Page last updated: 2024-09-04

cyc 202 and kinetin

cyc 202 has been researched along with kinetin in 59 studies

Compound Research Comparison

Studies (cyc 202)	Trials (cyc 202)	Recent Studies (post-2010) (cyc 202)	Studies (kinetin)	Trials (kinetin)	Recent Studies (post-2010) (kinetin)
979	7	393	921	2	246

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	19 (32.20)	18.2507
2000's	34 (57.63)	29.6817
2010's	6 (10.17)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
De Azevedo, WF; Havlicek, L; Kim, SH; Leclerc, S; Meijer, L; Strnad, M	1
Blow, JJ; Borgne, A; Chong, JP; Delcros, JG; Inagaki, M; Inagaki, N; Meijer, L; Moulinoux, JP; Mulner, O	1
Hanus, J; Havlícek, L; Leclerc, S; Meijer, L; Shaw, G; Strnad, M; Veselý, J	1
Hellmich, MR; Iseki, H; Ko, TC; Seapan, A; Townsend, CM; Xue, XY	1
Kuijpers, HJ; Ramaekers, FC; Reutelingsperger, CP; Schutte, B; van Engeland, M	1
Henfling, ME; Meijer, L; Nieland, L; Ramaekers, FC; Schutte, B; van Engeland, M	1
Krucher, NA; Meijer, L; Roberts, MH	1
Cruz, M; Eneroth, P; Idoyaga Vargas, V; Sidén, A; Yakisich, JS	1
Anneser, JM; Borasio, GD; Horstmann, S; Kahle, PJ; Maas, JW; Shooter, EM	1
Phillips, J; Schaffer, PA; Schang, LM	1
Bergounioux, C; Glab, N; Perennes, C; Planchais, S; Tregear, J; Tréhin, C	1
Alessi, F; Meijer, L; Prosperi, E; Quarta, S; Riva, F; Rossi, L; Savio, M; Scovassi, AI; Stivala, LA	1
Bisagni, E; Leclerc, S; Legraverend, M; Ludwig, O; Meijer, L	1
Eskin, A; Sankrithi, N	1
Elbaum, D; Lydon, NB; Toledo, LM	1
Détivaud, L; Doerig, C; Gray, N; Meijer, L	1
Choi, KS; Eom, YW; Ha, MJ; Kang, Y; Kim, SJ; Rhee, H; Yoon, JW	1
Baldassarre, G; Barone, MV; Belletti, B; Boccia, A; Bruni, P; Fusco, A; Pepe, S; Romano, A; Sandomenico, C; Spiezia, S; Vento, MT; Viglietto, G	1
David-Pfeuty, T	1
Prigge, ST; Waters, NC; Woodard, CL	1
Bertout, M; Bodart, JF; Browaeys, E; Flament, S; Rousseau, A; Vilain, JP	1
Atienza, C; Dong, YB; Elliott, MJ; Liu, TJ; McMasters, KM; Stilwell, A; Yang, HL	1
Edamatsu, H; Gau, CL; Guo, L; Nemoto, T; Tamanoi, F	1
Agid, Y; Lambeng, N; Michel, PP; Ruberg, M	1
Bibb, JA; Chen, J; Greengard, P; Nairn, AC; Nestler, EJ; Nishi, A; Ouimet, CC; Sagawa, ZK; Snyder, GL; Svenningsson, P; Taylor, JR; Yan, Z	1
Bang, YJ; Hong, SH; Jong, HS; Kim, NK; Kim, SG; Kim, SJ; Kim, SN	1
Doerig, C; Gray, N; Harmse, L; Havlik, I; Leclerc, S; Meijer, L; Schultz, P; van Zyl, R	1
Li, ST; Matsui, H; Matsushita, M; Moriwaki, A; Ohta, J; Takei, K; Tomizawa, K	1
Havlícek, L; Krystof, V; Kuzma, M; Lenobel, R; Strnad, M	1
Chung, BY; Kim, DC; Kim, DJ; Lee, YR; Shin, KJ; Yang, BS; Yoo, KH	1
Blagoeva, E; Gaudinová, A; Malbeck, J; Vanek, T; Vanková, R	1
Alemany, C; Ciudad, CJ; Noé, V; Peñuelas, S	1
Sharma, MC; Sharma, MR; Tuszynski, GP	1
Boix, J; Ribas, J	1
Beaman-Hall, CM; Mathur, A; Monaco, EA; Vallano, ML	1
Bu, B; Chakrabarty, P; Li, J; Vincent, I; Zhang, M	1
Alemany, C; Blasco, F; Calbó, J; Cascalló, M; Ciudad, CJ; Gómez, A; Hernández, JL; Masa, M; Mazo, A; Nicolás, M; Noé, V; Peñuelas, S; Pérez-Torras, S; Piulats, J; Soler, M; Tarrasón, G	1
Enders, GH; Maude, SL	1
Anghelescu, M; Buraei, Z; Elmslie, KS	1
Barrie, SE; Brunton, L; Clarke, SJ; Eccles, S; Fischer, PM; Garrett, MD; Kelland, LR; Lane, DP; McClue, S; Raynaud, FI; Rogers, P; Valenti, M; Walton, MI; Whittaker, SR; Workman, P	1
Byrnes, KR; Cernak, I; Di Giovanni, S; Faden, AI; Stoica, B	1
Arcuri, HA; Canduri, F; da Silveira, NJ; de Azevedo, WF; Manhani, KK; Uchôa, HB	1
Jaruchotikamol, A; Nemoto, N; Sakuma, T; Tamaki, H; Uchida, Y	1
Boix, J; Gomez-Arbones, X; Ribas, J	1
André, P; Appert-Collin, A; Coupin, G; Gies, JP; Hugel, B; Levy, R; Lombard, Y; Niederhoffer, N; Poindron, P	1
Cho, S; Meriney, SD	1
Schmid, G; Strosznajder, JB; Wesierska-Gadek, J	1
Castelli, LA; Konstantopoulos, N; Kyi, S; Macaulay, SL; Marcuccio, S; Stoichevska, V; Ward, CW	1
