Page last updated: 2024-09-04

cyc 202 and staurosporine

cyc 202 has been researched along with staurosporine in 20 studies

Compound Research Comparison

Studies (cyc 202)	Trials (cyc 202)	Recent Studies (post-2010) (cyc 202)	Studies (staurosporine)	Trials (staurosporine)	Recent Studies (post-2010) (staurosporine)
979	7	393	416	0	286
979	7	393	6,272	58	976

Protein Interaction Comparison

Protein	Taxonomy	staurosporine (IC50)
Chain A, Glycogen Synthase Kinase-3 Beta	Homo sapiens (human)	0.015
Chain B, Glycogen Synthase Kinase-3 Beta	Homo sapiens (human)	0.015
Chain A, Glycogen Synthase Kinase-3 Beta	Homo sapiens (human)	0.015
Chain A, Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	0.0558
Chain A, Tyrosine-protein kinase SYK	Homo sapiens (human)	0.012
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	Homo sapiens (human)	0.01
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	Homo sapiens (human)	0.01
Chain X, Proto-oncogene tyrosine-protein kinase Fyn	Homo sapiens (human)	0.0048
Chain A, Serine/threonine-protein kinase TAO2	Rattus norvegicus (Norway rat)	3
epidermal growth factor receptor isoform a precursor	Homo sapiens (human)	0.4467
Serine/threonine-protein kinase Sgk1	Homo sapiens (human)	0.01
Cell division cycle 7-related protein kinase	Homo sapiens (human)	0.0549
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	0.0083
Serine/threonine-protein kinase 25	Homo sapiens (human)	0.0029
Citron Rho-interacting kinase	Homo sapiens (human)	0.749
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	0.9255
Telomerase reverse transcriptase	Homo sapiens (human)	6.9517
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	0.1772
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	0.5561
Aurora kinase A	Homo sapiens (human)	0.0087
Cyclin-G-associated kinase	Homo sapiens (human)	0.011
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	0.267
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	0.1265
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	0.1161
Mitogen-activated protein kinase 13	Homo sapiens (human)	0.4137
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	0.0072
Death-associated protein kinase 3	Homo sapiens (human)	0.0026
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	0.0565
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	0.356
Dual specificity tyrosine-phosphorylation-regulated kinase 3	Homo sapiens (human)	0.0231
NUAK family SNF1-like kinase 1	Homo sapiens (human)	0.003
Cyclin-T1	Homo sapiens (human)	0.0118
Cyclin-T2	Homo sapiens (human)	0.0038
Tyrosine-protein kinase JAK2	Homo sapiens (human)	0.0016
Rho-associated protein kinase 2	Homo sapiens (human)	0.0045
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	0.0096
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	0.1246
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	0.0011
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	0.0071
Serine/threonine-protein kinase 16	Homo sapiens (human)	0.2385
Cyclin-K	Homo sapiens (human)	0.0948
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	0.0003
Serine/threonine-protein kinase 17B	Homo sapiens (human)	0.0258
Serine/threonine-protein kinase 10	Homo sapiens (human)	0.008
Serine/threonine-protein kinase D3	Homo sapiens (human)	0.1446
Cyclin-dependent kinase 14	Homo sapiens (human)	0.1145
G2/mitotic-specific cyclin-B2	Homo sapiens (human)	0.0107
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	0.2829
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	0.0005
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	0.013
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	0.0132
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	0.0212
G1/S-specific cyclin-E2	Homo sapiens (human)	0.011
cAMP-dependent protein kinase catalytic subunit alpha	Bos taurus (cattle)	0.0812
Tyrosine-protein kinase ABL1	Homo sapiens (human)	0.1233
Proto-oncogene tyrosine-protein kinase Src	Gallus gallus (chicken)	0.0063
Epidermal growth factor receptor	Homo sapiens (human)	0.083
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	0.1281
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	0.0713
High affinity nerve growth factor receptor	Homo sapiens (human)	0.2403
Protein kinase C gamma type	Homo sapiens (human)	0.1167
Platelet-derived growth factor receptor beta	Mus musculus (house mouse)	0.002
Protein kinase C alpha type	Rattus norvegicus (Norway rat)	0.2327
