Compounds > cycloguanil
Page last updated: 2024-08-20

cycloguanil and ps 15

cycloguanil has been researched along with ps 15 in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ager, AL; Bliss, RA; Canfield, CJ; Jacobus, DP; Jensen, NP; Kotecka, BM; Rieckmann, KH; Terpinski, J1
Diaz, DS; Jacobus, DP; Kozar, MP; Milhous, WK; O'Neil, MT; Schiehser, GA; Shearer, TW; Skillman, DR; Smith, PL; Yang, YS1
Ager, AL; Canfield, CJ; Jacobus, DP; Lewis, NJ; Milhous, WK; Rossan, RN; Sweeney, TR1
Bahr, S; Edstein, MD; Kotecka, B; Rieckmann, KH; Shanks, GD1
Asher, CO; Diaz, DS; Jacobus, DP; Kozar, MP; Milhous, WK; Schiehser, GA; Shearer, TW; Skillman, DR; Smith, KS; Sousa, JC1

Other Studies

5 other study(ies) available for cycloguanil and ps 15

ArticleYear
Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials.
    Journal of medicinal chemistry, 2001, Nov-08, Volume: 44, Issue:23

    Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Guanidines; Malaria; Male; Mice; Plasmodium berghei; Plasmodium falciparum; Prodrugs; Proguanil; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines

2001
In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.
    Journal of medicinal chemistry, 2005, Apr-21, Volume: 48, Issue:8

    Topics: Animals; Antimalarials; Biguanides; Chromatography, Liquid; Drug Resistance; Folic Acid Antagonists; Humans; In Vitro Techniques; Mass Spectrometry; Microsomes, Liver; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship; Triazines

2005
PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.
    The American journal of tropical medicine and hygiene, 1993, Volume: 49, Issue:1

    Topics: Administration, Oral; Animals; Antimalarials; Aotus trivirgatus; Atovaquone; Drug Synergism; Folic Acid Antagonists; Imides; Injections, Subcutaneous; Malaria, Falciparum; Mice; Naphthoquinones; Phenyl Ethers; Plasmodium falciparum; Proguanil; Sulfamethoxazole; Triazines

1993
In vitro activities of the biguanide PS-15 and its metabolite, WR99210, against cycloguanil-resistant Plasmodium falciparum isolates from Thailand.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:10

    Topics: Animals; Antimalarials; Drug Resistance, Microbial; Folic Acid Antagonists; Malaria; Plasmodium falciparum; Prodrugs; Proguanil; Saimiri; Thailand; Triazines

1997
Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:2

    Topics: Antibodies, Monoclonal; Antimalarials; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; Prodrugs; Proguanil; Protein Isoforms; Recombinant Proteins; Triazines

2008