cv 3988 has been researched along with 1-hexadecyl-2-acetyl-glycero-3-phosphocholine in 177 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (44.07) | 18.7374 |
| 1990's | 84 (47.46) | 18.2507 |
| 2000's | 12 (6.78) | 29.6817 |
| 2010's | 3 (1.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abete, P; Balbi, R; Caccese, P; Ferrara, N; Landino, P; Leosco, D; Rengo, F; Sederino, S | 1 |
| Adler, KB; Akley, NJ; Glasgow, WC | 1 |
| Bates, EJ; Ferrante, A; Kowanko, IC | 1 |
| Goto, F; Yoshikawa, D | 1 |
| Chang, SW; Chen, CR; Voelkel, NF | 1 |
| Ishikawa, M; Sengoku, K; Shimizu, T; Tamate, K | 1 |
| Ikegami, M; Jobe, AH; Lewis, JF; Tabor, BL | 1 |
| Ikeuchi, H; Mason, AD; Pruitt, BA; Sakano, T; Sanchez, J | 1 |
| Kawata, H; Mayer, JE; Sawatari, K | 1 |
| Bates, EJ; Ferrante, A; Harvey, DP | 1 |
| Asaka, M; Entani, C; Fujita, M; Iida, H; Izumino, K; Sasayama, S; Takata, M | 1 |
| McIntyre, TM; Prescott, SM; Smiley, PL; Stremler, KE; Zimmerman, GA | 1 |
| Kimura, H; Miyamoto, A; Ohshika, H | 1 |
| Blais, D; Forbes, RD; Hruby, ZW; Lowry, RP | 1 |
| Huang, SC; Misawa, M | 1 |
| Chiu, MH; Huang, SC; Misawa, M | 1 |
| Imura, Y; Kawamura, M; Nishikawa, K; Takatani, M; Terashita, Z; Tsushima, S | 1 |
| Ishikawa, M; Kasamo, M; Kikukawa, Y; Sengoku, K; Shimizu, T | 1 |
| Franklin, R; Gelfand, EW; Mazer, BD; Sawami, H | 1 |
| Ehrlich, YH; Kornecki, E | 2 |
| Horii, T; Kino, M; Kobayashi, Y; Okazaki, H; Saito, K; Satouchi, K | 1 |
| Ikeda, I; Oda, M; Sakakura, M; Yasunaga, K | 1 |
| Terao, M; Tokumura, A; Tsukatani, H; Yube, N | 1 |
| Hoshihara, Y; Miyamoto, T; Nogami, M; Shiga, J; Tabuchi, M; Tsubura, K; Yamamoto, T | 2 |
| Arimura, A; Harada, M | 1 |
| Fukushi, K; Ishitani, K; Ishitani, M; Mikami, T; Suzuki, M; Suzuki, S | 1 |
| Imaizumi, T | 1 |
| Terasawa, M | 1 |
| Hatakeyama, K; Watanabe, K; Yano, S | 2 |
| Katayama, T | 1 |
| Jamieson, WR; Poostizadeh, A; Qayumi, AK | 1 |
| Ganbo, T; Hisamatsu, K; Kamijo, A; Murakami, Y; Nakazawa, T | 1 |
| Hara, A; Ikeda, M; Kaneko, H; Shiba, T; Takeuchi, S; Yoshida, H | 1 |
| Abman, SH; Accurso, FJ; Henson, P; Wilkening, RB; Worthen, GS | 1 |
| Hirasawa, N; Mue, S; Ohuchi, K; Omata, M; Tsurufuji, S; Watanabe, M; Yagi, M | 1 |
| Kakishita, E; Nagai, K; Oura, Y; Suehiro, A | 1 |
| Hirasawa, N; Mue, S; Ohuchi, K; Omata, M; Sugidachi, A; Tsurufuji, S; Watanabe, M | 1 |
| Bazan, NG; Braquet, P; Domingo, MT; Marcheselli, VL; Rossowska, MJ | 1 |
| Inagaki, N; Koda, A; Miura, T; Nagai, H; Ohira, K; Xu, QA | 1 |
| Cioffi, WG; Ikeuchi, H; Mason, AD; Pruitt, BA; Shimazu, T | 1 |
| Aoki, S; Kurosawa, M; Tsukagoshi, H | 1 |
| Finn, CA; Milligan, SR | 1 |
| Hayashi, M; Oh-ishi, S; Qu, XF; Yamaki, K | 1 |