Protein kinase C beta type	Homo sapiens (human)	0.0684
Prostaglandin G/H synthase 1	Ovis aries (sheep)	0.056
Insulin receptor	Homo sapiens (human)	0.0706
Tyrosine-protein kinase Lck	Homo sapiens (human)	0.1784
Tyrosine-protein kinase Fyn	Homo sapiens (human)	0.0929
Retinoblastoma-associated protein	Homo sapiens (human)	0.066
Cyclin-dependent kinase 1	Homo sapiens (human)	0.0075
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	0.0039
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	0.1269
Tyrosine-protein kinase Yes	Homo sapiens (human)	0.0029
Tyrosine-protein kinase Lyn	Homo sapiens (human)	0.0012
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	0.0021
Insulin-like growth factor 1 receptor	Homo sapiens (human)	0.5534
Hepatocyte growth factor receptor	Homo sapiens (human)	0.1917
Tyrosine-protein kinase HCK	Homo sapiens (human)	0.0025
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	0.0004
Protein kinase C delta type	Rattus norvegicus (Norway rat)	0.274
Protein kinase C epsilon type	Rattus norvegicus (Norway rat)	0.274
Protein kinase C zeta type	Rattus norvegicus (Norway rat)	0.274
Platelet-derived growth factor receptor beta	Homo sapiens (human)	0.3707
Tyrosine-protein kinase Fgr	Homo sapiens (human)	0.0009
Cytochrome P450 2D6	Homo sapiens (human)	0.0002
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	0.0412
Breakpoint cluster region protein	Homo sapiens (human)	0.0945
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Rattus norvegicus (Norway rat)	0.059
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	0.0216
Fibroblast growth factor receptor 1	Homo sapiens (human)	0.0699
Cyclin-dependent kinase 1	Mus musculus (house mouse)	0.008
Cyclin-dependent kinase 4	Homo sapiens (human)	0.0429
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	0.3642
Acyl-CoA desaturase 1	Mus musculus (house mouse)	3.4
Insulin receptor-related protein	Homo sapiens (human)	0.0113
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	0.0088
Dipeptidyl peptidase 4	Rattus norvegicus (Norway rat)	0.003
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	4
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	0.0107
Insulin receptor	Mus musculus (house mouse)	0.2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	0.0004
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	0.0007
Tyrosine-protein kinase Fer	Homo sapiens (human)	0.0008
Protein kinase C alpha type	Homo sapiens (human)	0.0655
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	0.0115
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	0.0149
Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)	0.011
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	0.1
Amine oxidase [flavin-containing] B	Rattus norvegicus (Norway rat)	0.0025
Casein kinase II subunit alpha'	Homo sapiens (human)	2.0215
Cyclin-A2	Homo sapiens (human)	0.009
Cannabinoid receptor 1	Rattus norvegicus (Norway rat)	0.01
Serine/threonine-protein kinase MAK	Homo sapiens (human)	0.0257
Ephrin type-A receptor 1	Homo sapiens (human)	0.0947
Fibroblast growth factor receptor 2	Homo sapiens (human)	0.0504
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	0.0106
Fibroblast growth factor receptor 4	Homo sapiens (human)	0.17
Fibroblast growth factor receptor 3	Homo sapiens (human)	0.0554
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	0.0137
Cyclin-O	Homo sapiens (human)	0.0015
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	0.0148
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	0.0007
Tyrosine-protein kinase JAK1	Homo sapiens (human)	0.004
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	0.028
G1/S-specific cyclin-D1	Homo sapiens (human)	0.0355
Protein kinase C eta type	Homo sapiens (human)	0.1165
Cyclin-C	Homo sapiens (human)	0.0105
G1/S-specific cyclin-E1	Homo sapiens (human)	0.0108
Cyclin-dependent kinase 2	Homo sapiens (human)	0.0073
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	1.1595
Platelet-derived growth factor receptor alpha	Mus musculus (house mouse)	0.002
Mitogen-activated protein kinase 3	Homo sapiens (human)	4.6724
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	0.0004
cAMP-dependent protein kinase catalytic subunit alpha	Rattus norvegicus (Norway rat)	0.055
Mitogen-activated protein kinase 1	Homo sapiens (human)	2.6853
Ephrin type-A receptor 2	Homo sapiens (human)	0.1257
