals; Bucladesine; Cannabinoids; Caudate Nucleus; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraventricular; Male; Periaqueductal Gray; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Stereoisomerism; Virulence Factors, Bordetella | 1996 |
(Aminoalkyl)indole isothiocyanates as potential electrophilic affinity ligands for the brain cannabinoid receptor.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Line; Cyclohexanols; Isothiocyanates; Magnetic Resonance Spectroscopy; Mass Spectrometry; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug | 1996 |
Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens.
Topics: Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vas Deferens | 1995 |
Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes.
Topics: Animals; Arachidonic Acids; Binding Sites; Cannabinoids; Cyclohexanols; Endocannabinoids; Humans; Microglia; Mollusca; Monocytes; Nitric Oxide; Polyunsaturated Alkamides; Protein Sorting Signals; Receptors, Cannabinoid; Receptors, Drug | 1996 |
Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice.
Topics: Adenylyl Cyclase Inhibitors; Animals; Body Temperature Regulation; Cannabinoids; Cerebellum; Colforsin; Cyclohexanols; Down-Regulation; Drug Tolerance; Enzyme Inhibitors; Male; Mice; Mice, Inbred ICR; Motor Activity; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Species Specificity | 1996 |
Effects of cannabinoid receptor stimulation and blockade on catalepsy produced by dopamine receptor antagonists.
Topics: Animals; Benzazepines; Brain; Catalepsy; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Piperidines; Pyrazoles; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Salicylamides | 1996 |
Antisense oligodeoxynucleotide treatment to the brain cannabinoid receptor inhibits antinociception.
Topics: Analgesics; Animals; Base Sequence; Brain; Cyclohexanols; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligonucleotides, Antisense; Pain Measurement; Receptors, Cannabinoid; Receptors, Drug | 1996 |
Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats.
Topics: Animals; Columbidae; Cyclohexanols; Discrimination Learning; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reflex, Startle; Rimonabant | 1996 |
Characterization of two cloned human CB1 cannabinoid receptor isoforms.
Topics: Analgesics; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Receptors, Cannabinoid; Receptors, Drug | 1996 |
Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.
Topics: Animals; Binding, Competitive; Brain; Cannabinoids; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanols; Guanine Nucleotides; Humans; Ligands; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Sodium; Structure-Activity Relationship; Transfection | 1996 |
Further evidence for the presence of cannabinoid CB1 receptors in mouse vas deferens.
Topics: Animals; Cannabinoids; Colforsin; Cyclic AMP; Cyclohexanols; In Vitro Techniques; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Vas Deferens | 1996 |
Effects of intranigral cannabinoids on rotational behavior in rats: interactions with the dopaminergic system.
Topics: Animals; Benzazepines; Cannabinoids; Cyclohexanols; Dopamine; Dopamine Agonists; Ergolines; Injections; Male; Microinjections; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Drug; Rotation; Stereotyped Behavior; Substantia Nigra | 1996 |
Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine.
Topics: Acetylcholine; Analgesics; Animals; Cyclohexanols; Dose-Response Relationship, Drug; Guinea Pigs; Intestine, Small; Male; Muscle Contraction; Myenteric Plexus; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Aversive effects of the synthetic cannabinoid CP 55,940 in rats.
Topics: Analgesics; Animals; Avoidance Learning; Behavior, Animal; Body Temperature; Cyclohexanols; Locomotion; Male; Rats; Rats, Wistar; Taste; Time Factors | 1996 |
Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Blastocyst; Blotting, Western; Cannabinoids; Cyclohexanols; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Female; Immunohistochemistry; Male; Mice; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1996 |
Local pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABA.
Topics: Action Potentials; Analgesics; Analysis of Variance; Animals; Benzoxazines; Bicuculline; Cannabinoids; Cyclohexanols; gamma-Aminobutyric Acid; Iontophoresis; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pressure; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substantia Nigra | 1996 |
Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.
Topics: Adjuvants, Immunologic; Analgesics; Animals; Arachidonic Acids; Brain; Calcium Channel Blockers; Cyclohexanols; Endocannabinoids; Kinetics; Mice; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1996 |
Chronic cannabinoid, CP-55,940, administration alters biotransformation in the rat.
Topics: Analgesics; Animals; Behavior, Animal; Biotransformation; Cannabinoids; Cyclohexanols; Energy Metabolism; Male; Mitochondria, Liver; Motor Activity; Rats; Rats, Sprague-Dawley | 1996 |
Cannabinoid modulation of rat pup ultrasonic vocalizations.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Body Temperature; Cannabinoids; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Hypothermia; Motor Activity; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rimonabant; Vocalization, Animal | 1996 |
Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations.
Topics: Analgesics; Animals; Benzoxazines; Binding, Competitive; Cyclohexanols; Dronabinol; Guinea Pigs; Injections, Intraperitoneal; Intestine, Small; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Receptors, Cannabinoid; Receptors, Drug; Vas Deferens | 1996 |
Cannabinoid receptor-mediated inhibition of dopamine release in the retina.
Topics: Animals; Benzoxazines; Cyclohexanols; Dopamine; Guinea Pigs; Male; Morpholines; Naphthalenes; Norepinephrine; Piperazines; Receptors, Cannabinoid; Receptors, Drug; Retina; Tritium | 1996 |
Psychoactive cannabinoids increase mortality and alter acute phase cytokine responses in mice sublethally infected with Legionella pneumophila.
Topics: Acute-Phase Proteins; Animals; Cannabinol; Cyclohexanols; Cytokines; Dronabinol; Female; Legionnaires' Disease; Mice; Mice, Inbred BALB C; RNA, Messenger | 1997 |
Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Binding Sites; Cyclohexanols; Enzyme Inhibitors; Organophosphonates; Rats; Receptors, Cannabinoid; Receptors, Drug | 1997 |
Chronic treatment with a synthetic cannabinoid CP-55,940 alters G-protein expression in the rat central nervous system.
Topics: Analgesics; Animals; Brain; Brain Mapping; Cannabinoids; Cyclohexanols; GTP-Binding Proteins; In Situ Hybridization; Male; Nerve Tissue Proteins; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
Evaluation of agonist-antagonist properties of nitrogen mustard and cyano derivatives of delta 8-tetrahydrocannabinol.
Topics: Animals; Body Temperature Regulation; Cannabinoids; Catalepsy; Cyclohexanols; Dronabinol; Male; Maze Learning; Mice; Mice, Inbred ICR; Motor Activity; Nitrogen Mustard Compounds; Pain; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1996 |
Nonclassical and endogenous cannabinoids: effects on the ordering of brain membranes.
Topics: Analgesics; Animals; Arachidonic Acid; Arachidonic Acids; Benzoxazines; Brain; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Male; Membrane Lipids; Morpholines; Naphthalenes; Phenanthridines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Synaptic Membranes | 1997 |
Examination of the effect of the cannabinoid receptor agonist, CP 55,940, on electrically evoked transmitter release from rat brain slices.
Topics: Acetylcholine; Analgesics; Animals; Benzoxazines; Cannabinoids; Corpus Striatum; Cyclohexanols; Hippocampus; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Involvement of dynorphin B in the antinociceptive effects of the cannabinoid CP55,940 in the spinal cord.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dynorphins; Endorphins; Male; Mice; Mice, Inbred ICR; Rats; Spinal Cord | 1997 |
Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Dynorphins; Endocannabinoids; Injections, Intraperitoneal; Injections, Spinal; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 1997 |
Atypical location of cannabinoid receptors in white matter areas during rat brain development.
Topics: Animals; Animals, Newborn; Autoradiography; Benzoxazines; Brain; Brain Chemistry; Cannabinoids; Cyclohexanols; Female; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A.
Topics: Acetylcholine; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1997 |
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cells, Cultured; Cyclohexanols; Endocannabinoids; Hippocampus; Membrane Potentials; Morpholines; Naphthalenes; Neurons; Picrotoxin; Polyunsaturated Alkamides; Rats | 1997 |
(R)-methanandamide, but not anandamide, substitutes for delta 9-THC in a drug-discrimination procedure.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Generalization, Stimulus; Hallucinogens; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 1997 |
Changes in rat spleen cannabinoid receptors after chronic CP-55,940: an autoradiographic study.
Topics: Animals; Autoradiography; Cannabinoids; Cyclohexanols; Down-Regulation; Image Processing, Computer-Assisted; Male; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Spleen | 1997 |
A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions.
Topics: Adenylate Cyclase Toxin; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Enzyme Activation; Humans; Insulin; Insulin-Like Growth Factor I; Pertussis Toxin; Piperidines; Pyrazoles; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Virulence Factors, Bordetella | 1997 |
Cannabinoid CB1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat.
Topics: Action Potentials; Adrenalectomy; Animals; Benzoxazines; Blood Pressure; Cyclohexanols; Electric Stimulation; Heart Rate; Male; Morpholines; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Rats; Receptors, Cannabinoid; Receptors, Drug; Vagotomy; Vasoconstrictor Agents | 1997 |
Influence of cannabinoids on electrically evoked dopamine release and cyclic AMP generation in the rat striatum.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Arachidonic Acids; Cannabinoids; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclohexanols; Dopamine; Electric Stimulation; Endocannabinoids; In Vitro Techniques; Kinetics; Male; Phosphatidylinositols; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Second Messenger Systems | 1997 |
Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus.
Topics: Acetylcholine; Benzoxazines; Child, Preschool; Cyclohexanols; Histamine; Humans; In Vitro Techniques; Male; Morpholines; Myenteric Plexus; Naloxone; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism | 1997 |
Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs).
Topics: Analgesics; Animals; Benzoxazines; Brain; Cannabinoids; Cyclohexanols; Indoles; Magnetic Resonance Spectroscopy; Male; Mice; Models, Chemical; Models, Molecular; Molecular Mimicry; Morpholines; Motor Activity; Naphthalenes; Rats; Rats, Sprague-Dawley | 1997 |
Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors.
Topics: Animals; Autoradiography; Brain; Cyclohexanols; Iodine Radioisotopes; Male; Mice; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug | 1997 |
Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Calcium Channel Blockers; Cannabinoids; Cerebellum; Cyclohexanols; Endocannabinoids; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Hybrid Cells; Male; Membrane Proteins; Morpholines; Naphthalenes; Neuroblastoma; Polyunsaturated Alkamides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Sensitivity and Specificity; Tritium | 1997 |
The effect of hydroxylation of linoleoyl amides on their cannabinomimetic properties.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Endocannabinoids; Enzyme Inhibitors; Hydroxylation; Kinetics; Linoleic Acids; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Substrate Specificity | 1997 |
Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Male; Mice; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Receptors, N-Methyl-D-Aspartate; Rimonabant; Spinal Cord; Tritium | 1998 |
Regulation of immune functions in rat splenocytes after acute and chronic in vivo treatment with CP-55,940, a synthetic cannabinoid compound.
Topics: Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Cytotoxicity, Immunologic; Drug Administration Schedule; Immunosuppressive Agents; Injections, Intraperitoneal; Killer Cells, Natural; Lymphocyte Activation; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen | 1997 |
Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1.
Topics: Amino Acid Sequence; Animals; Benzoxazines; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; Humans; Ligands; Morpholines; Mutation; Naphthalenes; Receptors, Cannabinoid; Receptors, Drug | 1998 |
SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.
Topics: Adenylyl Cyclases; Administration, Oral; Animals; B-Lymphocytes; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinoids; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; Humans; Lymphocyte Activation; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins | 1998 |
Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain.
Topics: Animals; Arachidonic Acids; Autoradiography; Brain; Cannabinoids; Cyclohexanols; Endocannabinoids; Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Comparative receptor binding analyses of cannabinoid agonists and antagonists.
Topics: Analgesics; Animals; Binding, Competitive; Cannabinoids; Cyclohexanols; Male; Models, Molecular; Piperidines; Pyrazoles; Rats; Rats, Inbred F344; Rimonabant | 1998 |
Discovery of novel cannabinoid receptor ligands from diverse marine organisms.
Topics: Animals; Arachidonic Acids; Binding, Competitive; Cannabinoids; Cyclohexanols; Endocannabinoids; Eukaryota; Ligands; Molecular Structure; Polyunsaturated Alkamides; Porifera; Receptors, Cannabinoid; Receptors, Drug; Seawater | 1997 |
Identification and characterization of a novel synthetic cannabinoid CP 55,940 binder in rat brain cytosol.
Topics: Animals; Arachidonic Acids; Binding, Competitive; Cannabinoids; Cerebral Cortex; Cyclohexanols; Cytosol; Dithiothreitol; Dronabinol; Endocannabinoids; Kinetics; Male; Nucleotides; Organ Specificity; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Cytoplasmic and Nuclear; Receptors, Drug; Salts; Sulfhydryl Reagents; Temperature | 1998 |
The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinoids; Cell Division; CHO Cells; Cricetinae; Cyclohexanols; Endocannabinoids; Enzyme Activation; Gene Expression Regulation; Mice; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Signal Transduction; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1998 |
Antihyperalgesic effects of spinal cannabinoids.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoids; Capsaicin; Carrageenan; Cyclohexanols; Endocannabinoids; Injections, Spinal; Male; Mice; Pain Threshold; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Spinal Cord | 1998 |
A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing.
Topics: Animals; Arachidonic Acids; Benzoxazines; Conditioning, Operant; Cyclohexanols; Dronabinol; Male; Morpholines; Naphthalenes; Rats | 1998 |
Ipsilateral turning behavior induced by unilateral microinjections of a cannabinoid into the rat subthalamic nucleus.
Topics: Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Functional Laterality; Globus Pallidus; Injections, Intraventricular; Male; Mesencephalon; Microinjections; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Thalamic Nuclei | 1998 |
Chronic ethanol administration down-regulates cannabinoid receptors in mouse brain synaptic plasma membrane.
Topics: Administration, Inhalation; Animals; Brain; Cannabinoids; Cyclohexanols; Down-Regulation; Ethanol; Injections, Intraperitoneal; Male; Mice; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Synaptic Membranes | 1998 |
Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain.
Topics: Animals; Arachidonic Acids; Brain Chemistry; Corpus Striatum; Cyclohexanols; Dronabinol; Drug Tolerance; Enkephalins; In Situ Hybridization; Male; Mammillary Bodies; Nucleus Accumbens; Organ Specificity; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Ventromedial Hypothalamic Nucleus | 1998 |
Potent effects of a selective cannabinoid receptor agonist on some guinea pig medial vestibular nucleus neurons.
Topics: Animals; Cannabinoids; Cyclohexanols; Guinea Pigs; In Vitro Techniques; Neurons; Receptors, Cannabinoid; Receptors, Drug; Vestibular Nuclei | 1998 |
Cannabinoid effects in basal ganglia in a rat model of Parkinson's disease.
Topics: Animals; Basal Ganglia; Cannabinoids; Corpus Striatum; Cyclohexanols; Globus Pallidus; Injections, Intraventricular; Male; Motor Activity; Neural Pathways; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1998 |
Synthesis and characterization of diazomethylarachidonyl ketone: an irreversible inhibitor of N-arachidonylethanolamine amidohydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cyclohexanols; Diazomethane; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 1998 |
Cannabinoids decrease excitatory synaptic transmission and impair long-term depression in rat cerebellar Purkinje cells.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebellar Cortex; Cyclohexanols; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Morpholines; Naphthalenes; Nerve Fibers; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Synaptic Transmission | 1998 |
Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Cannabidiol; Cell Membrane; Cerebellar Cortex; Cyclohexanols; Dronabinol; Guanosine Triphosphate; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development.
Topics: Animals; Autoradiography; Benzoxazines; Brain; Colforsin; Cyclic AMP; Cyclohexanols; Dronabinol; Gene Expression Regulation, Developmental; Gestational Age; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Morpholines; Naphthalenes; Neuroglia; Protein Binding; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Signal Transduction | 1998 |
High-level expression of the human CB2 cannabinoid receptor using a baculovirus system.
Topics: Animals; Baculoviridae; Binding, Competitive; Cannabinoids; Cell Line, Transformed; Cyclohexanols; Fluorescent Antibody Technique; Gene Expression; Humans; Ligands; Microscopy, Electron; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Spodoptera; Virus Replication | 1998 |
Cannabinoid receptor binding did not vary in several hypothalamic nuclei after hypothalamic deafferentation.
Topics: Animals; Autoradiography; Cannabinoids; Cyclohexanols; Denervation; Hypothalamus; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Suprachiasmatic Nucleus | 1998 |
Local effects of cannabinoids on spontaneous activity and evoked inhibition in the globus pallidus.
Topics: Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Evoked Potentials; Globus Pallidus; Male; Morpholines; Motor Activity; Naphthalenes; Rats; Rats, Sprague-Dawley | 1998 |
Effects of intrastriatal cannabinoids on rotational behavior in rats: interactions with the dopaminergic system.
Topics: Animals; Benzazepines; Cannabinoids; Cyclohexanols; Dopamine; Dopamine Agonists; Male; Neostriatum; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Drug; Rotation; Stereotyped Behavior | 1998 |
Effects of pre-exposure and co-administration of the cannabinoid receptor agonist CP 55,940 on behavioral sensitization to cocaine.
Topics: Analgesics; Animals; Behavior, Animal; Cocaine; Cyclohexanols; Dopamine Uptake Inhibitors; Drug Interactions; Male; Rats; Rats, Inbred Lew; Receptors, Cannabinoid; Receptors, Drug; Sensitivity and Specificity | 1998 |
Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity.
Topics: Analgesics; Animals; Benzoxazines; Calcium; Cells, Cultured; Cyclohexanols; Hippocampus; Magnesium; Morpholines; Naphthalenes; Neurons; Rats; Receptors, Cannabinoid; Receptors, Drug; Synapses; Synaptic Transmission | 1998 |
Regulation of cannabinoid and mu opioid receptors in rat lumbar spinal cord following neonatal capsaicin treatment.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Autoradiography; Capsaicin; Cyclohexanols; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Immunosuppressive Agents; Nerve Fibers; Nociceptors; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Spinal Cord; Tritium | 1998 |
Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis.
Topics: Animals; Benzoxazines; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; In Vitro Techniques; Indoles; Models, Molecular; Molecular Conformation; Molecular Mimicry; Morpholines; Naphthalenes; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1998 |
The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery.
Topics: Amides; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Endothelium, Vascular; Ethanolamines; In Vitro Techniques; Ligands; Male; Mesenteric Arteries; Methoxamine; Morpholines; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Palmitic Acids; Polyunsaturated Alkamides; Rats; Rats, Wistar | 1998 |
Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation.
Topics: Animals; B-Lymphocyte Subsets; Camphanes; CD40 Antigens; Cell Differentiation; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Germinal Center; Humans; Microscopy, Confocal; Palatine Tonsil; Peptide Fragments; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Rimonabant; Transfection | 1998 |
Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Endocannabinoids; Female; Intraocular Pressure; Male; Ocular Hypotension; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine.
Topics: Analgesics; Animals; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; Cyclohexanols; Dronabinol; Guinea Pigs; Intestine, Small; Kinetics; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Neuromuscular Junction; Piperidines; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1998 |
Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arachidonic Acids; Benzoxazines; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; Humans; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transfection | 1998 |
Modulation of CB1 cannabinoid receptor functions after a long-term exposure to agonist or inverse agonist in the Chinese hamster ovary cell expression system.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Transfection | 1998 |
Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.
Topics: Animals; Binding, Competitive; Brain; Cannabinoids; Cell Membrane; Cyclohexanols; Dronabinol; Indicators and Reagents; Kinetics; Mice; Molecular Structure; Receptors, Cannabinoid; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship | 1998 |
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cell Line; Cyclohexanols; Dronabinol; Endocannabinoids; Models, Chemical; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 1999 |
A novel neurotransmitter system involved in the control of motor behavior by the basal ganglia.
Topics: Action Potentials; Analgesics; Animals; Basal Ganglia; Benzoxazines; Bicuculline; Cannabinoids; Cyclohexanols; Dopamine; Dopamine Agonists; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Morpholines; Motor Neurons; Naphthalenes; Nerve Degeneration; Neurotransmitter Agents; Oxidopamine; Piperidines; Pyrazoles; Quinpirole; Rats; Rimonabant; Sympatholytics; Thalamic Nuclei | 1998 |
Down-regulation of cannabinoid receptor agonist-stimulated [35S]GTP gamma S binding in synaptic plasma membrane from chronic ethanol exposed mouse.
Topics: Analgesics; Animals; Binding, Competitive; Brain Chemistry; Central Nervous System Depressants; Chronic Disease; Cyclohexanols; Dose-Response Relationship, Drug; Down-Regulation; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes; Synaptic Membranes | 1999 |
The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells.
Topics: Animals; Animals, Newborn; Cannabinoids; Cells, Cultured; Cyclohexanols; Immunohistochemistry; Microglia; Nitric Oxide; Nitric Oxide Synthase; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger | 1999 |
Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat.
Topics: Analgesics; Animals; Axotomy; Benzoxazines; Cannabinoids; Cyclohexanols; Hot Temperature; Injections, Intravenous; Injections, Intraventricular; Lumbosacral Region; Male; Mechanoreceptors; Microinjections; Morpholines; Naphthalenes; Neurons; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Spinal Cord | 1999 |
Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.
Topics: Alanine; Benzoxazines; Cell Line; Cyclohexanols; Fluorescent Antibody Technique; Humans; Ligands; Lysine; Models, Molecular; Morpholines; Mutation; Naphthalenes; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction | 1999 |
Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation.
