cycloastragenol has been researched along with sapogenins in 51 studies
| Studies (cycloastragenol) | Trials (cycloastragenol) | Recent Studies (post-2010) (cycloastragenol) | Studies (sapogenins) | Trials (sapogenins) | Recent Studies (post-2010) (sapogenins) |
|---|---|---|---|---|---|
| 62 | 0 | 55 | 987 | 8 | 443 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.96) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (3.92) | 29.6817 |
| 2010's | 29 (56.86) | 24.3611 |
| 2020's | 19 (37.25) | 2.80 |
| Authors | Studies |
|---|---|
| He, K; Wang, HK | 1 |
| Calis, I; Gazar, HA; Piacente, S; Pizza, C | 1 |
| Chin, AC; Effros, RB; Fauce, SR; Harley, CB; Jamieson, BD; Kitchen, CM; Mitsuyasu, RT; Ng, HL; Parish, ST; Yang, OO | 1 |
| Chen, YS; Ruan, M; Yu, B; Zhang, LY; Zhuang, Y | 1 |
| Bedir, E; Kuban, M; Ongen, G | 1 |
| Chin, AC; Harley, CB; Ho, MK; Hu, Y; Ip, FC; Ip, NY; Lee, S; Pang, H; Wong, YH; Zhu, J | 1 |
| Chin, AC; Harley, CB; Ho, MK; Hu, Y; Ip, FC; Ip, NY; Lam, WS; Pang, H; Wong, YH; Yung, LY | 1 |
| Ruan, JQ; Song, YL; Wang, YT; Yan, R; Zhou, RN | 1 |
| Chen, L; Li, T; Liang, R; Wang, Y; Yang, W; Zhang, D; Zhang, H | 1 |
| Bedir, E; Khan, IA; Kuban, M; Öngen, G | 1 |
| Ahuja, SS; Allsopp, R; Brampton, C; Davy, P; Fauce, S; Harley, CB; Le Saux, CJ; Nguyen, H; Pirot, Z; Ramaseshan, M; Shivshankar, P; Tressler, R | 1 |
| Szabo, NJ | 1 |
| Cao, J; Feng, LM; Guo, DA; Huang, FX; Lin, XH; Qiao, X; Ye, M | 1 |
| Li, S; Liu, Q; Qiao, Y; Ren, Z; Sun, S; Wang, S; Wang, X; Wu, Q; Zhai, C; Zhang, Y | 1 |
| An, HJ; Chin, AC; Dai, Y; Harley, CB; Hu, YQ; Ip, FC; Ip, NY; Ng, YP; Pang, HH; Wong, YH | 1 |
| Weiss, MA; Weiss, RA | 1 |
| Agra, LC; Barbosa, FT; Barreto, E; Ferro, JN | 1 |
| Li, J; Li, Q; Liu, B; Liu, K; Sun, Y; Zhang, N; Zhao, W; Zhao, Y | 1 |
| Chao, L; Han, L; Li, X; Ruan, J; Shi, P; Wang, T; Zhang, Y | 1 |
| Cao, YL; Chen, HY; Chen, N; Guo, CE; Ma, PK; Miao, Q; Wei, BH; Zhang, YJ | 1 |
| Li, SP; Meng, JJ; Mu, DZ; Qu, Y; Tong, Y; Zhao, FY | 1 |
| Fan, S; Gu, M; Huang, C; Huang, J; Ji, G; Li, Y; Tong, Q; Wang, Y; Yang, L; Zhang, S; Zhao, Y | 1 |
| Chen, Y; Wang, L | 1 |
| Akgün, İH; Bedir, E; Debeleç-Bütüner, B; Korkmaz, KS; Öztürk, MB; Tağ, Ö; Yetik-Anacak, G | 1 |
| Qi, R; Tuerdi, N; Wan, Y; Wang, Y; Xu, L; Ye, M | 1 |
| Cai, H; Cao, SP; Song, YH; Wang, J; Wu, ML; Zhao, ZM | 1 |
| Cao, Y; Chen, C; Qi, R; Wang, Q; Wang, Y; Xu, L | 1 |
| Chen, C; Chen, G; Huang, H; Jiang, B; Lin, H; Song, Y; Yang, M | 1 |
| Ahn, KS; Alharbi, SA; Chinnathambi, A; Hwang, ST; Kim, C; Lee, JH; Sethi, G; Shair, OHM | 1 |
| Chen, W; Deng, G; Gu, Z; Ji, X; Sun, Y; Wang, P; Wang, X; Zhan, T; Zheng, W | 1 |
| Dan, J; Gao, D; Liu, D; Liu, J; Luo, Y; Peng, L; Zhou, R | 1 |
| Chen, C; Chen, G; Fan, B; Huang, H; Jiang, B; Ni, Y; Xu, B; Yan, S | 1 |
| Bedir, E; Ekiz, G; Kırmızıbayrak, PB; Yılmaz, S; Yusufoglu, H | 1 |
