cyc 202 has been researched along with kinetin in 59 studies
Studies (cyc 202) | Trials (cyc 202) | Recent Studies (post-2010) (cyc 202) | Studies (kinetin) | Trials (kinetin) | Recent Studies (post-2010) (kinetin) |
---|---|---|---|---|---|
979 | 7 | 393 | 921 | 2 | 246 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 19 (32.20) | 18.2507 |
2000's | 34 (57.63) | 29.6817 |
2010's | 6 (10.17) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
De Azevedo, WF; Havlicek, L; Kim, SH; Leclerc, S; Meijer, L; Strnad, M | 1 |
Blow, JJ; Borgne, A; Chong, JP; Delcros, JG; Inagaki, M; Inagaki, N; Meijer, L; Moulinoux, JP; Mulner, O | 1 |
Hanus, J; Havlícek, L; Leclerc, S; Meijer, L; Shaw, G; Strnad, M; Veselý, J | 1 |
Hellmich, MR; Iseki, H; Ko, TC; Seapan, A; Townsend, CM; Xue, XY | 1 |
Kuijpers, HJ; Ramaekers, FC; Reutelingsperger, CP; Schutte, B; van Engeland, M | 1 |
Henfling, ME; Meijer, L; Nieland, L; Ramaekers, FC; Schutte, B; van Engeland, M | 1 |
Krucher, NA; Meijer, L; Roberts, MH | 1 |
Cruz, M; Eneroth, P; Idoyaga Vargas, V; Sidén, A; Yakisich, JS | 1 |
Anneser, JM; Borasio, GD; Horstmann, S; Kahle, PJ; Maas, JW; Shooter, EM | 1 |
Phillips, J; Schaffer, PA; Schang, LM | 1 |
Bergounioux, C; Glab, N; Perennes, C; Planchais, S; Tregear, J; Tréhin, C | 1 |
Alessi, F; Meijer, L; Prosperi, E; Quarta, S; Riva, F; Rossi, L; Savio, M; Scovassi, AI; Stivala, LA | 1 |
Bisagni, E; Leclerc, S; Legraverend, M; Ludwig, O; Meijer, L | 1 |
Eskin, A; Sankrithi, N | 1 |
Elbaum, D; Lydon, NB; Toledo, LM | 1 |
Détivaud, L; Doerig, C; Gray, N; Meijer, L | 1 |
Choi, KS; Eom, YW; Ha, MJ; Kang, Y; Kim, SJ; Rhee, H; Yoon, JW | 1 |
Baldassarre, G; Barone, MV; Belletti, B; Boccia, A; Bruni, P; Fusco, A; Pepe, S; Romano, A; Sandomenico, C; Spiezia, S; Vento, MT; Viglietto, G | 1 |
David-Pfeuty, T | 1 |
Prigge, ST; Waters, NC; Woodard, CL | 1 |
Bertout, M; Bodart, JF; Browaeys, E; Flament, S; Rousseau, A; Vilain, JP | 1 |
Atienza, C; Dong, YB; Elliott, MJ; Liu, TJ; McMasters, KM; Stilwell, A; Yang, HL | 1 |
Edamatsu, H; Gau, CL; Guo, L; Nemoto, T; Tamanoi, F | 1 |
Agid, Y; Lambeng, N; Michel, PP; Ruberg, M | 1 |
Bibb, JA; Chen, J; Greengard, P; Nairn, AC; Nestler, EJ; Nishi, A; Ouimet, CC; Sagawa, ZK; Snyder, GL; Svenningsson, P; Taylor, JR; Yan, Z | 1 |
Bang, YJ; Hong, SH; Jong, HS; Kim, NK; Kim, SG; Kim, SJ; Kim, SN | 1 |
Doerig, C; Gray, N; Harmse, L; Havlik, I; Leclerc, S; Meijer, L; Schultz, P; van Zyl, R | 1 |
Li, ST; Matsui, H; Matsushita, M; Moriwaki, A; Ohta, J; Takei, K; Tomizawa, K | 1 |
Havlícek, L; Krystof, V; Kuzma, M; Lenobel, R; Strnad, M | 1 |
Chung, BY; Kim, DC; Kim, DJ; Lee, YR; Shin, KJ; Yang, BS; Yoo, KH | 1 |
Blagoeva, E; Gaudinová, A; Malbeck, J; Vanek, T; Vanková, R | 1 |
Alemany, C; Ciudad, CJ; Noé, V; Peñuelas, S | 1 |
Sharma, MC; Sharma, MR; Tuszynski, GP | 1 |
Boix, J; Ribas, J | 1 |
Beaman-Hall, CM; Mathur, A; Monaco, EA; Vallano, ML | 1 |
Bu, B; Chakrabarty, P; Li, J; Vincent, I; Zhang, M | 1 |
Alemany, C; Blasco, F; Calbó, J; Cascalló, M; Ciudad, CJ; Gómez, A; Hernández, JL; Masa, M; Mazo, A; Nicolás, M; Noé, V; Peñuelas, S; Pérez-Torras, S; Piulats, J; Soler, M; Tarrasón, G | 1 |
Enders, GH; Maude, SL | 1 |
Anghelescu, M; Buraei, Z; Elmslie, KS | 1 |
Barrie, SE; Brunton, L; Clarke, SJ; Eccles, S; Fischer, PM; Garrett, MD; Kelland, LR; Lane, DP; McClue, S; Raynaud, FI; Rogers, P; Valenti, M; Walton, MI; Whittaker, SR; Workman, P | 1 |