Topics: Analgesics; Animals; Benzoxazines; Blood Pressure; Bradycardia; Cannabinoids; Cardiovascular Physiological Phenomena; Cisterna Magna; Consciousness; Cyclohexanols; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Rate; Infusions, Intravenous; Injections; Injections, Intravenous; Kidney; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Sympathetic Nervous System; Sympathomimetics | 1999 |
Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Artemisia; Behavior, Animal; Bicyclic Monoterpenes; Binding, Competitive; Brain Chemistry; Cannabinoids; Colforsin; Cyclohexanols; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Male; Monoterpenes; Palatine Tonsil; Plants, Medicinal; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Terpenes | 1999 |
Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord.
Topics: Analgesics; Analgesics, Opioid; Animals; Arachidonic Acids; Autoradiography; Calcium Channel Blockers; Cyclohexanols; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Functional Laterality; Male; Neurons, Afferent; Polyunsaturated Alkamides; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rhizotomy; Spinal Cord; Tritium | 1999 |
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630.
Topics: Animals; Benzoxazines; Binding, Competitive; Camphanes; Cannabinoids; CHO Cells; Chromans; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Morpholines; Naphthalenes; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Tritium | 1999 |
Chronic treatment with CP-55,940 regulates corticotropin releasing factor and proopiomelanocortin gene expression in the hypothalamus and pituitary gland of the rat.
Topics: Animals; Cannabinoids; Corticotropin-Releasing Hormone; Cyclohexanols; Gene Expression Regulation; Hypothalamus; Male; Pituitary Gland; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley | 1999 |
Involvement of the carboxyl terminus of the third intracellular loop of the cannabinoid CB1 receptor in constitutive activation of Gs.
Topics: Animals; CHO Cells; Cholera Toxin; Cricetinae; Cyclic AMP; Cyclohexanols; GTP-Binding Proteins; Humans; Mutation; Peptide Fragments; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Virulence Factors, Bordetella | 1999 |
Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60.
Topics: Analgesics; Blotting, Northern; Camphanes; Chemokine CCL2; Chemokine CCL4; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Cyclohexanols; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Growth Substances; HL-60 Cells; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8; Macrophage Inflammatory Proteins; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Time Factors; Transfection | 1999 |
Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors.
Topics: Amphetamines; Animals; Behavior, Animal; Cannabinoids; Cerebral Cortex; Cyclohexanols; Dronabinol; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Male; Motor Activity; Muscle Contraction; Oleic Acids; Phosphatidylinositols; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Cannabinoid; Receptors, Drug; Receptors, Serotonin; Reflex; Serotonin; Serotonin Receptor Agonists | 1999 |
Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Hydrogen-Ion Concentration; Piperidines; Protein Isoforms; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Sodium-Hydrogen Exchangers | 1999 |
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Central Nervous System; Cyclohexanols; Dronabinol; Gene Targeting; Mice; Mice, Knockout; Molecular Structure; Motor Activity; Receptors, Cannabinoid; Receptors, Drug | 1999 |
Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist.
Topics: Animals; Beer; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Ethanol; Male; Motor Activity; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant; Self Administration; Sucrose | 1999 |
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).
Topics: Adenylyl Cyclases; Animals; Arachidonic Acids; Binding, Competitive; Body Temperature; Cannabinoids; Cerebellum; CHO Cells; Cricetinae; Cyclohexanols; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Neurons; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Transfection; Vas Deferens | 1999 |
Cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for CB2 receptor participation.
Topics: Animals; Cannabinoids; Cyclohexanols; Dronabinol; Hybridomas; Interleukin-2; Lymphocyte Activation; Macrophages; Mice; Muramidase; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Transcription, Genetic | 1999 |
Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange.
Topics: Animals; Binding, Competitive; Cannabinoids; Cell Membrane; Cerebellum; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Ligands; Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1999 |
Cannabinoid penetration into mouse brain as determined by ex vivo binding.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Male; Mice; Morpholines; Naphthalenes; Perfusion; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Drug; Rimonabant; Tritium | 1999 |
Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor.
Topics: Animals; Binding Sites; Cannabinoids; CHO Cells; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclohexanols; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Gene Expression; Genes, Reporter; GTP-Binding Proteins; Humans; Isoquinolines; Luciferases; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Receptors, Cannabinoid; Receptors, Corticotropin-Releasing Hormone; Receptors, Drug; Recombinant Fusion Proteins; Rimonabant; Signal Transduction; Sulfonamides | 1999 |
Cannabinoid receptors undergo axonal flow in sensory nerves.
Topics: Animals; Autoradiography; Axonal Transport; Cyclohexanols; Ganglia, Spinal; In Situ Hybridization; Male; Neurons, Afferent; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Sciatic Nerve | 1999 |
Internalization and recycling of the CB1 cannabinoid receptor.
Topics: Acids; Ammonium Chloride; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cells, Cultured; Clathrin; Coated Vesicles; Cyclohexanols; Dronabinol; Drug Tolerance; Endocytosis; Endosomes; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Immunosuppressive Agents; Morpholines; Mutagenesis; Naphthalenes; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Tertiary; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Transfection; Up-Regulation; Virulence Factors, Bordetella | 1999 |
Cannabinoid CB1 receptor-mediated inhibition of NMDA- and kainate-stimulated noradrenaline and dopamine release in the brain.
Topics: Animals; Benzoxazines; Binding, Competitive; Brain Chemistry; Cannabinoids; Cerebral Cortex; Cyclohexanols; Dopamine; Excitatory Amino Acid Agonists; Guinea Pigs; Kainic Acid; Male; Membranes; Morpholines; N-Methylaspartate; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical | 1999 |
Identification of endocannabinoids and cannabinoid CB(1) receptor mRNA in the pituitary gland.
Topics: Animals; Autoradiography; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Gas Chromatography-Mass Spectrometry; In Situ Hybridization; Male; Pituitary Gland; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger | 1999 |
Effects of cannabinoids on dopamine release in the corpus striatum and the nucleus accumbens in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzoxazines; Cannabinoids; Corpus Striatum; Cyclohexanols; Dopamine; Dopamine Agonists; Electric Stimulation; Electrophysiology; In Vitro Techniques; Male; Membrane Potentials; Morpholines; Naphthalenes; Nucleus Accumbens; Patch-Clamp Techniques; Quinpirole; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, kappa | 1999 |
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dimethyl Sulfoxide; Dronabinol; Dynorphins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1999 |
Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship.
Topics: Adrenergic Uptake Inhibitors; Arachidonic Acids; Atrial Function; Corticosterone; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Electrophysiology; Endocannabinoids; Excitatory Amino Acid Agonists; Female; Guanidine; Humans; Imidazoles; Imidazoline Receptors; Ligands; Male; Norepinephrine; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Receptors, Presynaptic; Sympathetic Nervous System; Sympathomimetics | 1999 |
Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Dronabinol; Electric Stimulation; In Vitro Techniques; Male; Mice; Muscle Contraction; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship; Vas Deferens | 1999 |
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors.
Topics: Animals; Benzoxazines; Binding, Competitive; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Ethanolamines; Humans; Molecular Structure; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen; Transfection; Tumor Cells, Cultured | 1999 |
Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system.
Topics: Analgesics; Animals; Arachidonic Acids; Asparagine; Benzoxazines; Calcium Channel Blockers; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; GTP-Binding Proteins; Morpholines; Mutation; Naphthalenes; Oocytes; Polyunsaturated Alkamides; Potassium Channels; Receptors, Cannabinoid; Receptors, Drug; RNA, Complementary; Time Factors; Xenopus | 1999 |
Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374).
Topics: Acetylcholine; Amidohydrolases; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Drug Synergism; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Palmitates; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 1999 |
The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats.
Topics: Analgesics; Animals; Antidiarrheals; Benzoxazines; Castor Oil; Cyclohexanols; Defecation; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gastrointestinal Transit; Loperamide; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
Topics: Amides; Arachidonic Acids; Calcium Signaling; Camphanes; Cannabinoids; Cyclohexanols; Cyclooxygenase Inhibitors; Drug Interactions; Endocannabinoids; Ethanolamines; Glycerides; HL-60 Cells; Humans; Ligands; Lipoxygenase Inhibitors; Molecular Mimicry; Palmitic Acids; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Structure-Activity Relationship; Virulence Factors, Bordetella | 2000 |
Role of the superior colliculus in the motor effects of cannabinoids and dopamine.
Topics: Analgesics; Animals; Behavior, Animal; Benzazepines; Cannabinoids; Cyclohexanols; Dopamine; Dopamine Agonists; Male; Microinjections; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Drug; Superior Colliculi | 2000 |
Effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and mu-opioid receptor binding in the basal ganglia.
Topics: Animals; Autoradiography; Basal Ganglia; Cannabinoids; Caudate Nucleus; Corpus Striatum; Cyclohexanols; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Male; Neurotoxins; Nitro Compounds; Propionates; Putamen; Rats; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Tritium | 2000 |
Cloning and pharmacological characterization of the rat CB(2) cannabinoid receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug | 2000 |
Modulation of peristalsis by cannabinoid CB(1) ligands in the isolated guinea-pig ileum.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; Compliance; Cyclohexanols; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Morpholines; Muscle Contraction; Naphthalenes; Peristalsis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Delta(9)-THC and anandamide.
Topics: Analgesia; Analgesics; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dronabinol; Dynorphins; Endocannabinoids; Endorphins; Male; Pain; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Spinal Cord | 2000 |
Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Heart Atria; In Vitro Techniques; Male; Mesenteric Artery, Inferior; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Vascular Resistance | 2000 |
A beneficial aspect of a CB1 cannabinoid receptor antagonist: SR141716A is a potent inhibitor of macrophage infection by the intracellular pathogen Brucella suis.
Topics: Animals; Anti-Bacterial Agents; Antigens, CD; Benzoxazines; Brucella; Calcitriol; Camphanes; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Intercellular Adhesion Molecule-1; Macrophage Activation; Macrophages; Mice; Monocytes; Morpholines; Naphthalenes; Phagocytosis; Piperidines; Pyrazoles; Reactive Oxygen Species; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Synthesis and characterization of a fluorescent substrate for the N-arachidonoylethanolamine (anandamide) transmembrane carrier.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain Neoplasms; Cannabinoids; Carrier Proteins; Cell Membrane; Cerebellum; Cyclohexanols; Endocannabinoids; Esterases; Fluorescent Dyes; Glioma; Humans; Lactones; Microscopy, Fluorescence; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 2000 |
Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.
Topics: Animals; Arachidonic Acids; Binding, Competitive; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Drug Antagonism; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Insecta; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Sulfur Radioisotopes; Transfection | 2000 |
O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Binding, Competitive; Cannabinoids; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Dronabinol; Drug Interactions; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Solubility; Tritium; Vas Deferens; Water | 2000 |
Azido- and isothiocyanato-substituted aryl pyrazoles bind covalently to the CB1 cannabinoid receptor and impair signal transduction.
Topics: Adenylyl Cyclases; Animals; Cyclohexanols; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Phenanthridines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction | 2000 |
Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter.
Topics: Adjuvants, Immunologic; Amidohydrolases; Animals; Arachidonic Acids; Binding, Competitive; Biological Transport; Cannabinoid Receptor Modulators; Cannabinoids; Carrier Proteins; Cells, Cultured; Cerebellum; Cyclohexanols; Endocannabinoids; Glycerides; Immunosuppressive Agents; Ligands; Neurons; Polyunsaturated Alkamides; Prosencephalon; Rats; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship; Tritium | 2000 |
Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation.
Topics: Camphanes; Cannabinoids; Cell Differentiation; Cell Movement; Cyclohexanols; Cytokines; Gene Expression Regulation; HL-60 Cells; Humans; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotide Array Sequence Analysis; Phosphorylation; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Transfection | 2000 |
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.
Topics: Animals; Body Temperature; Catalepsy; Cyclohexanols; Dronabinol; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cannabinoid; Receptors, Drug; T-Lymphocytes | 2000 |
Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cyclohexanols; Electric Stimulation; Excitatory Postsynaptic Potentials; In Vitro Techniques; Learning; Lysine; Male; Memory; Morpholines; Naphthalenes; Neuronal Plasticity; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses | 2000 |
Cannabinoid-induced working memory impairment is reversed by a second generation cholinesterase inhibitor in rats.
Topics: Animals; Behavior, Animal; Cannabinoids; Cholinesterase Inhibitors; Cyclohexanols; Male; Maze Learning; Memory; Memory Disorders; Motor Activity; Physostigmine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2000 |
Cannabinoids cause central sympathoexcitation and bradycardia in rabbits.
Topics: Animals; Benzoxazines; Blood Pressure; Bradycardia; Cannabinoids; Cyclohexanols; Drug Interactions; Female; Heart Rate; Injections, Intraventricular; Kidney; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Sympathetic Nervous System | 2000 |
Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor.
Topics: Amino Acid Sequence; Animals; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; COS Cells; Cyclohexanols; Humans; Luciferases; Models, Molecular; Molecular Sequence Data; Morpholines; Mutagenesis, Site-Directed; Mutation; Naphthalenes; Protein Structure, Tertiary; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins | 2000 |
Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves.
Topics: Acetylcholine; Analgesics; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Binding, Competitive; Cannabinoids; Carbachol; Cyclohexanols; Electric Stimulation; Endocannabinoids; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympathetic Nervous System; Parasympatholytics; Polyunsaturated Alkamides; Trachea; Tritium | 2000 |
In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors.
Topics: Animals; Camphanes; Cannabinoids; Cell Movement; Cells, Cultured; Cyclohexanols; Dose-Response Relationship, Drug; Immunosuppressive Agents; In Vitro Techniques; Macrophages, Peritoneal; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations.
Topics: Action Potentials; Analgesics; Animals; Antibodies; Benzoxazines; Cannabinoids; Cyclohexanols; Electrophysiology; Epitopes; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Microscopy, Electron; Morpholines; Naphthalenes; Neural Inhibition; Neural Pathways; Periodicity; Piperidines; Presynaptic Terminals; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission | 2000 |
Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55,940.
Topics: Animals; Behavior, Animal; Brain; Cannabinoids; Cerebellum; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclohexanols; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Drug Tolerance; GTP-Binding Proteins; Hippocampus; Injections, Intraperitoneal; Male; Marijuana Abuse; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction | 2000 |
CP 55,940 protects against ischemia-induced electroencephalographic flattening and hyperlocomotion in Mongolian gerbils.
Topics: Analgesics; Animals; Brain; Brain Ischemia; Cyclohexanols; Electroencephalography; Gerbillinae; Hyperkinesis; Male; Neuroprotective Agents; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Separation of cannabinoid receptor affinity and efficacy in delta-8-tetrahydrocannabinol side-chain analogues.
Topics: Animals; Carboxylic Acids; Cell Membrane; Cerebellum; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 2001 |
Cannabinoid and dopamine interaction in rodent brain: effects on locomotor activity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dopamine Agonists; Immobilization; Male; Mice; Mice, Inbred ICR; Motor Activity; Phenanthridines; Quinolines | 2000 |
Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbens.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Receptors, Cannabinoid; Receptors, Drug; Synaptic Transmission | 2001 |
Signal transduction of cannabinoid CB1 receptors in a smooth muscle cell line.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Calcium; Cell Line; Cricetinae; Cyclic AMP; Cyclohexanols; In Vitro Techniques; Male; Membrane Potentials; Mesocricetus; Muscle, Smooth; Patch-Clamp Techniques; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Sarcoplasmic Reticulum; Signal Transduction | 2001 |
Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Calcium; Capsaicin; Cell Line; Cyclohexanols; Cytosol; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Ligands; Membranes; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship; Tritium; TRPV Cation Channels; Tumor Cells, Cultured | 2001 |
Cannabinoid CB1 receptor-mediated inhibition of acetylcholine release in the brain of NMRI, CD-1 and C57BL/6J mice.
Topics: Acetylcholine; Animals; Benzoxazines; Brain; Calcium; Choline; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Morpholines; Naphthalenes; Oxotremorine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 2001 |
Intrathecal cannabinoid administration suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in rat spinal cord: comparison with morphine.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Immunosuppressive Agents; Injections, Spinal; Male; Morphine; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 1999 |
Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzimidazoles; Conditioning, Operant; Cyclohexanols; Heroin; Male; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reinforcement Schedule; Rimonabant; Self Administration | 2001 |
Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens.
Topics: Animals; Benzofurans; Benzoxazines; Calcium Channel Blockers; Cyclohexanols; Electric Stimulation; In Vitro Techniques; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vas Deferens | 2001 |
Zebra finch CB1 cannabinoid receptor: pharmacology and in vivo and in vitro effects of activation.
Topics: Adenine; Amino Acid Sequence; Animals; Behavior, Animal; Benzoxazines; Birds; CHO Cells; Cricetinae; Cyclohexanols; Male; Molecular Sequence Data; Morpholines; Naphthalenes; Receptors, Cannabinoid; Receptors, Drug; Vocalization, Animal | 2001 |
Cannabinoid CB(1) receptor agonists produce cerebellar dysfunction in mice.
Topics: Animals; Behavior, Animal; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebellar Diseases; Cyclohexanols; Dopamine Agonists; Gait; Male; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart.
Topics: Adrenergic beta-Agonists; Animals; Benzoxazines; Blood Pressure; Cannabinoids; Cyclohexanols; Decerebrate State; Electric Stimulation; Female; Heart; Heart Rate; Isoproterenol; Male; Morpholines; Naphthalenes; Neuroeffector Junction; Parasympathetic Nervous System; Rabbits; Sympathetic Nervous System; Synaptic Transmission; Vagus Nerve | 2001 |
Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use.
Topics: Brain; Cannabinoids; Cannabis; Cyclohexanols; Dronabinol; Humans; In Vitro Techniques; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Schizophrenia; Substance-Related Disorders | 2001 |
Pharmacological properties of cannabinoid receptors in the avian brain: similarity of rat and chicken cannabinoid1 receptor recognition sites and expression of cannabinoid2 receptor-like immunoreactivity in the embryonic chick brain.
Topics: Amidohydrolases; Animals; Benzoxazines; Blotting, Western; Brain; Cell Membrane; Chick Embryo; Cyclohexanols; Drug Interactions; Ligands; Morpholines; Naphthalenes; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Species Specificity | 2001 |
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dronabinol; Hyperalgesia; Morpholines; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sciatica | 2001 |
Cannabinoid receptor activation and elevated cyclic AMP reduce glutamate neurotoxicity.
Topics: Animals; Bucladesine; Calcium; Calcium Channels; Cannabinoids; Colforsin; Cyclic AMP; Cyclohexanols; Glutamic Acid; Neurotoxins; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug | 2001 |
Cannabinoid receptor agonist-stimulated [35S]guanosine triphosphate gammaS binding in the brain of C57BL/6 and DBA/2 mice.
Topics: Analgesics; Animals; Brain; Cannabinoids; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Species Specificity | 2001 |
Effects of CP55,940 and methanandamide on detrusor activity.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cats; Cyclohexanols; Urinary Bladder | 2001 |
Involvement of the cerebellar adenosine A(1) receptor in cannabinoid-induced motor incoordination in the acute and tolerant state in mice.
Topics: Adenosine; Analgesics; Animals; Cannabinoids; Cerebellar Ataxia; Cerebellum; Cyclohexanols; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Male; Marijuana Abuse; Mice; Neurons; Phosphodiesterase Inhibitors; Psychomotor Performance; Receptors, Cannabinoid; Receptors, Drug; Receptors, Purinergic P1; Signal Transduction; Tritium; Xanthines | 2001 |
Comparative characterization in the rat of the interaction between cannabinoids and opiates for their immunosuppressive and analgesic effects.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Drug Interactions; Drug Tolerance; Immunosuppressive Agents; Male; Morphine; Narcotics; Rats; Rats, Sprague-Dawley | 2001 |
Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system.
Topics: Analgesics; Analgesics, Opioid; Animals; Brain; Conditioning, Psychological; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Heroin; Male; Naloxone; Narcotic Antagonists; Opioid Peptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant | 2001 |
Modulation of the cardiac autonomic transmission of pithed rats by presynaptic opioid OP4 and cannabinoid CB1 receptors.
Topics: Analysis of Variance; Animals; Autonomic Nervous System; Benzoxazines; Blood Pressure; Bradycardia; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Morpholines; Naphthalenes; Nociceptin; Opioid Peptides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Tachycardia; Vasodilator Agents | 2001 |
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Bronchi; Calcium Channel Blockers; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; In Vitro Techniques; Indomethacin; Lipoxygenase; Muscle Contraction; Oxazepines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Thiorphan | 2001 |
Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Camphanes; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Guinea Pigs; Ileum; In Vitro Techniques; Male; Methacholine Chloride; Muscle Contraction; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
CP55,940 increases intracellular Ca2+ levels in Madin-Darby canine kidney cells.
Topics: Animals; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Dogs; Estrenes; Extracellular Space; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Kidney; Morpholines; Piperidines; Pyrazoles; Pyrrolidinones; Receptors, Cannabinoid; Receptors, Drug | 2001 |
Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes.
Topics: Amidohydrolases; Arachidonic Acids; Binding Sites; Biological Transport; Cannabinoid Receptor Modulators; Cyclohexanols; Down-Regulation; Endocannabinoids; Gene Expression Regulation, Enzymologic; Humans; In Vitro Techniques; Lipopolysaccharides; Lymphocytes; Polyunsaturated Alkamides; Tritium | 2001 |
Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters.
Topics: Analgesics; Animals; Anxiety; Cannabinoids; Cyclohexanols; Drug Therapy, Combination; Exploratory Behavior; Hypothalamus; Male; Motor Activity; Neurotransmitter Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2001 |
Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages.
