cyclic-gmp has been researched along with citral* in 1 studies
1 other study(ies) available for cyclic-gmp and citral
| Article | Year |
|---|---|
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K
The objective of the present study was to scrutinize the effect of nitric oxide (NO), cyclic GMP (cGMP), potassium channel blockers, and metformin on the citral-produced peripheral antinociception. The rat paw 1% formalin test was used to assess nociception and antinociception. Rats were treated with local peripheral administration of citral (10-100 µg/paw). The antinociception of citral (100 µg/paw) was evaluated with and without the local pretreatment of naloxone, NG-L-nitro-arginine methyl ester (L-NAME, a NO synthesis inhibitor), 1H-(1,2,4)-oxadiazolo(4,2-a)quinoxalin-1-one (ODQ, a soluble guanylyl cyclase inhibitor), metformin, opioid receptors antagonists, and K Topics: Acyclic Monoterpenes; Analgesics; Animals; Cyclic GMP; Metformin; Nitric Oxide; Nociception; Pain Measurement; Potassium Channel Blockers; Rats; Rats, Wistar; Receptors, Opioid | 2022 |