cyclin-d1 and arctiin

cyclin-d1 has been researched along with arctiin* in 2 studies

Other Studies

2 other study(ies) available for cyclin-d1 and arctiin

ArticleYear
Arctiin elevates osteogenic differentiation of MC3T3-E1 cells by modulating cyclin D1.
    Bioengineered, 2022, Volume: 13, Issue:4

    Osteoporosis is a systemic disorder of bone metabolism. This study aimed to investigate the impacts and possible mechanisms of Arctiin, a lignin isolated from

    Topics: Animals; Cyclin D1; Furans; Glucosides; Mice; Osteoblasts; Osteogenesis; Osteoporosis

2022
Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression.
    Oncology reports, 2008, Volume: 19, Issue:3

    Arctiin is a major lignan constituent of Arctium lappa and has anti-cancer properties in animal models. It was recently reported that arctiin induces growth inhibition in human prostate cancer PC-3 cells. However, the growth inhibitory mechanism of arctiin remains unknown. Herein we report that arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. We also show that the growth inhibition caused by arctiin is associated with the down-regulation of cyclin D1 protein expression. Furthermore, the arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer. Depletion of the cyclin D1 protein using small interfering RNA-rendered human breast cancer MCF-7 cells insensitive to the growth inhibitory effects of arctiin, implicates cyclin D1 as an important target of arctiin. Taken together, these results suggest that arctiin down-regulates cyclin D1 protein expression and that this at least partially contributes to the anti-proliferative effect of arctiin.

    Topics: Antineoplastic Agents, Phytogenic; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Down-Regulation; Furans; Glucosides; Humans; Neoplasms; Retinoblastoma Protein

2008