Ephrin type-A receptor 3	Homo sapiens (human)	0.0347
Ephrin type-A receptor 8	Homo sapiens (human)	0.1061
Ephrin type-B receptor 2	Homo sapiens (human)	0.1191
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	0.0173
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	0.0137
G1/S-specific cyclin-D3	Homo sapiens (human)	0.055
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	0.0131
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	0.1848
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	0.4119
G protein-coupled receptor kinase 4	Homo sapiens (human)	0.0914
Kinesin-1 heavy chain	Homo sapiens (human)	0.0015
G protein-coupled receptor kinase 5	Homo sapiens (human)	0.0489
Hexokinase-4	Homo sapiens (human)	0.0006
Beta-adrenergic receptor kinase 2	Homo sapiens (human)	0.856
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	0.0146
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	0.1791
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	0.026
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	0.0014
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	4.288
Activin receptor type-1B	Homo sapiens (human)	9.118
TGF-beta receptor type-1	Homo sapiens (human)	2.2823
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	0.85
Tyrosine-protein kinase CSK	Homo sapiens (human)	0.2071
Protein kinase C iota type	Homo sapiens (human)	0.1739
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	0.442
Tyrosine-protein kinase Tec	Homo sapiens (human)	0.0338
Tyrosine-protein kinase TXK	Homo sapiens (human)	0.0203
Tyrosine-protein kinase ABL2	Homo sapiens (human)	0.0505
Tyrosine-protein kinase FRK	Homo sapiens (human)	0.0108
G protein-coupled receptor kinase 6	Homo sapiens (human)	0.0473
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	0.0175
Tyrosine-protein kinase SYK	Homo sapiens (human)	0.0057
Mitogen-activated protein kinase 8	Homo sapiens (human)	1.1067
Mitogen-activated protein kinase 9	Homo sapiens (human)	2.0555
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	0.863
Phosphorylase b kinase regulatory subunit alpha, liver isoform	Homo sapiens (human)	0.0005
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform	Homo sapiens (human)	0.0005
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	0.0099
Casein kinase I isoform alpha	Homo sapiens (human)	3.412
Casein kinase I isoform delta	Homo sapiens (human)	1.4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	9
MAP kinase-activated protein kinase 2	Homo sapiens (human)	0.735
Cyclin-dependent kinase 8	Homo sapiens (human)	0.0105
Casein kinase I isoform epsilon	Homo sapiens (human)	1.4
Dual specificity protein kinase CLK1	Homo sapiens (human)	0.0108
Dual specificity protein kinase CLK2	Homo sapiens (human)	0.6508
Dual specificity protein kinase CLK3	Homo sapiens (human)	0.92
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	0.0103
Glycogen synthase kinase-3 beta	Homo sapiens (human)	0.0435
D(1A) dopamine receptor	Sus scrofa (pig)	0.001
Cyclin-dependent kinase 7	Homo sapiens (human)	0.2793
Cyclin-dependent kinase 9	Homo sapiens (human)	0.0474
Tyrosine-protein kinase Blk	Homo sapiens (human)	0.0011
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	0.0377
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	0.0002
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	0.0046
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	0.0014
Cyclin-H	Homo sapiens (human)	0.2793
CDK-activating kinase assembly factor MAT1	Homo sapiens (human)	0.1216
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	1.7683
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	0.0851
Tyrosine-protein kinase JAK3	Homo sapiens (human)	0.0084
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	0.0036
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	0.4397
Death-associated protein kinase 1	Homo sapiens (human)	0.0101
LIM domain kinase 1	Homo sapiens (human)	0.0026
LIM domain kinase 2	Homo sapiens (human)	0.0956
Mitogen-activated protein kinase 12	Homo sapiens (human)	0.4512
Mitogen-activated protein kinase 10	Homo sapiens (human)	0.0731
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	1.1354
Ephrin type-B receptor 3	Homo sapiens (human)	1.2855
Ephrin type-A receptor 5	Homo sapiens (human)	0.0159
Ephrin type-B receptor 4	Homo sapiens (human)	0.1869
Ephrin type-B receptor 1	Homo sapiens (human)	0.0694
