Page last updated: 2024-08-20

cycloguanil and atovaquone

cycloguanil has been researched along with atovaquone in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.00)18.2507
2000's9 (45.00)29.6817
2010's7 (35.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Jomaa, H; Mitsch, A; Schlitzer, M; Wiesner, J; Wissner, P1
Bertaux, L; Bogreau, H; Bouchiba, H; Garnotel, E; Kraemer, P; Parzy, D; Pradines, B; Rogier, C; Savini, H; Simon, F1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Azas, N; Basmaciyan, L; Cohen, A; Crozet, MD; Dallemagne, P; Deharo, E; Dumètre, A; Hutter, S; Laget, M; Lancelot, JC; Lesnard, A; Lorthiois, A; Mazier, D; Paloque, L; Rathelot, P; Rault, S; Sibley, CH; Suzanne, P; Valentin, A; Vanelle, P; Verhaeghe, P1
Ager, AL; Canfield, CJ; Jacobus, DP; Lewis, NJ; Milhous, WK; Rossan, RN; Sweeney, TR1
Christopherson, RI; Rieckmann, KH; Seymour, KK; Yeo, AE1
Gillotin, C; Mamet, JP; Veronese, L1
Ashton, M; Bergqvist, Y; Björkman, A; Johansson, I; Lindegårdh, N; Nivelius, S; Thapar, MM1
Alifrangis, M; Jelinek, T; Salanti, A; Schwöbel, B1
Bienzle, U; Ehrhardt, S; Jelinek, T; Mockenhaupt, FP; Muehlen, M; Otchwemah, R; Schreiber, J1
Björkman, A; Gil, JP; Thapar, MM1
Kioy, D; Konsil, J; Manyando, C; Miller, GB; Mulenga, M; Na-Bangchang, K; Ruengweerayut, R1
Jiang, S; McConkey, GA; McRobert, L; Stead, A1
Kamau, EM; Nduati, EW1
Chua, HH; Cobbold, SA; Creek, DJ; McConville, MJ; Nijagal, B; Ralph, SA1
Dinter, D; Domijan, AM; Gajski, G; Garaj-Vrhovac, V1
Barata, L; Boutbibe, K; Clain, J; Franetich, JF; Houzé, P; Mazier, D; Zanghi, G1
Funakoshi, R; Furihata, K; Ito, K; Kudo, T; Kusuhara, H; Tomoda, Y1
Andrews, KT; Antonova-Koch, Y; Burrows, JN; Chopra, P; Clarke, M; Fidock, DA; Fisher, GM; Hutt, OE; Jarvis, KE; Meister, S; Riches, AG; Ryan, JH; Skinner-Adams, TS; von Itzstein, M; Wilson, T; Winzeler, EA1
Jang, IJ; Ji, SC; Lee, S; Yang, E1

Trials

5 trial(s) available for cycloguanil and atovaquone

ArticleYear
Lack of a pharmacokinetic interaction between atovaquone and proguanil.
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:4

    Topics: Adult; Antimalarials; Atovaquone; Cross-Over Studies; Drug Interactions; Female; Humans; Male; Naphthoquinones; Proguanil; Sex Factors; Triazines

1999
Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as chemoprophylaxis.
    European journal of clinical pharmacology, 2002, Volume: 58, Issue:1

    Topics: Adult; Antimalarials; Atovaquone; Biological Availability; Dose-Response Relationship, Drug; Drug Combinations; Female; Genotype; Humans; In Vitro Techniques; Male; Middle Aged; Naphthoquinones; Phenotype; Proguanil; Time Factors; Triazines

2002
The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women.
    European journal of clinical pharmacology, 2005, Volume: 61, Issue:8

    Topics: Adolescent; Adult; Antimalarials; Atovaquone; Drug Combinations; Female; Humans; Malaria, Falciparum; Naphthoquinones; Pregnancy; Proguanil; Thailand; Triazines; Zambia

2005
Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers.
    British journal of clinical pharmacology, 2019, Volume: 85, Issue:7

    Topics: Adult; Area Under Curve; Atovaquone; Chromatography, Liquid; Cytochrome P-450 CYP2C19; Drug Combinations; Esomeprazole; Humans; Male; Proguanil; Proton Pump Inhibitors; Pyrroles; Sulfonamides; Tandem Mass Spectrometry; Triazines; Young Adult

2019
Evaluation of CYP2C19-Mediated Pharmacokinetic Drug Interaction of Tegoprazan, Compared with Vonoprazan or Esomeprazole.
    Clinical pharmacokinetics, 2023, Volume: 62, Issue:4

    Topics: Atovaquone; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Interactions; Esomeprazole; Humans; Proguanil; Reducing Agents

2023

Other Studies

15 other study(ies) available for cycloguanil and atovaquone

ArticleYear
Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives.
    Bioorganic & medicinal chemistry letters, 2001, Feb-12, Volume: 11, Issue:3

