cyclin-d1 and isoxanthochymol

cyclin-d1 has been researched along with isoxanthochymol* in 1 studies

Other Studies

1 other study(ies) available for cyclin-d1 and isoxanthochymol

ArticleYear
Polycyclic polyprenylated acylphloroglucinols from Garcinia xanthochymus fruits exhibit antitumor effects through inhibition of the STAT3 signaling pathway.
    Food & function, 2020, Dec-01, Volume: 11, Issue:12

    The fruits of Garcinia xanthochymus can be eaten raw or processed into jams, preserves and vinegar. They provide not only vitamin and protein nutrients, but also pharmacologically active compounds, among which polycyclic polyprenylated acylphloroglucinols (PPAPs) are a major class. According to the literature, PPAPs exhibited good anti-cancer effects. This study investigated the antitumor effects and the underlying mechanism of S1 (the regioisomeric mixture of xanthochymol and guttiferone E) and S2 (the regioisomeric mixture of isoxanthochymol and cycloxanthochymol) isolated from the fruits of G. xanthochymus. In an H22 allograft mouse model, S1 and S2 could suppress the liver tumor growth and phosphorylation of STAT3. Computational modeling showed that S1 and S2 could form hydrogen bonds with the SH2 domain of STAT3. In HepG2 and MCF-7 cell lines, S1 and S2 downregulated the expression of p-STAT3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzophenones; Caspase 3; Cell Line, Tumor; Cyclin D1; Female; Fruit; Garcinia; Hep G2 Cells; Humans; Janus Kinase 2; Liver; Male; MCF-7 Cells; Mice; Molecular Docking Simulation; Phosphorylation; Plant Extracts; Signal Transduction; STAT3 Transcription Factor; Survivin

2020