| Calabrese, G; Castorina, S; Castrogiovanni, P; Di Rosa, M; Forte, S; Imbesi, R; Leonardi, R; Musumeci, G; Parrinello, NL; Pricoco, E; Ravalli, S; Szychlinska, MA | 1 |
| Hu, XM; Li, HH; Li, J; Liu, Z; Pan, LH; Peng, T; Ren, YS; Tan, YJ; Yao, JC; Yue, J; Zhang, GM; Zhao, LL | 1 |
| Dou, BK; Han, HZ; Ke, ZJ; Li, M; Li, SC; Liu, DX; Wang, ZF; Zou, YX | 1 |
| Du, M; Hu, W; Li, J; Li, L; Liu, Y; Luo, S; Wu, J; Yang, Y; Yao, W; Yu, Y; Zheng, X; Zhou, L | 1 |
| Huang, MY; Yu, GR | 1 |
| Li, Y; Qin, H; Wu, J; Xu, D; Zeng, Z; Zhou, C; Zuo, C | 1 |
| Çakır, Ö; Ceylan, M; Mhiri, W; Nalbantoğlu, B; Turgut-Kara, N | 1 |
| Ballar Kırmızıbayrak, P; Bedir, E; Duman, S; Ekiz, G; Yılmaz, S; Yusufoglu, H | 1 |
| Cao, Y; Chen, M; Dong, J; Li, C; Qin, J; Su, M; Tang, W; Teng, F; Tulake, W; Wang, S; Zhong, Y; Zhu, X | 1 |
| Ahmad, S; Choe, K; Ikram, M; Jo, MH; Khan, A; Kim, MO; Kim, MW; Saeed, K | 1 |
| Burk, K; Hudson, PL; Marangoni, AG; Wang, FC | 1 |
| Chen, J; Chen, X; Guo, X; Hu, W; Lai, J; Lin, S; Lin, W; Yao, H; Zeng, Y | 1 |
| Ballar Kirmizibayrak, P; Bedir, E; Yilmaz, S | 1 |
| Fukami, H; Kishino, S; Ogawa, J; Ozeki, Y; Takeuchi, DM | 1 |
| Al-Gayyar, MMH; Almasri, D; Bagalagel, A; Bakhsh, HT; Diri, R; Kutbi, HI; Noor, A | 1 |
| Chen, T; Gao, X; Li, S; Li, Z; Shu, S; Wang, Z; Zou, Y | 1 |
| Dai, L; Dong, P; Lan, X; Li, H; Li, Y; Wang, H; Wang, S; Zhang, J | 1 |
| Du, BY; Liang, HB; Liu, Z; Qin, GF; Sun, Y; Yao, JC; Yao, QQ; Zhang, GM; Zhang, X; Zhao, GF; Zhu, F; Zhu, XX | 1 |
2 review(s) available for cycloastragenol and sapogenins
| Article | Year |
|---|---|
[Recent development of chemical studies on some medicinal plants of Astragalus spp].
Topics: Chemical Phenomena; Chemistry; Drugs, Chinese Herbal; Glucosides; Glycosides; Sapogenins; Saponins; Triterpenes | 1988 |
Triterpenes with healing activity: A systematic review.
Topics: Cell Movement; Cell Proliferation; Collagen; Fibroblasts; Ginsenosides; Humans; Keratinocytes; Pentacyclic Triterpenes; Reactive Oxygen Species; Sapogenins; Saponins; Skin; Skin Diseases; Triterpenes; Ursolic Acid; Wound Healing | 2015 |
49 other study(ies) available for cycloastragenol and sapogenins
| Article | Year |
|---|---|
Secondary metabolites from the roots of Astragalus zahlbruckneri.
Topics: Astragalus Plant; Glycosides; Magnetic Resonance Spectroscopy; Molecular Structure; Phenols; Plant Roots; Plants, Medicinal; Sapogenins; Triterpenes; Turkey | 2001 |
Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes.
Topics: CD8-Positive T-Lymphocytes; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; HIV Infections; Humans; Interferon-gamma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oligonucleotides; Oligopeptides; Reverse Transcriptase Polymerase Chain Reaction; Sapogenins; Telomerase | 2008 |
[Transformation of astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus].