Ephrin type-A receptor 4	Homo sapiens (human)	0.0105
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	0.0009
Calcium-dependent protein kinase 1	Plasmodium falciparum K1	0.24
Protein kinase C gamma type	Rattus norvegicus (Norway rat)	0.2168
Casein kinase II subunit beta	Homo sapiens (human)	3.4
Casein kinase II subunit alpha	Homo sapiens (human)	3.4723
Protein kinase C beta type	Rattus norvegicus (Norway rat)	0.2029
SRSF protein kinase 2	Homo sapiens (human)	0.206
Casein kinase I isoform gamma-2	Homo sapiens (human)	1.9467
Cyclin-A1	Homo sapiens (human)	0.0013
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	0.0044
MO15-related protein kinase Pfmrk	Plasmodium falciparum (malaria parasite P. falciparum)	4
Cyclin-dependent kinase 3	Homo sapiens (human)	0.0118
Cyclin-dependent kinase 6	Homo sapiens (human)	0.0395
Cyclin-dependent-like kinase 5	Homo sapiens (human)	0.0141
Cyclin-dependent kinase 16	Homo sapiens (human)	0.0206
Cyclin-dependent kinase 17	Homo sapiens (human)	0.0135
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	0.048
Protein kinase C epsilon type	Homo sapiens (human)	0.0767
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	0.2314
Angiopoietin-1 receptor	Homo sapiens (human)	0.0823
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	0.1952
Protein kinase C theta type	Homo sapiens (human)	0.1168
Activin receptor type-1	Homo sapiens (human)	1.1354
Macrophage-stimulating protein receptor	Homo sapiens (human)	0.2195
Focal adhesion kinase 1	Homo sapiens (human)	0.078
Protein kinase C zeta type	Homo sapiens (human)	0.1722
Protein kinase C delta type	Homo sapiens (human)	0.1283
Tyrosine-protein kinase BTK	Homo sapiens (human)	0.0288
Aldehyde oxidase	Homo sapiens (human)	0.0023
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	0.0177
Cyclin-dependent kinase 18	Homo sapiens (human)	0.0587
Activated CDC42 kinase 1	Homo sapiens (human)	0.0299
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	0.9655
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	0.0068
Myotonin-protein kinase	Homo sapiens (human)	0.1735
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	0.0992
Tyrosine-protein kinase Mer	Homo sapiens (human)	0.0331
Serine/threonine-protein kinase 4	Homo sapiens (human)	0.0013
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	0.0004
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	0.0252
Mitogen-activated protein kinase 7	Homo sapiens (human)	4.0032
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	0.0021
Serine/threonine-protein kinase 3	Homo sapiens (human)	0.0034
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	0.438
cGMP-dependent protein kinase 2	Homo sapiens (human)	0.0161
Rho-associated protein kinase 1	Homo sapiens (human)	0.0038
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	0.0012
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	0.0018
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	0.0026
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	0.0024
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	0.0095
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	1.94
Protein-tyrosine kinase 6	Homo sapiens (human)	0.484
cGMP-dependent protein kinase 1	Homo sapiens (human)	0.0027
Cyclin-dependent kinase 13	Homo sapiens (human)	0.057
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	0.0032
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	0.0003
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	0.0095
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	0.0006
Lysine--tRNA ligase	Homo sapiens (human)	0.0049
Cyclin-dependent kinase 5 activator 1	Homo sapiens (human)	0.0141
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	Homo sapiens (human)	0.0005
Serine/threonine-protein kinase D1	Homo sapiens (human)	0.1448
Serine/threonine-protein kinase 38	Homo sapiens (human)	0.0037
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	0.183
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	0.0002
Ephrin type-A receptor 7	Homo sapiens (human)	0.0477
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	0.0004
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	0.1995
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	0.0448
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	Homo sapiens (human)	0.037
Mitogen-activated protein kinase 11	Homo sapiens (human)	1