| De Schepper, PJ; Itakura, K; Sugiro, T; Tjandra-Maga, TB; Verbesselt, R | 1 |
| Arimura, A; Harada, M; Nagata, M; Nakamura, K; Takeuchi, M; Watanabe, A | 1 |
| Farber, NE; Gross, GJ; Jacob, HS; Maruyama, M; Vercellotti, GM | 1 |
| Ishikawa, M; Kikukawa, Y; Sengoku, K; Shimizu, T | 1 |
| Cox, CP | 1 |
| Okuda, Y; Tsuyuguchi, I; Yamatodani, A | 1 |
| Dhar, A; Morrison, WJ; Shukla, SD | 1 |
| Morrison, WJ; Shukla, SD | 1 |
| Northover, AM | 1 |
| Endoh, K; Itoh, M; Iwai, A; Joh, T; Kawai, T; Matsusako, K; Miyamoto, T; Takeuchi, T; Yasue, N; Yokoyama, Y | 1 |
| Dodson, MG; Fortunato, SJ; Kumar, R; Minhas, BS; Ricker, DD; Roudebush, WE | 1 |
| Ikeda, K; Sasaki, H; Sasaki, T; Shimura, S; Takishima, T | 1 |
| Dixon, EJ; Page, CP; Robertson, DN; Wilsoncroft, P | 1 |
| Kadowitz, PJ; Underwood, DC | 1 |
| Aharony, D; Redkar-Brown, DG | 1 |
| Arroyo, V; Guarner, F; Ibbotson, GC; MacNaughton, WK; Rodés, J; Wallace, JL | 1 |
| Dunham, EW; Ma, YH | 1 |
| Fukuzawa, K; Takauchi, K; Terao, M; Tokumura, A; Tsukatani, H; Yoshida, J | 1 |
| Hayashi, M; Kimura, J; Nomura, H; Oh-Ishi, S; Tsushima, S | 1 |
| Fujimura, K; Miwa, M; Mizuno, T; Saito, K; Sameshima, Y; Sugatani, J | 1 |
| Imura, Y; Nishikawa, K; Terashita, Z | 2 |
| Hayashi, H; Inoue, K; Kudo, I; Nojima, S; Nomura, H; Onozaki, K; Tsushima, S | 1 |
| Beattie, TR; Biftu, T; Hwang, SB; Lam, MH; Shen, TY | 1 |
| Imura, Y; Nishikawa, K; Sumida, S; Terashita, Z | 2 |
| Tokumura, A; Tsukatani, H | 1 |
| Deacon, RW; Farley, C; Handley, DA; Saunders, RN | 1 |
| Chang, SW; Henson, PM; McMurtry, IF; Pfeffer, KD; Voelkel, NF; Worthen, SG | 1 |
| Hwang, SB; Lam, MH | 1 |
| Benveniste, J; Braquet, P; Chignard, M; Korth, R; Le Couedic, JP; Norel, X; Nunez, D; Spinnewyn, B | 1 |
| Adnot, S; Joseph, D; Vargaftig, BB | 1 |
| Imura, Y; Nishikawa, K; Shino, A; Terashita, Z | 1 |
| Hayashi, Y; Hirasawa, N; Ohuchi, K; Sugidachi, A; Tsurufuji, S; Watanabe, M | 1 |
| Azami, K; Hasegawa, T; Hoshi, M; Ohura, T; Ono, I; Tsutsumi, M | 1 |
| Blake, J; Denberg, P; Leff, AR; Mack, M; Munoz, NM; Popovich, KJ; Sheldon, G; White, SR | 1 |
| Chapman, RW; Danko, G; Grissom, B; Kreutner, W; Sherwood, JE | 1 |
| Bosia, A; Braquet, P; Bussolino, F; Camussi, G; Prosdocimi, M; Tessari, F; Turrini, F | 1 |
| Arnout, J; De Lepeleire, I; De Schepper, P; Holmes, I; Miyamoto, Y; van Hecken, A; Vermylen, J | 1 |
| Lagente, V; Steel, G; Vargaftig, B; Wallace, JL; Whittle, BJ | 1 |
| Adachi, M; Imai, T; Kamiya, I; Kobayashi, H; Nishikata, H; Okazawa, A; Satoh, H; Takahashi, T; Yamaguchi, H | 1 |
| Esumi, Y; Hohnoki, H; Kobayashi, T; Ohtsuki, T; Tanayama, S; Washino, T | 1 |
| Nakayama, R; Saito, K; Satouchi, K; Yasuda, K | 1 |
| Hashimoto, K; Kyougoku, T; Okuda, K; Tatsumi, N | 1 |
