Page last updated: 2024-09-04

cyc 202 and piperidines

cyc 202 has been researched along with piperidines in 32 studies

Compound Research Comparison

Studies (cyc 202)	Trials (cyc 202)	Recent Studies (post-2010) (cyc 202)	Studies (piperidines)	Trials (piperidines)	Recent Studies (post-2010) (piperidines)
979	7	393	40,235	5,221	14,545

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (9.38)	18.2507
2000's	19 (59.38)	29.6817
2010's	10 (31.25)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Coffey, ET; Courtney, MJ	1
Chang, TH; Lee, HR; Senderowicz, AM; Szabo, E; Tebalt, MJ	1
Détivaud, L; Doerig, C; Gray, N; Meijer, L	1
Gelman, IH; Klotman, PE; Nelson, PJ	1
Conrad, D; Dai, Y; Dent, P; Grant, S; Krystal, G; Rahmani, M; Yu, C	1
Bravo, R; Bruna, A; Caelles, C; Camarasa, J; Camins, A; Canudas, AM; Escubedo, E; Jiménez, A; Jorda, EG; Pallàs, M; Pubill, D; Verdaguer, E	1
Doniger, J; Mayner, R; Sadaie, MR	1
Canduri, F; de Azevedo, WF; Uchoa, HB	1
Cress, WD; Freeman, SN; Ma, Y	1
Blagden, S; de Bono, J	1
Fischer, PM; Gianella-Borradori, A	1
Byrnes, KR; Cernak, I; Di Giovanni, S; Faden, AI; Stoica, B	1
Bamba, D; Davis, C; Gallo, RC; Gwarzo, MY; Heredia, A; Le, N; Redfield, RR; Sadowska, M	1
Schmid, G; Wesierska-Gadek, J	1
André, P; Appert-Collin, A; Coupin, G; Gies, JP; Hugel, B; Levy, R; Lombard, Y; Niederhoffer, N; Poindron, P	1
Berro, R; Chao, SH; de la Fuente, C; Kashanchi, F; Nekhai, S; Pumfery, A	1
Bensaude, O; Biglione, S; Byers, SA; Maury, W; Nguyen, VT; Price, DH; Price, JP	1
Chen, XG; Zuo, MX	1
Chen, GD; Chiu, CH; Hsien, MC; Lai, CY; Lee, SD; Liao, JM; Lin, TB; Lu, HT; Peng, HY; Tung, KC	1
Chen, R; Chubb, S; Fox, JA; Gandhi, V; Hawtin, RE; Keating, MJ; Plunkett, W; Wierda, WG	1
De Clercq, E; Liu, XY; Wang, Y	1
Chen, L; Li, X; Salinas, GD	1
Bareford, MD; Dent, P; Eulitt, P; Hossein, H; Martin, AP; Mitchell, C; Nephew, KP; Yacoub, A; Yang, C	1
Abrol, R; Goddard, WA; Kudo, W; Nair, N; Reddy, VP; Smith, MA	1
Auladell, C; Beas-Zarate, C; Camins, A; de la Torre, AV; Folch, J; Junyent, F; Pallàs, M; Pelegrí, C; Verdaguer, E; Vilaplana, J	1
Hampson, P; Hazeldine, J; Krystof, V; M, J; Pechan, P; Strnad, M; Wang, K	1
Beider, K; Josefsberg Ben-Yehoshua, L; Nagler, A; Ostrovsky, O; Peled, A; Samookh, M; Shimoni, A	1
Boddy, N; Burrows, F; Pallis, M; Russell, N; Seedhouse, C; Whittall, A	1
Gu, X; Liu, X; Liu, Y; Ma, Z; Sun, YE; Zhang, J; Zhang, W	1
Giordano, A; Morales, F	1
Adiyasa, I; Cano, C; Hardcastle, IR; Heptinstall, AB	1
Cwiklinski, E; Hoffmann, TM; Hundal, HS; Hyde, R; Lipina, C; Stretton, C; Taylor, PM	1