Topics: Animals; Bone Marrow Cells; Camphanes; Cannabinoids; Cats; Cyclohexanols; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome; Histocytochemistry; Immunosuppressive Agents; Macrophages; Nitric Oxide; Phagocytosis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation.
Topics: Analgesics; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Cannabinol; Croton Oil; Cyclohexanols; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Motility; Inflammatory Bowel Diseases; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Effects of cannabinoids on adrenaline release from adrenal medullary cells.
Topics: Adrenal Glands; Adrenal Medulla; Analgesics; Animals; Benzoxazines; Blood Pressure; Cannabinoids; Chromaffin Cells; Cyclohexanols; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Epinephrine; Heart Rate; In Vitro Techniques; Injections, Intravenous; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Autoradiographic study of pre- and postnatal distribution of cannabinoid receptors in human brain.
Topics: Adolescent; Adult; Aged; Autoradiography; Brain; Cyclohexanols; Female; Gestational Age; Humans; Image Processing, Computer-Assisted; Infant, Newborn; Male; Middle Aged; Pregnancy; Receptors, Cannabinoid; Receptors, Drug; Reference Values | 2001 |
Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission.
Topics: Amygdala; Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Cholecystokinin; Cyclohexanols; gamma-Aminobutyric Acid; Interneurons; Male; Membrane Potentials; Mice; Mice, Knockout; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Organ Specificity; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-A; Synaptic Transmission | 2001 |
The distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and Wistar strain.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Brain; Cannabinoids; Catalepsy; Cell Count; Cyclohexanols; Dose-Response Relationship, Drug; Immunohistochemistry; Marijuana Abuse; Motor Activity; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Lew; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug | 2001 |
Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation.
Topics: Animals; Cannabinoids; Cyclohexanols; Gene Expression; Microglia; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger | 2001 |
Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cattle; Cell Separation; Ciliary Body; Cyclic AMP; Cyclohexanols; Endocannabinoids; Fluorescent Antibody Technique; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intraocular Pressure; Ligands; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Trabecular Meshwork | 2001 |
Protective effects of cannabinoid receptor agonists against cocaine and other convulsant-induced toxic behavioural symptoms.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Cocaine; Convulsants; Cyclohexanols; Dopamine Uptake Inhibitors; Drug Interactions; Endocannabinoids; Male; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Seizures; Survival Rate | 2001 |
Noradrenaline release-inhibiting receptors on PC12 cells devoid of alpha(2(-)) and CB(1) receptors: similarities to presynaptic imidazoline and edg receptors.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Clonidine; Cyclohexanols; Endocannabinoids; Heterotrimeric GTP-Binding Proteins; Imidazoles; Imidazoline Receptors; Kinetics; Morpholines; Naphthalenes; Norepinephrine; PC12 Cells; Polyunsaturated Alkamides; Rats; Receptors, Adrenergic, alpha-2; Receptors, Cannabinoid; Receptors, Cell Surface; Receptors, Drug; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Tritium; Veratridine | 2002 |
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Emetics; Endocannabinoids; Female; Glycerides; Humans; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews | 2002 |
Modulation of the release of endogenous gamma-aminobutyric acid by cannabinoids in the guinea pig ileum.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Electric Stimulation; Endocannabinoids; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Myenteric Plexus; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-B | 2002 |
Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats.
Topics: Animals; Benzazepines; Brain; Cannabinoids; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant; Self Stimulation | 2001 |
Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity.
Topics: Amino Acid Motifs; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinol; Cyclohexanols; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Dronabinol; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Nuclear Proteins; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; T-Lymphocytes; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transfection | 2002 |
Protective effects of cannabinoid receptor ligands analogous to anandamide against cocaine toxicity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cocaine; Cyclohexanols; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Hyperkinesis; Ligands; Mice; Mice, Inbred ICR; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Seizures | 2001 |
Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats.
Topics: Administration, Oral; Alcohol Drinking; Analgesics; Animals; Benzoxazines; Cyclohexanols; Male; Morpholines; Naphthalenes; Rats; Receptors, Cannabinoid; Receptors, Drug; Sucrose | 2002 |
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
Topics: Analgesics; Animals; Arachidonic Acids; Astrocytes; Calcium Channel Blockers; Camphanes; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Gene Expression; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Modulation of cannabinoid agonist binding by 5-HT in the rat cerebellum.
Topics: Animals; Benzoxazines; Binding, Competitive; Cannabinoids; Cell Membrane; Cerebellum; Cyclohexanols; Dronabinol; GTP-Binding Proteins; Male; Morpholines; Naphthalenes; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Cannabinoid; Receptors, Drug; Receptors, Serotonin; Serotonin | 2002 |
Differing effects of the cannabinoid agonist, CP 55,940, in an alcohol or Tween 80 solvent, on prepulse inhibition of the acoustic startle reflex in the rat.
Topics: Acoustic Stimulation; Animals; Cannabinoids; Cyclohexanols; Dopamine; Dose-Response Relationship, Drug; Ethanol; Limbic System; Male; Mesencephalon; Neural Inhibition; Pharmaceutical Vehicles; Polysorbates; Rats; Rats, Wistar; Reflex, Startle; Synaptic Transmission | 2002 |
Novel effect of CP55,940, a CB1/CB2 cannabinoid receptor agonist, on intracellular free Ca2+ levels in bladder cancer cells.
Topics: Calcium; Cyclohexanols; Humans; Receptors, Cannabinoid; Receptors, Drug; Tumor Cells, Cultured; Type C Phospholipases; Urinary Bladder Neoplasms | 2002 |
Down-regulation by cannabinoids of the immunological activation of human basophils and guinea pig mast cells.
Topics: Animals; Antigens, CD; Arachidonic Acids; Basophils; Camphanes; Cannabinoids; Cyclohexanols; Down-Regulation; Endocannabinoids; Glycerides; Guinea Pigs; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Macrophage Activation; Mast Cells; Platelet Membrane Glycoproteins; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Tetraspanin 30 | 2002 |
Characterization of the diarylether sulfonylester (-)-(R)-3-(2-hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties.
Topics: Animals; Binding, Competitive; Body Temperature; Brain Injuries; Brain Ischemia; Cyclohexanols; Discrimination, Psychological; Guanosine 5'-O-(3-Thiotriphosphate); Hematoma, Subdural; Indans; Male; Middle Cerebral Artery; Neuroprotective Agents; Rats; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Succinate Dehydrogenase; Sulfonic Acids | 2002 |
Pharmacological comparison of a recombinant CB1 cannabinoid receptor with its G(alpha 16) fusion product.
Topics: Calcium; Cyclic AMP; Cyclohexanols; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Sulfur Radioisotopes; Tritium | 2002 |
Antinociceptive, behavioural and neuroendocrine effects of CP 55,940 in young rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Corticosterone; Cyclohexanols; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Female; Grooming; Male; Marijuana Abuse; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Neostriatum; Neurosecretory Systems; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sex Characteristics | 2002 |
Lack of correlation between NF-kappaB activation and induction of programmed cell death in PC12 pheochromocytoma cells treated with 6-hydroxydopamine or the cannabinoid receptor 1-agonist CP55,940.
Topics: Adrenergic Agents; Animals; Apoptosis; Cyclic AMP; Cyclohexanols; DNA-Binding Proteins; I-kappa B Proteins; Immunosuppressive Agents; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidopamine; PC12 Cells; Pheochromocytoma; Rats; Receptors, Cannabinoid; Receptors, Drug; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2002 |
Role of the endocannabinoid system in MDMA intracerebral self-administration in rats.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acids, Unsaturated; Hallucinogens; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reinforcement, Psychology; Rimonabant; Self Administration | 2002 |
Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Binding, Competitive; Biological Transport; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Carrier Proteins; Chloroform; Cyclohexanols; Endocannabinoids; Glycerides; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Molecular Conformation; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Tumor Cells, Cultured; Water | 2002 |
Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB(1) receptors.
Topics: Administration, Oral; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Transit; Injections, Intraventricular; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
SR-141716A-induced stimulation of locomotor activity. A structure-activity relationship study.
Topics: Animals; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical; Structure-Activity Relationship | 2002 |
Effects of cannabinoid receptor ligands on psychosis-relevant behavior models in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Arousal; Attention; Behavior, Animal; Cyclohexanols; Dextroamphetamine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hallucinogens; Male; Motor Activity; Piperidines; Psychoses, Substance-Induced; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reflex, Startle; Rimonabant; Stereotyped Behavior | 2003 |
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.
Topics: Age Factors; Analgesics; Animals; Benzoxazines; Calcitonin Gene-Related Peptide; Calcium; Cannabinoids; Capsaicin; Cell Size; Cells, Cultured; Cyclohexanols; Ganglia, Spinal; Immunohistochemistry; Male; Membrane Potentials; Morpholines; Naphthalenes; Neurons, Afferent; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 2002 |
'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice.
Topics: Analgesics; Animals; Antibodies; Benzoxazines; Cyclohexanols; Dizocilpine Maleate; Dynorphins; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Oligodeoxyribonucleotides, Antisense; Pain; Receptors, Cannabinoid; Receptors, Drug; Spinal Cord; Tritium | 2002 |
(-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens.
Topics: Adenosine Triphosphate; Animals; Benzoxazines; Cannabidiol; Cyclohexanols; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Male; Methoxamine; Mice; Morpholines; Muscle Contraction; Naphthalenes; Norepinephrine; Phenylephrine; Receptors, Cannabinoid; Receptors, Drug; Vas Deferens; Vasoconstrictor Agents | 2002 |
Topically administered CB(2)-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits.
Topics: Administration, Topical; Animals; Antineoplastic Agents; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Female; Intraocular Pressure; Male; Rabbits; Receptors, Cannabinoid; Receptors, Drug | 2003 |
Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids.
Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cannabinoids; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; HT29 Cells; Humans; Immunoblotting; Indoles; Interleukin-8; Kinetics; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Necrosis Factor-alpha | 2003 |
Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation.
Topics: Animals; Antiemetics; Benzoxazines; Binding, Competitive; Brain; Cisplatin; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Sulfur Radioisotopes; Tritium; Vomiting | 2003 |
Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract.
Topics: Animals; Antiemetics; Binding, Competitive; Blotting, Western; Cyclohexanols; Digestive System; Dose-Response Relationship, Drug; Dronabinol; Gastric Mucosa; Gastrointestinal Transit; Immunohistochemistry; Intestine, Large; Intestine, Small; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stomach; Tritium | 2003 |
Long-term interactions between opioid and cannabinoid agonists at the cellular level: cross-desensitization and downregulation.
Topics: Animals; Cell Line; Cell Membrane; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclohexanols; Diprenorphine; Down-Regulation; Drug Interactions; Etorphine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Narcotic Antagonists; Rats; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Receptors, Opioid, delta; Signal Transduction; Transfection | 2003 |
Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Arachidonic Acids; Benzoxazines; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Encephalitis; Endocannabinoids; Glycerides; Inflammation Mediators; Microglia; Morpholines; Naphthalenes; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Tumor Necrosis Factor-alpha | 2003 |
Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Blotting, Western; Cannabinoids; Chlorocebus aethiops; COS Cells; Cyclohexanols; Dronabinol; Excitatory Amino Acid Antagonists; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Tertiary; Receptors, Cannabinoid; Receptors, Drug; Serine; Signal Transduction; Transfection | 2002 |
3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor.
Topics: Cannabinoids; Cyclohexanols; Dronabinol; Hydrogen Bonding; Indicators and Reagents; Indoles; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Naphthalenes; Receptors, Cannabinoid; Receptors, Drug; Spectrophotometry, Infrared; Stereoisomerism; Structure-Activity Relationship | 2003 |
Involvement of the kappa-opioid receptor in the anxiogenic-like effect of CP 55,940 in male rats.
Topics: Animals; Anxiety; Cannabinoids; Corticosterone; Cyclohexanols; Male; Maze Learning; Motor Activity; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2003 |
Cannabinoid-induced Fos expression within A10 dopaminergic neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cannabinoids; Cerebral Cortex; Clonidine; Cyclohexanols; Dopamine; Gene Expression Regulation; Genes, fos; Immunohistochemistry; Limbic System; Locus Coeruleus; Male; Mice; Mice, Inbred ICR; Neurons; Norepinephrine; Prazosin; Receptors, Cannabinoid; Receptors, Drug; Synaptic Transmission | 2003 |
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor.
Topics: Animals; Animals, Newborn; Animals, Suckling; Arachidonic Acids; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Modulators; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Endocannabinoids; Female; Glycerides; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Milk; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Survival Rate; Time Factors | 2003 |
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids, Neutral; Animals; Arachidonic Acids; Basal Ganglia; Cannabinoid Receptor Modulators; Capsaicin; Corpus Striatum; Cyclohexanols; Disease Models, Animal; Dopamine; Endocannabinoids; gamma-Aminobutyric Acid; Huntington Disease; Hyperkinesis; Male; Motor Activity; Nitro Compounds; Palmitates; Piperidines; Propionates; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells.
Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Humans; Indoles; Interleukin-2; Leukocytes, Mononuclear; Morpholines; Naphthalenes; Phytohemagglutinins; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Structure-activity relationships for 1',1'-dimethylalkyl-Delta8-tetrahydrocannabinols.
Topics: Animals; Binding, Competitive; Body Temperature; Cyclohexanols; Dronabinol; In Vitro Techniques; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Conformation; Motor Activity; Pain Measurement; Quantitative Structure-Activity Relationship; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Spectrophotometry, Infrared | 2003 |
Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice.
Topics: Animals; Autoradiography; Behavior, Animal; Benzoxazines; Binding, Competitive; Body Temperature; Brain; Cannabinoids; Corticosterone; Cyclohexanols; Disease Models, Animal; Drug Tolerance; Enkephalins; Exploratory Behavior; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morpholines; Motor Activity; Naphthalenes; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger; Substance Withdrawal Syndrome; Transcription, Genetic; Tyrosine 3-Monooxygenase | 2003 |
Pre-exposure to the cannabinoid receptor agonist CP 55940 enhances morphine behavioral sensitization and alters morphine self-administration in Lewis rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Drug Synergism; Male; Morphine; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Self Administration; Time Factors | 2003 |
The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression.
Topics: Animals; Atropine Derivatives; Benzoxazines; Bradycardia; Cannabinoids; Cardiovascular System; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Hypotension; Male; Medulla Oblongata; Microinjections; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sympathetic Fibers, Postganglionic; Sympathetic Nervous System | 2003 |
Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism.
Topics: Amidohydrolases; Animals; Antiparkinson Agents; Arachidonic Acids; Binding, Competitive; Cannabinoid Receptor Modulators; Cerebellum; Corpus Striatum; Cyclohexanols; Disease Models, Animal; Endocannabinoids; Excitatory Postsynaptic Potentials; Fatty Acids, Unsaturated; Glutamic Acid; Glycerides; In Vitro Techniques; Levodopa; Oxidopamine; Parkinsonian Disorders; Patch-Clamp Techniques; Phospholipase D; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug | 2003 |
Differential roles of CB1 and CB2 cannabinoid receptors in mast cells.
Topics: Animals; Cannabinoids; Cell Line; Cyclohexanols; Enzyme Activation; Gene Expression Regulation; Immunosuppressive Agents; Ligands; Mast Cells; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Receptors, Immunologic; Serotonin; Serotonin Antagonists; Signal Transduction; Tumor Cells, Cultured | 2003 |
Integrity of extracellular loop 1 of the human cannabinoid receptor 1 is critical for high-affinity binding of the ligand CP 55,940 but not SR 141716A.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Molecular Sequence Data; Piperidines; Protein Conformation; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Effect of (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol (CP55,940) on intracellular Ca2+ levels in human osteosarcoma cells.
Topics: Calcium; Cyclohexanols; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Osteoblasts; Osteosarcoma; Thapsigargin; Tumor Cells, Cultured; Type C Phospholipases | 2002 |
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.
Topics: Animals; Aspartic Acid; Axons; Benzoxazines; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Agonists; Gene Deletion; Humans; Mice; Mice, Transgenic; Monomeric GTP-Binding Proteins; Morpholines; Multiple Sclerosis; N-Methylaspartate; Naphthalenes; Nerve Degeneration; Nuclear Proteins; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Retina; Saccharomyces cerevisiae Proteins; Spinal Cord; Uveitis | 2003 |
Membrane assembly of the cannabinoid receptor 1: impact of a long N-terminal tail.
Topics: Animals; Cannabinoids; Cell Line; Cell Membrane; Cricetinae; Cyclohexanols; Endoplasmic Reticulum; Humans; Intracellular Membranes; Peptide Fragments; Protein Binding; Receptors, Cannabinoid; Receptors, Drug | 2003 |
Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood.
Topics: Analgesics; Analysis of Variance; Animals; Body Weight; Corticosterone; Cyclohexanols; Eating; Female; Growth; Male; Maze Learning; Motor Activity; Rats; Rats, Wistar; Sex Factors; Time Factors | 2003 |
Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.
Topics: Animals; Camphanes; Cannabinoids; Capsaicin; Consciousness; Cough; Cyclohexanols; Dinoprost; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Hypertonic Solutions; In Vitro Techniques; Male; Middle Aged; Neurons, Afferent; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Rimonabant; Vagus Nerve | 2003 |
Analysis of the respiratory effects of cannabinoids in rats.
Topics: Anesthesia; Animals; Atropine Derivatives; Benzoxazines; Blood Pressure; Cannabinoids; Cyclohexanols; Depression, Chemical; Dronabinol; Heart Rate; Hemodynamics; Morpholines; Muscarinic Agonists; Naphthalenes; Norepinephrine; Oxygen Consumption; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Respiration, Artificial; Respiratory Mechanics | 2003 |
Intrinsic activity estimation of cannabinoid CB1 receptor ligands in a drug discrimination paradigm.
Topics: Analgesics; Animals; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dronabinol; Hallucinogens; Male; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2003 |
Esters, retroesters, and a retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoylethanolamine-selective acid amidase.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Brain; Calcium Channel Blockers; CHO Cells; Cricetinae; Cyclohexanols; Endocannabinoids; Enzyme Inhibitors; Esters; Humans; Indicators and Reagents; Lung; Morpholines; Naphthalenes; Palmitates; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug | 2003 |
An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.
Topics: Benzoxazines; Binding Sites; Cyclohexanols; Humans; Immunochemistry; Ligands; Models, Molecular; Morpholines; Naphthalenes; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2003 |
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioactivity; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synaptosomes; Tritium | 2003 |
Regulation of exocytosis from single visualized GABAergic boutons in hippocampal slices.
Topics: Animals; Baclofen; Calcium Channels; Cyclohexanols; Electric Stimulation; Excitatory Postsynaptic Potentials; Exocytosis; Fluorescent Dyes; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Isoenzymes; Luminescent Proteins; Mice; Mice, Transgenic; Neural Inhibition; Patch-Clamp Techniques; Presynaptic Terminals; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Recombinant Fusion Proteins | 2003 |
Cannabinoids and opioids share cAMP pathway in rat splenocytes.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclic AMP; Cyclohexanols; Drug Combinations; Injections, Intraperitoneal; Male; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Opioid; Signal Transduction; Spleen | 2003 |
An immunohistochemical study of the thyroid parafollicular (C) cells in rats treated with cannabinoids - preliminary investigations.
Topics: Animals; Arachidonic Acids; Calcitonin; Cannabinoids; Cyclohexanols; Immunoenzyme Techniques; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Thyroid Gland | 2003 |
Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cyclohexanols; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Endocannabinoids; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Models, Animal; Neurons; Pipecolic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Telencephalon | 2003 |
Downregulation of class II transactivator (CIITA) expression by synthetic cannabinoid CP55,940.
Topics: Animals; Cyclohexanols; Down-Regulation; Histocompatibility Antigens Class II; Immunosuppressive Agents; Interferon-gamma; Mice; Microglia; Nuclear Proteins; Promoter Regions, Genetic; Trans-Activators | 2004 |
Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims.
Topics: Adolescent; Adult; Aged; Analgesics; Cyclohexanols; Depressive Disorder; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Prefrontal Cortex; Receptor, Cannabinoid, CB1; Suicide; Sulfur Radioisotopes; Tritium; Up-Regulation | 2004 |
Differential effects of CB1 and opioid agonists on two populations of adult rat dorsal root ganglion neurons.
Topics: Animals; Biological Assay; Calcitonin Gene-Related Peptide; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cyclohexanols; Ganglia, Spinal; Male; Morphine; Narcotic Antagonists; Narcotics; Neurons; Pertussis Toxin; Potassium; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Spinal Cord | 2004 |
Cannabinoid agonist, CP 55,940, facilitates intake of palatable foods when injected into the hindbrain.
Topics: Animals; Appetite Stimulants; Appetitive Behavior; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Eating; Female; Fourth Ventricle; Injections, Intraventricular; Lateral Ventricles; Male; Rats; Rhombencephalon; Sex Factors | 2004 |
Cannabinoid CB1 receptor-mediated modulation of evoked dopamine release and of adenylyl cyclase activity in the human neocortex.
Topics: Adenylyl Cyclases; Amygdala; Animals; Arachidonic Acids; Benzoxazines; Binding Sites; Colforsin; Cyclic AMP; Cyclohexanols; Dopamine; Dronabinol; Electric Stimulation; Endocannabinoids; Female; Humans; Ligands; Male; Morpholines; Naphthalenes; Neocortex; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Synaptosomes; Tetrodotoxin; Tritium | 2004 |
Unconditioned and conditioned anxiogenic effects of the cannabinoid receptor agonist CP 55,940 in the social interaction test.