Byrnes, KR; Cernak, I; Di Giovanni, S; Faden, AI; Stoica, B | 1 |
Arcuri, HA; Canduri, F; da Silveira, NJ; de Azevedo, WF; Manhani, KK; Uchôa, HB | 1 |
Jaruchotikamol, A; Nemoto, N; Sakuma, T; Tamaki, H; Uchida, Y | 1 |
Boix, J; Gomez-Arbones, X; Ribas, J | 1 |
André, P; Appert-Collin, A; Coupin, G; Gies, JP; Hugel, B; Levy, R; Lombard, Y; Niederhoffer, N; Poindron, P | 1 |
Cho, S; Meriney, SD | 1 |
Schmid, G; Strosznajder, JB; Wesierska-Gadek, J | 1 |
Castelli, LA; Konstantopoulos, N; Kyi, S; Macaulay, SL; Marcuccio, S; Stoichevska, V; Ward, CW | 1 |
Bibb, JA; Lynch, WJ; Nestler, EJ; Olausson, P; Sanchez, H; Taylor, JR | 1 |
Gueorguieva, M; Kramer, MP; Lindner, H; Ranftler, C; Sarg, B; Wesierska-Gadek, J | 1 |
Hajek, SB; Lindner, H; Sarg, B; Walzi, E; Wandl, S; Wesierska-Gadek, J | 1 |
An, R; Hagiya, Y; Ishikawa, T; Li, S; Saito, H; Tamura, A; Tokushima, D | 1 |
Chang, CI; Huang, HC; Jhou, RS; Lu, SY; Sun, GH; Sun, KH; Tang, SJ; Wang, HH | 1 |
Cruz, M; Siden, A; Tasat, DR; Vita, MF; Yakisich, JS | 1 |
Choi, HS; Chung, SH | 1 |
Cwiertka, K; Dzubak, P; Hajduch, M; Korinkova, G; Paprskarova, M | 1 |
Aremu, AO; Bairu, MW; Doležal, K; Finnie, JF; Novák, O; Plačková, L; Strnad, M; Van Staden, J; Zatloukal, M | 1 |
Hermosilla, V; Iribarren, C; Morin, V; Puchi, M | 1 |
Hyun, HW; Kim, JE; Min, SJ | 1 |
3 review(s) available for cyc 202 and kinetin
Article | Year |
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The structure-based design of ATP-site directed protein kinase inhibitors.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Anthraquinones; Binding Sites; Catalytic Domain; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Humans; Kinetin; Piperazines; Protein-Tyrosine Kinases; Purines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptors, Growth Factor; Roscovitine; Staurosporine; Structure-Activity Relationship | 1999 |
ATP-site directed inhibitors of cyclin-dependent kinases.
Topics: Adenine; Adenosine Triphosphate; Amino Acid Sequence; Antineoplastic Agents; Binding Sites; Cell Cycle; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Flavonoids; Humans; Isopentenyladenosine; Kinetin; Molecular Sequence Data; Piperidines; Purines; Roscovitine; Sequence Alignment; Sequence Homology, Amino Acid; Staurosporine; Suramin | 1999 |
Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Cycle; Cyclin-Dependent Kinase 5; Humans; Kinetin; Neurodegenerative Diseases; Neurons; Protein Kinase Inhibitors; Purines; Roscovitine; Tumor Suppressor Protein p53 | 2006 |
56 other study(ies) available for cyc 202 and kinetin
Article | Year |
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Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
Topics: Adenosine Triphosphate; Animals; Binding Sites; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Humans; Hydrogen Bonding; Kinetin; Ligands; Models, Molecular; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Purines; Roscovitine; Starfish | 1997 |
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Growth Inhibitors; Humans; Kinetin; Leukemia L1210; Maturation-Promoting Factor; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Oogenesis; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purines; Roscovitine; Sea Urchins; Starfish; Substrate Specificity; Vimentin; Xenopus laevis; Xenopus Proteins | 1997 |
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds.