Serine/threonine-protein kinase STK11	Homo sapiens (human)	0.0598
Rhodopsin kinase GRK1	Homo sapiens (human)	0.068
Coiled-coil domain-containing protein 6	Homo sapiens (human)	0.0022
NT-3 growth factor receptor	Homo sapiens (human)	0.0002
Serine/threonine-protein kinase N1	Homo sapiens (human)	0.0025
Serine/threonine-protein kinase N2	Homo sapiens (human)	0.0055
Mitogen-activated protein kinase 14	Homo sapiens (human)	0.5052
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	0.1475
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	0.016
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	0.0004
MAP kinase-activated protein kinase 3	Homo sapiens (human)	2.775
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	0.0017
Discoidin domain-containing receptor 2	Homo sapiens (human)	0.0008
Thioredoxin reductase 1, cytoplasmic	Homo sapiens (human)	0.0432
Rho-associated protein kinase 2	Bos taurus (cattle)	0.0417
Myosin light chain kinase 3	Homo sapiens (human)	0.1585
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	0.1464
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	0.0087
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	0.0077
Mitogen-activated protein kinase kinase kinase 21	Homo sapiens (human)	1.1175
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	0.0032
Sigma non-opioid intracellular receptor 1	Cavia porcellus (domestic guinea pig)	0.0067
Testis-specific serine/threonine-protein kinase 1	Mus musculus (house mouse)	0.0003
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus (Norway rat)	0.012
Protein kinase C eta type	Rattus norvegicus (Norway rat)	0.274
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	0.0005
Calcium/calmodulin-dependent protein kinase type 1B	Homo sapiens (human)	0.0044
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	0.0864
Serine/threonine-protein kinase N3	Homo sapiens (human)	0.0105
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	0.0027
Kinase suppressor of Ras 2	Homo sapiens (human)	5.4
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	0.0552
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	0.0416
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	0.0001
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	0.0008
Serine/threonine-protein kinase Nek8	Homo sapiens (human)	0.0263
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	0.0035
Serine/threonine-protein kinase 32C	Homo sapiens (human)	0.232
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	0.0001
Myosin light chain kinase family member 4	Homo sapiens (human)	0.0537
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	2.639
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	0.0003
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	0.0001
Kinase suppressor of Ras 1	Homo sapiens (human)	6.265
Cyclin-dependent kinase-like 3	Homo sapiens (human)	1.1
MAP kinase-activated protein kinase 5	Homo sapiens (human)	0.212
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	0.0028
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	0.1102
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	0.0032
Misshapen-like kinase 1	Homo sapiens (human)	0.0004
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	0.089
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	0.0359
Casein kinase I isoform alpha-like	Homo sapiens (human)	1.84
Cyclin-Y	Homo sapiens (human)	0.0518
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	0.226
Myosin-IIIa	Homo sapiens (human)	0.0425
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	0.521
Protein odd-skipped-related 1	Homo sapiens (human)	0.0402
Mitogen-activated protein kinase 15	Homo sapiens (human)	0.0081
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	0.101
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	0.0007
Serine/threonine-protein kinase haspin	Homo sapiens (human)	0.0422
Rhodopsin kinase GRK7	Homo sapiens (human)	0.0053
G2/mitotic-specific cyclin-B3	Homo sapiens (human)	0.0107
Myosin-IIIb	Homo sapiens (human)	0.0058
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	0.18
Phosphorylase b kinase regulatory subunit beta	Homo sapiens (human)	0.0005
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	0.073
Aurora kinase B	Homo sapiens (human)	0.007
Lymphokine-activated killer T-cell-originated protein kinase	Homo sapiens (human)	0.0691
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	0.0001