Bibb, JA; Lynch, WJ; Nestler, EJ; Olausson, P; Sanchez, H; Taylor, JR	1
Gueorguieva, M; Kramer, MP; Lindner, H; Ranftler, C; Sarg, B; Wesierska-Gadek, J	1
Hajek, SB; Lindner, H; Sarg, B; Walzi, E; Wandl, S; Wesierska-Gadek, J	1
An, R; Hagiya, Y; Ishikawa, T; Li, S; Saito, H; Tamura, A; Tokushima, D	1
Chang, CI; Huang, HC; Jhou, RS; Lu, SY; Sun, GH; Sun, KH; Tang, SJ; Wang, HH	1
Cruz, M; Siden, A; Tasat, DR; Vita, MF; Yakisich, JS	1
Choi, HS; Chung, SH	1
Cwiertka, K; Dzubak, P; Hajduch, M; Korinkova, G; Paprskarova, M	1
Aremu, AO; Bairu, MW; Doležal, K; Finnie, JF; Novák, O; Plačková, L; Strnad, M; Van Staden, J; Zatloukal, M	1
Hermosilla, V; Iribarren, C; Morin, V; Puchi, M	1
Hyun, HW; Kim, JE; Min, SJ	1

Reviews

3 review(s) available for cyc 202 and kinetin

Article	Year
The structure-based design of ATP-site directed protein kinase inhibitors. Current medicinal chemistry, 1999, Volume: 6, Issue:9 Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Anthraquinones; Binding Sites; Catalytic Domain; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Humans; Kinetin; Piperazines; Protein-Tyrosine Kinases; Purines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptors, Growth Factor; Roscovitine; Staurosporine; Structure-Activity Relationship	1999
ATP-site directed inhibitors of cyclin-dependent kinases. Current medicinal chemistry, 1999, Volume: 6, Issue:9 Topics: Adenine; Adenosine Triphosphate; Amino Acid Sequence; Antineoplastic Agents; Binding Sites; Cell Cycle; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Flavonoids; Humans; Isopentenyladenosine; Kinetin; Molecular Sequence Data; Piperidines; Purines; Roscovitine; Sequence Alignment; Sequence Homology, Amino Acid; Staurosporine; Suramin	1999
Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors. Molecular neurobiology, 2006, Volume: 34, Issue:1 Topics: Animals; Apoptosis; Brain Ischemia; Cell Cycle; Cyclin-Dependent Kinase 5; Humans; Kinetin; Neurodegenerative Diseases; Neurons; Protein Kinase Inhibitors; Purines; Roscovitine; Tumor Suppressor Protein p53	2006

Other Studies

56 other study(ies) available for cyc 202 and kinetin

Article	Year
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. European journal of biochemistry, 1997, Jan-15, Volume: 243, Issue:1-2 Topics: Adenosine Triphosphate; Animals; Binding Sites; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Humans; Hydrogen Bonding; Kinetin; Ligands; Models, Molecular; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Purines; Roscovitine; Starfish	1997
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. European journal of biochemistry, 1997, Jan-15, Volume: 243, Issue:1-2 Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Growth Inhibitors; Humans; Kinetin; Leukemia L1210; Maturation-Promoting Factor; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Oogenesis; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purines; Roscovitine; Sea Urchins; Starfish; Substrate Specificity; Vimentin; Xenopus laevis; Xenopus Proteins	1997
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds. Journal of medicinal chemistry, 1997, Feb-14, Volume: 40, Issue:4 Topics: Animals; CDC2 Protein Kinase; CDC28 Protein Kinase, S cerevisiae; Enzyme Inhibitors; Kinetin; Oocytes; Purines; Roscovitine; Starfish; Tumor Cells, Cultured	1997
Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells. Surgery, 1997, Volume: 122, Issue:2 Topics: Antineoplastic Agents; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Inhibitors; Histones; Humans; Kinetics; Kinetin; Protein Serine-Threonine Kinases; Purines; Roscovitine; Stomach Neoplasms; Substrate Specificity; Tumor Cells, Cultured	1997
