cyclic-gmp and glucose-1-6-bisphosphate

Topics: Aerobiosis; Aging; Anaerobiosis; Animals; Calcium; Cyclic AMP; Cyclic GMP; Fasting; Glucose-6-Phosphate; Glucosephosphates; Hormones; Islets of Langerhans; Kinetics; Lysophosphatidylcholines; Mice; Muscles; Muscular Dystrophy, Animal; Phospholipases A; Rats; Skin

The intracellular concentration of glucose-1,6-bisphosphate (Glc-1,6-P2) in rat tibialis anterior muscle was markedly decreased following the injection of bradykinin. Injection of bradykinin also induced a significant increase in the level of cyclic GMP in muscle. The activity of glucose-1,6-bisphosphatase, the enzyme that degrades Glc-1,6-P2, was markedly enhanced by bradykinin, which may account for the decrease in the level of Glc-1,6-P2. The decrease in Glc-1,6-P2, the potent activator of phosphofructokinase and phosphoglucomutase, was accompanied by a concomitant reduction in these enzymes' activities. The bradykinin-induced decrease in Glc-1,6-P2 and in the activity of phosphofructokinase, the rate-limiting enzyme in glycolysis, may be involved in the pathogenic influences of this hormone in various clinical conditions.

Topics: Animals; Bradykinin; Cyclic GMP; Dose-Response Relationship, Drug; Glucose-6-Phosphate; Glucosephosphates; Injections, Intramuscular; Muscles; Phosphofructokinase-1; Phosphoglucomutase; Phosphoric Monoester Hydrolases; Rats

Injection of serotonin (5-hydroxytryptamine) induced a marked decrease in the level of glucose 1,6-diphosphate (Glc-1,6-P2) in the rat tibialis anterior muscle. Concomitant to the decrease in Glc-1,6-P2, the potent activator of phosphofructokinase and phosphoglucomutase, the activities of both these enzymes were markedly reduced by serotonin. The level of Glc-1,6-P2 and the activities of phosphofructokinase and phosphoglucomutase increased with age in the tibialis anterior muscle and the effect of serotonin was more pronounced in the older animals. Serotonin also induced a significant increase in the level of cyclic GMP in muscle. The serotonin-induced changes in the normal muscle mimic the changes in carbohydrate metabolism we found previously in muscular dystrophy.

Topics: Animals; Cyclic GMP; Enzyme Activation; Glucose-6-Phosphate; Glucosephosphates; Muscles; Phosphofructokinase-1; Phosphoglucomutase; Rats; Serotonin

Topics: Animals; Bucladesine; Cyclic GMP; Diaphragm; Dibutyryl Cyclic GMP; Enzyme Activation; Glucose-6-Phosphate; Glucosephosphates; Male; Muscle, Smooth; Phosphofructokinase-1; Phosphoric Monoester Hydrolases; Rats