Topics: Animals; Anxiety; Cannabinoid Receptor Agonists; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Interpersonal Relations; Male; Motor Activity; Rats; Receptors, Cannabinoid | 2004 |
6"-Azidohex-2"-yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonist.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Binding, Competitive; Brain Chemistry; Cannabidiol; Cyclohexanols; Electric Stimulation; In Vitro Techniques; Male; Membranes; Mice; Phenylephrine; Receptor, Cannabinoid, CB1; Vas Deferens | 2004 |
The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner.
Topics: Acute Disease; Arachidonic Acids; Bucladesine; Cannabinoid Receptor Modulators; Cell Differentiation; Cell Movement; Cyclic AMP; Cyclohexanols; Down-Regulation; Endocannabinoids; Glycerides; Hematopoietic Stem Cells; Humans; Immunosuppressive Agents; Leukemia, Myeloid; Ligands; MAP Kinase Signaling System; Mutagenesis, Site-Directed; Neutrophils; Pertussis Toxin; Receptor, Cannabinoid, CB2; Receptors, Granulocyte Colony-Stimulating Factor | 2004 |
Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development.
Topics: Analgesics; Animals; Benzoxazines; Body Temperature; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Morpholines; Naphthalenes; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1 | 2004 |
Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm.
Topics: Animals; Appetitive Behavior; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Morpholines; Motivation; Naphthalenes; Piperidines; Premedication; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2004 |
Involvement of 5-HT1A receptors in behavioural effects of the cannabinoid receptor agonist CP 55,940 in male rats.
Topics: Animals; Arousal; Cannabinoids; Cyclohexanols; Drug Interactions; Exploratory Behavior; Fear; Grooming; Injections, Intraperitoneal; Male; Maze Learning; Motor Activity; Orientation; Piperazines; Premedication; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists | 2004 |
Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats.
Topics: Animals; Cannabinoids; Cyclohexanols; Fever; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin | 2004 |
Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Ligation; Male; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Nerves; Time Factors | 2004 |
A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amidohydrolases; Animals; Arachidonic Acids; Cerebral Cortex; Cocaine; Cyclohexanols; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neostriatum; Patch-Clamp Techniques; Polyunsaturated Alkamides; Quinpirole; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Synaptic Transmission; Synaptosomes | 2004 |
Spontaneous cannabinoid withdrawal produces a differential time-related responsiveness in cannabinoid CB1 receptor gene expression in the mouse brain.
Topics: Animals; Brain; Cannabinoids; Cyclohexanols; Drug Tolerance; Male; Mice; Motor Activity; Organ Specificity; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Time Factors; Up-Regulation | 2004 |
2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells.
Topics: Arachidonic Acid; Arachidonic Acids; Blotting, Northern; Calcitriol; Camphanes; Cell Differentiation; Chemokine CCL2; Chemokines; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Gene Expression; Glycerides; HL-60 Cells; Humans; Interleukin-8; Lipopolysaccharides; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB2; RNA, Messenger; Time Factors | 2004 |
Cannabinoids enhance N-methyl-D-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cyclohexanols; Drug Interactions; Electrophysiology; Endocannabinoids; Excitatory Amino Acid Agonists; In Vitro Techniques; Locus Coeruleus; Male; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Transdermal permeation of WIN 55,212-2 and CP 55,940 in human skin in vitro.
Topics: Administration, Cutaneous; Benzoxazines; Cyclohexanols; Humans; In Vitro Techniques; Morpholines; Naphthalenes; Skin Absorption | 2004 |
The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: involvement of nitric oxide and eicosanoids.
Topics: Animals; Arachidonic Acids; Blotting, Western; Cannabinoid Receptor Modulators; Cyclohexanols; Eicosanoids; Endocannabinoids; Enzyme Inhibitors; Glycerides; Guinea Pigs; Immunity; Immunosuppressive Agents; Male; Mast Cells; NG-Nitroarginine Methyl Ester; Nitric Oxide; Receptor, Cannabinoid, CB2 | 2004 |
Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide.
Topics: Adult; Arachidonic Acids; Cyclohexanols; Dronabinol; Endocannabinoids; Female; Humans; Male; Neutrophils; Polyunsaturated Alkamides; Receptors, Cannabinoid; Superoxides | 2004 |
Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.
Topics: Animals; Benzofurans; Benzoxazines; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Cyclohexanols; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Vasodilation | 2004 |
Effects of nicotine and a cannabinoid receptor agonist on negative contrast: distinction between anxiety and disappointment?
Topics: Animals; Anxiety; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Emotions; In Vitro Techniques; Interpersonal Relations; Male; Maze Learning; Nicotine; Rats; Receptors, Cannabinoid | 2004 |
Inhibition by anandamide and synthetic cannabimimetics of the release of [3H]D-aspartate and [3H]GABA from synaptosomes isolated from the rat hippocampus.
Topics: Animals; Arachidonic Acids; Aspartic Acid; Calcium; Cannabinoid Receptor Agonists; Cannabinoids; Capsaicin; Cyclohexanols; Endocannabinoids; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Male; Polyunsaturated Alkamides; Potassium; Rats; Rats, Wistar; Synaptosomes | 2004 |
Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala.
Topics: Amygdala; Analgesics; Animals; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dronabinol; Genes, fos; Male; Mice; Mice, Inbred ICR; Restraint, Physical; Stress, Psychological | 2005 |
Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons.
Topics: Action Potentials; Animals; Cannabinoids; Capsaicin; Cyclohexanols; Hot Temperature; Male; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2005 |
Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Calcium; Cell Line; Chromones; Colforsin; Cyclic AMP; Cyclohexanols; DNA, Complementary; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Humans; Indoles; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Radioligand Assay; Rats; Receptor, Cannabinoid, CB2; Species Specificity; Transfection; Tritium | 2004 |
Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat.
Topics: Alkanesulfonates; Amines; Amitriptyline; Animals; Baclofen; Behavior, Animal; Benzoxazines; Carbamazepine; Cyclohexanecarboxylic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Gabapentin; gamma-Aminobutyric Acid; Indans; Male; Molecular Structure; Morphine; Morpholines; Naphthalenes; Nitriles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sulfonic Acids | 2004 |
Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Cannabinoids; Cognition; Conditioning, Operant; Cyclohexanols; Dronabinol; Exploratory Behavior; Female; Hallucinogens; Interpersonal Relations; Learning; Memory Disorders; Memory, Short-Term; Motor Activity; Psychomotor Performance; Rats; Rats, Wistar | 2004 |
Influence of cannabinoids on immunoreactivity of regulatory peptides, produced in rat thyroid C cells; preliminary investigations.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoids; Cyclohexanols; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Somatostatin; Synaptophysin; Thyroid Gland | 2004 |
Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims.
Topics: Adolescent; Adult; Aged; Alcoholism; Binding, Competitive; Blotting, Western; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mass Spectrometry; Middle Aged; Prefrontal Cortex; Radioligand Assay; Receptor, Cannabinoid, CB1; Suicide; Sulfur Isotopes; Tritium | 2005 |
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.
Topics: Administration, Oral; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Hypotension; Hypothermia; Imidazoles; Mice; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2005 |
Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice.
Topics: Acute Disease; Adrenergic alpha-Agonists; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cannabinoids; Cyclohexanols; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Synergism; Injections, Spinal; Male; Mice; Morphine; Pain; Pain Measurement; Receptors, Opioid, mu | 2005 |
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Animal; Benzoxazines; Binding, Competitive; Catalepsy; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanecarboxylic Acids; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Immunosuppressive Agents; Indoles; Indomethacin; Inflammation; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Pain; Pain Measurement; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB2; Time Factors | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.
Topics: Animals; Benzoxazines; Blotting, Western; Cell Line; Cerebellum; CHO Cells; Cricetinae; Cyclohexanols; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isomerism; Ligands; Models, Molecular; Morpholines; Naphthalenes; Rats; Receptor, Cannabinoid, CB2; Receptor, Muscarinic M4; Receptors, G-Protein-Coupled; Receptors, Melatonin; Transfection | 2005 |
Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects.
Topics: Aminoacetonitrile; Analgesics; Animals; Autoradiography; Behavior, Animal; Blotting, Western; Brain; Cyclohexanols; Diagnostic Imaging; Dronabinol; Drug Administration Schedule; Drug Tolerance; Extracellular Signal-Regulated MAP Kinases; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Knockout; Motor Activity; Protease Inhibitors; Protein Binding; ras-GRF1; Receptor, Cannabinoid, CB1; Signal Transduction; Sulfur Isotopes; Tritium | 2005 |
Stimulation of cannabinoid (CB1) and prostanoid (EP2) receptors opens BKCa channels and relaxes ocular trabecular meshwork.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Adult; Aged; Animals; Benzoxazines; Calcium; Calcium Channel Blockers; Cannabinoids; Carbachol; Cattle; Cells, Cultured; Cholinergic Agonists; Cyclic AMP; Cyclohexanols; Endothelin-1; Humans; In Vitro Techniques; Ion Channel Gating; Middle Aged; Morpholines; Naphthalenes; Patch-Clamp Techniques; Peptides; Piperidines; Potassium Channels, Calcium-Activated; Prostanoic Acids; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Prostaglandin E; Stimulation, Chemical; Trabecular Meshwork | 2005 |
Different pharmacological profile of two closely related endocannabinoid ester analogs.
Topics: Animals; Arachidonic Acids; Binding, Competitive; Cannabinoid Receptor Modulators; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; Endocannabinoids; Ethylene Glycols; Female; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2 | 2005 |
Effects of repeated administration with CP-55,940, a cannabinoid CB1 receptor agonist on the metabolism of the hepatic heme.
Topics: Animals; Cyclohexanols; Heme; Liver; Male; Mice; Receptor, Cannabinoid, CB1 | 2005 |
The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Arachidonic Acids; Binding, Competitive; Biotransformation; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; Down-Regulation; Endocannabinoids; Enzyme Inhibitors; Glycerides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; In Vitro Techniques; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, G-Protein-Coupled; Transfection | 2005 |
Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat.
Topics: Analysis of Variance; Animals; Baclofen; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Injections, Spinal; Male; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-B; Rimonabant; Signal Transduction; Spinal Cord | 2005 |
Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores.
Topics: Animals; Benzoxazines; Calcium; Cell Culture Techniques; Cell Death; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclohexanols; Dantrolene; Drug Interactions; Estrenes; Fetus; Hippocampus; Macrocyclic Compounds; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Okadaic Acid; Oxazoles; Piperidines; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Thionucleotides | 2005 |
Cannabinoid CB(1) antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats.
Topics: Animals; Behavior, Addictive; Benzoxazines; Conditioning, Operant; Cyclohexanols; Drug Interactions; Extinction, Psychological; Heroin; Heroin Dependence; Male; Morpholines; Naloxone; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration | 2005 |
Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Catalepsy; Cell Line; Chromatography; Cricetinae; Cricetulus; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypothermia; Inflammation; Ligation; Male; Morpholines; Motor Activity; Naphthalenes; Pain; Pain Measurement; Pain Threshold; Radioligand Assay; Rats; Rats, Wistar; Rotarod Performance Test; Sciatic Neuropathy; Sulfur Isotopes; Time Factors; Tritium | 2005 |
Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Hypothalamus; Male; Neuropeptide Y; Organ Culture Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley | 2005 |
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities.
Topics: Amides; Animals; Binding Sites; Brain; Cell Membrane; Cyclohexanols; Humans; Mice; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Clozapine decreases [3H] CP 55940 binding to the cannabinoid 1 receptor in the rat nucleus accumbens.
Topics: Analgesics; Animals; Antipsychotic Agents; Autoradiography; Clozapine; Cyclohexanols; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2005 |
Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids.
Topics: Arachidonic Acids; Cannabinoids; Cyclohexanols; Cyclooxygenase Inhibitors; Endocannabinoids; Humans; In Vitro Techniques; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Polyunsaturated Alkamides; Reactive Oxygen Species; Receptor, Cannabinoid, CB2; Respiratory Burst; Stimulation, Chemical | 2005 |
Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems.
Topics: Animals; Area Under Curve; Behavior, Animal; Brain; Brain Chemistry; Cannabinoids; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Male; Narcotics; Pain Measurement; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Opioid; Sulfur Isotopes; Tritium | 2005 |
Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acids; Binding, Competitive; Blotting, Western; Calcium Signaling; Cannabinoid Receptor Modulators; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; DNA, Complementary; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Glycerides; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Indoles; Mitogen-Activated Protein Kinases; Receptor, Cannabinoid, CB2; Transfection | 2005 |
Cannabinoids modulate synaptic activity in the rat supraoptic nucleus.
Topics: Anesthetics, Local; Animals; Cannabinoids; Cyclohexanols; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Neurons, Afferent; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Supraoptic Nucleus; Synapses; Tetrodotoxin | 2005 |
Allosteric modulation of the cannabinoid CB1 receptor.
Topics: Allosteric Regulation; Animals; Binding Sites; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Vas Deferens | 2005 |
Expedient synthesis of potent cannabinoid receptor agonist (-)-CP55,940.
Topics: Cannabinoid Receptor Agonists; Cyclohexanes; Cyclohexanols; Molecular Structure; Phenols; Stereoisomerism | 2005 |
The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940).
Topics: Animals; Conditioning, Operant; Corn Oil; Cyclohexanols; Dietary Fats; Dietary Sucrose; Feeding Behavior; Female; Food, Formulated; Gene Deletion; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Taste; Time Factors | 2005 |
Persistent anxiogenic effects of a single or repeated doses of cocaine and methamphetamine: interactions with endogenous cannabinoid receptor ligands.
Topics: Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Cannabinoids; Cocaine; Cyclohexanols; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glycerides; Injections, Intraperitoneal; Male; Maze Learning; Methamphetamine; Mice; Mice, Inbred ICR; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Time Factors | 2005 |
Behavioral pharmacological properties of a novel cannabinoid 1',1'-dithiolane delta8-THC analog, AMG-3.
Topics: Animals; Behavior, Animal; Binding, Competitive; Cannabinoids; Catalepsy; Cell Membrane; Cerebral Cortex; Cyclohexanols; Dose-Response Relationship, Drug; Male; Molecular Structure; Motor Activity; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Time Factors; Tritium | 2005 |
Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons.
Topics: Animals; Cannabinoids; Catalepsy; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Cyclohexanols; Dopamine and cAMP-Regulated Phosphoprotein 32; Mice; Mice, Inbred C57BL; Neurons; Phosphorylation; Protein Subunits; Receptor, Cannabinoid, CB1 | 2005 |
Antinociceptive effect of spinally administered cannabinergic and 2-adrenoceptor drugs on the formalin test in rat: possible interactions.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Cyclohexanols; Formaldehyde; Injections, Spinal; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, alpha-2; Receptors, Cannabinoid; Rimonabant; Spinal Cord; Yohimbine | 2006 |
Subchronic haloperidol increases CB(1) receptor binding and G protein coupling in discrete regions of the basal ganglia.
Topics: Analgesics; Animals; Basal Ganglia; Binding, Competitive; Cyclohexanols; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Receptors, G-Protein-Coupled; Up-Regulation | 2005 |
Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides.
Topics: Animals; Binding Sites; Cyclohexanols; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Triazoles; Vas Deferens | 2006 |
Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala.
Topics: Amygdala; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Corticosterone; Cyclohexanols; Endocannabinoids; Glycerides; Male; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Signal Transduction | 2005 |
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Cytoplasm; DNA, Complementary; Dronabinol; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Glycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Humans; Immunosuppressive Agents; Morpholines; Naphthalenes; Neurons; Pertussis Toxin; Piperidines; Protein Binding; Protein Conformation; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Time Factors; Type C Phospholipases | 2005 |
Depolarization and Ca(2+) down regulate CB1 receptors and CB1-mediated signaling in cerebellar granule neurons.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Blotting, Northern; Calcium; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Cerebellum; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; In Situ Hybridization; Models, Biological; Neurons; Nifedipine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Tetrazolium Salts; Tetrodotoxin; Thiazoles; Time Factors | 2006 |
F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist.
Topics: Alanine; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; Molecular Structure; Pertussis Toxin; Phenylalanine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Tritium | 2006 |
Expression of functional CB1 cannabinoid receptors in retinoic acid-differentiated P19 embryonal carcinoma cells.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Benzoxazines; Blotting, Western; Calcium; Carcinoma; Cell Differentiation; Cell Line, Tumor; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; gamma-Aminobutyric Acid; Gene Expression; Mice; Morpholines; Naphthalenes; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temperature; Tretinoin; Tritium | 2006 |
Systemic effect of cannabinoids on the spontaneous firing rate of locus coeruleus neurons in rats.
Topics: Action Potentials; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; In Vitro Techniques; Injections, Intravenous; Injections, Intraventricular; Kinetics; Locus Coeruleus; Male; Morpholines; Naphthalenes; Neurons; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes.
Topics: Calcium; Cannabinoids; Chemokine CXCL12; Chemokines, CXC; Chemotaxis, Leukocyte; Cyclohexanes; Cyclohexanols; Endothelium, Vascular; Humans; Immunosuppressive Agents; Indoles; Jurkat Cells; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinases; Phenols; Receptor, Cannabinoid, CB2; Receptors, CXCR4; Signal Transduction; T-Lymphocytes; Umbilical Veins | 2006 |
Effects of the cannabinoid CB1 receptor agonist CP55,940 and antagonist SR141716A on d-amphetamine-induced behaviours in Cebus monkeys.
Topics: Animals; Anti-Anxiety Agents; Arousal; Behavior, Animal; Cebus; Central Nervous System Stimulants; Cyclohexanols; Dextroamphetamine; Drug Interactions; Female; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stereotyped Behavior | 2006 |
Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
Topics: Animals; Benzoxazines; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Endocytosis; Enzyme Activation; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Naphthalenes; Phenols; Piperidines; Propylene Glycols; Proto-Oncogene Proteins c-akt; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sphingosine | 2006 |
Cannabinoid system in the budgerigar brain.
Topics: Animals; Autoradiography; Benzoxazines; Brain; Brain Mapping; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Melopsittacus; Morpholines; Naphthalenes; Phenols; Protein Binding; Radioligand Assay; Receptors, Cannabinoid; Sulfur Isotopes; Tritium | 2006 |
Suppression by WIN55212-2, a cannabinoid receptor agonist, of inflammatory reactions in mouse ear: Interference with the actions of an endogenous ligand, 2-arachidonoylglycerol.
Topics: Administration, Cutaneous; Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoid Receptor Agonists; Cannabinoids; Cell Movement; Cyclohexanols; Dose-Response Relationship, Drug; Ear, External; Endocannabinoids; Glycerides; HL-60 Cells; Humans; Inflammation; Intracellular Fluid; Leukocytes; Ligands; Male; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Peroxidase; Tetradecanoylphorbol Acetate | 2006 |
Increased cannabinoid receptor density in the posterior cingulate cortex in schizophrenia.
Topics: Adult; Aged; Autoradiography; Case-Control Studies; Cyclohexanols; Gyrus Cinguli; Humans; Male; Middle Aged; Postmortem Changes; Receptors, Cannabinoid; Schizophrenia; Statistics, Nonparametric; Tritium | 2006 |
Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats.
Topics: Aging; Animals; Animals, Newborn; Anxiety; Cannabinoid Receptor Agonists; Cannabinoids; Cognition Disorders; Cyclohexanols; Exploratory Behavior; Interpersonal Relations; Male; Memory; Memory, Short-Term; Motor Activity; Rats; Rats, Wistar; Recognition, Psychology | 2006 |
Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.
Topics: Aconitine; Animals; Arachidonic Acids; Azetidines; Benzamides; Benzoxazines; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Male; Mecamylamine; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Nicotinic | 2006 |
Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.
Topics: Animals; Anti-Obesity Agents; Blood-Brain Barrier; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Cyclohexanols; Eating; Ethanol; Feeding Behavior; Male; Maze Learning; Membranes, Artificial; Motor Activity; Permeability; Phenols; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rats, Zucker; Rimonabant; Self Administration; Triazoles | 2006 |
Effect of chronic ethanol exposure and its withdrawal on the endocannabinoid system.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Central Nervous System Depressants; Chromatography, Liquid; Cyclohexanols; Endocannabinoids; Ethanol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mass Spectrometry; Mice; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Sulfur Radioisotopes | 2006 |
Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Ischemia; Cyclohexanols; Dizocilpine Maleate; Down-Regulation; Excitatory Amino Acid Antagonists; Male; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rimonabant | 2006 |
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acids; Binding, Competitive; Cannabinoids; Cell Line; Cyclic AMP; Cyclohexanes; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Mutation; Phenols; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells.
Topics: Analysis of Variance; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line; Cell Movement; Chemotaxis; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Endothelial Cells; Flow Cytometry; Humans; Indoles; Interleukin-8; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Thapsigargin; Tumor Necrosis Factor-alpha | 2006 |
Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; Animals; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cocaine; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Ketamine; Macaca mulatta; Male; Midazolam; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2006 |
Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Hallucinogens; Humans; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Macaca mulatta; Male; Midazolam; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
Avoidance of Abeta[(25-35)] / (H(2)O(2)) -induced apoptosis in lymphocytes by the cannabinoid agonists CP55,940 and JWH-015 via receptor-independent and PI3K-dependent mechanisms: role of NF-kappaB and p53.
