Page last updated: 2024-09-04

cyc 202 and paclitaxel

cyc 202 has been researched along with paclitaxel in 16 studies

Compound Research Comparison

Studies
(cyc 202)
Trials
(cyc 202)
Recent Studies (post-2010)
(cyc 202)
Studies
(paclitaxel)
Trials
(paclitaxel)
Recent Studies (post-2010) (paclitaxel)
979739331,8745,72915,395

Protein Interaction Comparison

ProteinTaxonomycyc 202 (IC50)paclitaxel (IC50)
Integrin beta-3Homo sapiens (human)0.034
Integrin alpha-V Homo sapiens (human)0.034
ATP-dependent translocase ABCB1Homo sapiens (human)2.598
Botulinum neurotoxin type A Clostridium botulinum5.2
UDP-glucuronosyltransferase 2B7Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1-6Homo sapiens (human)4.9
Substance-K receptorHomo sapiens (human)6.125
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1A4Homo sapiens (human)4.9
UDP-glucuronosyltransferase 2B10 Homo sapiens (human)4.9
Delta-type opioid receptorHomo sapiens (human)4.202
Tyrosine-protein kinase MerHomo sapiens (human)4.9
Tubulin beta-3 chainHomo sapiens (human)0.0082
Beta-tubulin Leishmania donovani1
Nucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)7.9433
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)0.26
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.28

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.25)18.2507
2000's8 (50.00)29.6817
2010's5 (31.25)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Beauchard, A; Besson, T; Ferandin, Y; Guguen-Guillouzo, C; Laborie, H; Le Guével, R; Lozach, O; Meijer, L; Rouillard, H; Thiéry, V1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Brown, ML; Dakshanamurthy, S; Deb, TB; Grindrod, SC; Paige, M; Yang, Y; Yenugonda, VM1
Babu, KS; Bondon, A; Boustie, J; Ferron, S; Graton, J; Jacquemin, D; Le Lamer, AC; Le Pogam, P; Legouin, B; Obermayer, W; Rouaud, I; Siva, B1
Dilasser, F; Dubreuil, D; Le Gall, E; Le Guével, R; Lebreton, J; Léonel, E; Loirand, G; Martens, T; Pipelier, M; Rousselle, M; Sauzeau, V; Sengmany, S; Sitter, M1
Aparna, P; Bach, S; Baratte, B; Brahmaiah, D; Grée, R; Kanaka Durga Bhavani, A; Le Guevel, R; Levoin, N; Mosset, P; Raji Reddy, C; Roisnel, T; Ruchaud, S; Sampath Kumar, N; Singh Jadav, S; Solhi, H1
Binarova, P; Bögre, L; Calderini, O; Heberle-Bors, E; Vicente, O; Wilson, C1
Dangi, S; Shapiro, P1
Fernando, R; Foster, JS; Henley, D; Isbill, M; Wimalasena, J1
McNeely, SC; States, JC; Taylor, BF1
Abaza, MS; Al-Attiyah, RJ; Bahman, AM1
Chen, Y; Dong, J; Ji, M; Xiao, L; Yang, S; Zhang, L1
Sakai, M; Yoshimura, R1

Other Studies

16 other study(ies) available for cyc 202 and paclitaxel

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Synthesis and kinase inhibitory activity of novel substituted indigoids.
    Bioorganic & medicinal chemistry, 2009, Sep-01, Volume: 17, Issue:17

    Topics: Alzheimer Disease; Casein Kinase I; Cyclin B1; Cyclin-Dependent Kinase 5; Dyrk Kinases; Glycogen Synthase Kinase 3; Humans; Indoles; Neuroprotective Agents; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases

2009
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Adenine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Dansyl Compounds; Female; Fluorescent Dyes; Humans; Protein Kinase Inhibitors

2011
Minor Pyranonaphthoquinones from the Apothecia of the Lichen Ophioparma ventosa.
    Journal of natural products, 2016, Apr-22, Volume: 79, Issue:4

    Topics: Antineoplastic Agents; Biphenyl Compounds; Circular Dichroism; Drug Screening Assays, Antitumor; Fruiting Bodies, Fungal; Humans; Inhibitory Concentration 50; Lichens; Molecular Structure; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Picrates; Pyrans

