Compounds > cyc 202
Page last updated: 2024-09-04

cyc 202 and butyrolactone i

cyc 202 has been researched along with butyrolactone i in 21 studies

Compound Research Comparison

Studies
(cyc 202)		Trials
(cyc 202)		Recent Studies (post-2010)
(cyc 202)		Studies
(butyrolactone i)		Trials
(butyrolactone i)		Recent Studies (post-2010) (butyrolactone i)
9797393118026

Protein Interaction Comparison

ProteinTaxonomycyc 202 (IC50)butyrolactone i (IC50)
G1/S-specific cyclin-E2Homo sapiens (human)1.5
Cyclin-dependent kinase 1Homo sapiens (human)0.6
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.6
G1/S-specific cyclin-E1Homo sapiens (human)1.5
Cyclin-dependent kinase 2Homo sapiens (human)1.5

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (9.52)18.2507
2000's15 (71.43)29.6817
2010's3 (14.29)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Bhattacharjee, AK; Ellis, W; Gerena, L; Geyer, JA; Kathcart, AK; Kyle, DE; Li, Z; Lopez-Sanchez, M; Nichols, DA; Prigge, ST; Terrell, J; Waters, NC; Woodard, CL1
Akula, N; Pattabiraman, N; Sridhar, J1
Dahse, HM; Grabley, S; Lozach, O; Meijer, L; Menzel, KD; Niu, X; Sattler, I; Walther, G1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Eskin, A; Sankrithi, N1
Hayashi, K; Matsumoto, Y; Nishida, E1
Faerge, I; Hyttel, P; Mayes, M; Sirard, MA1
Crotti, G; Galli, C; Lagutina, I; Lazzari, G; Ponderato, N; Turini, P1
Choi, YH; Hinrichs, K; Love, CC; Reinoehl, C; Varner, DD; Wiggins, CN1
Crotti, G; Duchi, R; Galli, C; Lazzari, G; Ponderato, N; Turini, P1
Boland, M; Faerge, I; Fair, T; Hyttel, PM; Lonergan, P1
Le Beux, G; Richard, FJ; Sirard, MA1
Juang, JL; Lin, H; Wang, PS1
Beaman-Hall, CM; Mathur, A; Monaco, EA; Vallano, ML1
Donnay, I; Faerge, I; Galli, C; Grøndahl, C; Lazzari, G; Ponderato, N; Sayoud, H; Verhaeghe, B1
Adona, PR; Lima Verde Leal, C1
Adona, PR; Leal, CL; Pires, PR; Quetglas, MD; Schwarz, KR1
Hanna, C; Kraemer, D; Long, CR; Menges, S1
Jin, X; Kong, X; Li, G; Liu, T; Wang, L1
Guaitolini, CR; Guastali, MD; Kievitsbosch, T; Landim-Alvarenga, FC; Maziero, RR; Moraes, CN; Paschoal, DM1
Crespilho, AM; Guaitolini, CRF; Landim-Alvarenga, FDC; Lima, JS; Maziero, RRD; Monteiro, BA; Paschoal, DM; Sestari, DAO1

Reviews

1 review(s) available for cyc 202 and butyrolactone i

ArticleYear
Selectivity and potency of cyclin-dependent kinase inhibitors.
    The AAPS journal, 2006, Mar-24, Volume: 8, Issue:1

    Topics: Animals; Binding Sites; Cyclin-Dependent Kinases; Humans; Protein Kinase Inhibitors; Signal Transduction

2006

Other Studies

20 other study(ies) available for cyc 202 and butyrolactone i

ArticleYear
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.
    Journal of medicinal chemistry, 2003, Aug-28, Volume: 46, Issue:18

    Topics: Amino Acid Sequence; Animals; Antimalarials; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Indoles; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Structure-Activity Relationship

2003
Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety.
    Journal of natural products, 2008, Volume: 71, Issue:4

    Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Aspergillus; Brain; CDC2 Protein Kinase; Cyclin-Dependent Kinase 5; Drug Screening Assays, Antitumor; Dyrk Kinases; Glycogen Synthase Kinase 3; Humans; Oocytes; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Starfish; Sulfates; Swine

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia.
    Journal of neurochemistry, 1999, Volume: 72, Issue:2

    Topics: 4-Butyrolactone; Action Potentials; Animals; Aplysia; Circadian Rhythm; Cyclin-Dependent Kinases; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinetin; Macromolecular Substances; Neural Conduction; Ocular Physiological Phenomena; Purines; RNA, Messenger; Roscovitine; Transcription, Genetic

1999
Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells.
    Current biology : CB, 1999, Apr-22, Volume: 9, Issue:8

    Topics: 4-Butyrolactone; Animals; CDC2-CDC28 Kinases; Cell Cycle; Centrosome; CHO Cells; Cricetinae; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; G1 Phase; Gene Expression; Hydroxyurea; Mimosine; Protein Serine-Threonine Kinases; Purines; Roscovitine; S Phase

1999
Nuclear ultrastructure in bovine oocytes after inhibition of meiosis by chemical and biological inhibitors.
    Molecular reproduction and development, 2001, Volume: 59, Issue:4

    Topics: 4-Butyrolactone; Adenine; Animals; Antineoplastic Agents; Cattle; Cell Nucleolus; Cell Nucleus; Cells, Cultured; Cycloheximide; Enzyme Inhibitors; Female; Meiosis; Microscopy, Electron; Nuclear Envelope; Oocytes; Protein Synthesis Inhibitors; Purines; Roscovitine

2001
Bovine oocytes treated prior to in vitro maturation with a combination of butyrolactone I and roscovitine at low doses maintain a normal developmental capacity.
    Molecular reproduction and development, 2001, Volume: 60, Issue:4

    Topics: 4-Butyrolactone; Animals; Cattle; Cell Nucleus; Drug Synergism; Embryo, Mammalian; Embryonic and Fetal Development; Female; Freezing; In Vitro Techniques; Meiosis; Oocytes; Purines; Roscovitine; Survival Rate; Time Factors

2001
Suppression of meiosis by inhibitors of m-phase proteins in horse oocytes with low meiotic competence.
    Zygote (Cambridge, England), 2002, Volume: 10, Issue:1

    Topics: 4-Butyrolactone; Adenine; Animals; Chromatin; Dimethyl Sulfoxide; Horses; Meiosis; Oocytes; Oogenesis; Purines; Roscovitine

2002
Embryonic and foetal development of bovine oocytes treated with a combination of butyrolactone I and roscovitine in an enriched medium prior to IVM and IVF.
    Molecular reproduction and development, 2002, Volume: 62, Issue:4

    Topics: 4-Butyrolactone; Animals; Cattle; Drug Interactions; Embryonic and Fetal Development; Fertilization in Vitro; Freezing; Oocytes; Purines; Roscovitine

2002
Ultrastructural modifications in bovine oocytes maintained in meiotic arrest in vitro using roscovitine or butyrolactone.
    Molecular reproduction and development, 2003, Volume: 64, Issue:3

    Topics: 4-Butyrolactone; Animals; Cattle; Cell Nucleus; Enzyme Inhibitors; Growth Inhibitors; Meiosis; Oocytes; Purines; Roscovitine; Zona Pellucida

2003
Effect of cycloheximide, 6-DMAP, roscovitine and butyrolactone I on resumption of meiosis in porcine oocytes.
    Theriogenology, 2003, Oct-01, Volume: 60, Issue:6

    Topics: 4-Butyrolactone; Adenine; Animals; Cells, Cultured; Cyclin-Dependent Kinases; Cycloheximide; Enzyme Inhibitors; Female; Meiosis; Oocytes; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Purines; Roscovitine; Swine

2003
Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis.
    The Journal of biological chemistry, 2004, Jul-09, Volume: 279, Issue:28