    Topics: Animals; Antimalarials; Cinnamates; Combinatorial Chemistry Techniques; Inhibitory Concentration 50; Microbial Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship

2001
First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: Animals; Antimalarials; Atovaquone; Comoros; Drug Resistance; France; Genotype; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Travel; Treatment Failure

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium.
    European journal of medicinal chemistry, 2015, May-05, Volume: 95

    Topics: Animals; Antimalarials; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Drug Discovery; Erythrocytes; Hep G2 Cells; Humans; Liver; Malaria; Male; Mice; Parasitemia; Plasmodium falciparum; Pyrimidines; Structure-Activity Relationship; Trophozoites

2015
PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.
    The American journal of tropical medicine and hygiene, 1993, Volume: 49, Issue:1

    Topics: Administration, Oral; Animals; Antimalarials; Aotus trivirgatus; Atovaquone; Drug Synergism; Folic Acid Antagonists; Imides; Injections, Subcutaneous; Malaria, Falciparum; Mice; Naphthoquinones; Phenyl Ethers; Plasmodium falciparum; Proguanil; Sulfamethoxazole; Triazines

1993
Effects of folic and folinic acids in the activities of cycloguanil and WR99210 against Plasmodium falciparum in erythrocytic culture.
    Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:1

    Topics: Animals; Antimalarials; Atovaquone; Drug Interactions; Folic Acid; Humans; Leucovorin; Naphthoquinones; Plasmodium falciparum; Proguanil; Purine Nucleotides; Pyrimethamine; Pyrimidine Nucleotides; Triazines

1997
Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker.
    Malaria journal, 2003, Mar-19, Volume: 2

    Topics: Animals; Antimalarials; Antiprotozoal Agents; Atovaquone; Codon; Drug Resistance; Electron Transport Complex III; Genetic Markers; Humans; Malaria, Falciparum; Mutation; Naphthoquinones; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proguanil; Triazines

2003
Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana.
    Tropical medicine & international health : TM & IH, 2004, Volume: 9, Issue:3

    Topics: Animals; Antimalarials; Atovaquone; Child, Preschool; Cytochromes b; Drug Combinations; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid Antagonists; Ghana; Humans; Infant; Malaria, Falciparum; Male; Mutation; Naphthoquinones; Plasmodium falciparum; Polymorphism, Restriction Fragment Length; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Triazines

2004
In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanil.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2005, Volume: 99, Issue:1

    Topics: Animals; Antimalarials; Atovaquone; Culture Media; Cytochrome b Group; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Naphthoquinones; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Recurrence; Triazines

2005
Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.
    Experimental parasitology, 2005, Volume: 111, Issue:3

    Topics: Animals; Antimalarials; Atovaquone; Drug Interactions; Naphthoquinones; Plasmodium falciparum; Proguanil; Pyrimethamine; Shikimic Acid; Triazines

2005
Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy.
    Acta tropica, 2006, Volume: 97, Issue:3

    Topics: Animals; Antimalarials; Atovaquone; Dapsone; Drug Synergism; Drug Therapy, Combination; Folic Acid Antagonists; Naphthoquinones; Plasmodium falciparum; Proguanil; Triazines

2006
Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs.
    The Journal of infectious diseases, 2016, Jan-15, Volume: 213, Issue:2

    Topics: Antimalarials; Artemisinins; Atovaquone; Chloroquine; Fosfomycin; Gas Chromatography-Mass Spectrometry; Hemoglobins; Inhibitory Concentration 50; Methylene Blue; Naphthyridines; Plasmodium falciparum; Proguanil; Triazines

2016
Cytogenetic and oxidative status of human lymphocytes after exposure to clinically relevant concentrations of antimalarial drugs atovaquone and proguanil hydrochloride in vitro.
    Fundamental & clinical pharmacology, 2015, Volume: 29, Issue:6

    Topics: Adult; Antimalarials; Atovaquone; Cell Survival; Cytogenetics; DNA Damage; Dose-Response Relationship, Drug; Drug Combinations; Glutathione; Humans; Lymphocytes; Malaria, Falciparum; Male; Malondialdehyde; Oxidative Stress; Plasmodium falciparum; Proguanil; Triazines

2015
In Vitro Analysis of the Interaction between Atovaquone and Proguanil against Liver Stage Malaria Parasites.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:7

    Topics: Antimalarials; Atovaquone; Drug Combinations; Hepatocytes; Humans; Inhibitory Concentration 50; Liver; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Triazines

2016
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone.
    Communications biology, 2019, Volume: 2

    Topics: Animals; Anopheles; Antimalarials; Atovaquone; Cyclization; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Drug Combinations; Electron Transport Complex III; Enzyme Inhibitors; Erythrocytes; Folic Acid; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium berghei; Plasmodium falciparum; Proguanil; Sporozoites; Terpenes; Triazines

2019