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	0.0047
Testis-specific serine/threonine-protein kinase 2	Homo sapiens (human)	0.0038
Testis-specific serine/threonine-protein kinase 3	Homo sapiens (human)	0.0051
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	0.0122
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	0.0107
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	0.0246
SRSF protein kinase 1	Homo sapiens (human)	0.0337
Mitogen-activated protein kinase kinase kinase 14	Homo sapiens (human)	2.3
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	0.215
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	0.0092
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	0.0531
Testis-specific serine/threonine-protein kinase 6	Homo sapiens (human)	0.1525
Serine/threonine-protein kinase 33	Homo sapiens (human)	0.0374
Serine/threonine-protein kinase D2	Homo sapiens (human)	0.0014
NUAK family SNF1-like kinase 2	Homo sapiens (human)	0.0018
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	0.3669
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	0.0147
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	0.0142
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	0.0017
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	0.3655
Tyrosine-protein kinase Srms	Homo sapiens (human)	6.5
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	0.456
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	0.203
Inactive tyrosine-protein kinase PEAK1	Homo sapiens (human)	0.0025
Dual specificity protein kinase CLK4	Homo sapiens (human)	0.0723
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	0.0221
Serine/threonine-protein kinase Sgk2	Homo sapiens (human)	0.0159
Casein kinase I isoform gamma-1	Homo sapiens (human)	5.3367
NADPH oxidase 4	Homo sapiens (human)	0.0708
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	0.0327
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	0.0059
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	0.0062
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	0.0122
Serine/threonine-protein kinase 32B	Homo sapiens (human)	0.0375
Cyclin-dependent kinase 12	Homo sapiens (human)	0.053
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	0.546
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	0.0003
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	0.0813
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	0.0039
Serine/threonine-protein kinase 26	Homo sapiens (human)	0.0124
Serine/threonine-protein kinase NLK	Homo sapiens (human)	0.0666
Ribosomal protein S6 kinase beta-2	Homo sapiens (human)	0.0015
Protein DBF4 homolog A	Homo sapiens (human)	0.0549
Serine/threonine-protein kinase 17A	Homo sapiens (human)	0.0386
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	0.0158
Ephrin type-A receptor 6	Homo sapiens (human)	0.0161
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	0.003
Death-associated protein kinase 2	Homo sapiens (human)	0.0064
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	0.0001
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	0.0103
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	0.0295
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	0.0076
ALK tyrosine kinase receptor	Homo sapiens (human)	0.0044
SRSF protein kinase 3	Homo sapiens (human)	1.77
Serine/threonine-protein kinase ICK	Homo sapiens (human)	0.0443
Aurora kinase C	Homo sapiens (human)	0.0022
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	0.0024
Protein kinase C theta type	Rattus norvegicus (Norway rat)	0.274
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	0.3701
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	0.0012
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	0.1541
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	0.0335
Serine/threonine-protein kinase WNK2	Homo sapiens (human)	1.455
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	0.0017
5'-AMP-activated protein kinase subunit beta-1	Homo sapiens (human)	1.1354
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	0.0002
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	0.0027
Serine/threonine-protein kinase 24	Homo sapiens (human)	0.0065
Casein kinase I isoform gamma-3	Homo sapiens (human)	2.675
Chain A, Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	0.0003
Chain X, Tyrosine-protein kinase Lyn	Homo sapiens (human)	0.0013