Topics: Antioxidants; Astragalus propinquus; Chromatography, High Pressure Liquid; Fermentation; Ganoderma; Molecular Structure; Plant Roots; Plants, Medicinal; Sapogenins; Saponins; Triterpenes | 2010 |
Biotransformation of cycloastragenol by Cunninghamella blakesleeana NRRL 1369 resulting in a novel framework.
Topics: Cunninghamella; Magnetic Resonance Spectroscopy; Molecular Structure; Sapogenins | 2010 |
In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator.
Topics: Animals; Caco-2 Cells; Carrier Proteins; Diffusion; Egtazic Acid; Enterocytes; Enzyme Activators; Glucuronides; Humans; Hydroxylation; Intestinal Absorption; Intestinal Mucosa; Kinetics; Liver; Male; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Microsomes, Liver; Oxidation-Reduction; Permeability; Rats; Sapogenins; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Telomerase; Transcytosis | 2010 |
Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types.
Topics: Astragalus Plant; Brain; Breast; Cell Line; Dose-Response Relationship, Drug; Endothelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Lung; Phosphorylation; Plant Extracts; Sapogenins; Saponins; src-Family Kinases; Telomerase; Triterpenes | 2012 |
Pharmacokinetic evidence on the contribution of intestinal bacterial conversion to beneficial effects of astragaloside IV, a marker compound of astragali radix, in traditional oral use of the herb.
Topics: Administration, Oral; Animals; Area Under Curve; Bacteria; Biotransformation; Drugs, Chinese Herbal; Feces; Intestinal Mucosa; Intestines; Male; Rats; Rats, Sprague-Dawley; Sapogenins; Saponins; Triterpenes | 2012 |
Development of an SPE-HPLC-MS method for simultaneous determination and pharmacokinetic study of bioactive constituents of Yu Ping Feng San in rat plasma after oral administration.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Chromones; Drugs, Chinese Herbal; Isoflavones; Male; Mass Spectrometry; Rats; Rats, Wistar; Reproducibility of Results; Sapogenins; Solid Phase Extraction | 2013 |
Microbial transformation of cycloastragenol.
Topics: Biotransformation; Cunninghamella; Fungi; Magnetic Resonance Spectroscopy; Molecular Structure; Mycobacterium; Phyllachorales; Sapogenins | 2013 |
A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.
Topics: Alveolar Epithelial Cells; Animals; Bleomycin; Cellular Senescence; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activators; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Inflammation; Lung; Mice; Respiratory Mucosa; Sapogenins; Telomerase | 2013 |
Dietary safety of cycloastragenol from Astragalus spp.: subchronic toxicity and genotoxicity studies.
Topics: Animals; Astragalus Plant; Chromosome Aberrations; Dose-Response Relationship, Drug; Feeding Behavior; Female; Male; Micronucleus Tests; No-Observed-Adverse-Effect Level; Organ Size; Plant Extracts; Rats; Rats, Sprague-Dawley; Sapogenins; Toxicity Tests, Subchronic | 2014 |
Smith degradation, an efficient method for the preparation of cycloastragenol from astragaloside IV.
Topics: Acids; Astragalus propinquus; Chromatography, Liquid; Drugs, Chinese Herbal; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Sapogenins; Saponins; Triterpenes | 2014 |
Cycloastragenol, a triterpene aglycone derived from Radix astragali, suppresses the accumulation of cytoplasmic lipid droplet in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Astragalus Plant; Astragalus propinquus; Calcium; Cytoplasm; Drugs, Chinese Herbal; Lipid Metabolism; Mice; Sapogenins | 2014 |
Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.
Topics: Animals; Antidepressive Agents; Cyclic AMP Response Element-Binding Protein; Depression; Humans; Keratinocytes; Mice; Nerve Growth Factor; Neurons; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Sapogenins; Telomerase | 2014 |
Evaluation of a novel anti-aging topical formulation containing cycloastragenol, growth factors, peptides, and antioxidants.
Topics: Administration, Cutaneous; Adult; Aged; Antioxidants; Chemistry, Pharmaceutical; Drug Evaluation; Female; Humans; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Peptides; Sapogenins; Skin Aging; Skin Care | 2014 |
Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium.
Topics: Apoptosis; Carrier Proteins; Caspase 3; Cells, Cultured; Endoplasmic Reticulum Stress; Endoribonucleases; Endothelial Cells; Humans; Inflammasomes; Membrane Potential, Mitochondrial; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Sapogenins; Saponins; Triterpenes | 2015 |
Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao.
Topics: Astragalus propinquus; Hep G2 Cells; Humans; Hypolipidemic Agents; Plant Extracts; Plant Stems; Sapogenins; Saponins; Triglycerides | 2016 |
Pharmacokinetics, metabolism, and excretion of cycloastragenol, a potent telomerase activator in rats.