Plasma membrane alterations and cytoskeletal changes in apoptosis. Experimental cell research, 1997, Sep-15, Volume: 235, Issue:2 Topics: Actins; Annexin A5; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Membrane; Chromatin; Cytoskeleton; Ethylmaleimide; Humans; Keratins; Kinetin; Lung Neoplasms; Neuroblastoma; Phosphatidylserines; Purines; Roscovitine; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Vimentin	1997
The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics. Experimental cell research, 1997, Oct-10, Volume: 236, Issue:1 Topics: Antimetabolites; Apoptosis; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; CDC2 Protein Kinase; Cell Cycle; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Kinetin; Lung Neoplasms; Mitosis; Neuroblastoma; Purines; Roscovitine; S Phase; Tumor Cells, Cultured	1997
The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker. Cellular and molecular neurobiology, 1997, Volume: 17, Issue:5 Topics: Animals; Biological Clocks; Circadian Rhythm; Cyclin-Dependent Kinases; Cycloheximide; Darkness; Dichlororibofuranosylbenzimidazole; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetin; Mollusca; Nucleic Acid Synthesis Inhibitors; Ocular Physiological Phenomena; Photoperiod; Protein Synthesis Inhibitors; Purines; Roscovitine	1997
Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine. Biochemical and biophysical research communications, 1998, Feb-24, Volume: 243, Issue:3 Topics: Animals; Cell Cycle; Cerebral Cortex; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Etoposide; Kinetin; Nucleic Acid Synthesis Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Staurosporine; Thymidine; Tritium	1998
Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitors. Journal of neurochemistry, 1998, Volume: 70, Issue:4 Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Chick Embryo; Cyclin-Dependent Kinases; Ganglia; Kinetin; Neurons; Proto-Oncogene Proteins c-jun; Purines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Roscovitine	1998
Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription. Journal of virology, 1998, Volume: 72, Issue:7 Topics: Amino Acid Sequence; Animals; Cell Cycle; Chlorocebus aethiops; Cyclin-Dependent Kinases; DNA Replication; Kinetin; Molecular Sequence Data; Purines; Roscovitine; Simplexvirus; Transcription, Genetic; Vero Cells; Virus Replication	1998
Cell cycle regulation by plant growth regulators: involvement of auxin and cytokinin in the re-entry of Petunia protoplasts into the cell cycle. Planta, 1998, Volume: 206, Issue:2 Topics: 2,4-Dichlorophenoxyacetic Acid; Adenine; Benzyl Compounds; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cell Cycle; Cytokinins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Indoleacetic Acids; Kinetin; Molecular Sequence Data; Plant Cells; Plant Growth Regulators; Plants; Protoplasts; Purines; Roscovitine	1998
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Experimental cell research, 1998, Nov-25, Volume: 245, Issue:1 Topics: CDC2-CDC28 Kinases; Cell Line; Cyclin B; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Fibroblasts; G1 Phase; Humans; Kinetin; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Purines; Retinoblastoma Protein; Roscovitine	1998
Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases. Bioorganic & medicinal chemistry letters, 1998, Apr-07, Volume: 8, Issue:7 Topics: Alkynes; Animals; CDC2 Protein Kinase; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Kinetin; Oocytes; Purines; Roscovitine; Starfish; Structure-Activity Relationship	1998
Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia. Journal of neurochemistry, 1999, Volume: 72, Issue:2 Topics: 4-Butyrolactone; Action Potentials; Animals; Aplysia; Circadian Rhythm; Cyclin-Dependent Kinases; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinetin; Macromolecular Substances; Neural Conduction; Ocular Physiological Phenomena; Purines; RNA, Messenger; Roscovitine; Transcription, Genetic	1999
Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. The Journal of biological chemistry, 1999, Nov-05, Volume: 274, Issue:45 Topics: Animals; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Death; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Kinetin; Liver Neoplasms, Experimental; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Purines; Rats; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Transforming Growth Factor beta; Tumor Cells, Cultured	1999
Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation. Oncogene, 1999, Nov-04, Volume: 18, Issue:46 Topics: Acetamides; Antigens, Neoplasm; Antigens, Surface; Antigens, Tumor-Associated, Carbohydrate; Apoptosis; Carcinoma, Embryonal; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Gene Expression Regulation, Neoplastic; Glycosphingolipids; Humans; Kinetin; Macromolecular Substances; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Purines; Retinoblastoma Protein; Roscovitine; Stage-Specific Embryonic Antigens; Tumor Cells, Cultured; Tumor Suppressor Proteins	1999
Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells. Oncogene, 1999, Dec-09, Volume: 18, Issue:52 Topics: Blotting, Western; Breast Neoplasms; Carcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Death; Cell Line; Cell Line, Transformed; Cell Nucleolus; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; G1 Phase; Humans; Inhibitory Concentration 50; Kinetin; Mitomycin; Nucleic Acid Synthesis Inhibitors; Nucleolin; Phosphoproteins; Protein Serine-Threonine Kinases; Purines; RNA-Binding Proteins; Roscovitine; Tumor Cells, Cultured; Tumor Suppressor Protein p53	1999
Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum. Molecular and biochemical parasitology, 2000, Mar-15, Volume: 107, Issue:1 Topics: Amino Acid Sequence; Animals; Cyclin H; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Humans; Kinetin; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Protein Conformation; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Roscovitine	2000
Differential effects of 6-DMAP, olomoucine and roscovitine on Xenopus oocytes and eggs. Zygote (Cambridge, England), 2000, Volume: 8, Issue:1 Topics: Adenine; Animals; Blotting, Western; CDC2 Protein Kinase; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; In Vitro Techniques; Kinetin; Meiosis; Microinjections; Mitogen-Activated Protein Kinase 1; Oocytes; Ovum; Protein Kinases; Purines; Roscovitine; Xenopus laevis	2000
Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors. International journal of molecular medicine, 2000, Volume: 6, Issue:1 Topics: Adenoviridae; Apoptosis; bcl-2-Associated X Protein; Carrier Proteins; Caspases; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Gene Transfer Techniques; Humans; Kinetin; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; Retinoblastoma-Binding Protein 1; Roscovitine; Stomach Neoplasms; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured	2000
Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene, 2000, Jun-22, Volume: 19, Issue:27 Topics: Alkyl and Aryl Transferases; Apoptosis; Benzazepines; Caspases; Cell Line; Chromones; Cyclin-Dependent Kinases; Cytochrome c Group; Cytosol; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; HL-60 Cells; Humans; Kinetin; Mitochondria; Morpholines; Phosphorylation; Purines; Retinoblastoma Protein; Roscovitine	2000
The relationship between differentiation and survival in PC12 cells treated with cyclic adenosine monophosphate in the presence of epidermal growth factor or nerve growth factor. Neuroscience letters, 2001, Jan-12, Volume: 297, Issue:2 Topics: Animals; Cell Differentiation; Cell Survival; Colforsin; Cyclic AMP; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Epidermal Growth Factor; Kinetin; Nerve Growth Factor; Neurons; PC12 Cells; Purines; Rats; Roscovitine	2001