Topics: Adult; Amyloid beta-Peptides; Apoptosis; Cannabinoids; Cyclohexanes; Cyclohexanols; Cytoprotection; Humans; Hydrogen Peroxide; Indoles; Lymphocytes; Male; NF-kappa B; Peptide Fragments; Phenols; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Receptors, Cannabinoid; Tumor Suppressor Protein p53 | 2006 |
Cannabinoids reveal importance of spike timing coordination in hippocampal function.
Topics: Action Potentials; Animals; Cannabinoids; Cortical Synchronization; Cyclohexanes; Cyclohexanols; Dronabinol; Hippocampus; Periodicity; Phenols; Rats; Receptors, Cannabinoid; Theta Rhythm | 2006 |
Characterization of cannabinoid-binding sites in zebrafish brain.
Topics: Animals; Benzoxazines; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Protein Binding; Radioligand Assay; Tritium; Zebrafish | 2007 |
Effect of CP55,940 on mechanosensory spinal neurons following chronic inflammation.
Topics: Afferent Pathways; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Chronic Disease; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Inflammation; Male; Mechanoreceptors; Nociceptors; Pain; Phenols; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid | 2007 |
Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors.
Topics: Animals; Arachidonic Acids; Benzoxazines; Bone Marrow Cells; Cannabinoid Receptor Modulators; Cannabinoids; Cells, Cultured; Colony-Forming Units Assay; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Indomethacin; Male; Mesenchymal Stem Cells; Morpholines; Naphthalenes; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Stem Cells | 2007 |
Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.
Topics: Animals; Benzoxazines; Body Temperature; Cross Reactions; Cyclohexanols; Encephalomyelitis, Autoimmune, Experimental; Mice; Mice, Knockout; Morpholines; Multiple Sclerosis; Muscle Spasticity; Naphthalenes; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2007 |
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Brain; Camphanes; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Phenols; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Rimonabant; Transfection | 2007 |
The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.
Topics: Analgesics, Non-Narcotic; Animals; Benzoxazines; Binding, Competitive; Body Temperature; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Locomotion; Male; Mice; Mice, Inbred ICR; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Pain Measurement; Pain Threshold; Phenols; Protein Binding; Psychotropic Drugs; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Vas Deferens | 2007 |
Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia.
Topics: Animals; Apomorphine; Benzoxazines; Cannabinoid Receptor Agonists; Catalepsy; Cyclohexanes; Cyclohexanols; Hyperalgesia; Male; Mice; Mice, Inbred C3H; Morpholines; Naphthalenes; Phenols; Receptors, Cannabinoid; Sarcoma, Experimental | 2007 |
Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Body Weight; Cannabinoid Receptor Modulators; Carbamates; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Endocannabinoids; Food Deprivation; Food Preferences; Male; Mice; Mice, Inbred ICR; Phenols; Piperidines; Pyrazoles; Restraint, Physical; Reward; Rimonabant; Stress, Psychological; Sucrose; Time Factors; Water Deprivation | 2007 |
Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
Topics: Amides; Animals; Anti-Obesity Agents; Binding, Competitive; Body Temperature; Body Weight; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Eating; Humans; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Obesity; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Transfection | 2007 |
Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells.
Topics: Animals; Benzoxazines; beta-N-Acetylhexosaminidases; Calcium; Cannabidiol; Cannabinoids; Capsaicin; Cell Degranulation; Cell Line; Cyclohexanols; Dronabinol; Intracellular Fluid; Mast Cells; Morpholines; Naphthalenes; Rats; TRPV Cation Channels | 2007 |
Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew.
Topics: Animals; Antiemetics; Benzoxazines; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Dronabinol; Gamma Rays; Locomotion; Morpholines; Naphthalenes; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Shrews; Vomiting | 2007 |
Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells.
Topics: Animals; Arachidonic Acids; Benzofurans; Benzoxazines; Camphanes; Cannabinoid Receptor Modulators; Cells, Cultured; Chromones; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Endothelial Cells; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Morpholines; Naphthalenes; Nitric Oxide; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Pyrazoles; Rabbits; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Rimonabant; Signal Transduction | 2007 |
Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.
Topics: Binding, Competitive; Cyclohexanols; Humans; Models, Molecular; Mutation; Protein Structure, Secondary; Receptor, Cannabinoid, CB1; Serine | 2007 |
Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision.
Topics: Animals; Cyclohexanes; Cyclohexanols; Indoles; Male; Neuroglia; Pain, Postoperative; Phenols; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Reflex; Spinal Cord | 2007 |
Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2.
Topics: Analgesics, Opioid; Animals; Benzoxazines; Brain; Cannabinoids; Cyclohexanols; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; Humans; Male; Morpholines; Naphthalenes; Rats; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Self Administration | 2007 |
Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Aspartic Acid; Astrocytes; Benzoxazines; Biological Transport; Biomarkers; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cannabinoids; Cells, Cultured; Cerebral Cortex; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acids; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kinetics; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Proteins; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sodium; Time Factors | 2007 |
Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides.
Topics: Amides; Arachidonic Acids; Cyclohexanols; Echinacea; Endocannabinoids; Humans; Models, Biological; Molecular Structure; Plants, Medicinal; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB2 | 2007 |
Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Catecholamines; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Dronabinol; Gene Expression Regulation, Enzymologic; Ligands; Mice; Models, Biological; Neuroblastoma; Neurons; Neuroprotective Agents; Promoter Regions, Genetic; Protein Transport; Receptor, Cannabinoid, CB1; Signal Transduction; Tyrosine 3-Monooxygenase | 2007 |
Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers.
Topics: Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Camphanes; Cannabinoids; Carrageenan; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Indoles; Mice; Morpholines; Naphthalenes; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB2; Species Specificity; Stereoisomerism; Tritium | 2007 |
Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Arachidonic Acids; Blotting, Western; Bronchi; Camphanes; Cannabinoids; Cell Line; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Drug Antagonism; Epithelial Cells; Humans; Immunosuppressive Agents; Interleukin-8; Pertussis Toxin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Tumor Necrosis Factor-alpha | 2007 |
PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats.
Topics: Allosteric Regulation; Animals; Appetite Depressants; Cell Line; Cell Membrane; Cerebral Cortex; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Eating; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Molecular Structure; Phenylurea Compounds; Piperidines; Pyrazoles; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Saccharomyces cerevisiae; Silicone Elastomers; Sulfur Radioisotopes; Weight Gain | 2007 |
Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.
Topics: Amino Acid Sequence; Analgesics; Benzoxazines; Cyclohexanols; Dronabinol; Humans; Leucine; Lipid Bilayers; Molecular Sequence Data; Morpholines; Mutagenesis; Naphthalenes; Pertussis Toxin; Protein Structure, Secondary; Protein Structure, Tertiary; Receptor, Cannabinoid, CB1; Signal Transduction | 2007 |
Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB2) in rodents and primates.
Topics: Animals; Binding, Competitive; Cell Membrane; Chemotaxis; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Macaca fascicularis; Mice; Quinolizines; Rats; Receptor, Cannabinoid, CB2; Species Specificity | 2007 |
Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Adrenergic Fibers; Animals; Arachidonic Acids; Benzofurans; Benzoxazines; Camphanes; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; In Vitro Techniques; Male; Mesenteric Arteries; Morpholines; Muscle Tonus; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Perfusion; Polyunsaturated Alkamides; Prazosin; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Purinergic P2 | 2007 |
Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Binding, Competitive; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Female; Guanosine 5'-O-(3-Thiotriphosphate); Litter Size; Male; Morpholines; Motor Activity; Naphthalenes; Phospholipase D; Polyunsaturated Alkamides; Pregnancy; Prenatal Exposure Delayed Effects; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Sulfur Radioisotopes; Weight Gain | 2007 |
Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2008 |
Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice.
Topics: Amidohydrolases; Amygdala; Analysis of Variance; Animals; Cannabinoid Receptor Modulators; Corpus Striatum; Corticosterone; Cyclohexanols; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Glycerides; Male; Mice; Mice, Inbred ICR; Prefrontal Cortex; Protein Binding; Restraint, Physical; Stress, Psychological; Time Factors; Tritium | 2008 |
Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling.
Topics: Arrestins; beta-Arrestins; Cell Line, Transformed; Cyclohexanols; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Transport; Receptor, Cannabinoid, CB1; Signal Transduction; Time Factors; Transfection | 2008 |
Activation of cannabinoid receptors reduces allergen-induced oxidative stress damage during asthma-like reaction in sensitised guinea-pigs.
Topics: Allergens; Animals; Antioxidants; Asthma; Cannabinoids; Cyclohexanols; Guinea Pigs; Immunosuppressive Agents; Male; Malondialdehyde; Oxidative Stress; Receptors, Cannabinoid | 2007 |
The orphan receptor GPR55 is a novel cannabinoid receptor.
Topics: Amino Acid Sequence; Animals; Arachidonic Acids; Binding Sites; Binding, Competitive; Cannabidiol; Cannabinoids; Cell Line; Cloning, Molecular; Cyclohexanols; Down-Regulation; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mice; Molecular Sequence Data; Organ Specificity; Polymerase Chain Reaction; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Structure-Activity Relationship | 2007 |
Vascular pharmacology of a novel cannabinoid-like compound, 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide (VSN16) in the rat.
Topics: Animals; Apamin; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cerebellum; Charybdotoxin; Cyclohexanols; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Molecular Structure; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cannabinoid; Resorcinols; Rimonabant; Tritium; TRPV Cation Channels; Vascular Resistance; Vasodilation | 2007 |
Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940.
Topics: Cannabinoids; Cyclohexanols; Protein Binding; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid | 2008 |
Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cells.
Topics: Arachidonic Acids; Benzoxazines; Blotting, Western; Calcium Signaling; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line; Cells, Cultured; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Trabecular Meshwork; Type C Phospholipases | 2007 |
The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats.
Topics: Amphetamine-Related Disorders; Animals; Binding, Competitive; Calcineurin; Cyclic AMP; Cyclohexanols; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Male; Methamphetamine; Nucleus Accumbens; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Signal Transduction; Substance Withdrawal Syndrome | 2007 |
In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models.
Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Cells, Cultured; Constriction, Pathologic; Cyclic AMP-Dependent Protein Kinases; Cyclohexanols; Cyclopropanes; Humans; Hyperalgesia; Immunosuppressive Agents; Joints; Male; Microscopy, Fluorescence; Morpholines; Motor Activity; Pain; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Sciatica | 2008 |
Cannabinoid regulation in identified synapse of terrestrial snail.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Radiation; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Nervous System; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Snails; Synapses; Tritium | 2007 |
Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue- and CB1-receptor-specific mechanism.
Topics: Adult; Amnion; Blotting, Western; Cannabinoid Receptor Modulators; Chorion; Cyclohexanols; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Decidua; Dinoprostone; Female; Humans; In Vitro Techniques; Nitrobenzenes; Piperidines; Placenta; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant; Sulfonamides | 2008 |
Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Corticosterone; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Hippocampus; Immunosuppressive Agents; Male; Polyunsaturated Alkamides; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Tritium | 2008 |
Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cell.
Topics: Analgesics; Analgesics, Opioid; Animals; Cell Line; Cell Line, Tumor; Central Nervous System; Cyclohexanols; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; Etorphine; Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Kinase 1; Mice; Neuroblastoma; Neurons; Rats; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vascular Endothelial Growth Factor Receptor-1 | 2008 |
Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.
Topics: Animals; Benzoxazines; Cells, Cultured; Cyclohexanols; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morpholines; Naphthalenes; Protein Conformation; Receptor, Cannabinoid, CB1; Signal Transduction; Spodoptera | 2008 |
Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes.
Topics: Animals; B-Lymphocytes; Camphanes; Cannabinoids; Cyclohexanols; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunoglobulin Class Switching; Immunoglobulin E; Immunoglobulin M; In Vitro Techniques; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Rimonabant; Th2 Cells | 2008 |
The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.
Topics: Animals; Arachidonic Acids; Camphanes; Chemokine CCL5; Chemotaxis; Cyclohexanols; Dronabinol; Female; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, CCR1; Receptors, CCR5; Receptors, G-Protein-Coupled; Rimonabant; RNA, Messenger; Signal Transduction | 2008 |
The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: implications for olanzapine-induced weight gain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Binding, Competitive; Cyclohexanols; Female; Immunosuppressive Agents; Medulla Oblongata; Olanzapine; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Tritium; Weight Gain | 2008 |
Activation of cannabinoid-1 receptors disrupts sensory gating and neuronal oscillation: relevance to schizophrenia.
Topics: Acoustic Stimulation; Action Potentials; Animals; Biological Clocks; Brain; Cyclohexanols; Disease Models, Animal; Electroencephalography; Evoked Potentials, Auditory; Fourier Analysis; Gait Disorders, Neurologic; Male; Maximum Tolerated Dose; Neural Pathways; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Wakefulness | 2008 |
Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis.
Topics: Animals; Behavior, Animal; Cell Line, Transformed; Corpus Striatum; Cyclohexanols; Dopamine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Fluorescence Resonance Energy Transfer; Guanylyl Imidodiphosphate; Humans; Luminescent Proteins; Male; Motor Activity; Protein Binding; Quinpirole; Radiography; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, Dopamine D2; Transfection | 2008 |
Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antigens; Asthma; Camphanes; Cyclic AMP; Cyclohexanols; Deoxyguanosine; DNA Damage; Guinea Pigs; Humans; Leukocytes; Lung; Male; Mast Cells; Models, Biological; Ovalbumin; Piperidines; Prostaglandin D2; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha | 2008 |
Sex-dependent effects of periadolescent exposure to the cannabinoid agonist CP-55,940 on morphine self-administration behaviour and the endogenous opioid system.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Brain; Conditioning, Operant; Cyclohexanols; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Guanosine 5'-O-(3-Thiotriphosphate); Male; Morphine; Protein Binding; Rats; Rats, Wistar; Receptors, Opioid, mu; Reinforcement Schedule; Self Administration; Sex Characteristics; Statistics, Nonparametric; Sulfur Isotopes | 2008 |
Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.
Topics: Animals; Anti-Obesity Agents; Benzodioxoles; Body Weight; Crystallography, X-Ray; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Humans; Hypothermia; Ligands; Male; Mice; Microsomes; Models, Molecular; Molecular Structure; Obesity; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Structure-Activity Relationship | 2008 |
Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor.
Topics: Animals; Anti-Obesity Agents; Binding, Competitive; Blood-Brain Barrier; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Drug Inverse Agonism; Eating; Humans; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins; Transfection; Triazoles; Weight Gain | 2008 |
Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury.
Topics: Animals; Behavior, Animal; Cyclohexanols; Drug Tolerance; Indoles; Male; Microglia; Oligodendroglia; Pain Measurement; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Spinal Cord | 2008 |
Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal!
Topics: Animals; Antibodies; Antibody Specificity; Autoradiography; Brain; Cell Line, Transformed; Cyclohexanols; Fluorescent Antibody Technique; Hemagglutination; Humans; Mice; Protein Structure, Tertiary; Rats; Receptor, Cannabinoid, CB1; Transfection; Tritium | 2008 |
Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells.
Topics: Arachidonic Acids; Caco-2 Cells; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Deoxyglucose; Dronabinol; Endocannabinoids; Humans; Indoles; Intestinal Absorption; Piperidines; Polyunsaturated Alkamides; Pyrazoles | 2008 |
Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Analgesics; Animals; Binding, Competitive; Brain; Cyclohexanols; Disease Models, Animal; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant; Species Specificity | 2008 |
Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor.
Topics: Animals; Cell Line, Tumor; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Enhancer Elements, Genetic; Genes, Reporter; GTP-Binding Protein alpha Subunits, Gi-Go; Luciferases, Renilla; Mice; Protein Kinase Inhibitors; Receptor, Cannabinoid, CB1; Signal Transduction; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2008 |
The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: implications in Parkinson's disease.
Topics: Animals; Anthracenes; Antioxidants; Behavior, Animal; Cyclohexanols; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Interactions; Enzyme Inhibitors; Feeding Behavior; Female; Glucose; Herbicides; Immunosuppressive Agents; Male; Motor Activity; Paraquat; Survival Analysis; Time Factors; Tocopherols | 2008 |
Cannabinoids and hamster circadian activity rhythms.
Topics: Analgesics; Animals; Benzofurans; Cannabinoids; Circadian Rhythm; Cricetinae; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2008 |
The cannabinoid receptor agonist CP-55,940 and ethyl arachidonate interfere with [(3)H]batrachotoxinin A 20 alpha-benzoate binding to sodium channels and inhibit sodium channel function.
Topics: Animals; Arachidonic Acids; Batrachotoxins; Brain; Cannabinoid Receptor Agonists; Cyclohexanols; Mice; Piperidines; Pyrazoles; Sodium Channels; Veratridine | 2008 |
Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice.
Topics: Animals; Arachidonic Acids; Arrestins; beta-Arrestins; Body Temperature; Brain; Cyclohexanols; Dronabinol; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Pain Threshold; Radioligand Assay; Receptor, Cannabinoid, CB1 | 2008 |
Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment.
Topics: Analgesics; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Cyclohexanols; Depressive Disorder, Major; Disease Models, Animal; Endocannabinoids; Imipramine; Male; Motivation; Polyunsaturated Alkamides; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Sexual Behavior, Animal; Stress, Psychological | 2008 |
Temporal and site-specific brain alterations in CB1 receptor binding in high fat diet-induced obesity in C57Bl/6 mice.
Topics: Animals; Body Weight; Brain; Cannabinoids; Cyclohexanols; Diet; Dietary Fats; Energy Intake; Humans; Leptin; Male; Mice; Mice, Inbred C57BL; Obesity; Receptor, Cannabinoid, CB1 | 2008 |
Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism.
Topics: Amphetamine; Animals; Cocaine; Corpus Striatum; Cyclohexanols; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Image Processing, Computer-Assisted; Macaca fascicularis; Male; Manganese; Parkinsonian Disorders; Positron-Emission Tomography; Substantia Nigra; Synaptic Transmission; Tetrabenazine; Tyrosine 3-Monooxygenase | 2008 |
CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Calcium; Calcium Channels; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; GTP-Binding Proteins; Immunosuppressive Agents; Mice; Mice, Knockout; Oligodendroglia; Optic Nerve; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Time Factors | 2009 |
Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein G(alpha)i2beta1gamma2.
Topics: Animals; Cell Line, Transformed; Cyclohexanols; Dose-Response Relationship, Drug; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein gamma Subunits; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Insecta; Protein Binding; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Time Factors | 2008 |
Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells.
Topics: Animals; Cell Line, Tumor; Cyclohexanols; Dronabinol; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptor, Cannabinoid, CB1; Signal Transduction | 2008 |
The type 1 cannabinoid receptor is highly expressed in embryonic cortical projection neurons and negatively regulates neurite growth in vitro.
Topics: Analgesics; Animals; Cell Adhesion Molecules, Neuronal; Cell Compartmentation; Cells, Cultured; Cerebral Cortex; Cyclohexanols; Dendrites; Endosomes; Extracellular Matrix Proteins; Glutamic Acid; Growth Cones; Growth Inhibitors; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neurites; Neurogenesis; Rats; Receptor, Cannabinoid, CB1; Reelin Protein; Serine Endopeptidases; Stem Cells | 2008 |
Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression.
Topics: Adenylyl Cyclases; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Cell Line, Tumor; Colforsin; Cyclohexanols; DNA Primers; Dronabinol; Enzyme Activation; Excitatory Amino Acid Antagonists; Genes, Reporter; Luciferases; Mice; Neuroblastoma; Pertussis Toxin; Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tyrosine 3-Monooxygenase | 2009 |
mu-Opioid receptor forms a functional heterodimer with cannabinoid CB1 receptor: electrophysiological and FRET assay analysis.
Topics: Animals; Blotting, Western; Calcium; Cell Line; Cell Membrane; Chloride Channels; Cyclohexanols; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fluorescence Resonance Energy Transfer; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Immunoprecipitation; Membrane Potentials; Patch-Clamp Techniques; Pertussis Toxin; Protein Multimerization; Rats; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Recombinant Fusion Proteins; Signal Transduction; Transfection; Type C Phospholipases; Xenopus | 2008 |
Effect of cannabinoids upon the uptake of folic acid by BeWo cells.
Topics: Arachidonic Acids; Carrier Proteins; Cell Culture Techniques; Cell Line, Tumor; Cyclohexanols; Dronabinol; Drug Administration Schedule; Endocannabinoids; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Hydrogen-Ion Concentration; Indoles; Membrane Transport Proteins; Piperidines; Placenta; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cell Surface | 2009 |
PKCepsilon regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2.
Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Benzoxazines; Competitive Bidding; Cyclohexanols; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Hypothermia; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Motor Activity; Naphthalenes; Peptides; Protein Binding; Protein Kinase C-epsilon; Receptor, Cannabinoid, CB1; Serine; Tritium | 2009 |
Chronic nicotine alters cannabinoid-mediated locomotor activity and receptor density in periadolescent but not adult male rats.
Topics: Adolescent; Aging; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dronabinol; Female; Humans; Male; Motor Activity; Nicotine; Nicotinic Agonists; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid | 2009 |
HU210-induced downregulation in cannabinoid CB1 receptor binding strongly correlates with body weight loss in the adult rat.
Topics: Animals; Autoradiography; Basal Ganglia; Brain; Cerebral Cortex; Cyclohexanols; Down-Regulation; Dronabinol; Male; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Weight Loss | 2009 |
Altered CB receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Cyclohexanols; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Exploratory Behavior; Fluoxetine; Guanosine 5'-O-(3-Thiotriphosphate); Immunosuppressive Agents; Isotopes; Male; Olfactory Bulb; Prefrontal Cortex; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Time Factors | 2009 |
Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter.
