cyc 202 has been researched along with abemaciclib in 9 studies
| Studies (cyc 202) | Trials (cyc 202) | Recent Studies (post-2010) (cyc 202) | Studies (abemaciclib) | Trials (abemaciclib) | Recent Studies (post-2010) (abemaciclib) |
|---|---|---|---|---|---|
| 979 | 7 | 393 | 352 | 43 | 343 |
| Protein | Taxonomy | cyc 202 (IC50) | abemaciclib (IC50) |
|---|---|---|---|
| Cyclin-T1 | Homo sapiens (human) | 0.0734 | |
| Cyclin-K | Homo sapiens (human) | 0.065 | |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | 0.7586 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 6.62 | |
| Cyclin-dependent kinase 4 | Homo sapiens (human) | 0.0097 | |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | 0.7484 | |
| Cyclin-A2 | Homo sapiens (human) | 0.1036 | |
| G1/S-specific cyclin-D1 | Homo sapiens (human) | 0.0048 | |
| G1/S-specific cyclin-E1 | Homo sapiens (human) | 0.232 | |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | 0.1847 | |
| G1/S-specific cyclin-D3 | Homo sapiens (human) | 0.0112 | |
| Cyclin-dependent kinase 7 | Homo sapiens (human) | 2.027 | |
| Cyclin-dependent kinase 9 | Homo sapiens (human) | 0.0693 | |
| Cyclin-H | Homo sapiens (human) | 2.6027 | |
| CDK-activating kinase assembly factor MAT1 | Homo sapiens (human) | 3.106 | |
| Cyclin-dependent kinase 6 | Homo sapiens (human) | 0.0168 | |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | 0.405 | |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | 0.405 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Baltus, CB; Bazgier, V; Berka, K; Jorda, R; Kryštof, V; Marot, C; Prié, G; Viaud-Massuard, MC | 1 |
| Joshi, G; Kalra, S; Kumar, R; Munshi, A | 1 |
| Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP | 1 |
| Cheng, W; Kan, Q; Li, Y; Tian, X; Wang, S; Wei, H; Yang, Z | 1 |
| Marzaro, G; Poratti, M | 1 |
| Chen, K; Jiang, H; Li, J; Li, Y; Lin, T; Liu, L; Luo, C; Xu, P; Zhou, B | 1 |
| Caballero, E; García-Cárceles, J; Gil, C; Martínez, A | 1 |
| Li, J; Liang, C; Liu, C; Qiang, T; Ren, X; Shi, Z; Tian, L; Xing, Y | 1 |
| Bouclier, C; Bouzada, D; Eugenio Vázquez, M; González-Vera, JA; Morris, MC | 1 |
5 review(s) available for cyc 202 and abemaciclib
| Article | Year |
|---|---|
Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors.
Topics: Amino Acid Sequence; Animals; Computer-Aided Design; Crystallography, X-Ray; Cyclin-Dependent Kinases; Drug Design; Humans; Models, Molecular; Neoplasms; Protein Conformation; Protein Kinase Inhibitors; Sequence Alignment | 2017 |
Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures.
Topics: Animals; Crystallography, X-Ray; Cyclin-Dependent Kinases; Humans; Molecular Structure; Protein Binding; Protein Kinase Inhibitors | 2019 |
Third-generation CDK inhibitors: A review on the synthesis and binding modes of Palbociclib, Ribociclib and Abemaciclib.
Topics: Aminopyridines; Benzimidazoles; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Structure-Activity Relationship | 2019 |
Kinase Inhibitors as Underexplored Antiviral Agents.
Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses | 2022 |
From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer Therapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinases; Female; Humans; Pharmaceutical Preparations; Protein Kinase Inhibitors | 2022 |
4 other study(ies) available for cyc 202 and abemaciclib
| Article | Year |
|---|---|
Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclin E; Cyclin-Dependent Kinase 2; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Heterocyclic Compounds; Humans; Indoles; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship | 2016 |
The target landscape of clinical kinase drugs.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays | 2017 |
Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Protein Binding; Protein Kinase Inhibitors; Pyrazoles; Signal Transduction; Structure-Activity Relationship | 2021 |
Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity.
Topics: Aminopyridines; Benzimidazoles; Binding Sites; Biosensing Techniques; Cell Line, Tumor; Coordination Complexes; Cyclin-Dependent Kinase 4; Fluorescence; Fluorescent Dyes; Heterocyclic Compounds, 1-Ring; Humans; Peptides; Phosphorylation; Purines; Roscovitine; Terbium; Tryptophan | 2017 |