Topics: Animals; CDC2 Protein Kinase; CDC28 Protein Kinase, S cerevisiae; Enzyme Inhibitors; Kinetin; Oocytes; Purines; Roscovitine; Starfish; Tumor Cells, Cultured | 1997 |
Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Inhibitors; Histones; Humans; Kinetics; Kinetin; Protein Serine-Threonine Kinases; Purines; Roscovitine; Stomach Neoplasms; Substrate Specificity; Tumor Cells, Cultured | 1997 |
Plasma membrane alterations and cytoskeletal changes in apoptosis.
Topics: Actins; Annexin A5; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Membrane; Chromatin; Cytoskeleton; Ethylmaleimide; Humans; Keratins; Kinetin; Lung Neoplasms; Neuroblastoma; Phosphatidylserines; Purines; Roscovitine; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Vimentin | 1997 |
The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics.
Topics: Antimetabolites; Apoptosis; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; CDC2 Protein Kinase; Cell Cycle; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Kinetin; Lung Neoplasms; Mitosis; Neuroblastoma; Purines; Roscovitine; S Phase; Tumor Cells, Cultured | 1997 |
The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker.
Topics: Animals; Biological Clocks; Circadian Rhythm; Cyclin-Dependent Kinases; Cycloheximide; Darkness; Dichlororibofuranosylbenzimidazole; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetin; Mollusca; Nucleic Acid Synthesis Inhibitors; Ocular Physiological Phenomena; Photoperiod; Protein Synthesis Inhibitors; Purines; Roscovitine | 1997 |
Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine.
Topics: Animals; Cell Cycle; Cerebral Cortex; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Etoposide; Kinetin; Nucleic Acid Synthesis Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Staurosporine; Thymidine; Tritium | 1998 |
Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitors.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Chick Embryo; Cyclin-Dependent Kinases; Ganglia; Kinetin; Neurons; Proto-Oncogene Proteins c-jun; Purines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Roscovitine | 1998 |
Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription.
Topics: Amino Acid Sequence; Animals; Cell Cycle; Chlorocebus aethiops; Cyclin-Dependent Kinases; DNA Replication; Kinetin; Molecular Sequence Data; Purines; Roscovitine; Simplexvirus; Transcription, Genetic; Vero Cells; Virus Replication | 1998 |
Cell cycle regulation by plant growth regulators: involvement of auxin and cytokinin in the re-entry of Petunia protoplasts into the cell cycle.
Topics: 2,4-Dichlorophenoxyacetic Acid; Adenine; Benzyl Compounds; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cell Cycle; Cytokinins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Indoleacetic Acids; Kinetin; Molecular Sequence Data; Plant Cells; Plant Growth Regulators; Plants; Protoplasts; Purines; Roscovitine | 1998 |
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity.
Topics: CDC2-CDC28 Kinases; Cell Line; Cyclin B; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Fibroblasts; G1 Phase; Humans; Kinetin; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Purines; Retinoblastoma Protein; Roscovitine | 1998 |
Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases.
Topics: Alkynes; Animals; CDC2 Protein Kinase; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Kinetin; Oocytes; Purines; Roscovitine; Starfish; Structure-Activity Relationship | 1998 |
Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia.
Topics: 4-Butyrolactone; Action Potentials; Animals; Aplysia; Circadian Rhythm; Cyclin-Dependent Kinases; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinetin; Macromolecular Substances; Neural Conduction; Ocular Physiological Phenomena; Purines; RNA, Messenger; Roscovitine; Transcription, Genetic | 1999 |
Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells.
Topics: Animals; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Death; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Kinetin; Liver Neoplasms, Experimental; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Purines; Rats; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation.
Topics: Acetamides; Antigens, Neoplasm; Antigens, Surface; Antigens, Tumor-Associated, Carbohydrate; Apoptosis; Carcinoma, Embryonal; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Gene Expression Regulation, Neoplastic; Glycosphingolipids; Humans; Kinetin; Macromolecular Substances; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Purines; Retinoblastoma Protein; Roscovitine; Stage-Specific Embryonic Antigens; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1999 |
Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells.