Topics: Allosteric Regulation; Animals; Calcium; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Dopamine Plasma Membrane Transport Proteins; Humans; Isoxazoles; Male; Mice; Motor Activity; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Tropanes | 2009 |
(Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bronchi; Calcium; Cannabinoid Receptor Modulators; Cannabinoids; Cell Line; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Epithelial Cells; Humans; RNA, Messenger; TRPC Cation Channels | 2009 |
Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol.
Topics: Analysis of Variance; Animals; Catheterization; Central Nervous System Agents; Cyclohexanols; Dronabinol; Hippocampus; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Microinjections; Piperidines; Psychotropic Drugs; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells.
Topics: Arachidonic Acids; Benzoxazines; Blotting, Western; Calcium; Cannabinoid Receptor Modulators; Cannabinoids; Cell Line; Cyclic GMP; Cyclohexanols; Endocannabinoids; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Humans; Morpholines; Naphthalenes; Neurons; Nitric Oxide Synthase Type I; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2009 |
Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Binding, Competitive; Brain; Cyclohexanols; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Emotions; Injections, Subcutaneous; Male; Mice; Models, Animal; Motor Activity; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Salvia; Swimming | 2009 |
Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats.
Topics: Analgesics; Animals; Arachidonic Acids; Baroreflex; Blood Pressure; Cannabinoid Receptor Modulators; Cyclohexanols; Endocannabinoids; GABA Antagonists; Hypertension; Male; Protein Binding; Pyridazines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cannabinoid, CB1; Solitary Nucleus; Sympathetic Nervous System; Time Factors; Tritium | 2009 |
Investigation of endocannabinoid modulation of conditioned responding evoked by a nicotine CS and the Pavlovian stimulus effects of CP 55,940 in adult male rats.
Topics: Animals; Conditioning, Classical; Cyclohexanols; Discrimination Learning; Drug Interactions; Male; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Pharmacological characterization of receptor redistribution and beta-arrestin recruitment assays for the cannabinoid receptor 1.
Topics: Arrestins; Benzoxazines; beta-Arrestins; Biological Assay; Cell Line, Tumor; Cyclohexanols; Endocytosis; Genes, Reporter; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Imaging, Three-Dimensional; Ligands; Luciferases; Morpholines; Naphthalenes; Pertussis Toxin; Receptor, Cannabinoid, CB1 | 2009 |
Location, structure, and dynamics of the synthetic cannabinoid ligand CP-55,940 in lipid bilayers.
Topics: Cannabinoids; Cyclohexanols; Diffusion; Ligands; Lipid Bilayers; Magnetic Resonance Spectroscopy; Molecular Structure | 2009 |
Antinociceptive effects of the non-selective cannabinoid receptor agonist CP 55,940 are absent in CB1(-/-) and not CB2(-/-) mice in models of acute and persistent pain.
Topics: Analgesics; Animals; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Hot Temperature; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain; Pain Measurement; Physical Stimulation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Nerves | 2009 |
Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells.
Topics: Adult; Amidohydrolases; Blotting, Western; Butadienes; Cell Line; Cell Survival; Cyclohexanols; Gene Expression Regulation; Humans; Hydrogen Peroxide; Male; Microscopy, Fluorescence; Middle Aged; Mitogen-Activated Protein Kinases; Nitriles; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Retinal Pigment Epithelium; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242.
Topics: Animals; Cannabinoids; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Indoles; Rats; Receptor, Cannabinoid, CB2 | 2009 |
Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory.
Topics: Animals; Anxiety; Cannabinoids; Corticosterone; Cues; Cyclohexanols; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory; Neural Cell Adhesion Molecules; Presenilin-1; Rats; Rats, Wistar; Synaptosomes | 2009 |
Inhibition of fatty-acid amide hydrolase and CB1 receptor antagonism differentially affect behavioural responses in normal and PCP-treated rats.
Topics: Amidohydrolases; Amphetamine; Animals; Autoradiography; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Cyclohexanols; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Hallucinogens; Interpersonal Relations; Male; Memory, Short-Term; Motor Activity; Neuropsychological Tests; Phencyclidine; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Sulfur Isotopes; Time Factors | 2010 |
Central cannabinoid signaling mediating food intake: a pharmacological-challenge magnetic resonance imaging and functional histology study in rat.
Topics: Animals; Brain; Brain Mapping; Cannabinoids; Central Nervous System Agents; Cyclohexanols; Drug Interactions; Eating; Genes, Immediate-Early; Hyperphagia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Oxygen; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization.
Topics: Amino Acid Sequence; Benzofurans; Cell Line; Cyclohexanols; Humans; Ligands; Microscopy, Confocal; Models, Molecular; Molecular Sequence Data; Mutagenesis; Radioligand Assay; Receptor, Cannabinoid, CB1; Sequence Homology, Amino Acid; X-Ray Diffraction | 2009 |
Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.
Topics: Acetic Acid; Analgesics; Animals; Anti-Obesity Agents; Camphanes; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger | 2009 |
Urethane, but not pentobarbitone, attenuates presynaptic receptor function in rats: a contribution to the choice of anaesthetic.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics; Animals; Cardiovascular System; Cerebral Cortex; Cyclohexanols; Decerebrate State; Electric Stimulation; Histamine Agonists; Imidazoles; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Thiourea; Urethane; Vasoconstrictor Agents | 2009 |
Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects.
Topics: Analgesics; Analgesics, Opioid; Animals; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Excitatory Amino Acid Antagonists; Hot Temperature; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Morphine; Pain; Pain Measurement; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate | 2010 |
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
Topics: Analgesics; Arrestins; beta-Arrestins; Cannabinoid Receptor Agonists; Cannabinoids; Cell Line; Cyclohexanols; Humans; Ligands; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Obesity; Phosphorylation; Piperidines; Protein Kinase C; Protein Kinase C beta; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant | 2009 |
Alteration of theta timescale dynamics of hippocampal place cells by a cannabinoid is associated with memory impairment.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Choice Behavior; Cyclohexanols; Hippocampus; Memory Disorders; Motor Activity; Pyramidal Cells; Rats; Rats, Long-Evans; Running; Theta Rhythm | 2009 |
Risperidone treatment increases CB1 receptor binding in rat brain.
Topics: Adiponectin; Animals; Antipsychotic Agents; Brain; Cyclohexanols; Dopamine Antagonists; Eating; Ghrelin; Male; Motor Activity; Neuropeptide Y; Pro-Opiomelanocortin; Prolactin; Protein Binding; Raclopride; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D2; Receptors, Ghrelin; Risperidone; RNA, Messenger; Tritium; Weight Gain | 2010 |
Acute cannabinoid administration attenuates female socio-sexual motivation.
Topics: Animals; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Estrus; Female; Male; Motivation; Rats; Rats, Long-Evans; Sexual Behavior, Animal | 2010 |
In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists.
Topics: Analgesics; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Drug Inverse Agonism; Formaldehyde; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Molecular Structure; Pain; Quinolones; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship | 2010 |
Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant.
Topics: Amides; Analysis of Variance; Animals; Autoradiography; Benzoxazines; Body Weight; Brain; Cyclohexanols; Diet Fads; Disease Models, Animal; Eating; Female; Guanosine 5'-O-(3-Thiotriphosphate); International Cooperation; Morpholines; Naphthalenes; Obesity; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Isotopes; Time Factors; Tomography Scanners, X-Ray Computed; Tritium; Whole Body Imaging | 2010 |
A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.
Topics: Animals; Arachidonic Acids; Autoradiography; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Cyclohexanols; Densitometry; Dopamine; Endocannabinoids; Environment; Glycerides; Limbic System; Lipid Metabolism; Male; Mass Spectrometry; Motor Activity; Olfactory Bulb; Piperidines; Pyrazoles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments.
Topics: Analgesics; Animals; Animals, Newborn; Arachidonic Acids; Astrocytes; Benzoxazines; Cannabinoids; Cells, Cultured; Cerebral Cortex; Connexin 43; Connexins; Culture Media, Conditioned; Cyclohexanols; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Ethidium; Gene Expression Regulation; Interleukin-1beta; Lipopolysaccharides; Maximum Tolerated Dose; Mice; Microglia; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Tumor Necrosis Factor-alpha | 2009 |
Cannabinoid inhibition of macrophage migration to the trans-activating (Tat) protein of HIV-1 is linked to the CB(2) cannabinoid receptor.
Topics: Cannabinoids; Chemotaxis; Cyclohexanols; Dronabinol; Gene Knockdown Techniques; HIV-1; Humans; Macrophages; Receptor, Cannabinoid, CB2; RNA, Small Interfering; tat Gene Products, Human Immunodeficiency Virus; U937 Cells | 2010 |
Characterization of active and inactive states of CB1 receptor and the differential binding state modulation by cannabinoid agonists, antagonists and inverse agonists.
Topics: Animals; Binding, Competitive; Brain; Cyclohexanols; Dogs; Drug Inverse Agonism; In Vitro Techniques; Ligands; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cyclohexanols; Dronabinol; Electric Stimulation; Endocannabinoids; Female; Ileum; In Vitro Techniques; Male; Morpholines; Myenteric Plexus; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid | 2010 |
TRPA1 receptor induced relaxation of the human urethra involves TRPV1 and cannabinoid receptor mediated signals, and cyclooxygenase activation.
Topics: Acrolein; Analysis of Variance; Arginine; Calcium Channels; Capsaicin; Cyclohexanols; Female; Humans; Immunohistochemistry; Indomethacin; Isothiocyanates; Male; Middle Aged; Nerve Tissue Proteins; Receptors, Cannabinoid; Signal Transduction; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels; Urethra | 2010 |
Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids.
Topics: Anemia, Sickle Cell; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Disease Models, Animal; Female; Hemoglobin, Sickle; Humans; Hyperalgesia; Male; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Neuroglia; Pain; Receptors, Opioid, mu; Recombinant Proteins; Skin; Spinal Cord; Substance P | 2010 |
Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs.
Topics: Adrenergic Agonists; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Clonidine; Cyclohexanols; Discrimination, Psychological; Dronabinol; Female; Heart Rate; Macaca mulatta; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2010 |
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhythm; COS Cells; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Drug Administration Routes; Eating; Food Deprivation; Green Fluorescent Proteins; Hemoglobins; Hyperphagia; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Peptide Fragments; Piperidines; Protein Transport; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Transfection | 2010 |
Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure.
Topics: Analgesics; Animals; Calcium; Cannabinoids; Cerebral Cortex; Cyclohexanols; Herbicides; Hydrogen Peroxide; Indoles; Membrane Potential, Mitochondrial; Mitochondria; Molecular Structure; Neuroprotective Agents; Oxidants; Paraquat; Rats; Superoxides | 2010 |
Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB(1) cannabinoid receptors.
Topics: Animals; Autoradiography; Body Weight; Brain; Cyclohexanols; Female; Male; Maze Learning; Memory Disorders; Nicotine; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Nicotinic; Sex Characteristics | 2011 |
The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats.
Topics: Animals; Behavior, Animal; Benzoxazines; Conditioning, Operant; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Morpholines; Naphthalenes; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Salicylic Acid; Tinnitus | 2010 |
Revisiting the complex influences of cannabinoids on motor functions unravels pharmacodynamic differences between cannabinoid agonists.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoids; Catalepsy; Cyclohexanols; Dronabinol; Male; Motor Activity; Rats; Rats, Wistar; Time Factors | 2010 |
Periadolescent exposure to cannabinoids alters the striatal and hippocampal dopaminergic system in the adult rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Cannabinoids; Corpus Striatum; Cyclohexanols; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Hippocampus; Male; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Sex Factors | 2010 |
The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dronabinol; Drug Tolerance; Exploratory Behavior; Genotype; Heterozygote; Male; Mice; Mice, Mutant Strains; Motor Activity; Neuregulin-1; Proto-Oncogene Proteins c-fos; Psychotropic Drugs; Reflex, Startle; Schizophrenia | 2011 |
Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure.
Topics: Age Distribution; Animals; Brain; Cyclohexanols; Dronabinol; Drug Administration Schedule; Drug Tolerance; Female; Male; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Sexual Maturation | 2010 |
Inhibition of monoacylglycerol lipase by troglitazone, N-arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Modulators; Chromans; Cyclohexanols; Dopamine; Enzyme Assays; Glycerides; Humans; Monoacylglycerol Lipases; Nitrophenols; Piperidines; PPAR gamma; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiazolidinediones; Troglitazone | 2010 |
Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.
Topics: Analgesics; Animals; Benzimidazoles; Biological Assay; Calcium; Cannabinoids; CHO Cells; Chromones; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Cycloleucine; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indoles; Naphthalenes; Neuroprotective Agents; Quinolines; Quisqualic Acid; Receptor, Cannabinoid, CB2; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Thiazoles | 2010 |
Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Blotting, Western; Bone Marrow Cells; Cannabinoid Receptor Modulators; Cell Communication; Cell Movement; Cells, Cultured; Cyclohexanols; Endocannabinoids; Female; Flow Cytometry; Glycerides; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Side-Population Cells; Stem Cell Niche; Stromal Cells | 2010 |
Cannabinoid effects on CB1 receptor density in the adolescent brain: an autoradiographic study using the synthetic cannabinoid HU210.
Topics: Age Factors; Analgesics; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Brain; Brain Mapping; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Male; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Tissue Distribution; Tritium | 2010 |
Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.
Topics: Analgesics; Animals; Binding Sites; Brain; Calcium; Cell Line; Cricetinae; Cricetulus; Cyclohexanols; Drug Inverse Agonism; Humans; In Vitro Techniques; Ligands; Male; Mice; Protein Multimerization; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship | 2010 |
Human platelets express authentic CB₁ and CB₂ receptors.
Topics: Adult; Binding, Competitive; Blood Platelets; Calcium; Camphanes; Cyclic AMP; Cyclohexanols; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Integrin beta3; Male; Piperidines; Platelet Count; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tritium; Young Adult | 2010 |
Cannabinoids increase conditioned ultrasonic vocalisations and cat odour avoidance in rats: strain differences in drug-induced anxiety.
Topics: Animals; Anxiety; Avoidance Learning; Cannabinoids; Cats; Conditioning, Psychological; Cyclohexanols; Male; Odorants; Rats; Rats, Inbred Lew; Rats, Wistar; Species Specificity; Ultrasonics; Vocalization, Animal | 2010 |
hCB2 ligand-interaction landscape: cysteine residues critical to biarylpyrazole antagonist binding motif and receptor modulation.
Topics: Amino Acid Substitution; Cyclohexanols; Cysteine; HEK293 Cells; Humans; Ligands; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB2; Tritium | 2010 |
Dual neuroprotective and neurotoxic effects of cannabinoid drugs in vitro.
Topics: Cannabinoids; Caspase 3; Cell Differentiation; Cell Proliferation; Cell Survival; Culture Media, Serum-Free; Cyclohexanols; Glucose; HEK293 Cells; Humans; L-Lactate Dehydrogenase; Neuroprotective Agents; Neurotoxins; Receptor, Cannabinoid, CB1; Stress, Physiological | 2011 |
Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.
Topics: Animals; Bone Marrow Cells; Cannabinoid Receptor Modulators; Cannabinoids; Cell Movement; Cyclohexanols; Female; Flow Cytometry; Hematopoiesis; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Cannabinoid, CB2; Stromal Cells | 2011 |
Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue.
Topics: Amino Acids; Animals; Binding, Competitive; Brain Chemistry; Cyclic AMP; Cyclohexanols; Cyclooxygenase 2 Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Isoxazoles; Male; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sulfonamides; Transfection | 2011 |
Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
The interaction of cannabinoid receptor agonists, CP55940 and WIN55212-2 with membranes using solid state 2H NMR.
Topics: Benzoxazines; Cannabinoids; Cell Membrane; Chemistry, Pharmaceutical; Crystallization; Cyclohexanols; Drug Evaluation, Preclinical; Immunosuppressive Agents; Ligands; Lipid Bilayers; Magnetic Resonance Spectroscopy; Models, Chemical; Morpholines; Naphthalenes; Phospholipids; Protein Conformation; Temperature | 2011 |
CB1 receptors and post-ischemic brain damage: studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzoxazines; Brain Ischemia; Cannabinoids; Cyclohexanols; Gerbillinae; Glucose; Hippocampus; Hypoxia; Morpholines; Naphthalenes; Neurons; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2011 |
Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Cyclohexanols; Disease Models, Animal; Estradiol; Estrogens; Female; Functional Laterality; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Infarction, Middle Cerebral Artery; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sulfur Isotopes; Time Factors; Tritium | 2011 |
Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.
Topics: Alkyl and Aryl Transferases; Benzoxazoles; Cell Line; Cell Membrane; Cloning, Molecular; Cyclohexanols; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Phenylurea Compounds; Phosphorylation; Piperidines; Plasmids; Pyrazoles; Pyrrolidines; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Rimonabant; Thiazoles; Urea | 2011 |
Dynamic mass redistribution as a means to measure and differentiate signaling via opioid and cannabinoid receptors.
Topics: Analgesics, Opioid; Animals; Butadienes; Cannabinoids; Carrier Proteins; Chemistry Techniques, Analytical; CHO Cells; Cricetinae; Cyclohexanols; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Protein alpha Subunits; Indoles; Male; Morphine; Nitriles; Optical Phenomena; Pertussis Toxin; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, G-Protein-Coupled; Receptors, Opioid; Signal Transduction | 2011 |
Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's disease.
Topics: Animals; Antioxidants; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dopamine; Dronabinol; Glutamic Acid; Lipopolysaccharides; Male; Mice; Motor Activity; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Substantia Nigra; Tyrosine 3-Monooxygenase | 2011 |
A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Calcium; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cannabinoids; Cerebellum; Cyclohexanols; Cytokines; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Inflammation; Lipopolysaccharides; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour.
Topics: Adrenocorticotropic Hormone; Analgesics; Animals; Arousal; Attention; Behavior, Animal; Body Weight; Cannabinoids; Cyclohexanols; Exploratory Behavior; Female; Hypothalamo-Hypophyseal System; Inhibition, Psychological; Injections, Intraperitoneal; Leptin; Male; Maternal Deprivation; Maze Learning; Motor Activity; Organ Size; Pituitary-Adrenal System; Rats; Rats, Wistar; Risk-Taking; Sensory Gating; Sex Factors | 2011 |
Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor.
Topics: Adenylyl Cyclases; Amino Acid Substitution; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; Cell Line, Transformed; Cell Membrane; Colforsin; Computer Simulation; Cyclic AMP; Cyclohexanols; HEK293 Cells; Humans; Ligands; Models, Molecular; Morpholines; Mutagenesis, Site-Directed; Naphthalenes; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction | 2011 |
Convulsant doses of a dopamine D1 receptor agonist result in Erk-dependent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrus.
Topics: Animals; Benzazepines; Convulsants; Cyclohexanols; Cytoskeletal Proteins; Dentate Gyrus; Early Growth Response Protein 1; Electrophysiology; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Phosphorylation; Receptors, Dopamine D1 | 2011 |
AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Dronabinol; Humans; Indoles; Ligands; Morpholines; Naphthalenes; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB2 | 2012 |
Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Area Under Curve; Body Weight; Cyclohexanols; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Edema; Enzyme-Linked Immunosorbent Assay; Freezing Reaction, Cataleptic; Hyperalgesia; Inflammation; Locomotion; Male; Mice; Neuralgia; Oleanolic Acid; Oligodeoxyribonucleotides, Antisense; Pain Threshold; Pentacyclic Triterpenes; Peroxidase; Protein Binding; Rats; Rats, Wistar; Receptors, Cannabinoid; Tritium | 2011 |
Dissimilar cannabinoid substitution patterns in mice trained to discriminate Δ(9)-tetrahydrocannabinol or methanandamide from vehicle.
Topics: Animals; Arachidonic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Generalization, Stimulus; Male; Mice; Mice, Inbred C57BL; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors | 2011 |
The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro.
Topics: Animals; Benzoxazines; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Mice; Morpholines; Naphthalenes; Phthalic Acids; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant | 2011 |
Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activation.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Cannabinoids; Cyclohexanols; Dronabinol; HEK293 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Receptor, Cannabinoid, CB1; Structure-Activity Relationship | 2011 |
Cannabinoids disrupt hippocampal sharp wave-ripples via inhibition of glutamate release.
Topics: Animals; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Female; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Nerve Net; Neural Inhibition; Receptor, Cannabinoid, CB1 | 2012 |
Cannabinoids attenuate hippocampal γ oscillations by suppressing excitatory synaptic input onto CA3 pyramidal neurons and fast spiking basket cells.
Topics: Animals; Benzoxazines; CA3 Region, Hippocampal; Cannabinoids; Carbachol; Cholinergic Agonists; Cyclohexanols; Excitatory Postsynaptic Potentials; Female; Inhibitory Postsynaptic Potentials; Interneurons; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Patch-Clamp Techniques; Pyramidal Cells; Receptor, Cannabinoid, CB1 | 2011 |
Cannabinoid receptor involvement in stress-induced cocaine reinstatement: potential interaction with noradrenergic pathways.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Addictive; Cannabinoids; Cocaine; Conditioning, Psychological; Cyclohexanols; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Imidazoles; Isoindoles; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Self Administration; Stress, Psychological | 2012 |
Cloning and pharmacological characterization of the dog cannabinoid CB₂receptor.