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature, 2001, Mar-15, Volume: 410, Issue:6826 Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinetin; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Oligonucleotide Array Sequence Analysis; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Purines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Roscovitine; Signal Transduction	2001
Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells. Oncogene, 2001, Mar-08, Volume: 20, Issue:10 Topics: Annexin A5; Apoptosis; Blotting, Western; Bromodeoxyuridine; Caspase 3; Caspases; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; In Situ Nick-End Labeling; Kinetin; Microtubule-Associated Proteins; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Purines; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Stomach Neoplasms; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Suppressor Proteins	2001
Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum. Biochemical pharmacology, 2001, Aug-01, Volume: 62, Issue:3 Topics: Adenine; Animals; Antimalarials; Cell Cycle; Dose-Response Relationship, Drug; Isopentenyladenosine; Kinetin; Parasitic Sensitivity Tests; Phosphotransferases; Plasmodium falciparum; Purines; Roscovitine; Structure-Activity Relationship	2001
Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Apr-01, Volume: 22, Issue:7 Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, P-Type; Calcium Channels, Q-Type; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Down-Regulation; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Exocytosis; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetin; Male; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Phosphorylation; Protein Isoforms; Purines; Rats; Rats, Wistar; Roscovitine; Synaptosomes	2002
Synthesis and biological activity of olomoucine II. Bioorganic & medicinal chemistry letters, 2002, Nov-18, Volume: 12, Issue:22 Topics: Antineoplastic Agents; CDC2 Protein Kinase; CDC28 Protein Kinase, S cerevisiae; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Kinetin; Purines; Roscovitine; Structure-Activity Relationship; Tumor Cells, Cultured	2002
Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitors. European journal of medicinal chemistry, 2003, Volume: 38, Issue:5 Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cyclin-Dependent Kinases; Enzyme Inhibitors; ErbB Receptors; Humans; Inhibitory Concentration 50; Kinetin; Magnetic Resonance Spectroscopy; Purines; Pyrazoles; Pyrimidines; Roscovitine; Spodoptera; Structure-Activity Relationship; Tumor Cells, Cultured	2003
Cyclin-dependent kinase inhibitor, roscovitine, in combination with exogenous cytokinin, N6-benzyladenine, causes increase of cis-cytokinins in immobilized tobacco cells. Biotechnology letters, 2003, Volume: 25, Issue:6 Topics: Adenine; Alginates; Benzyl Compounds; Cell Survival; Cells, Cultured; Cells, Immobilized; Cyclin-Dependent Kinases; Cytokinins; Glucuronic Acid; Hexuronic Acids; Isopentenyladenosine; Kinetin; Nicotiana; Purines; Reproducibility of Results; Roscovitine; Sensitivity and Specificity	2003
The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors. European journal of biochemistry, 2003, Volume: 270, Issue:24 Topics: Animals; Blotting, Western; Cell Division; Cell Nucleus; CHO Cells; Cloning, Molecular; Cricetinae; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Flow Cytometry; HeLa Cells; Humans; Indoles; K562 Cells; Kinetin; Luciferases; Maleimides; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Protein Synthesis Inhibitors; Purines; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Sp1 Transcription Factor; Staurosporine; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription, Genetic; Transfection	2003
Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. Journal of cellular biochemistry, 2004, Feb-01, Volume: 91, Issue:2 Topics: Angiogenesis Inhibitors; Angiostatins; Animals; Aorta; Apoptosis; Cattle; Cell Differentiation; Cell Division; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Down-Regulation; Endothelial Cells; Fibroblast Growth Factors; Kinetin; Mice; NIH 3T3 Cells; Purines; Roscovitine	2004
Cell differentiation, caspase inhibition, and macromolecular synthesis blockage, but not BCL-2 or BCL-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs. Experimental cell research, 2004, Apr-15, Volume: 295, Issue:1 Topics: Apoptosis; bcl-X Protein; Caspase Inhibitors; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Kinetics; Kinetin; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Purines; Roscovitine	2004
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. Biochemical pharmacology, 2004, May-15, Volume: 67, Issue:10 Topics: 4-Butyrolactone; Animals; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cerebellum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinases; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Kinetin; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Proto-Oncogene Proteins; Purines; Pyrimidines; Rats; Rats, Sprague-Dawley; Roscovitine; Signal Transduction; Sulfonamides	2004
Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice. The American journal of pathology, 2004, Volume: 165, Issue:3 Topics: Animals; Apoptosis; Cyclin-Dependent Kinases; Cytoskeleton; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Intracellular Signaling Peptides and Proteins; Kinetin; Male; Mice; Mice, Inbred BALB C; Mice, Neurologic Mutants; Motor Activity; Nerve Degeneration; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Phosphorylation; Proteins; Purines; Purkinje Cells; Roscovitine; tau Proteins	2004
Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy. Oncology, 2004, Volume: 67, Issue:3-4 Topics: Adenoviridae; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Decorin; DNA Primase; DNA-Binding Proteins; Down-Regulation; Extracellular Matrix Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, p16; Genetic Vectors; Histone Deacetylase 1; Histone Deacetylases; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Kinetin; Nuclear Proteins; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proteoglycans; Purines; Reverse Transcriptase Polymerase Chain Reaction; Roscovitine; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein	2004
Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. Cancer research, 2005, Feb-01, Volume: 65, Issue:3 Topics: Ataxia Telangiectasia Mutated Proteins; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; HeLa Cells; Histones; Humans; Kinetin; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Roscovitine; Tumor Suppressor Proteins	2005
Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine. Biophysical journal, 2005, Volume: 89, Issue:3 Topics: Action Potentials; Animals; Calcium; Calcium Channels, N-Type; Calcium Channels, P-Type; Calcium Channels, Q-Type; Computer Simulation; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Ganglia, Sympathetic; Ion Channel Gating; Kinetics; Kinetin; Markov Chains; Membrane Potentials; Models, Chemical; Neurons; Neurotransmitter Agents; Protein Kinase Inhibitors; Protein Structure, Tertiary; Purines; Rana catesbeiana; Roscovitine	2005
