cyclo(glycyltryptophyl) and 1-1-diphenyl-2-picrylhydrazyl

Four known compounds had been isolated from the Streptomyces sp. YIM66017, and their structures were elucidated by spectral analysis as 2,6-dimethoxy terephthalic acid (1), yangjinhualine A (2), α-hydroxyacetovanillone (3) and cyclo(Gly-Trp) (4). Compound 1 was isolated from natural resources for the first time, and compounds 2-4 were isolated from streptomycetes for the first time. The 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity assays showed that 1 showed higher activity than rutin with IC50 of 4.61 μg/mL and 2 showed the activity with IC50 of 57.12 μg/mL.

Topics: Alpinia; Biphenyl Compounds; Dipeptides; Free Radical Scavengers; Inhibitory Concentration 50; Molecular Structure; Peptides, Cyclic; Phthalic Acids; Picrates; Rutin; Streptomyces