Topics: Amino Acid Sequence; Animals; Arachidonic Acids; Base Sequence; Benzoxazines; Binding, Competitive; Camphanes; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dogs; Dronabinol; Endocannabinoids; Humans; Mice; Molecular Sequence Data; Morpholines; Naphthalenes; Pan troglodytes; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Sequence Alignment | 2011 |
Corticosteroid dependent and independent effects of a cannabinoid agonist on core temperature, motor activity, and prepulse inhibition of the acoustic startle reflex in Wistar rats.
Topics: Animals; Body Temperature; Cannabinoid Receptor Agonists; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Inhibition, Psychological; Male; Metyrapone; Motor Activity; Rats; Rats, Wistar; Reflex, Startle | 2012 |
Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cannabinoids; Cyclohexanols; Female; Hippocampus; Male; Maternal Deprivation; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sex Characteristics | 2012 |
Dietary conditions and highly palatable food access alter rat cannabinoid receptor expression and binding density.
Topics: Analysis of Variance; Animals; Autoradiography; Body Weight; Brain; Bulimia; Cannabinoids; Cyclohexanols; Diet; Disease Models, Animal; Eating; Female; Food Deprivation; Food Preferences; Gene Expression Regulation; Genes; Nodose Ganglion; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Tritium | 2012 |
Pregabalin and topiramate regulate behavioural and brain gene transcription changes induced by spontaneous cannabinoid withdrawal in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Body Temperature; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Drug Tolerance; Fructose; gamma-Aminobutyric Acid; Male; Marijuana Abuse; Mice; Models, Animal; Motor Activity; Nucleus Accumbens; Pregabalin; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Topiramate; Transcription, Genetic; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2013 |
Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation.
Topics: Action Potentials; Analysis of Variance; Animals; Biological Clocks; Brain Waves; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Confidence Intervals; Cyclohexanols; Dronabinol; Electric Stimulation; Evoked Potentials; Hippocampus; Immunosuppressive Agents; Male; Maze Learning; Memory, Short-Term; Mental Disorders; Nerve Net; Neurons; Prefrontal Cortex; Rats; Rats, Long-Evans; Reaction Time; Receptors, Cannabinoid; Statistics, Nonparametric; Time Factors | 2011 |
Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes.
Topics: Alleles; Animals; Anxiety; Benzophenones; Benzoxazines; Biogenic Monoamines; Cannabinoid Receptor Agonists; Cannabinoids; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Cyclohexanols; Enzyme Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Nitrophenols; Pain Measurement; Phenotype; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Social Behavior; Swimming; Tolcapone | 2012 |
3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism.
Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Drug Inverse Agonism; Female; Freezing Reaction, Cataleptic; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship; Transfection | 2012 |
Recombinant cannabinoid type 2 receptor in liposome model activates g protein in response to anionic lipid constituents.
Topics: Cholesterol Esters; Cyclohexanols; GTP-Binding Proteins; Humans; Liposomes; Nuclear Magnetic Resonance, Biomolecular; Phospholipids; Receptor, Cannabinoid, CB2; Recombinant Proteins | 2012 |
Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness.
Topics: Age Factors; Analgesics; Anemia, Sickle Cell; Animals; Cannabinoid Receptor Antagonists; Cyclohexanols; Disease Models, Animal; Humans; Hyperalgesia; Hypoxia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pain; Pain Measurement; Temperature | 2012 |
Sex differences in cannabinoid 1 vs. cannabinoid 2 receptor-selective antagonism of antinociception produced by delta9-tetrahydrocannabinol and CP55,940 in the rat.
Topics: Analgesics; Animals; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Morphine; Motor Activity; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sex Characteristics | 2012 |
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium | 2012 |
Sex-specific disturbances of the glutamate/GABA balance in the hippocampus of adult rats subjected to adolescent cannabinoid exposure.
Topics: Animals; Cannabinoids; Cyclohexanols; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Neurons; Rats; Rats, Wistar; Sex Factors; Synaptic Transmission | 2012 |
Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation.
Topics: Allosteric Regulation; Animals; Cyclohexanols; Drug Synergism; Endocytosis; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Hippocampus; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neurons; Pertussis Toxin; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Secondary; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.
Topics: Animals; Cannabinoids; Corpus Striatum; Cyclohexanols; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Male; Protein Binding; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Tyrosine 3-Monooxygenase | 2012 |
Long-lasting increase in [³H]CP55,940 binding to CB1 receptors following cocaine self-administration and its withdrawal in rats.
Topics: Animals; Behavior, Animal; Brain; Cannabinoids; Cocaine; Cyclohexanols; Dopamine Uptake Inhibitors; Extinction, Psychological; Ligands; Male; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Self Administration; Up-Regulation | 2012 |
Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cyclohexanols; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Pain; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1 | 2012 |
Effects of CP 55,940--agonist of CB1 cannabinoid receptors on ghrelin and somatostatin producing cells in the rat pancreas.
Topics: Animals; Cyclohexanols; Ghrelin; Islets of Langerhans; Male; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Somatostatin | 2012 |
Chronic cannabinoid treatment during young adulthood induces sex-specific behavioural deficits in maternally separated rats.
Topics: Acoustic Stimulation; Analgesics; Analysis of Variance; Animals; Behavioral Symptoms; Cannabinoids; Cyclohexanols; Female; Food Preferences; Inhibition, Psychological; Male; Maternal Deprivation; Maze Learning; Motor Activity; Rats; Rats, Wistar; Recognition, Psychology; Reflex, Startle; Sex Characteristics; Sucrose | 2012 |
Apparent inverse relationship between cannabinoid agonist efficacy and tolerance/cross-tolerance produced by Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys.
Topics: Animals; Cannabinoids; Cannabis; Cyclohexanols; Dronabinol; Drug Tolerance; Female; Indoles; Macaca mulatta; Male; Naphthalenes; Receptor, Cannabinoid, CB1 | 2012 |
Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure.
Topics: Amidohydrolases; Amygdala; Animals; Anxiety; Arachidonic Acids; Chronic Disease; Cyclohexanols; Dendrites; Drug Evaluation, Preclinical; Endocannabinoids; Exploratory Behavior; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Polyunsaturated Alkamides; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Stress, Psychological | 2013 |
Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors.
Topics: Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Cannabinoid Receptor Agonists; Cannabinoids; Cells, Cultured; Clathrin; Cyclohexanols; Endocytosis; Indenes; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptor, Serotonin, 5-HT2A; RNA, Small Interfering; Up-Regulation | 2013 |
CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation.
Topics: Amidohydrolases; Animals; Autoradiography; Avoidance Learning; Brain; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Male; Maze Learning; Mice; Mice, Inbred C57BL; Motivation; Receptor, Cannabinoid, CB1 | 2012 |
Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission.
Topics: Animals; Anxiety; Behavior, Animal; Cannabinoids; Cyclohexanols; Cyclopentanes; Dose-Response Relationship, Drug; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pyrimidines; Receptor, Cannabinoid, CB1; Receptors, GABA-B; Synaptic Transmission | 2012 |
Dissociable effects of the cannabinoid receptor agonists Δ9-tetrahydrocannabinol and CP55940 on pain-stimulated versus pain-depressed behavior in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain; Cannabinoid Receptor Agonists; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Eating; Electrodes, Implanted; Ketoprofen; Lactic Acid; Male; Pain; Rats; Rats, Sprague-Dawley; Self Stimulation | 2012 |
Activation-dependent subcellular distribution patterns of CB1 cannabinoid receptors in the rat forebrain.
Topics: Animals; Cyclohexanols; Endosomes; Intracellular Space; Male; Neurons; Piperidines; Prosencephalon; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2013 |
Pharmacological effects of cannabinoids on the reference and working memory functions in mice.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Male; Maze Learning; Memory; Memory, Short-Term; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity | 2013 |
Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Antibodies, Monoclonal, Murine-Derived; Binding, Competitive; Brain; Cannabinoid Receptor Modulators; CHO Cells; Cricetinae; Cyclohexanols; Epitope Mapping; Female; Hemoglobins; HL-60 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NZB; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Transport; Rats; Receptor, Cannabinoid, CB1; Signal Transduction; Sus scrofa; Tandem Mass Spectrometry | 2012 |
Long-term cognitive impairments induced by chronic cannabinoid exposure during adolescence in rats: a strain comparison.
Topics: Age Factors; Animals; Cannabinoids; Cognition Disorders; Cyclohexanols; Male; Memory, Short-Term; Rats; Rats, Wistar; Spatial Behavior; Species Specificity; Time Factors | 2013 |
Upregulation of CB₁ receptor binding in the ventromedial prefrontal cortex promotes proactive stress-coping strategies following chronic stress exposure.
Topics: Adaptation, Psychological; Analgesics; Animals; Cues; Cyclohexanols; Disease Models, Animal; Male; Prefrontal Cortex; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Psychological; Swimming; Tritium; Up-Regulation | 2013 |
Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT(2A)) receptor activity via ERK1/2 signaling.
Topics: Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Extracellular Signal-Regulated MAP Kinases; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptor, Serotonin, 5-HT2A; RNA, Messenger; Transcription, Genetic; Up-Regulation | 2013 |
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.
Topics: Allosteric Regulation; Animals; Arrestins; Benzoxazines; beta-Arrestins; Brain; Cell Line; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Indoles; Kinetics; Ligands; Male; MAP Kinase Signaling System; Mice; Morpholines; Naphthalenes; Phosphorylation; Piperidines; Protein Binding; Receptor, Cannabinoid, CB1; Signal Transduction | 2013 |
Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors.
Topics: Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Concanavalin A; Cyclohexanols; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptor, Serotonin, 5-HT2A; RNA, Messenger; RNA, Small Interfering; Up-Regulation | 2013 |
Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony.
Topics: Animals; Cannabinoids; Cerebral Cortex; Corpus Striatum; Cortical Synchronization; Cyclohexanols; Electromyography; GABAergic Neurons; Glutamic Acid; Mice; Mice, Mutant Strains; Nerve Net; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Substantia Nigra; Thalamus | 2013 |
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Benzodioxoles; Brain Chemistry; Cyclohexanols; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders | 2013 |
Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.
Topics: Amino Acid Sequence; Benzoxazines; Binding, Competitive; Cell Line; Cyclohexanols; Energy Metabolism; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Models, Chemical; Molecular Sequence Data; Morpholines; Mutagenesis, Site-Directed; Naphthalenes; Piperidines; Protein Conformation; Protein Structure, Secondary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2013 |
Long-term CB₁ receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Up-Regulation | 2013 |
Interactions between μ-opioid receptor agonists and cannabinoid receptor agonists in rhesus monkeys: antinociception, drug discrimination, and drug self-administration.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cyclohexanols; Data Interpretation, Statistical; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Heroin Dependence; Hot Temperature; Macaca mulatta; Morphine; Morpholines; Naphthalenes; Pain Measurement; Receptors, Cannabinoid; Receptors, Opioid, mu; Self Administration | 2013 |
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Male; Phencyclidine; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Quinazolinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Schizophrenia; Social Behavior | 2013 |
Further evaluation of the neuropharmacological determinants of the antidepressant-like effects of curcumin.
Topics: Animals; Antidepressive Agents; Brain; Curcumin; Cyclohexanols; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Immunosuppressive Agents; Male; Mice; Mice, Knockout; Monoamine Oxidase Inhibitors; Protein Binding; Receptor, Cannabinoid, CB1; Receptors, Biogenic Amine; Swimming | 2013 |
G-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors.
Topics: Analgesics; Animals; Anxiety; Arrestins; beta-Arrestin 2; beta-Arrestins; Calcium; Cell Culture Techniques; Cyclohexanols; G-Protein-Coupled Receptor Kinase 5; Humans; Lentivirus; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 3; Models, Biological; Nerve Tissue Proteins; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptor, Serotonin, 5-HT2A; RNA Interference; Schizophrenia; Up-Regulation | 2013 |
Identification of raloxifene as a novel CB2 inverse agonist.
Topics: Benzoxazines; Binding, Competitive; Bone Density Conservation Agents; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Approval; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Morpholines; Naphthalenes; Raloxifene Hydrochloride; Receptor, Cannabinoid, CB2; Transfection; Tritium; United States; United States Food and Drug Administration | 2013 |
Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats.
Topics: Animals; Anxiety; Behavior, Animal; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Male; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Up-Regulation | 2013 |
Developmental effects of cannabinoids on zebrafish larvae.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cyclohexanols; Dronabinol; Embryo, Nonmammalian; Female; Larva; Lethal Dose 50; Locomotion; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Toxicity Tests, Acute; Toxicity Tests, Chronic; Zebrafish | 2013 |
Do cannabinoids exhibit a tyramine-like effect?
Topics: Adrenergic Uptake Inhibitors; Animals; Arachidonic Acids; Benzoxazines; Cannabidiol; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Glycerides; Kidney Cortex; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Time Factors; Tyramine | 2013 |
Cannabinoids in disguise: Δ9-tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Protein Binding; Receptor, Cannabinoid, CB1; Sulfur Isotopes; Transfection; Tritium | 2013 |
Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line, Tumor; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Indoles; Kinetics; Ligands; Membrane Potentials; Mice; Phenylurea Compounds; Piperidines; Potassium Channels, Inwardly Rectifying; Protein Transport; Pyridines; Rats; Receptor, Cannabinoid, CB1; Signal Transduction; Transfection | 2013 |
Crosstalk between dopamine D₂ receptors and cannabinoid CB₁ receptors regulates CNR1 promoter activity via ERK1/2 signaling.
Topics: Animals; Base Sequence; Blotting, Western; Cell Line, Tumor; Cyclohexanols; DNA; Female; Genes, Reporter; Glioma; MAP Kinase Signaling System; Molecular Sequence Data; Neostriatum; Plasmids; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; RNA; Transfection | 2013 |
Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cyclic AMP; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Indoles; Isomerism; Male; Molecular Structure; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
The membrane proximal region of the cannabinoid receptor CB1 N-terminus can allosterically modulate ligand affinity.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Chlorocebus aethiops; COS Cells; Cyclohexanols; Cysteine; Disulfides; Dithiothreitol; Humans; Indoles; Ligands; Phenylurea Compounds; Piperidines; Pyridines; Rats; Receptor, Cannabinoid, CB1 | 2013 |
Benzophenanthridine alkaloid, piperonyl butoxide and (S)-methoprene action at the cannabinoid-1 receptor (CB1-receptor) pathway of mouse brain: Interference with [(3)H]CP55940 and [(3)H]SR141716A binding and modification of WIN55212-2-dependent inhibition
Topics: Animals; Benzophenanthridines; Benzoxazines; Binding Sites; Brain; Cyclohexanols; Glutamic Acid; Isoquinolines; Male; Methoprene; Mice; Morpholines; Naphthalenes; Piperidines; Piperonyl Butoxide; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spleen; Synaptosomes | 2014 |
The role of cannabinoid 1 receptor expressing interneurons in behavior.
Topics: Amphetamine; Analgesics; Animals; Behavior, Animal; Brain; Central Nervous System Stimulants; Conditioning, Psychological; Cyclohexanols; Exploratory Behavior; Glutamate Decarboxylase; Interneurons; Locomotion; Mice; Mice, Transgenic; Mutation; Neuropeptide Y; Receptor, Cannabinoid, CB1; RNA, Messenger; Sensory Gating | 2014 |
The agonist binding mechanism of human CB2 receptor studied by molecular dynamics simulation, free energy calculation and 3D-QSAR studies.
Topics: Binding Sites; Cyclohexanols; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Pyrans; Pyrimidines; Quantitative Structure-Activity Relationship; Receptor, Cannabinoid, CB2 | 2013 |
The cannabinoid agonist HU-210: pseudo-irreversible discriminative stimulus effects in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Time Factors | 2014 |
Cannabinoid neuromodulation in the adult early visual cortex.
Topics: Animals; Cannabinoids; Cyclohexanols; Electrophysiological Phenomena; Macaca mulatta; Neurons; Photic Stimulation; Visual Cortex | 2014 |
In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.
Topics: Allosteric Regulation; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Catalepsy; Cyclohexanols; Dronabinol; Drug Evaluation; Eating; Endocannabinoids; Female; Hypothermia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nociception; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Strain differences in the expression of endocannabinoid genes and in cannabinoid receptor binding in the brain of Lewis and Fischer 344 rats.
Topics: Amidohydrolases; Animals; Autoradiography; Brain; Cyclohexanols; Immunosuppressive Agents; Lipoprotein Lipase; Male; Phospholipase D; Protein Binding; Radiography; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Species Specificity; Tritium | 2014 |
Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.
Topics: Blood-Brain Barrier; Cannabinoid Receptor Agonists; Cell Adhesion; Collagen Type IV; Cyclohexanols; Dronabinol; Extracellular Matrix; Extracellular Matrix Proteins; HIV-1; Humans; Inflammation; Laminin; Monocytes; Receptor, Cannabinoid, CB2; Recombinant Proteins; tat Gene Products, Human Immunodeficiency Virus; U937 Cells | 2014 |
Modulation of pilocarpine-induced seizures by cannabinoid receptor 1.
Topics: Animals; Cyclohexanols; Male; Mice; Mice, Knockout; Muscarinic Agonists; Pilocarpine; Proliferating Cell Nuclear Antigen; Receptor, Cannabinoid, CB1; Seizures | 2014 |
Effects of dietary glucose and fructose upon cannabinoid CB1 receptor functionality in the rat brain: a pilot study.
Topics: Adiponectin; Analysis of Variance; Animals; Autoradiography; Brain; Cyclohexanols; Dietary Carbohydrates; Fructose; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); Leptin; Male; Pilot Projects; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Statistics, Nonparametric | 2014 |
Type-1 cannabinoid receptor activity during Alzheimer's disease progression.
Topics: Alzheimer Disease; Analgesics; Benzoxazines; Brain; Cyclohexanols; Diagnosis; Disease Progression; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isotopes; Male; Morpholines; Naphthalenes; Radionuclide Imaging; Receptor, Cannabinoid, CB1; Statistics, Nonparametric | 2014 |
JWH-018 in rhesus monkeys: differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects.
Topics: Animals; Benzoxazines; Body Temperature; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dronabinol; Hypothermia; Indoles; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Brain Injuries; Cannabinoid Receptor Modulators; Cyclohexanols; Disease Models, Animal; Female; Isoquinolines; Piperidines; Protein Binding; Pyrazoles; Radionuclide Imaging; Receptors, Cannabinoid; Receptors, GABA; Rimonabant; Swine; Time Factors; Tritium | 2014 |
The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells.
Topics: Arachidonic Acids; Benzodioxoles; Cannabinoids; Cell Line, Tumor; Cell Proliferation; Cyclohexanols; Endocannabinoids; Enzyme Inhibitors; ErbB Receptors; Ethanolamines; Gene Expression Regulation, Neoplastic; Glycerides; Humans; Male; Monoacylglycerol Lipases; Piperidines; Polyunsaturated Alkamides; Prostate; Receptor, Cannabinoid, CB1; Signal Transduction | 2014 |
Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons.
Topics: Animals; Arachidonic Acids; Arrestin; Benzoxazines; Blotting, Western; Cannabinoid Receptor Agonists; Cannabinoids; Cells, Cultured; Corpus Striatum; Cyclohexanols; Dendritic Spines; Dronabinol; Endocannabinoids; Fluorescence Resonance Energy Transfer; Glycerides; GTP-Binding Proteins; Ligands; Luminescent Proteins; Mice; Models, Biological; Morpholines; Naphthalenes; Neurons; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Signal Transduction | 2014 |
Examining the critical roles of human CB2 receptor residues Valine 3.32 (113) and Leucine 5.41 (192) in ligand recognition and downstream signaling activities.
Topics: Animals; Binding Sites; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; CHO Cells; Cricetulus; Cyclic AMP; Cyclohexanols; Escherichia coli; Humans; Hydrophobic and Hydrophilic Interactions; Leucine; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB2; Recombinant Proteins; Signal Transduction; Valine | 2014 |
Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex.
Topics: Age Factors; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Developmental Disabilities; Dizocilpine Maleate; Dronabinol; Estradiol; Estrous Cycle; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Neurites; Piperidines; Prefrontal Cortex; Pyrazoles; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptic Potentials; Tritium | 2015 |
Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459.
Topics: Animals; Benzoxazines; Brain; Cannabinoid Receptor Antagonists; Cyclohexanols; Electroencephalography; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Sleep; Sleep, REM; Wakefulness | 2015 |
CP55,940 attenuates spatial memory retrieval in mice.
Topics: Analgesics; Animals; Blood-Brain Barrier; Cognition; Cyclohexanols; Dose-Response Relationship, Drug; Male; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Spatial Memory | 2014 |
Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells.
Topics: Animals; Carrier Proteins; Cell Line, Tumor; Cyclic AMP; Cyclohexanols; GTP-Binding Protein alpha Subunits, Gi-Go; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction | 2015 |
Cannabinoid receptor agonists reduce the short-term mitochondrial dysfunction and oxidative stress linked to excitotoxicity in the rat brain.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cell Survival; Cells, Cultured; Cyclohexanols; Endocannabinoids; Excitatory Amino Acid Agents; Lipid Peroxidation; Male; Mitochondria; Morpholines; Naphthalenes; Neurons; Oxidative Stress; Polyunsaturated Alkamides; Quinolinic Acid; Rats, Wistar; Reactive Oxygen Species; Receptors, Cannabinoid; Synaptosomes | 2015 |
A potential role for cannabinoid receptors in the therapeutic action of fenofibrate.
