Page last updated: 2024-09-04

cyc 202 and indirubin-3'-monoxime

cyc 202 has been researched along with indirubin-3'-monoxime in 11 studies

Compound Research Comparison

Studies
(cyc 202)
Trials
(cyc 202)
Recent Studies (post-2010)
(cyc 202)
Studies
(indirubin-3'-monoxime)
Trials
(indirubin-3'-monoxime)
Recent Studies (post-2010) (indirubin-3'-monoxime)
9797393139082

Protein Interaction Comparison

ProteinTaxonomycyc 202 (IC50)indirubin-3'-monoxime (IC50)
Chain A, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)0.022
Chain B, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)0.022
Chain A, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)0.022
Glycogen synthase kinase-3 beta Sus scrofa (pig)0.022
[Tau protein] kinase Sus scrofa (pig)0.022
Serine/threonine-protein kinase Sgk1Homo sapiens (human)0.38
Aurora kinase AHomo sapiens (human)4
Cyclin-T1Homo sapiens (human)2.4
Serine/threonine-protein kinase 17BHomo sapiens (human)0.71
G2/mitotic-specific cyclin-B2Homo sapiens (human)0.099
Tyrosine-protein kinase LckHomo sapiens (human)0.3
Cyclin-dependent kinase 1Homo sapiens (human)0.126
Insulin-like growth factor 1 receptorHomo sapiens (human)5.3
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)8.2
Fibroblast growth factor receptor 1Homo sapiens (human)2.5
Cyclin-dependent kinase 4Homo sapiens (human)3.33
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.099
Interferon-induced, double-stranded RNA-activated protein kinaseHomo sapiens (human)0.1
Cyclin-A2Homo sapiens (human)0.515
G1/S-specific cyclin-D1Homo sapiens (human)3.33
G1/S-specific cyclin-E1Homo sapiens (human)0.7
Cyclin-dependent kinase 2Homo sapiens (human)0.5767
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.0785
Glycogen synthase kinase-3 alphaHomo sapiens (human)0.022
Glycogen synthase kinase-3 betaHomo sapiens (human)0.0599
Cyclin-dependent kinase 9Homo sapiens (human)2.4
Cyclin-dependent-like kinase 5 Homo sapiens (human)0.1
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)0.1
G2/mitotic-specific cyclin-B3Homo sapiens (human)0.099
Aurora kinase BHomo sapiens (human)2.3
Aurora kinase CHomo sapiens (human)0.3

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (63.64)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bhattacharjee, AK; Ellis, W; Gerena, L; Geyer, JA; Kathcart, AK; Kyle, DE; Li, Z; Lopez-Sanchez, M; Nichols, DA; Prigge, ST; Terrell, J; Waters, NC; Woodard, CL1
Crovace, C; Mapelli, M; Massimiliano, L; Meijer, L; Musacchio, A; Seeliger, MA; Tsai, LH1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Bravo-Altamirano, K; DeStefino, NR; Liang, M; Mazzarisi, CM; Meriney, SD; Olszewski, RA; Rensch, G; Swanson, L; Tarr, TB; Valdomir, G; Wilson, GM; Wipf, P1
Chen, CY; Cheng, JJ; Chiou, CT; Lee, WC; Li, WT; Liao, JH; Lin, LC; Shia, KS; Song, JS; Wu, MH1
Cheng, X; Christ, J; Eisenbrand, G; Merz, KH; Muehlbeyer, S; Thommet, A; Vatter, S; Wölfl, S; Zeller, J1
Bamba, D; Davis, C; Gallo, RC; Gwarzo, MY; Heredia, A; Le, N; Redfield, RR; Sadowska, M1
Lim, KM; Tan, VB; Tay, TE; Zhang, B; Zhuang, S1

Other Studies

11 other study(ies) available for cyc 202 and indirubin-3'-monoxime

ArticleYear
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.
    Journal of medicinal chemistry, 2003, Aug-28, Volume: 46, Issue:18

    Topics: Amino Acid Sequence; Animals; Antimalarials; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Indoles; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Structure-Activity Relationship

2003
Mechanism of CDK5/p25 binding by CDK inhibitors.
    Journal of medicinal chemistry, 2005, Feb-10, Volume: 48, Issue:3

    Topics: Crystallography, X-Ray; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Indoles; Models, Molecular; Molecular Conformation; Nerve Tissue Proteins; Oximes; Protein Binding; Purines; Roscovitine; Stereoisomerism

2005
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist.
    ACS medicinal chemistry letters, 2012, Dec-13, Volume: 3, Issue:12

    Topics:

2012
Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents.
    European journal of medicinal chemistry, 2015, Jun-15, Volume: 98

    Topics: Acetamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indoles; Mice; Mice, Inbred BALB C; Models, Molecular; Xenograft Model Antitumor Assays

2015
Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.
    Journal of medicinal chemistry, 2017, 06-22, Volume: 60, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; Indoles; Oximes; Protein Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Solubility; Structure-Activity Relationship

2017
Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication.
    AIDS (London, England), 2005, Dec-02, Volume: 19, Issue:18

    Topics: Cyclin-Dependent Kinases; Drug Evaluation; Flavonoids; HIV-1; Humans; Indoles; Inhibitory Concentration 50; Leukocytes, Mononuclear; Macrophages; Oximes; Piperidines; Positive Transcriptional Elongation Factor B; Protein Kinase Inhibitors; Purines; Reverse Transcriptase Polymerase Chain Reaction; Roscovitine; U937 Cells; Virus Replication

2005
Study of the inhibition of cyclin-dependent kinases with roscovitine and indirubin-3'-oxime from molecular dynamics simulations.
    Journal of molecular modeling, 2007, Volume: 13, Issue:1

    Topics: Binding Sites; Computer Simulation; Cyclin-Dependent Kinases; Humans; Hydrogen Bonding; Indoles; Models, Chemical; Models, Molecular; Oximes; Protein Binding; Protein Kinase Inhibitors; Purines; Roscovitine; Software; Static Electricity; Thermodynamics; Water

2007