Page last updated: 2024-09-04

cyc 202 and 6-bromoindirubin-3'-oxime

cyc 202 has been researched along with 6-bromoindirubin-3'-oxime in 6 studies

Compound Research Comparison

Studies
(cyc 202)
Trials
(cyc 202)
Recent Studies (post-2010)
(cyc 202)
Studies
(6-bromoindirubin-3'-oxime)
Trials
(6-bromoindirubin-3'-oxime)
Recent Studies (post-2010) (6-bromoindirubin-3'-oxime)
97973931710114

Protein Interaction Comparison

ProteinTaxonomycyc 202 (IC50)6-bromoindirubin-3'-oxime (IC50)
SUMO1/sentrin specific peptidase 7Homo sapiens (human)5.6
Glycogen synthase kinase-3 beta Sus scrofa (pig)0.005
[Tau protein] kinase Sus scrofa (pig)0.005
caspase-3 isoform a preproproteinHomo sapiens (human)64.3
matrix metalloproteinase-14 preproproteinHomo sapiens (human)5.335
melanocortin receptor 4Homo sapiens (human)6.37
Aurora kinase AHomo sapiens (human)0.6
Casein kinase I isoform alphaSus scrofa (pig)1.2
Cyclin-T1Homo sapiens (human)0.45
G2/mitotic-specific cyclin-B2Homo sapiens (human)0.32
Cyclin-dependent kinase 1Homo sapiens (human)0.3117
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)2.0333
Cyclin-dependent kinase 4Homo sapiens (human)0.527
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.3075
Interferon-induced, double-stranded RNA-activated protein kinaseHomo sapiens (human)0.6
Cyclin-A2Homo sapiens (human)0.069
G1/S-specific cyclin-D1Homo sapiens (human)0.527
G1/S-specific cyclin-E1Homo sapiens (human)0.014
Cyclin-dependent kinase 2Homo sapiens (human)0.0415
Dual specificity protein kinase CLK1Homo sapiens (human)2.1
Glycogen synthase kinase-3 alphaHomo sapiens (human)0.062
Glycogen synthase kinase-3 betaHomo sapiens (human)0.3298
Cyclin-dependent kinase 7Homo sapiens (human)3.5
Cyclin-dependent kinase 9Homo sapiens (human)0.45
Cyclin-HHomo sapiens (human)3.5
CDK-activating kinase assembly factor MAT1Homo sapiens (human)3.5
Cyclin-dependent-like kinase 5 Homo sapiens (human)0.078
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)0.052
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)0.0746
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrialHomo sapiens (human)1.5
Dual specificity tyrosine-phosphorylation-regulated kinase 1ARattus norvegicus (Norway rat)1.11
G2/mitotic-specific cyclin-B3Homo sapiens (human)0.32
Dual specificity tyrosine-phosphorylation-regulated kinase 2Homo sapiens (human)2.1
Aurora kinase BHomo sapiens (human)0.9
Bile acid receptorHomo sapiens (human)3.4
Aurora kinase CHomo sapiens (human)0.2

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Cheng, X; Christ, J; Eisenbrand, G; Merz, KH; Muehlbeyer, S; Thommet, A; Vatter, S; Wölfl, S; Zeller, J1
Esclaire, F; Magnaudeix, A; Martin, L; Terro, F; Yardin, C1
Chen, L; Li, X; Salinas, GD1

Other Studies

6 other study(ies) available for cyc 202 and 6-bromoindirubin-3'-oxime

ArticleYear
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.
    Journal of medicinal chemistry, 2017, 06-22, Volume: 60, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; Indoles; Oximes; Protein Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Solubility; Structure-Activity Relationship

2017
Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A.
    Brain research, 2009, Feb-03, Volume: 1252

    Topics: Analysis of Variance; Animals; Blotting, Western; Calcineurin; Calcineurin Inhibitors; Cells, Cultured; Cyclin-Dependent Kinase 5; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Lithium Chloride; Neurons; Okadaic Acid; Oximes; Phosphorylation; Protein Phosphatase 2; Purines; Rats; Rats, Wistar; Roscovitine; Tacrolimus; tau Proteins

2009
Regulation of serotonin 1B receptor by glycogen synthase kinase-3.
    Molecular pharmacology, 2009, Volume: 76, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Benzazepines; Cell Line; CHO Cells; Cholera Toxin; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Glycogen Synthase Kinase 3; Humans; Indoles; Male; Maleimides; Mice; Mice, Inbred BALB C; Oxadiazoles; Oximes; Piperidines; Piperidones; Protein Kinase Inhibitors; Purines; Pyridines; Receptor, Serotonin, 5-HT1B; Roscovitine; Serotonin; Spiro Compounds

2009