cyc 202 has been researched along with dichlororibofuranosylbenzimidazole in 11 studies
| Studies (cyc 202) | Trials (cyc 202) | Recent Studies (post-2010) (cyc 202) | Studies (dichlororibofuranosylbenzimidazole) | Trials (dichlororibofuranosylbenzimidazole) | Recent Studies (post-2010) (dichlororibofuranosylbenzimidazole) |
|---|---|---|---|---|---|
| 979 | 7 | 393 | 528 | 2 | 64 |
| Protein | Taxonomy | cyc 202 (IC50) | dichlororibofuranosylbenzimidazole (IC50) |
|---|---|---|---|
| Chain A, Cell division protein kinase 9 | Homo sapiens (human) | 34.29 | |
| Chain A, Cell division protein kinase 2 | Homo sapiens (human) | 34.29 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, S; Frame, S; Gianella-Borradori, A; Green, SR; Lane, DP; MacCallum, DE; Melville, J; Watt, K | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Baumli, S; Endicott, JA; Fischer, PM; Hole, AJ; Huang, S; Noble, ME; Pepper, C; Shao, H; Shi, S; Wang, S | 1 |
| Krucher, NA; Meijer, L; Roberts, MH | 1 |
| Ball, HM; Blaydes, JP; Craig, AL; Gibbs, NK; Hupp, TR; Traynor, NJ; Wallace, M | 1 |
| David-Pfeuty, T; Hernandez-Verdun, D; Nouvian-Dooghe, Y; Roussel, P; Sirri, V | 1 |
| Bensaude, O; Biglione, S; Byers, SA; Maury, W; Nguyen, VT; Price, DH; Price, JP | 1 |
| Cheng, JQ; Chu, B; Djeu, J; Mohapatra, S; Pledger, WJ; Zhao, X | 1 |
| Gritsch, D; Komina, O; Maurer, M; Węsierska-Gądek, J; Zulehner, N | 1 |
| Duffin, R; Haslett, C; Leitch, AE; Lucas, CD; Marwick, JA; Rossi, AG | 1 |
| He, X; Liu, Y; Sui, Y; Xu, G; Yu, R | 1 |
11 other study(ies) available for cyc 202 and dichlororibofuranosylbenzimidazole
| Article | Year |
|---|---|
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
Topics: Apoptosis; Cell Line, Tumor; Dichlororibofuranosylbenzimidazole; Down-Regulation; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Messenger; Roscovitine; Transcription, Genetic | 2005 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
Topics: Cyclin-Dependent Kinase 9; Humans; Models, Molecular; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship | 2013 |
The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker.
Topics: Animals; Biological Clocks; Circadian Rhythm; Cyclin-Dependent Kinases; Cycloheximide; Darkness; Dichlororibofuranosylbenzimidazole; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetin; Mollusca; Nucleic Acid Synthesis Inhibitors; Ocular Physiological Phenomena; Photoperiod; Protein Synthesis Inhibitors; Purines; Roscovitine | 1997 |
Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways.
Topics: Amino Acid Sequence; Cyclin-Dependent Kinases; Dichlororibofuranosylbenzimidazole; DNA Damage; Enzyme Inhibitors; Gene Expression Regulation; Humans; Melanoma; Molecular Sequence Data; Phosphorylation; Purines; RNA Polymerase II; Roscovitine; Serine; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays; X-Rays | 2000 |
Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells.
Topics: Casein Kinase II; CDC2-CDC28 Kinases; Cell Cycle; Cell Line; Cell Nucleolus; Cell Nucleus; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Dichlororibofuranosylbenzimidazole; Enzyme Inhibitors; Gene Expression Regulation; Humans; Mitomycin; Models, Biological; Protein Serine-Threonine Kinases; Purines; Ribosomes; RNA, Ribosomal; Roscovitine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex.
Topics: Cyclin-Dependent Kinase 9; Dichlororibofuranosylbenzimidazole; Enzyme Inhibitors; Flavonoids; HIV-1; Kinetics; Piperidines; Positive Transcriptional Elongation Factor B; Purines; Roscovitine; Viral Proteins; Virus Replication | 2007 |
Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Caspase 9; Cell Line, Tumor; Chlorpropamide; Chromones; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinases; Dichlororibofuranosylbenzimidazole; DNA; Drug Synergism; Humans; Male; Membrane Proteins; Mitochondria; Morpholines; Nucleic Acid Synthesis Inhibitors; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purines; RNA, Small Interfering; Roscovitine; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinases; Dichlororibofuranosylbenzimidazole; Drug Synergism; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogens; Female; Humans; Neoplasms, Hormone-Dependent; Phosphorylation; Purines; RNA Polymerase II; Roscovitine; Tamoxifen; Tumor Suppressor Protein p53 | 2011 |
Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation.
Topics: Apoptosis; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Dichlororibofuranosylbenzimidazole; Hep G2 Cells; HL-60 Cells; Humans; Inflammation; Neutrophils; Phosphorylation; Protein Kinase Inhibitors; Purines; RNA Polymerase II; Roscovitine; Transcription, Genetic | 2012 |
Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Dichlororibofuranosylbenzimidazole; HEK293 Cells; Humans; Ikaros Transcription Factor; Immunoblotting; Multiple Myeloma; Protein Kinase Inhibitors; Protein Stability; Proteolysis; Purines; Roscovitine; Time Factors; Ubiquitination | 2015 |