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (15.00)	18.2507
2000's	10 (50.00)	29.6817
2010's	6 (30.00)	24.3611
2020's	1 (5.00)	2.80

Authors

Authors	Studies
Bhattacharjee, AK; Ellis, W; Gerena, L; Geyer, JA; Kathcart, AK; Kyle, DE; Li, Z; Lopez-Sanchez, M; Nichols, DA; Prigge, ST; Terrell, J; Waters, NC; Woodard, CL	1
Atteridge, CE; Azimioara, MD; Benedetti, MG; Biggs, WH; Carter, TA; Ciceri, P; Edeen, PT; Fabian, MA; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Lockhart, DJ; Mehta, SA; Milanov, ZV; Patel, HK; Treiber, DK; Velasco, AM; Wodicka, LM; Zarrinkar, PP	1
Akula, N; Pattabiraman, N; Sridhar, J	1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M	1
Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Gallant, P; Herrgard, S; Hunt, JP; Karaman, MW; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Treiber, DK; Wodicka, LM; Zarrinkar, PP	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Russu, WA; Shallal, HM	1
Baumli, S; Endicott, JA; Fischer, PM; Hole, AJ; Huang, S; Noble, ME; Pepper, C; Shao, H; Shi, S; Wang, S	1
Baek, NI; Cho, JG; Jeon, YJ; Kim, GS; Lee, DY; Natarajan, S; Park, JH; Shrestha, S; Yang, DC; Yeon, SW	1
Cheng, X; Christ, J; Eisenbrand, G; Merz, KH; Muehlbeyer, S; Thommet, A; Vatter, S; Wölfl, S; Zeller, J	1
Jarhad, DB; Jeong, LS; Kim, HR; Mashelkar, KK; Noh, M	1
Abdel-Aziz, HA; Abou-Seri, SM; Bonardi, A; Eldehna, WM; Elgazar, AA; Fahim, SH; Gratteri, P; Kryštof, V; Nocentini, A; Said, MA; Soliman, DH; Supuran, CT	1
Cruz, M; Eneroth, P; Idoyaga Vargas, V; Sidén, A; Yakisich, JS	1
Elbaum, D; Lydon, NB; Toledo, LM	1
Détivaud, L; Doerig, C; Gray, N; Meijer, L	1
Fischer, K; Hescheler, J; Sauer, H; Wartenberg, M	1
Alemany, C; Ciudad, CJ; Noé, V; Peñuelas, S	1
Bartek, J; Fugger, K; Hansen, LT; Helleday, T; Johansson, F; Lukas, J; Lundin, C; Sehested, M; Syljuåsen, RG; Sørensen, CS	1
Blagden, S; de Bono, J	1
Chen, XG; Zuo, MX	1

Reviews

6 review(s) available for cyc 202 and staurosporine

Article	Year
Selectivity and potency of cyclin-dependent kinase inhibitors. The AAPS journal, 2006, Mar-24, Volume: 8, Issue:1 Topics: Animals; Binding Sites; Cyclin-Dependent Kinases; Humans; Protein Kinase Inhibitors; Signal Transduction	2006
Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics. Journal of medicinal chemistry, 2018, 11-21, Volume: 61, Issue:22 Topics: Animals; Biological Products; Disease; Dyrk Kinases; Enzyme Activation; Humans; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases	2018
The structure-based design of ATP-site directed protein kinase inhibitors. Current medicinal chemistry, 1999, Volume: 6, Issue:9 Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Anthraquinones; Binding Sites; Catalytic Domain; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Humans; Kinetin; Piperazines; Protein-Tyrosine Kinases; Purines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptors, Growth Factor; Roscovitine; Staurosporine; Structure-Activity Relationship	1999
ATP-site directed inhibitors of cyclin-dependent kinases. Current medicinal chemistry, 1999, Volume: 6, Issue:9 Topics: Adenine; Adenosine Triphosphate; Amino Acid Sequence; Antineoplastic Agents; Binding Sites; Cell Cycle; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Flavonoids; Humans; Isopentenyladenosine; Kinetin; Molecular Sequence Data; Piperidines; Purines; Roscovitine; Sequence Alignment; Sequence Homology, Amino Acid; Staurosporine; Suramin	1999
Drugging cell cycle kinases in cancer therapy. Current drug targets, 2005, Volume: 6, Issue:3 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles	2005
[Research on cyclin-dependent kinase inhibitors: state of the art and perspective]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2007, Volume: 29, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cyclin-Dependent Kinases; Cyclins; Flavonoids; Humans; Neoplasms; Piperidines; Purines; Roscovitine; Staurosporine	2007