Topics: Blotting, Western; Breast Neoplasms; Carcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Death; Cell Line; Cell Line, Transformed; Cell Nucleolus; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; G1 Phase; Humans; Inhibitory Concentration 50; Kinetin; Mitomycin; Nucleic Acid Synthesis Inhibitors; Nucleolin; Phosphoproteins; Protein Serine-Threonine Kinases; Purines; RNA-Binding Proteins; Roscovitine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Cyclin H; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Humans; Kinetin; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Protein Conformation; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Roscovitine | 2000 |
Differential effects of 6-DMAP, olomoucine and roscovitine on Xenopus oocytes and eggs.
Topics: Adenine; Animals; Blotting, Western; CDC2 Protein Kinase; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; In Vitro Techniques; Kinetin; Meiosis; Microinjections; Mitogen-Activated Protein Kinase 1; Oocytes; Ovum; Protein Kinases; Purines; Roscovitine; Xenopus laevis | 2000 |
Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors.
Topics: Adenoviridae; Apoptosis; bcl-2-Associated X Protein; Carrier Proteins; Caspases; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Gene Transfer Techniques; Humans; Kinetin; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; Retinoblastoma-Binding Protein 1; Roscovitine; Stomach Neoplasms; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 2000 |
Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines.
Topics: Alkyl and Aryl Transferases; Apoptosis; Benzazepines; Caspases; Cell Line; Chromones; Cyclin-Dependent Kinases; Cytochrome c Group; Cytosol; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; HL-60 Cells; Humans; Kinetin; Mitochondria; Morpholines; Phosphorylation; Purines; Retinoblastoma Protein; Roscovitine | 2000 |
The relationship between differentiation and survival in PC12 cells treated with cyclic adenosine monophosphate in the presence of epidermal growth factor or nerve growth factor.
Topics: Animals; Cell Differentiation; Cell Survival; Colforsin; Cyclic AMP; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Epidermal Growth Factor; Kinetin; Nerve Growth Factor; Neurons; PC12 Cells; Purines; Rats; Roscovitine | 2001 |
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinetin; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Oligonucleotide Array Sequence Analysis; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Purines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Roscovitine; Signal Transduction | 2001 |
Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells.
Topics: Annexin A5; Apoptosis; Blotting, Western; Bromodeoxyuridine; Caspase 3; Caspases; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; In Situ Nick-End Labeling; Kinetin; Microtubule-Associated Proteins; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Purines; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Stomach Neoplasms; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.
Topics: Adenine; Animals; Antimalarials; Cell Cycle; Dose-Response Relationship, Drug; Isopentenyladenosine; Kinetin; Parasitic Sensitivity Tests; Phosphotransferases; Plasmodium falciparum; Purines; Roscovitine; Structure-Activity Relationship | 2001 |
Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, P-Type; Calcium Channels, Q-Type; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Down-Regulation; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Exocytosis; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetin; Male; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Phosphorylation; Protein Isoforms; Purines; Rats; Rats, Wistar; Roscovitine; Synaptosomes | 2002 |
Synthesis and biological activity of olomoucine II.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; CDC28 Protein Kinase, S cerevisiae; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Kinetin; Purines; Roscovitine; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitors.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cyclin-Dependent Kinases; Enzyme Inhibitors; ErbB Receptors; Humans; Inhibitory Concentration 50; Kinetin; Magnetic Resonance Spectroscopy; Purines; Pyrazoles; Pyrimidines; Roscovitine; Spodoptera; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Cyclin-dependent kinase inhibitor, roscovitine, in combination with exogenous cytokinin, N6-benzyladenine, causes increase of cis-cytokinins in immobilized tobacco cells.
Topics: Adenine; Alginates; Benzyl Compounds; Cell Survival; Cells, Cultured; Cells, Immobilized; Cyclin-Dependent Kinases; Cytokinins; Glucuronic Acid; Hexuronic Acids; Isopentenyladenosine; Kinetin; Nicotiana; Purines; Reproducibility of Results; Roscovitine; Sensitivity and Specificity | 2003 |
The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors.
Topics: Animals; Blotting, Western; Cell Division; Cell Nucleus; CHO Cells; Cloning, Molecular; Cricetinae; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Flow Cytometry; HeLa Cells; Humans; Indoles; K562 Cells; Kinetin; Luciferases; Maleimides; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Protein Synthesis Inhibitors; Purines; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Sp1 Transcription Factor; Staurosporine; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription, Genetic; Transfection | 2003 |
Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5.