Topics: Administration, Oral; Animals; Bile; Body Fluids; Chromatography, High Pressure Liquid; Enzyme Activators; Feces; Rats; Sapogenins; Tandem Mass Spectrometry; Telomerase; Tissue Distribution | 2017 |
[Effect of telomerase activation on biological behaviors of neural stem cells in rats with hypoxic-ischemic insults].
Topics: Animals; Cell Survival; Enzyme Activation; Hypoxia-Ischemia, Brain; Neural Stem Cells; Rats; Sapogenins; Telomerase | 2017 |
Cycloastragenol improves hepatic steatosis by activating farnesoid X receptor signalling.
Topics: Animals; Drugs, Chinese Herbal; Female; Hep G2 Cells; Humans; Liver; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear; Sapogenins; Signal Transduction | 2017 |
Efficient Biotransformation of Astragaloside IV to Cycloastragenol by Bacillus sp. LG-502.
Topics: Bacillus; Biotransformation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Sapogenins; Saponins; Triterpenes | 2017 |
Cycloartane-type sapogenol derivatives inhibit NFκB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis.
Topics: Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Chemoprevention; Dinoprostone; Humans; Inflammation; Male; NF-kappa B; Prostatic Neoplasms; Sapogenins; Signal Transduction; Transcription, Genetic; Triterpenes | 2018 |
Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome.
Topics: Animals; Cardiovascular Diseases; Cells, Cultured; Disease Models, Animal; Drugs, Chinese Herbal; Fibroblasts; Fibrosis; Heart; Humans; Inflammasomes; Isoproterenol; Male; Mice; Mice, Inbred BALB C; Myocardium; NLR Family, Pyrin Domain-Containing 3 Protein; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sapogenins; Saponins; Triterpenes | 2018 |
Cycloastragenol ameliorates experimental heart damage in rats by promoting myocardial autophagy via inhibition of AKT1-RPS6KB1 signaling.
Topics: Animals; Astragalus propinquus; Autophagy; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drugs, Chinese Herbal; Heart Failure; Isoproterenol; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocardium; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Sapogenins; Signal Transduction | 2018 |
Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms.
Topics: Administration, Oral; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Conformation; Oxidative Stress; Pancreatic Elastase; Rats; Rats, Sprague-Dawley; Sapogenins; Signal Transduction | 2019 |
Microbial transformation of the anti-aging agent cycloastragenol by
Topics: Animals; Biotransformation; Caenorhabditis elegans; Drug Evaluation, Preclinical; Longevity; Molecular Structure; Mucor; Sapogenins; Stereoisomerism; Structure-Activity Relationship | 2019 |
Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 1; Janus Kinase 2; Paclitaxel; Phosphorylation; Phytotherapy; Sapogenins; Signal Transduction; STAT3 Transcription Factor; Stomach Neoplasms | 2019 |
Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
Topics: Animals; Astragalus propinquus; Cell Movement; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Inflammasomes; Inflammation; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Pyroptosis; Sapogenins; Skin | 2019 |
The protective effect of cycloastragenol on aging mouse circadian rhythmic disorder induced by d-galactose.
Topics: Aging; Animals; ARNTL Transcription Factors; Chronobiology Disorders; Galactose; Mice; Mice, Transgenic; Period Circadian Proteins; Sapogenins | 2019 |
Anti-aging derivatives of cycloastragenol produced by biotransformation.
Topics: Animals; Aspergillus oryzae; Biotransformation; Caenorhabditis elegans; Hydroxylation; Longevity; Mucor; Sapogenins | 2021 |
Microbial Transformation of Cycloastragenol and Astragenol by Endophytic Fungi Isolated from
Topics: Astragalus Plant; Cell Line; Endophytes; Enzyme Activators; Humans; Infant, Newborn; Keratinocytes; Magnetic Resonance Spectroscopy; Molecular Structure; Sapogenins; Telomerase | 2019 |
Cycloastragenol as an Exogenous Enhancer of Chondrogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells. A Morphological Study.
Topics: Aggrecans; Cell Death; Cell Differentiation; Cell Shape; Cells, Cultured; Chondrogenesis; Collagen; Female; Glycoproteins; Glycosaminoglycans; Humans; Male; Mesenchymal Stem Cells; Middle Aged; Sapogenins; SOX9 Transcription Factor; Time Factors | 2020 |
Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats.
