cyclic-gmp and glycocyamine

cyclic-gmp has been researched along with glycocyamine* in 1 studies

Other Studies

1 other study(ies) available for cyclic-gmp and glycocyamine

Article	Year
Identification of guanidino succinate as a putative endogenous source of the endothelium derived relaxing factor. Biochemical and biophysical research communications, 1992, Mar-16, Volume: 183, Issue:2 Using a specific HPLC analysis for guanidines, we find that rat aorta contains guanidino succinate (GS), guanidino acetate (GA), guanidino propionate (GP), guanidino butyrate (GB), methyl guanidine (MG) and guanidine. The concentration of L-arginine (0.05 nmol/mg tissue) is significantly lower than the other guanidines. GS is found to be the most potent vasodilator-guanidine in the rat aorta preparation and this vasodilation depends predominantly on the presence of the endothelium. This effect of GS is antagonized by NG-monomethyl L-arginine (L-NMMA), NW-nitro L-arginine benzyl ester (L-NABA), hemoglobin and by methylene blue, all of which are known to block or attenuate endothelium dependent relaxation. Further, the relaxation mediated by GS is accompanied by the formation of cGMP in the rat aorta. From these results we suggest that GS may be a major endogenous source of EDRF. Topics: Animals; Aorta; Arginine; Cyclic GMP; Endothelium, Vascular; Glycine; Guanidines; Muscle Relaxation; Nitric Oxide; Propionates; Rats; Succinates	1992

Article

Year

Identification of guanidino succinate as a putative endogenous source of the endothelium derived relaxing factor.

Biochemical and biophysical research communications, 1992, Mar-16, Volume: 183, Issue:2

Using a specific HPLC analysis for guanidines, we find that rat aorta contains guanidino succinate (GS), guanidino acetate (GA), guanidino propionate (GP), guanidino butyrate (GB), methyl guanidine (MG) and guanidine. The concentration of L-arginine (0.05 nmol/mg tissue) is significantly lower than the other guanidines. GS is found to be the most potent vasodilator-guanidine in the rat aorta preparation and this vasodilation depends predominantly on the presence of the endothelium. This effect of GS is antagonized by NG-monomethyl L-arginine (L-NMMA), NW-nitro L-arginine benzyl ester (L-NABA), hemoglobin and by methylene blue, all of which are known to block or attenuate endothelium dependent relaxation. Further, the relaxation mediated by GS is accompanied by the formation of cGMP in the rat aorta. From these results we suggest that GS may be a major endogenous source of EDRF.

Topics: Animals; Aorta; Arginine; Cyclic GMP; Endothelium, Vascular; Glycine; Guanidines; Muscle Relaxation; Nitric Oxide; Propionates; Rats; Succinates

1992