    Topics: 4-Butyrolactone; Apoptosis; Calcium; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Digoxin; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Nerve Tissue Proteins; Prostatic Neoplasms; Purines; RNA, Small Interfering; Roscovitine

2004
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons.
    Biochemical pharmacology, 2004, May-15, Volume: 67, Issue:10

    Topics: 4-Butyrolactone; Animals; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cerebellum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinases; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Kinetin; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Proto-Oncogene Proteins; Purines; Pyrimidines; Rats; Rats, Sprague-Dawley; Roscovitine; Signal Transduction; Sulfonamides

2004
Effect of prematuration, meiosis activating sterol and enriched maturation medium on the nuclear maturation and competence to development of calf oocytes.
    Theriogenology, 2004, Sep-15, Volume: 62, Issue:6

    Topics: 4-Butyrolactone; Animals; Cattle; Cell Nucleus; Culture Media; Cytoplasm; Embryonic and Fetal Development; Female; Fertilization in Vitro; Follicular Fluid; Glutathione; Growth Inhibitors; Meiosis; Oocytes; Ovarian Follicle; Purines; Roscovitine; Sterols

2004
Meiotic inhibition with different cyclin-dependent kinase inhibitors in bovine oocytes and its effects on maturation and embryo development.
    Zygote (Cambridge, England), 2004, Volume: 12, Issue:3

    Topics: 4-Butyrolactone; Animals; Cattle; Cyclin-Dependent Kinases; Embryo, Mammalian; Meiosis; Oocytes; Purines; Roscovitine

2004
Nuclear maturation kinetics and in vitro embryo development of cattle oocytes prematured with butyrolactone I combined or not combined with roscovitine.
    Animal reproduction science, 2008, Mar-03, Volume: 104, Issue:2-4

    Topics: 4-Butyrolactone; Animals; Cattle; Cell Culture Techniques; Culture Media; Embryonic Development; Female; Fertilization in Vitro; Male; Oocytes; Pregnancy; Protein Kinase Inhibitors; Purines; Roscovitine

2008
Synchronisation of canine germinal vesicle stage oocytes prior to in vitro maturation alters the kinetics of nuclear progression during subsequent resumption of meiosis.
    Reproduction, fertility, and development, 2008, Volume: 20, Issue:5

    Topics: 4-Butyrolactone; Animals; Antimitotic Agents; Cell Culture Techniques; Cell Nucleus; Cells, Cultured; Dogs; Drug Combinations; Estradiol; Female; Gonadotropins, Equine; Meiosis; Oocyte Retrieval; Oocytes; Oogenesis; Purines; Roscovitine

2008
Hippocampal glycogen synthase kinase 3β is critical for the antidepressant effect of cyclin-dependent kinase 5 inhibitor in rats.
    Journal of molecular neuroscience : MN, 2014, Volume: 54, Issue:1

    Topics: 4-Butyrolactone; Animals; Antidepressive Agents; Chromones; Cyclin-Dependent Kinase 5; Depression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Helplessness, Learned; Hippocampus; Indoles; Male; Maleimides; Morpholines; Purines; Rats; Rats, Sprague-Dawley; Roscovitine

2014
Effect of Temporary Meiotic Attenuation of Oocytes with Butyrolactone I and Roscovitine in Resistance to Bovine Embryos on Vitrification.
    Reproduction in domestic animals = Zuchthygiene, 2016, Volume: 51, Issue:2

    Topics: 4-Butyrolactone; Animals; Apoptosis; Cattle; Cell Cycle Checkpoints; Drug Therapy, Combination; Embryo Culture Techniques; Meiosis; Protein Kinase Inhibitors; Purines; Roscovitine

2016
Treatment with roscovitine and butyrolactone I prior to
    Zygote (Cambridge, England), 2020, Volume: 28, Issue:1

    Topics: 4-Butyrolactone; Animals; Blastocyst; Cattle; Embryo, Mammalian; Female; Fertilization in Vitro; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Protein Kinase Inhibitors; Roscovitine

2020