Reviews

10 review(s) available for cyc 202 and piperidines

Article	Year
ATP-site directed inhibitors of cyclin-dependent kinases. Current medicinal chemistry, 1999, Volume: 6, Issue:9 Topics: Adenine; Adenosine Triphosphate; Amino Acid Sequence; Antineoplastic Agents; Binding Sites; Cell Cycle; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Flavonoids; Humans; Isopentenyladenosine; Kinetin; Molecular Sequence Data; Piperidines; Purines; Roscovitine; Sequence Alignment; Sequence Homology, Amino Acid; Staurosporine; Suramin	1999
A novel approach to develop anti-HIV drugs: adapting non-nucleoside anticancer chemotherapeutics. Antiviral research, 2004, Volume: 61, Issue:1 Topics: Anti-HIV Agents; Antimetabolites; Antineoplastic Agents; Apoptosis; Camptothecin; Cyclin-Dependent Kinases; Flavonoids; HIV; HIV Infections; Humans; Piperidines; Purines; Receptors, Estrogen; Roscovitine; Topoisomerase I Inhibitors; Virus Replication	2004
Drugging cell cycle kinases in cancer therapy. Current drug targets, 2005, Volume: 6, Issue:3 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles	2005
Recent progress in the discovery and development of cyclin-dependent kinase inhibitors. Expert opinion on investigational drugs, 2005, Volume: 14, Issue:4 Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Clinical Trials as Topic; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; Female; Flavonoids; Glomerulonephritis; Hematologic Neoplasms; HIV Infections; Humans; Molecular Sequence Data; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Transcription, Genetic	2005
Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein. Expert opinion on investigational drugs, 2006, Volume: 15, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Proliferation; Clinical Trials as Topic; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinases; Drug Evaluation, Preclinical; Flavonoids; Gene Expression Regulation; Humans; Mutation; Neoplasms; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Transcription, Genetic; Tumor Suppressor Protein p53	2006
Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics. Current pharmaceutical design, 2006, Volume: 12, Issue:16 Topics: Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Flavonoids; Gene Expression Regulation, Viral; HIV Infections; Humans; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Virus Replication	2006
[Research on cyclin-dependent kinase inhibitors: state of the art and perspective]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2007, Volume: 29, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cyclin-Dependent Kinases; Cyclins; Flavonoids; Humans; Neoplasms; Piperidines; Purines; Roscovitine; Staurosporine	2007
Role of the HIV-1 positive elongation factor P-TEFb and inhibitors thereof. Mini reviews in medicinal chemistry, 2009, Volume: 9, Issue:3 Topics: Flavonoids; HIV Infections; HIV-1; Humans; Models, Biological; Piperidines; Positive Transcriptional Elongation Factor B; Protein Kinase Inhibitors; Purines; RNA, Small Nuclear; Roscovitine; Transcription, Genetic	2009
Overview of CDK9 as a target in cancer research. Cell cycle (Georgetown, Tex.), 2016, Volume: 15, Issue:4 Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Flavonoids; Humans; Indolizines; Molecular Targeted Therapy; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridinium Compounds; Roscovitine; Thiazoles; Urea	2016
Recent advances in CDK inhibitors for cancer therapy. Future medicinal chemistry, 2018, 06-01, Volume: 10, Issue:11 Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Flavonoids; Humans; Molecular Structure; Piperidines; Protein Kinase Inhibitors; Roscovitine; Signal Transduction	2018