2016
Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents.
    Bioorganic & medicinal chemistry letters, 2019, 03-01, Volume: 29, Issue:5

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Pyridazines

2019
Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase.
    Bioorganic & medicinal chemistry, 2021, 02-01, Volume: 31

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Dyrk Kinases; Humans; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship

2021
A cell cycle regulated MAP kinase with a possible role in cytokinesis in tobacco cells.
    Journal of cell science, 1998, Volume: 111 ( Pt 20)

    Topics: Anaphase; Benzamides; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cell Line; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Fungal Proteins; Immunoblotting; Metaphase; Microtubules; Mitogen-Activated Protein Kinases; Mitosis; Nicotiana; Nitrobenzenes; Organothiophosphorus Compounds; Paclitaxel; Plant Proteins; Plants, Toxic; Protein Kinases; Purines; Roscovitine; Schizosaccharomyces pombe Proteins; Telophase

1998
Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis.
    The Journal of biological chemistry, 2005, Jul-01, Volume: 280, Issue:26

    Topics: CDC2 Protein Kinase; Cell Line, Tumor; Densitometry; Enzyme Activation; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanine Nucleotide Exchange Factors; HeLa Cells; Humans; Immunoblotting; Immunoprecipitation; Mitosis; Models, Biological; Nocodazole; Paclitaxel; Phosphorylation; Protein Binding; Protein Biosynthesis; Proto-Oncogene Proteins c-raf; Purines; Roscovitine; Signal Transduction; SOS1 Protein; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Vinblastine

2005
Paclitaxel induced apoptosis in breast cancer cells requires cell cycle transit but not Cdc2 activity.
    Cancer chemotherapy and pharmacology, 2007, Volume: 59, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-Associated Death Protein; Blotting, Western; Breast Neoplasms; CDC2 Protein Kinase; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Survival; DNA Fragmentation; Estradiol; Flow Cytometry; Fulvestrant; Humans; Hydroxyurea; Inhibitor of Apoptosis Proteins; JNK Mitogen-Activated Protein Kinases; Microtubule-Associated Proteins; Microtubules; Neoplasm Proteins; Paclitaxel; Purines; RNA, Small Interfering; Roscovitine; Spindle Apparatus; Survivin; Thymidine; Transfection

2007
Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent.
    Toxicology and applied pharmacology, 2008, Aug-15, Volume: 231, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Arsenites; Blotting, Western; CDC2 Protein Kinase; Fluorescent Antibody Technique; Humans; Melanoma, Experimental; Mitosis; Nocodazole; Paclitaxel; Protein Serine-Threonine Kinases; Purines; RNA, Small Interfering; Roscovitine; Sodium Compounds

2008
Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells.
    World journal of gastroenterology, 2008, Sep-07, Volume: 14, Issue:33

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; DNA Fragmentation; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Humans; Paclitaxel; Purines; Roscovitine; Time Factors; Vinblastine

2008
Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.
    The Biochemical journal, 2012, Oct-01, Volume: 447, Issue:1

    Topics: Amino Acid Sequence; Binding Sites; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin B; Dual-Specificity Phosphatases; HEK293 Cells; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Molecular Sequence Data; Paclitaxel; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Tyrosine Phosphatases; Purines; Recombinant Fusion Proteins; Roscovitine

2012
Mechanotransduction-Targeting Drugs Attenuate Stiffness-Induced Hepatic Stellate Cell Activation in Vitro.
    Biological & pharmaceutical bulletin, 2021, Mar-01, Volume: 44, Issue:3

    Topics: Actins; Adenosine Triphosphate; Animals; Benzamides; Cells, Cultured; Colchicine; Collagen Type I; Hepatic Stellate Cells; Imidazoles; Integrins; Male; Mechanotransduction, Cellular; Paclitaxel; Piperazines; Pyrazines; Quinoxalines; Rats, Sprague-Dawley; Roscovitine; Sulfonamides; Transforming Growth Factor beta; Tubulin Modulators

2021