| Hasegawa, T; Nakajima, S | 1 |
| Grue-Sørensen, G; Nielsen, CK; Nielsen, IM | 1 |
| Cirino, M; Desquand, S; Hadvary, P; Lagente, V; Lefort, J; Lellouch-Tubiana, A; Vargaftig, BB | 1 |
| Hoshihara, Y; Nogami, M; Tabuchi, M; Tsubura, K; Yamamoto, T | 1 |
| Kohno, SW; Ohata, K; Taira, M; Yamamura, H | 1 |
| Ishii, A; Miyamoto, T; Shiga, J; Suzuki, S; Takizawa, H | 1 |
| Bray, MA; Steiger, J; Subramanian, N | 1 |
| Hayashi, M; Oh, S; Yamaki, K | 1 |
| Steel, G; Wallace, JL; Whittle, BJ | 1 |
| Hahn, HL; Hansen, D; Lang, M | 1 |
| Chang, SW; Feddersen, CO; Henson, PM; Voelkel, NF | 1 |
| Knee, CD; Krell, RD; Kusner, EJ | 1 |
| Malo, PE; Pfeiffer, DF; Wasserman, MA | 1 |
| Fukuzawa, K; Okasaka, N; Tokumura, A; Tsukatani, H; Yoshida, J | 1 |
| Cox, CP; Wood, KL | 1 |
| Fukuzawa, K; Maruyama, T; Tokumura, A; Tsukatani, H; Yoshida, J | 1 |
| Baggiolini, M; Dewald, B | 1 |
| Genovese, A; Levi, R; Robertson, DA | 1 |
| Robertson, DN; Smith, GM | 1 |
| Wallace, JL; Whittle, BJ | 1 |
| Buxton, DB; Hanahan, DJ; Olson, MS | 1 |
| Alloatti, G; Benedetto, C; Camussi, G; Emanuelli, G; Massobrio, M; Montrucchio, G; Roffinello, C; Tetta, C | 1 |
| Alloatti, G; Camussi, G; Emanuelli, G; Montrucchio, G; Roffinello, C; Tetta, C | 1 |
| Mikulaschek, AW; Toth, PD | 1 |
| Oda, M; Saito, K; Satouchi, K; Yasunaga, K | 1 |
| Hayashi, M; Nomura, H; Oh-ishi, S; Tsushima, S; Yamaki, K | 1 |
| Hanahan, DJ; Homma, H; Tokumura, A | 1 |
| Kogo, H; Matsudaira, T; Satoh, T | 1 |
| Shukla, SD | 1 |
| Issekutz, AC; Szpejda, M | 1 |
| Valone, FH | 1 |
| Handley, DA; Lee, ML; Saunders, RN | 1 |
| Kumahara, Y; Masugi, F; Ogihara, T; Otsuka, A; Saeki, S | 2 |
| Inada, Y; Nishikawa, K; Nomura, H; Terashita, Z; Tsushima, S; Yoshioka, Y | 1 |
| Aglietta, M; Arese, M; Bussolino, F; Camussi, G; Costamagna, C; Garbarino, G; Pescarmona, G; Sanavio, F; Silvagno, F; Soldi, R | 1 |
| Kosugi, T; Nakahodo, K; Nakamura, M; Saitoh, S | 1 |
| Bennett, SA; Birnboim, HC | 2 |
| Rezaul, K; Sada, K; Taniguchi, T; Yamamura, H; Yanagi, S | 1 |
| Okano, S; Tagawa, M; Urakawa, N | 2 |
| Evans, RJ; Jarvis, GE | 2 |
| Chiba, Y; Misawa, M | 1 |
| Ballagi, G; Bleese, N; Nagasawa, K; Roth, M; Sawa, Y; Schaper, J; Schaper, W | 1 |
| Iwama, T; Nagai, H; Sakurai, T; Yamaguchi, S | 1 |
| Kimura, J; Namura, Y; Shio, H | 1 |
| Arakida, Y; Hirasawa, N; Mue, S; Ohuchi, K; Sugidachi, A; Tanabe, J; Watanabe, M | 1 |
| Harper, MJ; Kudolo, GB; Newton, ER; Norris, CJ; Peairs, WA | 1 |
| Hara, N; Ichinose, M; Maeno, T; Sawada, M | 1 |
| Kumagai, H; Nakayama, R; Saito, K | 1 |
| Ishikawa, M; Sengoku, K; Takaoka, Y; Tamate, K | 1 |
| Chesonis, RS; Harbison, ML; Schmolze, D; Symington, J; Thomas, TK; Walser, A; Will, PC | 1 |
| Itoh, M; Joh, T; Katoh, N; Yokoyama, Y | 1 |