In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jul-01, Volume: 11, Issue:13 Topics: Animals; Area Under Curve; Blotting, Western; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; HCT116 Cells; Humans; Inhibitory Concentration 50; Kinetin; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Phosphorylation; Purines; Recombinant Proteins; Retinoblastoma Protein; Roscovitine; Time Factors; Tissue Distribution; Xenograft Model Antitumor Assays	2005
Role of the cell cycle in the pathobiology of central nervous system trauma. Cell cycle (Georgetown, Tex.), 2005, Volume: 4, Issue:9 Topics: Animals; Antineoplastic Agents; Astrocytes; Brain; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Central Nervous System; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Etoposide; Flavonoids; Kinetin; Magnetic Resonance Spectroscopy; Microglia; Mitosis; Neurons; Piperidines; Purines; Rats; Roscovitine; Up-Regulation	2005
Molecular models of protein kinase 6 from Plasmodium falciparum. Journal of molecular modeling, 2005, Volume: 12, Issue:1 Topics: Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Cyclin-Dependent Kinases; Hydrogen Bonding; Kinetin; Mitogen-Activated Protein Kinases; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Protein Kinase Inhibitors; Protein Structure, Tertiary; Protozoan Proteins; Purines; Roscovitine; Sequence Alignment; Static Electricity	2005
Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes. Toxicology, 2005, Dec-15, Volume: 216, Issue:2-3 Topics: Animals; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genistein; Hepatocytes; Hydrogen Peroxide; Hydroquinones; Insulin; Isoflavones; Kinetin; Mice; Mice, Inbred C57BL; Okadaic Acid; Phosphorylation; Purines; RNA, Messenger; Roscovitine; Time Factors; Transcriptional Activation	2005
Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs. European journal of pharmacology, 2005, Nov-07, Volume: 524, Issue:1-3 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 10; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Jurkat Cells; Kinetin; Neuroblastoma; Purines; Roscovitine; Time Factors	2005
Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons. Life sciences, 2006, Jun-27, Volume: 79, Issue:5 Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Flavonoids; Kinetin; Mice; Mitosis; Motor Neurons; Nerve Growth Factors; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine	2006
The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction. The European journal of neuroscience, 2006, Volume: 23, Issue:12 Topics: 4-Aminopyridine; Amifampridine; Animals; Calcium Channels; Excitatory Postsynaptic Potentials; Kinetin; Neuromuscular Junction; Patch-Clamp Techniques; Potassium Channel Blockers; Presynaptic Terminals; Protein Kinase Inhibitors; Purines; Rana pipiens; Roscovitine; Synaptic Transmission; Xenopus laevis	2006
A purine analog kinase inhibitor, calcium/calmodulin-dependent protein kinase II inhibitor 59, reveals a role for calcium/calmodulin-dependent protein kinase II in insulin-stimulated glucose transport. Endocrinology, 2007, Volume: 148, Issue:1 Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Glucose; Glucose Transporter Type 4; Green Fluorescent Proteins; Hypoglycemic Agents; Insulin; Kinetin; Mice; Protein Kinase Inhibitors; Purines; Retroviridae; Roscovitine; Transfection	2007
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America, 2007, Mar-06, Volume: 104, Issue:10 Topics: Animals; Cocaine; Conditioning, Operant; Cyclin-Dependent Kinase 5; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Kinetin; Male; Nucleus Accumbens; Purines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Roscovitine; Signal Transduction	2007
A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein. Journal of cellular biochemistry, 2007, Dec-15, Volume: 102, Issue:6 Topics: Animals; Breast Neoplasms; Cell Line, Transformed; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinases; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; HL-60 Cells; Humans; Kinetin; Lung; Membrane Proteins; Mice; Purines; Roscovitine; Skin; Time Factors; Up-Regulation	2007
Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells. Biochemical pharmacology, 2008, Dec-01, Volume: 76, Issue:11 Topics: Cell Cycle; Cell Line; Cell Line, Tumor; Cyclin-Dependent Kinases; Humans; Kinetin; Phosphorylation; Protein Kinase Inhibitors; Purines; Roscovitine; Tumor Suppressor Protein p53	2008
Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro. Pharmaceutical research, 2009, Volume: 26, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell Membrane; Cell Survival; Chlorophyll; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Hematoporphyrins; Humans; Kinetin; Models, Molecular; Molecular Conformation; Molecular Structure; Neoplasm Proteins; Photosensitizing Agents; Protein Kinase Inhibitors; Purines; Quantitative Structure-Activity Relationship; Quinazolines; Roscovitine; Spodoptera; Transfection	2009
Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB. Cell proliferation, 2009, Volume: 42, Issue:2 Topics: Animals; Cell Line, Tumor; Cyclin-Dependent Kinases; Down-Regulation; E2F1 Transcription Factor; Enzyme Inhibitors; Gene Expression; Inflammation; Interleukin-1alpha; Interleukin-6; Kinetin; Lipopolysaccharides; Macrophages; Mice; Models, Biological; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Purines; RNA Interference; Roscovitine; Transcription Factor RelA; Tumor Necrosis Factor-alpha	2009
Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine. Investigational new drugs, 2010, Volume: 28, Issue:3 Topics: Age Factors; Animals; Animals, Newborn; Anticarcinogenic Agents; Cell Line, Tumor; Cerebral Cortex; DNA; DNA Damage; DNA Repair; Drug Screening Assays, Antitumor; Glioma; Humans; In Vitro Techniques; Kinetin; Nucleic Acid Synthesis Inhibitors; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine	2010
Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells. Neuroscience letters, 2010, Jan-18, Volume: 469, Issue:1 Topics: Animals; Calcium; Calcium Signaling; Cell Differentiation; Cyclin-Dependent Kinase 5; Intracellular Space; Kinetin; Nerve Growth Factor; PC12 Cells; Purines; Rats; Roscovitine	2010
The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors. Neoplasma, 2010, Volume: 57, Issue:2 Topics: Adenocarcinoma; Apoptosis; Blotting, Western; Cell Cycle; Cyclin-Dependent Kinases; Flow Cytometry; Humans; Kinetin; Lung Neoplasms; Protein Kinase Inhibitors; Purines; Radiation-Sensitizing Agents; Roscovitine; Tumor Cells, Cultured; X-Rays	2010
Physiological responses and endogenous cytokinin profiles of tissue-cultured 'Williams' bananas in relation to roscovitine and an inhibitor of cytokinin oxidase/dehydrogenase (INCYDE) treatments. Planta, 2012, Volume: 236, Issue:6 Topics: Adenine; Benzyl Compounds; Biomass; Cyclin-Dependent Kinases; Cytokinins; Kinetin; Musa; Oxidoreductases; Phenols; Photosynthesis; Plant Components, Aerial; Plant Growth Regulators; Plant Proteins; Purines; Roscovitine; Signal Transduction; Tissue Culture Techniques	2012
Functional studies of MP62 during male chromatin decondensation in sea urchins. Journal of cellular biochemistry, 2013, Volume: 114, Issue:8 Topics: Animals; Chromatin Assembly and Disassembly; Histones; Kinetin; Male; Nucleoplasmins; Protein Kinase Inhibitors; Purines; Roscovitine; Sea Urchins; Spermatozoa	2013
CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus. Neuroscience research, 2017, Volume: 119 Topics: Animals; Apoptosis; Astrocytes; CA1 Region, Hippocampal; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Dentate Gyrus; Dynamins; Gliosis; Kinetin; Male; Nerve Degeneration; Phosphorylation; Protein Kinase Inhibitors; Purines; Rats; Roscovitine; Status Epilepticus	2017