cyc 202 has been researched along with benzyloxycarbonylleucyl-leucyl-leucine aldehyde in 11 studies
| Studies (cyc 202) | Trials (cyc 202) | Recent Studies (post-2010) (cyc 202) | Studies (benzyloxycarbonylleucyl-leucyl-leucine aldehyde) | Trials (benzyloxycarbonylleucyl-leucyl-leucine aldehyde) | Recent Studies (post-2010) (benzyloxycarbonylleucyl-leucyl-leucine aldehyde) |
|---|---|---|---|---|---|
| 979 | 7 | 393 | 2,473 | 3 | 1,057 |
| Protein | Taxonomy | cyc 202 (IC50) | benzyloxycarbonylleucyl-leucyl-leucine aldehyde (IC50) |
|---|---|---|---|
| Proteasome subunit beta type-11 | Homo sapiens (human) | 1.9893 | |
| Calpain-9 | Homo sapiens (human) | 9.88 | |
| Proteasome subunit alpha type-7 | Homo sapiens (human) | 1.9893 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | 3.9 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 3.8999 | |
| Aromatase | Homo sapiens (human) | 0.044 | |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | 0.5 | |
| Proteasome subunit beta type-1 | Homo sapiens (human) | 1.0853 | |
| Proteasome subunit alpha type-1 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha type-2 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha type-3 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha type-4 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-8 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-9 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha type-5 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-4 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-6 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-5 | Homo sapiens (human) | 0.6088 | |
| Proteasome subunit beta type-10 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-3 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-2 | Homo sapiens (human) | 2.0443 | |
| Proteasome subunit alpha type-6 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha-type 8 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-7 | Homo sapiens (human) | 1.9893 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, S; Frame, S; Gianella-Borradori, A; Green, SR; Lane, DP; MacCallum, DE; Melville, J; Watt, K | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Advani, SJ; Hagglund, R; Roizman, B; Weichselbaum, RR | 1 |
| Gilbert, DM; Keezer, SM | 1 |
| Henfling, ME; Ramaekers, FC; Schutte, B | 1 |
| Hirabayashi, M; Hochi, S; Ito, J; Ito, M; Kato, M; Shimada, M; Takeuchi, A | 1 |
| Dejsuphong, D; Hochegger, H; Hunt, T; Kirk, J; Rajendra, E; Saberi, A; Sonoda, E; Takeda, S | 1 |
| Indorato, RL; Lacroix, F; Margolis, RL; Panopoulos, A; Skoufias, DA | 1 |
| Boulanger, J; Coulombe, G; Duchesne, C; Renaud, MA; Rivard, N; Simoneau, M | 1 |
| Bonni, A; Huynh, MA; Litterman, N; Stegmüller, J | 1 |
| Chen, Z; Ginsberg, MH; Huang, C; Jacobson, K; Rajfur, Z; Yousefi, N | 1 |
11 other study(ies) available for cyc 202 and benzyloxycarbonylleucyl-leucyl-leucine aldehyde
| Article | Year |
|---|---|
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
Topics: Apoptosis; Cell Line, Tumor; Dichlororibofuranosylbenzimidazole; Down-Regulation; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Messenger; Roscovitine; Transcription, Genetic | 2005 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize.
Topics: CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Line; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Herpesvirus 1, Human; Humans; Immediate-Early Proteins; Leupeptins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Purines; Roscovitine; Subcellular Fractions; Tumor Cells, Cultured; Ubiquitin-Protein Ligases | 2001 |
Evidence for a pre-restriction point Cdk3 activity.
Topics: Animals; Cells, Cultured; CHO Cells; Cricetinae; Cyclin-Dependent Kinases; Cycloheximide; Cysteine Endopeptidases; Enzyme Inhibitors; G1 Phase; Leupeptins; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Kinases; Protein Synthesis Inhibitors; Purines; Replication Origin; Roscovitine | 2002 |
Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lung Neoplasms; Membrane Potentials; Mitochondria; Proteasome Endopeptidase Complex; Purines; Roscovitine; Signal Transduction; Tumor Cells, Cultured | 2004 |
Contribution of high p34cdc2 kinase activity to premature chromosome condensation of injected somatic cell nuclei in rat oocytes.
Topics: Animals; CDC2 Protein Kinase; Cell Culture Techniques; Cell Nucleus; Chromatin; Chromosome Pairing; Cysteine Proteinase Inhibitors; Embryonic Development; Female; Leupeptins; Mice; Microinjections; Nuclear Transfer Techniques; Oocytes; Oogenesis; Protein Kinase Inhibitors; Purines; Rats; Rats, Wistar; Roscovitine | 2005 |
An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells.
Topics: Alleles; Animals; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line; Chickens; Cysteine Proteinase Inhibitors; Geminin; HeLa Cells; Humans; Leupeptins; Models, Biological; Mutation; Purines; Roscovitine; S Phase | 2007 |
Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed.
Topics: 2-Aminopurine; CDC2 Protein Kinase; Coloring Agents; Cysteine Proteinase Inhibitors; Drug Interactions; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; HCT116 Cells; HeLa Cells; Humans; Hydrolysis; Lactams; Leupeptins; Mitosis; Phosphoprotein Phosphatases; Propidium; Protein Kinase Inhibitors; Purines; Roscovitine | 2007 |
Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells.
Topics: Cell Line, Tumor; Cell Nucleus; Cyclin-Dependent Kinase 2; Enzyme Inhibitors; Epithelial Cells; Humans; Intestines; Leupeptins; Models, Biological; Phosphorylation; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Purines; Roscovitine; Two-Hybrid System Techniques | 2008 |
Regulation of Cdh1-APC function in axon growth by Cdh1 phosphorylation.
Topics: Analysis of Variance; Anaphase-Promoting Complex-Cyclosome; Animals; Animals, Newborn; Axons; Cadherins; Carrier Proteins; Cell Cycle Proteins; Cell Movement; Cells, Cultured; Cyclin-Dependent Kinases; Enzyme Inhibitors; Gene Expression Regulation; Green Fluorescent Proteins; Leupeptins; Mutation; Neurons; Phosphorylation; Purines; Rats; Rats, Long-Evans; Roscovitine; Time Factors; Transfection; Ubiquitin-Protein Ligase Complexes | 2009 |
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cricetinae; Cricetulus; Cyclin-Dependent Kinase 5; Focal Adhesions; Humans; Leupeptins; Mice; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Interaction Domains and Motifs; Pseudopodia; Purines; Rats; Recombinant Proteins; Roscovitine; Serine; Talin; Ubiquitin-Protein Ligases; Ubiquitination | 2009 |