| Bennett, SA; Birnboim, HC; Leite, LC | 1 |
| Arnout, J; Deckmyn, H; Hoet, B; Kienast, J; Pfliegler, G; Vermylen, J; Wittevrongel, C | 1 |
| Misawa, M; Sugiyama, Y | 1 |
| Furukawa, M; Kubo, N; Yamashita, T | 1 |
| Calligerou, M; Galanopoulou, D; Mavri-Vavayanni, M; Siafaka-Kapadai, A; Weintraub, ST | 1 |
| Baranton, G; Fujii, N; Ishii, N; Isogai, E; Isogai, H; Kimura, K; Nishikawa, T; Postic, D | 1 |
| Camussi, G; Lupia, E; Montrucchio, G; Savu, SR; Silvestro, L; Sörgel, F | 1 |
| Fleming, TP; Stoddart, NR; Wild, AE | 1 |
| Johnston, JM; Kanzaki, H; Matsubara, T; Matsuoka, S; Okada, H; Sanezumi, M; Yasuda, K | 1 |
| Bazan, HE; Tao, Y | 1 |
| Cornu, E; Denizot, Y; Dulery, C; Dupuis, F; Praloran, V; Rougier, F | 1 |
| Akiyama, M; Ino, M; Miwa, M; Shimura, M; Sugatani, J; Suzuki, M; Suzuki, Y; Yamazaki, R | 1 |
| Beadle, RE; Holmes, EP; Seahorn, TL; Venugopalan, CS | 1 |
| Biancone, L; Bussolati, B; Camussi, G; Conaldi, PG; Del Sorbo, L; DeMartino, A; Toniolo, A | 1 |
| Alloatti, G; Camussi, G; De Martino, A; Montrucchio, G; Penna, C | 1 |
| Albini, A; Biancone, L; Boccellino, M; Bussolati, B; Camussi, G; Cantaluppi, V; Conaldi, PG; Del Sorbo, L; Toniolo, A | 1 |
| Battaglia, E; Biancone, L; Boccellino, M; Camussi, G; Del Sorbo, L; Emanuelli, G; Lupia, E; Montrucchio, G | 1 |
| Michibayashi, T | 1 |
| Barbour, SE; Best, AM; Ishihara, Y; Quinn, SM; Schenkein, HA; Tew, JG; Zhang, JB | 1 |
| Biancone, L; Bussolati, B; Camussi, G; Cassoni, P; Montrucchio, G; Rola-Pleszczynski, M; Russo, S | 1 |
| Ishiguro, K; Nagata, S; Oku, H; Yamaki, M | 1 |
| Kolaczkowska, E; Plytycz, B; Seljelid, R; Shahzidi, S; van Rooijen, N | 1 |
| Gokorsch, S; Grimminger, F; Krüll, M; Lohmeyer, J; Mayer, K; Merfels, M; Muhly-Reinholz, M; Rosseau, S; Schwarzer, N; Seeger, W; Suttorp, N | 1 |
| Aikawa, T; Hirose, T; Matsumoto, I; Shimada, T | 1 |
| Cloutier, S; Richter, M; Sirois, P | 1 |
| Beer, DG; Behar, J; Cao, W; Chin, YE; Lambeth, D; Si, J; Wands, J | 1 |
| Baenziger, JE; Bennett, SA; Carswell, CL; Harris, CS; Ryan, SD | 1 |
| Corl, CM; Gandy, JC; Sordillo, LM | 1 |
| McHowat, J; Rastogi, P; Young, DM | 1 |
| Davoine, F; Druey, KM; Dyer, KD; Kim, JD; Lacy, P; Moqbel, R; Percopo, CM; Rosenberg, HF; Xie, Z; Yang, Z | 1 |
| Marentette, JO; McHowat, J; Rastogi, P; Sharma, J; Turk, J; Young, DM | 1 |
| Balestrieri, ML; D'Onofrio, N; Giordano, A; Giovane, A; Iannuzzi, C; Irace, G; Maritato, R; Sirangelo, I | 1 |
1 review(s) available for cv 3988 and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine
| Article | Year |
|---|---|
[Antagonists of platelet activating factor].
Topics: Animals; Benzofurans; Benzopyrans; Depression, Chemical; Guinea Pigs; Lignans; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Thiazoles | 1985 |