Topics: Angiogenesis Inhibitors; Angiostatins; Animals; Aorta; Apoptosis; Cattle; Cell Differentiation; Cell Division; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Down-Regulation; Endothelial Cells; Fibroblast Growth Factors; Kinetin; Mice; NIH 3T3 Cells; Purines; Roscovitine | 2004 |
Cell differentiation, caspase inhibition, and macromolecular synthesis blockage, but not BCL-2 or BCL-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs.
Topics: Apoptosis; bcl-X Protein; Caspase Inhibitors; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Kinetics; Kinetin; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Purines; Roscovitine | 2004 |
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons.
Topics: 4-Butyrolactone; Animals; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cerebellum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinases; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Kinetin; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Proto-Oncogene Proteins; Purines; Pyrimidines; Rats; Rats, Sprague-Dawley; Roscovitine; Signal Transduction; Sulfonamides | 2004 |
Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice.
Topics: Animals; Apoptosis; Cyclin-Dependent Kinases; Cytoskeleton; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Intracellular Signaling Peptides and Proteins; Kinetin; Male; Mice; Mice, Inbred BALB C; Mice, Neurologic Mutants; Motor Activity; Nerve Degeneration; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Phosphorylation; Proteins; Purines; Purkinje Cells; Roscovitine; tau Proteins | 2004 |
Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy.
Topics: Adenoviridae; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Decorin; DNA Primase; DNA-Binding Proteins; Down-Regulation; Extracellular Matrix Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, p16; Genetic Vectors; Histone Deacetylase 1; Histone Deacetylases; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Kinetin; Nuclear Proteins; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proteoglycans; Purines; Reverse Transcriptase Polymerase Chain Reaction; Roscovitine; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein | 2004 |
Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response.
Topics: Ataxia Telangiectasia Mutated Proteins; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; HeLa Cells; Histones; Humans; Kinetin; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Roscovitine; Tumor Suppressor Proteins | 2005 |
Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.
Topics: Action Potentials; Animals; Calcium; Calcium Channels, N-Type; Calcium Channels, P-Type; Calcium Channels, Q-Type; Computer Simulation; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Ganglia, Sympathetic; Ion Channel Gating; Kinetics; Kinetin; Markov Chains; Membrane Potentials; Models, Chemical; Neurons; Neurotransmitter Agents; Protein Kinase Inhibitors; Protein Structure, Tertiary; Purines; Rana catesbeiana; Roscovitine | 2005 |
In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.
Topics: Animals; Area Under Curve; Blotting, Western; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; HCT116 Cells; Humans; Inhibitory Concentration 50; Kinetin; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Phosphorylation; Purines; Recombinant Proteins; Retinoblastoma Protein; Roscovitine; Time Factors; Tissue Distribution; Xenograft Model Antitumor Assays | 2005 |
Role of the cell cycle in the pathobiology of central nervous system trauma.
Topics: Animals; Antineoplastic Agents; Astrocytes; Brain; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Central Nervous System; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Etoposide; Flavonoids; Kinetin; Magnetic Resonance Spectroscopy; Microglia; Mitosis; Neurons; Piperidines; Purines; Rats; Roscovitine; Up-Regulation | 2005 |
Molecular models of protein kinase 6 from Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Cyclin-Dependent Kinases; Hydrogen Bonding; Kinetin; Mitogen-Activated Protein Kinases; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Protein Kinase Inhibitors; Protein Structure, Tertiary; Protozoan Proteins; Purines; Roscovitine; Sequence Alignment; Static Electricity | 2005 |
Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes.
Topics: Animals; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genistein; Hepatocytes; Hydrogen Peroxide; Hydroquinones; Insulin; Isoflavones; Kinetin; Mice; Mice, Inbred C57BL; Okadaic Acid; Phosphorylation; Purines; RNA, Messenger; Roscovitine; Time Factors; Transcriptional Activation | 2005 |
Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 10; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Jurkat Cells; Kinetin; Neuroblastoma; Purines; Roscovitine; Time Factors | 2005 |
Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Flavonoids; Kinetin; Mice; Mitosis; Motor Neurons; Nerve Growth Factors; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine | 2006 |
The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction.