Topics: Animals; Apoptosis; Humans; I-kappa B Kinase; Monomeric GTP-Binding Proteins; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Proteomics; Rats; Sapogenins | 2020 |
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Infarction, Middle Cerebral Artery; Inflammation; Male; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Neuroprotective Agents; NF-kappa B p50 Subunit; Sapogenins; Signal Transduction; Sirtuin 1; Tight Junctions; Tumor Suppressor Protein p53; Up-Regulation | 2020 |
Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats.
Topics: 3T3 Cells; Age Factors; Animals; Bone Density Conservation Agents; Bone Remodeling; Disease Models, Animal; Female; Femur; Galactose; Male; Membrane Glycoproteins; Mice; Osteoclasts; Osteogenesis; Osteoporosis; Rats, Sprague-Dawley; Sapogenins; Up-Regulation | 2020 |
Cycloastragenol inhibits Aβ
Topics: Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Line; Mice; Molecular Structure; Peptide Fragments; Sapogenins | 2021 |
Cycloastragenol protects against glucocorticoid-induced osteogenic differentiation inhibition by activating telomerase.
Topics: Animals; Cell Differentiation; Drugs, Chinese Herbal; Glucocorticoids; Humans; Osteogenesis; Sapogenins; Telomerase; Zebrafish | 2021 |
Transcriptomic analysis reveals responses to Cycloastragenol in Arabidopsis thaliana.
Topics: Arabidopsis; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Metabolic Networks and Pathways; Plant Proteins; Sapogenins; Sequence Analysis, RNA | 2020 |
Telomerase activators from 20(27)-octanor-cycloastragenol via biotransformation by the fungal endophytes.
Topics: Astragalus Plant; Biotransformation; Fungi; Gene Expression Regulation, Enzymologic; Sapogenins; Species Specificity; Telomerase | 2021 |
Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Autophagy; Autophagy-Related Proteins; Biomarkers; Biopsy; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Management; Disease Models, Animal; Disease Susceptibility; Drugs, Chinese Herbal; Female; Immunoglobulin E; Immunohistochemistry; Inflammation Mediators; Mice; Microtubule-Associated Proteins; Sapogenins; Structure-Activity Relationship | 2021 |
Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Astrocytes; Brain; Cyclic AMP Response Element-Binding Protein; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Inflammation; Inflammation Mediators; Memory Disorders; Mice, Inbred C57BL; Microglia; Nerve Growth Factors; Nerve Tissue Proteins; Neurodegenerative Diseases; Oxidative Stress; Phosphorylation; Sapogenins; Saponins; Triterpenes | 2021 |
Encapsulation of cycloastragenol in phospholipid vesicles enhances transport and delivery across the skin barrier.
Topics: Administration, Cutaneous; Animals; Drug Carriers; Phospholipids; Sapogenins; Skin Absorption; Swine | 2022 |
Cycloastragenol Confers Cerebral Protection after Subarachnoid Hemorrhage by Suppressing Oxidative Insults and Neuroinflammation via the SIRT1 Signaling Pathway.
Topics: Animals; Neuroinflammatory Diseases; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sapogenins; Signal Transduction; Sirtuin 1; Subarachnoid Hemorrhage | 2022 |
The role of cycloastragenol at the intersection of NRF2/ARE, telomerase, and proteasome activity.
Topics: Hydrogen Peroxide; NF-E2-Related Factor 2; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Sapogenins; Telomerase | 2022 |
Analysis of astragaloside IV metabolism to cycloastragenol in human gut microorganism, bifidobacteria, and lactic acid bacteria.
Topics: Bacteria; Bifidobacterium; Glucose; Humans; Lactobacillales; Sapogenins; Saponins; Triterpenes; Xylose | 2022 |
The therapeutic effects of cycloastragenol in ulcerative colitis by modulating SphK/MIP-1α/miR-143 signalling.
Topics: Animals; bcl-2-Associated X Protein; Chemokine CCL3; Colitis, Ulcerative; Eosine Yellowish-(YS); Female; Male; MicroRNAs; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Rats; Sapogenins; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2022 |
Cycloastragenol suppresses M1 and promotes M2 polarization in LPS-stimulated BV-2 cells and ischemic stroke mice.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; NF-E2-Related Factor 2; NF-kappa B; Sapogenins | 2022 |
Comprehensive Study of
Topics: Animals; Chromatography, High Pressure Liquid; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Sapogenins | 2023 |
Using UPLC-LTQ-Orbitrap-MS and HPLC-CAD to Identify Impurities in Cycloastragenol, Which Is a Pre-Clinical Candidate for COPD.
Topics: Astragalus Plant; Chromatography, High Pressure Liquid; Pulmonary Disease, Chronic Obstructive; Sapogenins | 2023 |