1 trial(s) available for cv 3988 and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine
| Article | Year |
|---|---|
Effectiveness and tolerability of CV-3988, a selective PAF antagonist, after intravenous administration to man.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Hemoglobins; Hemolysis; Humans; Injections, Intravenous; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Random Allocation | 1988 |
175 other study(ies) available for cv 3988 and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine
| Article | Year |
|---|---|
Age-related effects of platelet activating factor (PAF) in the isolated perfused rat heart.
Topics: Aging; Animals; Biomechanical Phenomena; Heart; Heart Conduction System; In Vitro Techniques; Male; Pacemaker, Artificial; Perfusion; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar | 1992 |
Platelet-activating factor provokes release of mucin-like glycoproteins from guinea pig respiratory epithelial cells via a lipoxygenase-dependent mechanism.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Epithelium; Glyceryl Ethers; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Mucins; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Trachea | 1992 |
Platelet-activating factor inhibits proteoglycan synthesis and enhances neutrophil-mediated proteoglycan degradation in cartilage explants.
Topics: Animals; Azepines; Cartilage, Articular; Cattle; Cells, Cultured; Granulocyte-Macrophage Colony-Stimulating Factor; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sulfur Radioisotopes; Triazoles; Tumor Necrosis Factor-alpha | 1992 |
Effect of platelet-activating factor antagonist and leukotriene antagonist on endotoxin shock in the rat: role of the leukocyte.
Topics: Animals; Chromones; Leukocyte Count; Leukocytes; Leukotriene Antagonists; Male; Neutropenia; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar; Shock, Septic; Vinblastine | 1992 |
Pulmonary vascular reactivity: effect of PAF and PAF antagonists.
Topics: Angiotensin II; Animals; Azepines; Hypoxia; In Vitro Techniques; Male; Phospholipid Ethers; Platelet Activating Factor; Pulmonary Circulation; Pulmonary Edema; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Triazoles; Vasoconstriction; Vasodilation | 1992 |
Effects of platelet activating factor on mouse sperm function.
Topics: Acrosome; Animals; Female; Fertilization in Vitro; Male; Mice; Mice, Inbred ICR; Phospholipid Ethers; Platelet Activating Factor; Sperm Capacitation; Sperm Motility; Spermatozoa; Zona Pellucida | 1992 |
Platelet-activating factor antagonists decrease lung protein leak in preterm ventilated rabbits.
