cyclic-gmp and methylphosphonothiolate

cyclic-gmp has been researched along with methylphosphonothiolate* in 1 studies

Other Studies

1 other study(ies) available for cyclic-gmp and methylphosphonothiolate

Article	Year
Cardiac abnormalities in rats treated with methylphosphonothiolate. Toxicology and applied pharmacology, 1987, Volume: 87, Issue:2 Cardiac toxicity of methylphosphonothiolate (MPT), an organophosphorus compound, has been investigated in the rat. Subcutaneous injection of MPT (12 micrograms/kg body wt) induced cardiac arrhythmias, the occurrence of which was significantly more frequent than in the control group. Death rate among MPT-treated animals appeared to be in relationship with cardiac arrhythmias. Plasma nonesterified fatty acid concentrations increased in MPT-poisoned rats. cAMP and cGMP contents in myocardial tissue were unchanged 150 min after MPT administration, as compared with control. Similarly, no change has occurred in high energy compound levels. Topics: Animals; Arrhythmias, Cardiac; Cyclic AMP; Cyclic GMP; Electrocardiography; Fatty Acids, Nonesterified; Heart; Lethal Dose 50; Male; Myocardium; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains	1987

Article

Year

Cardiac abnormalities in rats treated with methylphosphonothiolate.

Toxicology and applied pharmacology, 1987, Volume: 87, Issue:2

Cardiac toxicity of methylphosphonothiolate (MPT), an organophosphorus compound, has been investigated in the rat. Subcutaneous injection of MPT (12 micrograms/kg body wt) induced cardiac arrhythmias, the occurrence of which was significantly more frequent than in the control group. Death rate among MPT-treated animals appeared to be in relationship with cardiac arrhythmias. Plasma nonesterified fatty acid concentrations increased in MPT-poisoned rats. cAMP and cGMP contents in myocardial tissue were unchanged 150 min after MPT administration, as compared with control. Similarly, no change has occurred in high energy compound levels.

Topics: Animals; Arrhythmias, Cardiac; Cyclic AMP; Cyclic GMP; Electrocardiography; Fatty Acids, Nonesterified; Heart; Lethal Dose 50; Male; Myocardium; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains

1987