Other Studies

14 other study(ies) available for cyc 202 and staurosporine

Article	Year
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases. Journal of medicinal chemistry, 2003, Aug-28, Volume: 46, Issue:18 Topics: Amino Acid Sequence; Animals; Antimalarials; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Indoles; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Structure-Activity Relationship	2003
A small molecule-kinase interaction map for clinical kinase inhibitors. Nature biotechnology, 2005, Volume: 23, Issue:3 Topics: Benzamides; Drug Design; Escherichia coli; Escherichia coli Proteins; Imatinib Mesylate; Microchemistry; Pharmaceutical Preparations; Piperazines; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Pyrimidines	2005
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51 Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases	2007
A quantitative analysis of kinase inhibitor selectivity. Nature biotechnology, 2008, Volume: 26, Issue:1 Topics: Binding Sites; Enzyme Activation; Humans; Phosphotransferases; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Proteome; Quantitative Structure-Activity Relationship	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Stereoisomerism; Structure-Activity Relationship	2011
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Cyclin-Dependent Kinase 9; Humans; Models, Molecular; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship	2013
Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora. Bioorganic & medicinal chemistry letters, 2013, Sep-15, Volume: 23, Issue:18 Topics: Cyclin-Dependent Kinase 5; Flavonoids; Humans; Models, Molecular; Molecular Structure; Nerve Tissue Proteins; Neuroprotective Agents; Rhus	2013
Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. Journal of medicinal chemistry, 2017, 06-22, Volume: 60, Issue:12 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; Indoles; Oximes; Protein Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Solubility; Structure-Activity Relationship	2017
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. European journal of medicinal chemistry, 2020, Mar-01, Volume: 189 Topics: Antineoplastic Agents; Azo Compounds; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Molecular Docking Simulation; Molecular Structure; Neoplasms; Pyrazoles; Structure-Activity Relationship; Sulfonamides	2020
Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine. Biochemical and biophysical research communications, 1998, Feb-24, Volume: 243, Issue:3 Topics: Animals; Cell Cycle; Cerebral Cortex; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Etoposide; Kinetin; Nucleic Acid Synthesis Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Staurosporine; Thymidine; Tritium	1998
Modulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by cell cycle inhibitors. Biochimica et biophysica acta, 2002, Feb-13, Volume: 1589, Issue:1 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Male; Mimosine; Mitomycin; Prostatic Neoplasms; Purines; Roscovitine; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Proteins	2002
The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors. European journal of biochemistry, 2003, Volume: 270, Issue:24 Topics: Animals; Blotting, Western; Cell Division; Cell Nucleus; CHO Cells; Cloning, Molecular; Cricetinae; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Flow Cytometry; HeLa Cells; Humans; Indoles; K562 Cells; Kinetin; Luciferases; Maleimides; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Protein Synthesis Inhibitors; Purines; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Sp1 Transcription Factor; Staurosporine; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription, Genetic; Transfection	2003
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Molecular and cellular biology, 2005, Volume: 25, Issue:9 Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Checkpoint Kinase 1; Checkpoint Kinase 2; Chromosomal Proteins, Non-Histone; DNA Damage; DNA Replication; DNA-Binding Proteins; DNA, Single-Stranded; Histones; Humans; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Replication Protein A; RNA, Small Interfering; Roscovitine; Staurosporine; Tumor Suppressor Protein p53	2005