cyclic-gmp and formamide

cyclic-gmp has been researched along with formamide* in 1 studies

Other Studies

1 other study(ies) available for cyclic-gmp and formamide

Article	Year
May cyclic nucleotides be a source for abiotic RNA synthesis? Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2011, Volume: 41, Issue:6 Nucleic bases are obtained by heating formamide in the presence of various catalysts. Formamide chemistry also allows the formation of acyclonucleosides and the phosphorylation of nucleosides in every possible position, also affording 2',3' and 3',5' cyclic forms. We have reported that 3',5' cyclic GMP and 3',5' cyclic AMP polymerize in abiotic conditions yielding short oligonucleotides. The characterization of this reaction is being pursued, several of its parameters have been determined and experimental caveats are reported. The yield of non-enzymatic polymerization of cyclic purine nucleotides is very low. Polymerization is strongly enhanced by the presence of base-complementary RNA sequences. Topics: Cyclic AMP; Cyclic GMP; Formamides; Oligonucleotides; Polymerization; Purines; RNA, Complementary	2011

Article

Year

May cyclic nucleotides be a source for abiotic RNA synthesis?

Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2011, Volume: 41, Issue:6

Nucleic bases are obtained by heating formamide in the presence of various catalysts. Formamide chemistry also allows the formation of acyclonucleosides and the phosphorylation of nucleosides in every possible position, also affording 2',3' and 3',5' cyclic forms. We have reported that 3',5' cyclic GMP and 3',5' cyclic AMP polymerize in abiotic conditions yielding short oligonucleotides. The characterization of this reaction is being pursued, several of its parameters have been determined and experimental caveats are reported. The yield of non-enzymatic polymerization of cyclic purine nucleotides is very low. Polymerization is strongly enhanced by the presence of base-complementary RNA sequences.

Topics: Cyclic AMP; Cyclic GMP; Formamides; Oligonucleotides; Polymerization; Purines; RNA, Complementary

2011