Other Studies

22 other study(ies) available for cyc 202 and piperidines

Article	Year
The mechanism of Ara-C-induced apoptosis of differentiating cerebellar granule neurons. The European journal of neuroscience, 1999, Volume: 11, Issue:3 Topics: Androstadienes; Animals; Antimetabolites, Antineoplastic; Apoptosis; Benzamides; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Differentiation; Cell Survival; Cerebellum; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cytarabine; Enzyme Inhibitors; Flavonoids; Imatinib Mesylate; Imidazoles; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Neurons; Piperazines; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Purines; Pyridines; Pyrimidines; Rats; Roscovitine; Signal Transduction; Stress, Physiological; Wortmannin	1999
Induction of differentiation accompanies inhibition of Cdk2 in a non-small cell lung cancer cell line. International journal of oncology, 1999, Volume: 15, Issue:1 Topics: Carcinoma, Non-Small-Cell Lung; CDC2-CDC28 Kinases; Cell Differentiation; Cell Division; Cyclin D; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Flavonoids; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasm Proteins; Piperidines; Protein Serine-Threonine Kinases; Purines; Roscovitine; Signal Transduction; Transfection; Tumor Cells, Cultured	1999
Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytes. Journal of the American Society of Nephrology : JASN, 2001, Volume: 12, Issue:12 Topics: Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genes, Viral; HIV Infections; HIV-1; Kidney; Mice; Piperidines; Purines; Roscovitine; Transcription, Genetic	2001
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer research, 2003, Apr-15, Volume: 63, Issue:8 Topics: 2-Aminopurine; Antineoplastic Agents; Apoptosis; Chromones; Cyclin-Dependent Kinases; Drug Synergism; Enzyme Inhibitors; Flavonoids; Humans; Leukemia; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purines; Roscovitine; Tumor Cells, Cultured	2003
Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis. Neuropharmacology, 2003, Volume: 45, Issue:5 Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Anthracenes; Anti-Bacterial Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Bromodeoxyuridine; Carrier Proteins; Caspase 3; Caspases; CDC2-CDC28 Kinases; Cell Count; Cell Survival; Cells, Cultured; Cerebellum; Chromatin; Colchicine; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Flow Cytometry; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Kinase 4; Microtubules; Minocycline; Mitogen-Activated Protein Kinase Kinases; Neurons; Neuroprotective Agents; Piperidines; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Time Factors; Tubulin	2003
Molecular models of cyclin-dependent kinase 1 complexed with inhibitors. Biochemical and biophysical research communications, 2004, Nov-12, Volume: 324, Issue:2 Topics: Amino Acid Sequence; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Drug Design; Flavonoids; Humans; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Purines; Roscovitine; Sequence Homology, Amino Acid	2004
E2F4 deficiency promotes drug-induced apoptosis. Cancer biology & therapy, 2004, Volume: 3, Issue:12 Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; Fibroblasts; Flavonoids; Humans; Lung Neoplasms; Mice; Mice, Knockout; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Roscovitine; Thiazoles; Transcription Factors; Tumor Cells, Cultured	2004
Role of the cell cycle in the pathobiology of central nervous system trauma. Cell cycle (Georgetown, Tex.), 2005, Volume: 4, Issue:9 Topics: Animals; Antineoplastic Agents; Astrocytes; Brain; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Central Nervous System; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Etoposide; Flavonoids; Kinetin; Magnetic Resonance Spectroscopy; Microglia; Mitosis; Neurons; Piperidines; Purines; Rats; Roscovitine; Up-Regulation	2005
Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication. AIDS (London, England), 2005, Dec-02, Volume: 19, Issue:18 Topics: Cyclin-Dependent Kinases; Drug Evaluation; Flavonoids; HIV-1; Humans; Indoles; Inhibitory Concentration 50; Leukocytes, Mononuclear; Macrophages; Oximes; Piperidines; Positive Transcriptional Elongation Factor B; Protein Kinase Inhibitors; Purines; Reverse Transcriptase Polymerase Chain Reaction; Roscovitine; U937 Cells; Virus Replication	2005
Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons. Life sciences, 2006, Jun-27, Volume: 79, Issue:5 Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Flavonoids; Kinetin; Mice; Mitosis; Motor Neurons; Nerve Growth Factors; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine	2006
Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex. Retrovirology, 2007, Jul-11, Volume: 4 Topics: Cyclin-Dependent Kinase 9; Dichlororibofuranosylbenzimidazole; Enzyme Inhibitors; Flavonoids; HIV-1; Kinetics; Piperidines; Positive Transcriptional Elongation Factor B; Purines; Roscovitine; Viral Proteins; Virus Replication	2007
Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats. Pain, 2009, Volume: 142, Issue:1-2 Topics: Animals; Colon; Cyclin-Dependent Kinase 5; Electric Stimulation; Excitatory Amino Acid Agents; Glutamic Acid; Inflammation; Male; Mustard Plant; Pelvis; Piperidines; Plant Oils; Protein Kinase Inhibitors; Purines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex; RNA, Small Interfering; Roscovitine; TRPV Cation Channels; Urethra	2009
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood, 2009, May-07, Volume: 113, Issue:19 Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Caspases; Cyclin-Dependent Kinases; Female; Flavonoids; Humans; Immunoblotting; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Male; Membrane Potential, Mitochondrial; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Neoplasm; Roscovitine; Thiazoles; Transcription, Genetic; X-Linked Inhibitor of Apoptosis Protein	2009
Regulation of serotonin 1B receptor by glycogen synthase kinase-3. Molecular pharmacology, 2009, Volume: 76, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Benzazepines; Cell Line; CHO Cells; Cholera Toxin; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Glycogen Synthase Kinase 3; Humans; Indoles; Male; Maleimides; Mice; Mice, Inbred BALB C; Oxadiazoles; Oximes; Piperidines; Piperidones; Protein Kinase Inhibitors; Purines; Pyridines; Receptor, Serotonin, 5-HT1B; Roscovitine; Serotonin; Spiro Compounds	2009
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo. Cancer biology & therapy, 2010, Nov-01, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cyclin-Dependent Kinases; Drug Synergism; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Female; Flavonoids; Fluorescent Antibody Technique; Gene Knockout Techniques; Humans; Indoles; Lapatinib; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Piperidines; Proto-Oncogene Proteins c-bcl-2; Purines; Pyrroles; Quinazolines; Roscovitine	2010
Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies. Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13 Topics: Animals; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase 5; Flavonoids; Fluorine; Hippocampus; Humans; Hydrogen Bonding; Mice; Models, Molecular; Molecular Structure; Neuroprotective Agents; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Triazoles	2011
GSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons. Pharmacological research, 2012, Volume: 65, Issue:1 Topics: Animals; Apoptosis; Cells, Cultured; Cerebellum; Cyclin-Dependent Kinases; Cytoprotection; Dose-Response Relationship, Drug; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-jun; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Signal Transduction	2012
Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis. PloS one, 2012, Volume: 7, Issue:1 Topics: Apoptosis; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Flavonoids; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Neutrophils; Piperidines; Proto-Oncogene Proteins c-bcl-2; Purines; Roscovitine	2012
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. PloS one, 2012, Volume: 7, Issue:4 Topics: Apoptosis; Cell Line, Tumor; Cyclin D1; Cyclin E; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Gene Silencing; Genomic Instability; Humans; Multiple Myeloma; Oncogene Proteins; Piperidines; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Roscovitine	2012
Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells. BMC pharmacology & toxicology, 2013, Jun-15, Volume: 14 Topics: Acute Disease; Adenine Nucleotides; Antineoplastic Agents; Apoptosis; Arabinonucleosides; Azacitidine; Cell Line, Tumor; Cell Survival; Clofarabine; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Humans; Leukemia, Myeloid; Piperidines; Purines; RNA Polymerase II; RNA, Neoplasm; Roscovitine; Sirolimus; TOR Serine-Threonine Kinases	2013
Intrathecal administration of roscovitine prevents remifentanil-induced postoperative hyperalgesia and decreases the phosphorylation of N-methyl-D-aspartate receptor and metabotropic glutamate receptor 5 in spinal cord. Brain research bulletin, 2014, Volume: 106 Topics: Analgesics, Opioid; Animals; Cyclin-Dependent Kinase 5; Hyperalgesia; Injections, Spinal; Male; Motor Activity; Pain Threshold; Pain, Postoperative; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Remifentanil; Roscovitine; Spinal Cord	2014
CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation. Biochimica et biophysica acta. Molecular cell research, 2019, Volume: 1866, Issue:6 Topics: Activating Transcription Factor 4; Amino Acid Transport System A; Amino Acids; Aminophenols; Animals; Cell Line; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Flavonoids; HEK293 Cells; HeLa Cells; Humans; Maleimides; Phenylenediamines; Piperidines; Protein Serine-Threonine Kinases; Pyrimidines; Rats; Roscovitine; Stress, Physiological	2019