Topics: Allosteric Regulation; Animals; Binding, Competitive; CHO Cells; Cricetulus; Cyclohexanols; Fenofibrate; Guinea Pigs; Humans; Ileum; In Vitro Techniques; MAP Kinase Signaling System; PPAR alpha; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins | 2015 |
Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting the cannabinoid receptor type 1.
Topics: Benzimidazoles; Binding Sites; Binding, Competitive; Cannabinoid Receptor Agonists; Computer-Aided Design; Cyclohexanols; Drug Design; Ligands; Molecular Docking Simulation; Molecular Structure; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Receptor, Cannabinoid, CB1 | 2015 |
The effect of phytocannabinoids on airway hyper-responsiveness, airway inflammation, and cough.
Topics: Airway Resistance; Animals; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cannabinoid Receptor Agonists; Cannabinoids; Cannabis; Citric Acid; Cough; Cyclohexanols; Guinea Pigs; Inflammation; Isometric Contraction; Lipopolysaccharides; Male; Muscle, Smooth; Respiratory Hypersensitivity; Respiratory System; Trachea; Tumor Necrosis Factor-alpha | 2015 |
Effects of acute and repeated dosing of the synthetic cannabinoid CP55,940 on intracranial self-stimulation in mice.
Topics: Animals; Brain; Catalepsy; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Drug Tolerance; Male; Medial Forebrain Bundle; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation | 2015 |
The effects of beta-arrestin1 deletion on acute cannabinoid activity, brain cannabinoid receptors and tolerance to cannabinoids in mice.
Topics: Animals; Arrestins; beta-Arrestins; Brain; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Dronabinol; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sequence Deletion | 2015 |
The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents.
Topics: Amidohydrolases; Animals; Benzodioxoles; Carbamates; Colon; Cyclohexanols; Inflammation; Male; Mice; Mice, Inbred BALB C; Monoacylglycerol Lipases; Pain Measurement; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Visceral Pain | 2015 |
CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain.
Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Mice, Knockout; Neuralgia; Paclitaxel; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Treatment Outcome | 2015 |
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.
Topics: Allosteric Regulation; Animals; Benzoxazines; Cannabinoid Receptor Agonists; CHO Cells; Cricetulus; Cyclohexanols; Dronabinol; Humans; Indoles; MAP Kinase Signaling System; Morpholines; Naphthalenes; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2015 |
Effects of amphetamine, morphine, and CP 55, 940 on Go/No-Go task performance in rhesus monkeys.
Topics: Amphetamine; Animals; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Female; Food; Impulsive Behavior; Macaca mulatta; Male; Morphine; Psychological Tests; Psychomotor Performance; Psychotropic Drugs; Reinforcement, Psychology | 2015 |
Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus.
Topics: Amidohydrolases; Anesthesia; Animals; Arachidonic Acids; Blood Pressure; Cannabinoids; Cerebral Cortex; Cyclohexanols; Endocannabinoids; Heart Rate; Male; Microinjections; Morpholines; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1.
Topics: Algorithms; Animals; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Chlorocebus aethiops; COS Cells; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Kinetics; Models, Biological; Models, Molecular; Mutation; Piperidines; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Sex-specific alterations in hippocampal cannabinoid 1 receptor expression following adolescent delta-9-tetrahydrocannabinol treatment in the rat.
Topics: Age Factors; Animals; Autoradiography; Cyclohexanols; Dronabinol; Female; Hippocampus; Male; Psychotropic Drugs; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Factors | 2015 |
On the effects of CP 55-940 and other cannabinoid receptor agonists in C6 and U373 cell lines.
Topics: Animals; Apoptosis; Arachidonic Acids; Astrocytes; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cyclohexanols; DNA; Endocannabinoids; Humans; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Wistar | 2015 |
Additive antinociceptive effects of mixtures of the κ-opioid receptor agonist spiradoline and the cannabinoid receptor agonist CP55940 in rats.
Topics: Analgesics; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hot Temperature; Male; Nociceptive Pain; Pain Threshold; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2016 |
Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acids; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Dopamine; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Humans; Ligands; Phosphorylation; Potassium Channels; Protein Transport; Rats; Receptor, Cannabinoid, CB1; Signal Transduction | 2016 |
Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cerebral Cortex; Corpus Striatum; Cyclohexanols; Dopamine; Dopamine Agents; Dronabinol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Mice; Mice, Transgenic; Morpholines; Naphthalenes; Protein Binding; Protein Kinases; Receptor, Cannabinoid, CB1; Synapses; Time Factors; Tritium | 2016 |
Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s).
Topics: Affinity Labels; Allosteric Site; Animals; Arrestins; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Drug Discovery; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Ligands; Models, Molecular; Phenylurea Compounds; Piperidines; Pyridines; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Structure-Activity Relationship | 2016 |
The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Catheters, Indwelling; Cerebral Cortex; Conditioning, Psychological; Cyclohexanols; Extinction, Psychological; Fear; Male; Memory Consolidation; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Cannabinoid receptor activation in the juvenile rat brain results in rapid biomechanical alterations: Neurovascular mechanism as a putative confounding factor.
Topics: Animals; Biomechanical Phenomena; Brain; Cannabinoid Receptor Agonists; Cerebrovascular Circulation; Confounding Factors, Epidemiologic; Cyclohexanols; Hippocampus; Magnetic Resonance Imaging; Neurons; Rats; Receptors, Cannabinoid; Viscoelastic Substances | 2016 |
Chronic cannabinoid exposure during adolescence leads to long-term structural and functional changes in the prefrontal cortex.
Topics: Animals; Blotting, Western; Cannabinoids; Chronic Disease; Cyclohexanols; Dendrites; Disease Models, Animal; Disks Large Homolog 4 Protein; Hippocampus; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Male; Marijuana Abuse; Membrane Proteins; Microelectrodes; Prefrontal Cortex; Pyramidal Cells; Rats, Wistar; Synaptophysin; Vesicular Glutamate Transport Proteins | 2016 |
Involvement of the infralimbic cortex and CA1 hippocampal area in reconsolidation of a contextual fear memory through CB1 receptors: Effects of CP55,940.
Topics: Animals; CA1 Region, Hippocampal; Cyclohexanols; Fear; Male; Memory Consolidation; Prefrontal Cortex; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2016 |
Disruption of social cognition in the sub-chronic PCP rat model of schizophrenia: Possible involvement of the endocannabinoid system.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Modulators; Cyclohexanols; Discrimination, Psychological; Disease Models, Animal; Endocannabinoids; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Odorants; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Social Behavior Disorders; Social Perception | 2016 |
Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor, neurological and neurochemical responses in mice.
Topics: Animals; Anisoles; Brain; Cells, Cultured; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Feedback, Sensory; Gait Disorders, Neurologic; Humans; Hypothermia; Indoles; Male; Mice; Mice, Inbred ICR; Naphthalenes; Nervous System Diseases; Pain Threshold; Reflex, Acoustic; Spleen; Vision, Ocular | 2016 |
Quantification of pain in sickle mice using facial expressions and body measurements.
Topics: Analgesics; Anemia, Sickle Cell; Animals; Behavior, Animal; Cold Temperature; Cyclohexanols; Disease Models, Animal; Facial Expression; Female; Humans; Male; Mice; Mice, Transgenic; Pain; Pain Measurement; Posture; Reproducibility of Results; Research Design | 2016 |
Combined Treatment with Morphine and Δ9-Tetrahydrocannabinol in Rhesus Monkeys: Antinociceptive Tolerance and Withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Heart Rate; Macaca mulatta; Morphine; Morpholines; Naphthalenes; Opioid-Related Disorders; Pain Measurement; Substance Withdrawal Syndrome | 2016 |
Effects of cannabinoid receptor activation by CP55,940 on normal bladder function and irritation-induced bladder overactivity in non-awake anaesthetised rats.
Topics: Acetic Acid; Administration, Intravesical; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Disease Models, Animal; Female; Indoles; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Treatment Outcome; Urinary Bladder; Urinary Bladder, Overactive; Urination; Urodynamics | 2016 |
Computational analysis of the CB1 carboxyl-terminus in the receptor-G protein complex.
Topics: Amino Acid Sequence; Analgesics; Binding Sites; Cell Membrane; Cyclohexanols; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Domains; Protein Structure, Secondary; Protein Subunits; Receptor, Cannabinoid, CB1; Recombinant Proteins | 2016 |
CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function.
Topics: Animals; Cannabinoids; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dronabinol; GTP-Binding Proteins; Humans; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Signal Transduction | 2016 |
Interactions between cannabinoid receptor agonists and mu opioid receptor agonists in rhesus monkeys discriminating fentanyl.
Topics: Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Discrimination, Psychological; Dronabinol; Drug Interactions; Female; Fentanyl; Macaca mulatta; Nalbuphine; Receptors, Opioid, mu | 2016 |
Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice.
Topics: Acetamides; Amidohydrolases; Animals; Carbamates; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases | 2016 |
Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues.
Topics: Analgesics; Animals; Body Temperature; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Heart Rate; Humans; Indazoles; Indoles; Leucine; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Valine | 2016 |
Cannabinoid receptor interacting protein suppresses agonist-driven CB
Topics: Animals; Benzoxazines; Carrier Proteins; Cell Line; Cell Membrane; Cyclohexanols; Endocannabinoids; Gene Dosage; Gene Knockdown Techniques; Mice; Morpholines; Naphthalenes; Piperidines; Protein Transport; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cell Surface; Rimonabant; RNA, Small Interfering; Signal Transduction | 2016 |
The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries.
Topics: Adult; Aged; Aged, 80 and over; Aorta; Arachidonic Acids; Cannabinoids; Cyclohexanols; Endocannabinoids; Endothelial Cells; Endothelium, Vascular; Female; Humans; Intracellular Signaling Peptides and Proteins; Male; Mesenteric Arteries; Middle Aged; Nitric Oxide; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Vasodilation | 2016 |
Behavioral Characterization of κ Opioid Receptor Agonist Spiradoline and Cannabinoid Receptor Agonist CP55940 Mixtures in Rats.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cyclohexanols; Drug Synergism; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Opioid, kappa | 2017 |
Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Breast Neoplasms; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Isomerism; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Selective Estrogen Receptor Modulators; Tamoxifen | 2016 |
Behavioral Determinants of Cannabinoid Self-Administration in Old World Monkeys.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Cercopithecidae; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Macaca fascicularis; Macaca mulatta; Male; Reaction Time; Receptors, Cannabinoid; Reinforcement, Psychology; Self Administration | 2017 |
Chronic inhibition of fatty acid amide hydrolase by URB597 produces differential effects on cardiac performance in normotensive and hypertensive rats.
Topics: Amidohydrolases; Animals; Antihypertensive Agents; Benzamides; Blood Pressure; Carbamates; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Isoproterenol; Male; Myocardial Contraction; Rats; Rats, Inbred SHR; Rats, Wistar; Structure-Activity Relationship | 2017 |
Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.
Topics: Adaptation, Ocular; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Agonists; Cyclohexanols; Disease Models, Animal; Dronabinol; Endocannabinoids; Excitatory Postsynaptic Potentials; Glycerides; Heterocyclic Compounds, 1-Ring; Locomotion; Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyridines; Signal Transduction | 2017 |
A Novel Selective Inverse Agonist of the CB
Topics: Animals; Cannabinoids; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Dose-Response Relationship, Drug; Drug Inverse Agonism; Humans; Protein Binding; Receptor, Cannabinoid, CB2; Tritium | 2017 |
The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB
Topics: Allosteric Regulation; Animals; Cannabinoid Receptor Modulators; Cerebellum; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Phenylurea Compounds; Piperidines; Pregnenolone; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant | 2017 |
Characterization of structurally novel G protein biased CB
Topics: Animals; beta-Arrestin 2; Cannabinoid Receptor Agonists; CHO Cells; Cricetulus; Cyclohexanols; GTP-Binding Proteins; Indoles; Male; Mice; Naphthalenes; Quinuclidines; Receptor, Cannabinoid, CB1 | 2017 |
Effects of morphine/CP55940 mixtures on an impulsive choice task in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Choice Behavior; Cyclohexanols; Dose-Response Relationship, Drug; Impulsive Behavior; Macaca mulatta; Male; Morphine; Pain; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Reinforcement, Psychology | 2018 |
Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism.
Topics: Animals; Binding, Competitive; Cannabinoid Receptor Antagonists; CHO Cells; Cricetulus; Cyclohexanols; Kinetics; Ligands; Protein Binding; Radioligand Assay; Receptor, Cannabinoid, CB1; Structure-Activity Relationship | 2018 |
Antinociceptive effects of mixtures of mu opioid receptor agonists and cannabinoid receptor agonists in rats: Impact of drug and fixed-dose ratio.
Topics: Analgesics; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2018 |
Sex differences in antinociceptive response to Δ-9-tetrahydrocannabinol and CP 55,940 in the mouse formalin test.
Topics: Analgesics; Analysis of Variance; Animals; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Female; Formaldehyde; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Pain; Pain Measurement; Receptor, Cannabinoid, CB1; Sex Characteristics; Time Factors; Treatment Outcome | 2018 |
Reinforcing effects of opioid/cannabinoid mixtures in rhesus monkeys responding under a food/drug choice procedure.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Choice Behavior; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Eating; Female; Macaca mulatta; Male; Reaction Time; Reinforcement, Psychology; Self Administration | 2018 |
Endocannabinoid and Muscarinic Signaling Crosstalk in the 3xTg-AD Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Brain; Cannabinoids; Cholinergic Agents; Cyclohexanols; Disease Models, Animal; Endocannabinoids; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Oxazines; Presenilin-1; Radioisotopes; Signal Transduction; tau Proteins | 2018 |
β-lactams modulate astroglial glutamate transporters and attenuate dependence to CP 55,940, a CB1 receptor agonist, in rat model.
Topics: Amino Acid Transport System X-AG; Ampicillin; Animals; Astrocytes; beta-Lactams; Brain; Cannabinoid Receptor Agonists; Central Nervous System Agents; Cyclohexanols; Disease Models, Animal; Drug-Seeking Behavior; Gene Expression; Male; Rats; Receptor, Cannabinoid, CB1; Substance-Related Disorders; Sulbactam | 2019 |
The role of (E)-6-chloro-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-2-styrylquinazolin-4(3H)-one in the modulation of cannabinoidergic system. A pilot study.
Topics: Animals; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Locomotion; Pilot Projects; Quinazolines; Rats; Rats, Wistar; Recognition, Psychology; Styrenes | 2018 |
Investigation of non-CB
Topics: Amphibians; Animals; Benzoxazines; Birds; Brain; Cannabinoids; Cyclohexanols; Dogs; Mammals; Morpholines; Naphthalenes; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, G-Protein-Coupled | 2018 |
Activity in nodose ganglia neurons after treatment with CP 55,940 and cholecystokinin.
Topics: Animals; Cannabinoid Receptor Agonists; Cells, Cultured; Cholecystokinin; Cyclohexanols; Male; Neurons; Nodose Ganglion; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2018 |
The effect of the cannabinoid receptor agonist and antagonist on the light-induced changes in the suprachiasmatic nucleus of rats.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Light; Male; Motor Activity; Piperidines; Pyrazoles; Rats, Wistar; Suprachiasmatic Nucleus | 2019 |
Do you feel it now? Route of administration and Δ
Topics: Administration, Inhalation; Aerosols; Animals; Behavior, Animal; Cannabinoids; Conditioning, Operant; Cyclohexanols; Electronic Nicotine Delivery Systems; Female; Indazoles; Injections, Intraperitoneal; Male; Mice, Inbred C57BL; Valine; Vaping | 2019 |
Revealing the Mechanism of Agonist-Mediated Cannabinoid Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric Modulation.
Topics: Allosteric Regulation; Cyclohexanols; Molecular Docking Simulation; Molecular Dynamics Simulation; Phospholipids; Protein Conformation; Receptor, Cannabinoid, CB1 | 2019 |
In vitro determination of the efficacy of illicit synthetic cannabinoids at CB
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line, Tumor; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Illicit Drugs; Mice; Receptor, Cannabinoid, CB1 | 2019 |
Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.
Topics: Allosteric Regulation; Crystallization; Cyclohexanols; Humans; Protein Binding; Receptor, Cannabinoid, CB1 | 2019 |
Allosteric modulators restore orthosteric agonist binding to mutated CB
Topics: Binding Sites; Cannabinoid Receptor Agonists; Cyclohexanols; HEK293 Cells; Humans; Indoles; Ligands; Mutation; Phenylurea Compounds; Piperidines; Protein Binding; Protein Conformation; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2020 |
Topics: Animals; Cell Cycle Proteins; CHO Cells; Cricetulus; Cyclohexanols; Drug Antagonism; Fatty Acids, Unsaturated; Glycine; Hydrophobic and Hydrophilic Interactions; Molecular Docking Simulation; Palmitic Acids; Peptidomimetics; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction; Structural Homology, Protein; Telmisartan | 2019 |
Disrupting the endocannabinoid system in early adolescence negatively impacts sociability.
Topics: Age Factors; Analgesics; Animals; Conditioning, Operant; Cyclohexanols; Endocannabinoids; Female; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Social Interaction | 2020 |
Effects of opioid/cannabinoid mixtures on impulsivity and memory in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Cognition; Cyclohexanols; Delay Discounting; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Impulsive Behavior; Macaca mulatta; Male; Memory; Morphine; Receptors, Opioid, mu | 2020 |
Effects of the cannabinoid receptor agonist CP-55,940 on incentive salience attribution.
Topics: Amygdala; Analgesics; Animals; Cannabinoid Receptor Agonists; Conditioning, Classical; Cyclohexanols; Dose-Response Relationship, Drug; Male; Motivation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2020 |
Cannabinoid CP55940 selectively induces apoptosis in Jurkat cells and in ex vivo T-cell acute lymphoblastic leukemia through H
Topics: Antineoplastic Agents; Apoptosis; Cyclohexanols; Humans; Hydrogen Peroxide; Jurkat Cells; Oxidative Stress; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Signal Transduction | 2020 |
THC Regulates Tearing via Cannabinoid CB1 Receptors.
Topics: Animals; Blotting, Western; Cyclohexanols; Dronabinol; Dry Eye Syndromes; Female; Lacrimal Apparatus; Male; Mice; Mice, Knockout; Receptor, Cannabinoid, CB1; Sex Factors; Tears | 2020 |
Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Diuresis; Endocannabinoids; Loop of Henle; Male; Mice; Mice, Inbred C57BL; Natriuresis; Ouabain; Piperidines; Polyunsaturated Alkamides; Pyridines; Rimonabant; Sodium; Sodium-Potassium-Exchanging ATPase | 2021 |
Synthetic cannabinoid CP-55,940 induces apoptosis in a human skeletal muscle model via regulation of CB
Topics: Annexins; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cannabinoids; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclohexanols; Humans; Membrane Potential, Mitochondrial; Muscle, Skeletal; Oxygen; Receptor, Cannabinoid, CB1 | 2021 |
Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer's Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor.
Topics: Alzheimer Disease; Animals; Cholinergic Neurons; Cyclohexanols; Drug Delivery Systems; Humans; Immunosuppressive Agents; Presenilin-1; Receptor, Cannabinoid, CB1 | 2021 |
Negative allosteric modulators of cannabinoid receptor 1: Ternary complexes including CB1, orthosteric CP55940 and allosteric ORG27569.
Topics: Allosteric Regulation; Allosteric Site; Cyclohexanols; Indoles; Molecular Docking Simulation; Piperidines; Protein Binding; Receptors, Cannabinoid | 2022 |
Site-selective labeling and electron paramagnetic resonance studies of human cannabinoid receptor CB
Topics: Camphanes; Cyclohexanols; Cysteine; Electron Spin Resonance Spectroscopy; Humans; Mutagenesis, Site-Directed; Protein Conformation; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Spin Labels | 2021 |
Interactive effects of (±)-trans-U50488 and its stereoisomers with cannabinoids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Diuretics; Dose-Response Relationship, Drug; Male; Morphine; Morpholines; Naphthalenes; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Reinforcement, Psychology; Stereoisomerism | 2021 |
Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia.
Topics: Alcohol Drinking; Animals; Anxiety; Behavior, Animal; Cannabinoid Receptor Antagonists; Catalepsy; Cyclohexanols; Elevated Plus Maze Test; Endotoxemia; Endotoxins; Ethanol; Gastrointestinal Tract; Hypothermia, Induced; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stereoisomerism; Sulfonamides | 2021 |
Dynamic Changes in the Endocannabinoid System during the Aging Process: Focus on the Middle-Age Crisis.
Topics: Aging; Animals; Cyclohexanols; Endocannabinoids; Lipoprotein Lipase; Mice; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid | 2022 |
Novel Cannabinoid Receptor 2 (CB2) Low Lipophilicity Agonists Produce Distinct cAMP and Arrestin Signalling Kinetics without Bias.
Topics: Arrestin; Cannabinoid Receptor Agonists; Cyclic AMP; Cyclohexanols; Pyridones; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Signal Transduction | 2023 |
CP55940-induced vasorelaxation is endothelial-dependent and mediated by the CB1R through NOS, COX and EDHF pathways in porcine cerebral arteries.
Topics: Animals; Cerebral Arteries; Cyclohexanols; Endothelium, Vascular; Female; Nitric Oxide; Swine; Vasodilation | 2023 |
A kinetic model for positive allosteric modulator (PAM)-antagonists for the type 1 cannabinoid (CB
Topics: Allosteric Regulation; Cannabinoids; Cyclohexanols; Ligands; Protein Binding; Receptor, Cannabinoid, CB1 | 2023 |