cyclic-gmp and rhodioloside

cyclic-gmp has been researched along with rhodioloside* in 1 studies

Other Studies

1 other study(ies) available for cyclic-gmp and rhodioloside

Article	Year
Salidroside attenuates hydrogen peroxide-induced cell damage through a cAMP-dependent pathway. Molecules (Basel, Switzerland), 2011, Apr-19, Volume: 16, Issue:4 Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H(2)O(2))-induced HL-7702 cell damage, inhibit H(2)O(2)-induced cytosolic free Ca2+ ([Ca2+]i) elevation, scavenge reactive oxygen species (ROS) and increase 3'-5'-cyclic adenosine monophosphate (cAMP) level in a dose-dependent manner, but it couldn't influence 3'-5'-cyclic guanosine monophosphate (cGMP) levels. Therefore, these results indicated that the antioxidant effects of salidroside were associated with down-regulation of [Ca2+]i, ROS occur via a cAMP-dependent pathway. Topics: Animals; Cell Line; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Glucosides; Hydrogen Peroxide; Phenols	2011

Article

Year

Salidroside attenuates hydrogen peroxide-induced cell damage through a cAMP-dependent pathway.

Molecules (Basel, Switzerland), 2011, Apr-19, Volume: 16, Issue:4

Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H(2)O(2))-induced HL-7702 cell damage, inhibit H(2)O(2)-induced cytosolic free Ca2+ ([Ca2+]i) elevation, scavenge reactive oxygen species (ROS) and increase 3'-5'-cyclic adenosine monophosphate (cAMP) level in a dose-dependent manner, but it couldn't influence 3'-5'-cyclic guanosine monophosphate (cGMP) levels. Therefore, these results indicated that the antioxidant effects of salidroside were associated with down-regulation of [Ca2+]i, ROS occur via a cAMP-dependent pathway.

Topics: Animals; Cell Line; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Glucosides; Hydrogen Peroxide; Phenols

2011