cyclic-gmp and glycolaldehyde

Growing evidence supports the role of advanced glycation end products (AGEs) in the development of diabetic vascular complications and cardiovascular diseases (CVDs). We have shown that high-molecular-weight AGEs (HMW-AGEs), present in our Western diet, impair cardiac function. Whether HMW-AGEs affect vascular function remains unknown. In this study, we aimed to investigate the impact of chronic HMW-AGEs exposure on vascular function and structure. Adult male Sprague Dawley rats were daily injected with HMW-AGEs or control solution for 6 weeks. HMW-AGEs animals showed intracardiac pressure overload, characterized by increased systolic and mean pressures. The contraction response to PE was increased in aortic rings from the HMW-AGEs group. Relaxation in response to ACh, but not SNP, was impaired by HMW-AGEs. This was associated with reduced plasma cyclic GMP levels. SOD restored ACh-induced relaxation of HMW-AGEs animals to control levels, accompanied by a reduced half-maximal effective dose (EC

Topics: Acetaldehyde; Acetylcholine; Animals; Aorta; Blood Pressure; Cardiovascular Diseases; Collagen; Cyclic GMP; Endothelium, Vascular; Glycation End Products, Advanced; Heart; Male; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vascular Remodeling; Vasoconstriction; Vasodilation