cyclic-gmp and efonidipine

cyclic-gmp has been researched along with efonidipine* in 1 studies

Other Studies

1 other study(ies) available for cyclic-gmp and efonidipine

Article	Year
Inhibitory effect of NZ-105, a 1,4-dihydropyridine derivative, on cyclic nucleotide phosphodiesterase activity. The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:6 The effects of NZ-105, a 1,4-dihydropyridine calcium antagonist, on the intracellular cyclic nucleotide system were investigated in-vitro. In rabbit isolated aorta, both NZ-105 (1 and 10 microM) and nicardipine significantly and in a concentration-dependent manner increased intracellular cyclic AMP and cyclic GMP content. NZ-105 inhibited bovine cardiac phosphodiesterase activity (Ki 30 microM) by competitive antagonism. The concentration ranges for inhibition were consistent with the range of increases in cyclic nucleotides. Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Calcium Channel Blockers; Cattle; Cyclic AMP; Cyclic GMP; Dihydropyridines; In Vitro Techniques; Intracellular Fluid; Male; Myocardium; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rabbits	1993

Article

Year

Inhibitory effect of NZ-105, a 1,4-dihydropyridine derivative, on cyclic nucleotide phosphodiesterase activity.

The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:6

The effects of NZ-105, a 1,4-dihydropyridine calcium antagonist, on the intracellular cyclic nucleotide system were investigated in-vitro. In rabbit isolated aorta, both NZ-105 (1 and 10 microM) and nicardipine significantly and in a concentration-dependent manner increased intracellular cyclic AMP and cyclic GMP content. NZ-105 inhibited bovine cardiac phosphodiesterase activity (Ki 30 microM) by competitive antagonism. The concentration ranges for inhibition were consistent with the range of increases in cyclic nucleotides.

Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Calcium Channel Blockers; Cattle; Cyclic AMP; Cyclic GMP; Dihydropyridines; In Vitro Techniques; Intracellular Fluid; Male; Myocardium; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rabbits

1993