Topics: 4-Aminopyridine; Amifampridine; Animals; Calcium Channels; Excitatory Postsynaptic Potentials; Kinetin; Neuromuscular Junction; Patch-Clamp Techniques; Potassium Channel Blockers; Presynaptic Terminals; Protein Kinase Inhibitors; Purines; Rana pipiens; Roscovitine; Synaptic Transmission; Xenopus laevis | 2006 |
A purine analog kinase inhibitor, calcium/calmodulin-dependent protein kinase II inhibitor 59, reveals a role for calcium/calmodulin-dependent protein kinase II in insulin-stimulated glucose transport.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Glucose; Glucose Transporter Type 4; Green Fluorescent Proteins; Hypoglycemic Agents; Insulin; Kinetin; Mice; Protein Kinase Inhibitors; Purines; Retroviridae; Roscovitine; Transfection | 2007 |
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine.
Topics: Animals; Cocaine; Conditioning, Operant; Cyclin-Dependent Kinase 5; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Kinetin; Male; Nucleus Accumbens; Purines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Roscovitine; Signal Transduction | 2007 |
A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein.
Topics: Animals; Breast Neoplasms; Cell Line, Transformed; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinases; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; HL-60 Cells; Humans; Kinetin; Lung; Membrane Proteins; Mice; Purines; Roscovitine; Skin; Time Factors; Up-Regulation | 2007 |
Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells.
Topics: Cell Cycle; Cell Line; Cell Line, Tumor; Cyclin-Dependent Kinases; Humans; Kinetin; Phosphorylation; Protein Kinase Inhibitors; Purines; Roscovitine; Tumor Suppressor Protein p53 | 2008 |
Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell Membrane; Cell Survival; Chlorophyll; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Hematoporphyrins; Humans; Kinetin; Models, Molecular; Molecular Conformation; Molecular Structure; Neoplasm Proteins; Photosensitizing Agents; Protein Kinase Inhibitors; Purines; Quantitative Structure-Activity Relationship; Quinazolines; Roscovitine; Spodoptera; Transfection | 2009 |
Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB.
Topics: Animals; Cell Line, Tumor; Cyclin-Dependent Kinases; Down-Regulation; E2F1 Transcription Factor; Enzyme Inhibitors; Gene Expression; Inflammation; Interleukin-1alpha; Interleukin-6; Kinetin; Lipopolysaccharides; Macrophages; Mice; Models, Biological; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Purines; RNA Interference; Roscovitine; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2009 |
Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine.
Topics: Age Factors; Animals; Animals, Newborn; Anticarcinogenic Agents; Cell Line, Tumor; Cerebral Cortex; DNA; DNA Damage; DNA Repair; Drug Screening Assays, Antitumor; Glioma; Humans; In Vitro Techniques; Kinetin; Nucleic Acid Synthesis Inhibitors; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine | 2010 |
Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells.
Topics: Animals; Calcium; Calcium Signaling; Cell Differentiation; Cyclin-Dependent Kinase 5; Intracellular Space; Kinetin; Nerve Growth Factor; PC12 Cells; Purines; Rats; Roscovitine | 2010 |
The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors.
Topics: Adenocarcinoma; Apoptosis; Blotting, Western; Cell Cycle; Cyclin-Dependent Kinases; Flow Cytometry; Humans; Kinetin; Lung Neoplasms; Protein Kinase Inhibitors; Purines; Radiation-Sensitizing Agents; Roscovitine; Tumor Cells, Cultured; X-Rays | 2010 |
Physiological responses and endogenous cytokinin profiles of tissue-cultured 'Williams' bananas in relation to roscovitine and an inhibitor of cytokinin oxidase/dehydrogenase (INCYDE) treatments.
Topics: Adenine; Benzyl Compounds; Biomass; Cyclin-Dependent Kinases; Cytokinins; Kinetin; Musa; Oxidoreductases; Phenols; Photosynthesis; Plant Components, Aerial; Plant Growth Regulators; Plant Proteins; Purines; Roscovitine; Signal Transduction; Tissue Culture Techniques | 2012 |
Functional studies of MP62 during male chromatin decondensation in sea urchins.
Topics: Animals; Chromatin Assembly and Disassembly; Histones; Kinetin; Male; Nucleoplasmins; Protein Kinase Inhibitors; Purines; Roscovitine; Sea Urchins; Spermatozoa | 2013 |
CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus.
Topics: Animals; Apoptosis; Astrocytes; CA1 Region, Hippocampal; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Dentate Gyrus; Dynamins; Gliosis; Kinetin; Male; Nerve Degeneration; Phosphorylation; Protein Kinase Inhibitors; Purines; Rats; Roscovitine; Status Epilepticus | 2017 |