Topics: Animals; Animals, Newborn; Gestational Age; Lung; Permeability; Phospholipid Ethers; Platelet Activating Factor; Proteins; Pulmonary Surfactants; Rabbits; Respiration, Artificial | 1992 |
The effects of platelet-activating factor (PAF) and a PAF antagonist (CV-3988) on smoke inhalation injury in an ovine model.
Topics: Animals; Dinoprostone; Lipid Peroxidation; Male; Malondialdehyde; Phospholipid Ethers; Platelet Activating Factor; Platelet Count; Sheep; Smoke Inhalation Injury; Thromboxane B2; Time Factors | 1992 |
Evidence for the role of neutrophils in reperfusion injury after cold cardioplegic ischemia in neonatal lambs.
Topics: Acetylcholine; Animals; Animals, Newborn; Cardioplegic Solutions; Coronary Circulation; Coronary Vessels; Endothelium, Vascular; Heart Arrest, Induced; Myocardial Reperfusion Injury; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Sheep; Time Factors; Vascular Resistance | 1992 |
Inhibition of neutrophil respiratory burst and degranulation responses to platelet-activating factor by antagonists WEB 2086, CV 6209 and CV 3988.
Topics: Azepines; Cell Degranulation; Cell Survival; Humans; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Pyridinium Compounds; Respiratory Burst; Triazoles | 1992 |
Effects of the platelet-activating factor antagonists CV-6209 and CV-3988 on nephrotoxic serum nephritis in the rat.
Topics: Animals; Anions; Basement Membrane; Binding Sites; Kidney Glomerulus; Male; Nephritis; Phospholipid Ethers; Platelet Activating Factor; Proteinuria; Pyridinium Compounds; Rats; Rats, Inbred Strains | 1992 |
Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor.
Topics: Azepines; Cell Adhesion; Furans; Humans; Hydrolysis; In Vitro Techniques; Indicators and Reagents; Kinetics; Neutrophils; Oxidation-Reduction; Phosphatidylcholines; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
Interaction between PAF and drugs that stimulate formation of inositol phosphates.
Topics: Animals; Calcium; Carbachol; In Vitro Techniques; Inositol; Inositol Phosphates; Male; Norepinephrine; Parotid Gland; Phospholipid Ethers; Platelet Activating Factor; Potassium; Prazosin; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic | 1991 |
Mechanisms of glomerular injury in experimental immune nephritis. II. Effect of a platelet activating factor receptor antagonist in an autologous nephritis model.
Topics: Albuminuria; Animals; Creatinine; Disease Models, Animal; Kidney Glomerulus; Male; Nephritis; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Lew; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1991 |
The effect of platelet-activating factor on histamine release from rat peritoneal mast cells.
Topics: Aging; Animals; Ascitic Fluid; Buffers; Calcimycin; Calcium; Histamine Release; In Vitro Techniques; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains | 1990 |
The effect of platelet-activating factor on histamine release from guinea pig peritoneal mast cells.
Topics: Animals; Calcimycin; Guinea Pigs; Histamine Release; In Vitro Techniques; Male; Mast Cells; Peritoneal Cavity; Phospholipid Ethers; Platelet Activating Factor; Serum Albumin, Bovine | 1991 |
Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents.
Topics: Anaphylaxis; Animals; Azepines; Furans; Hemolysis; Humans; Hypotension; Isoquinolines; Male; Microsomes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridinium Compounds; Rabbits; Rats; Rats, Inbred Strains; Shock, Septic; Tetrahydroisoquinolines; Triazoles | 1992 |
The effect of platelet activating factor on ovulation.
Topics: Animals; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Embryo Implantation; Female; Fertilization in Vitro; Gonadotropins, Equine; Mice; Mice, Inbred ICR; Oocytes; Ovulation; Phospholipid Ethers; Platelet Activating Factor; Pregnancy | 1991 |
B-cell activation and regulation of immunoglobulin synthesis by platelet activating factor.
Topics: Azepines; B-Lymphocytes; Calcium; Cell Differentiation; Cell Line; Inositol; Lymphocyte Activation; Phospholipid Ethers; Platelet Activating Factor; Receptors, Antigen, B-Cell; Triazoles | 1991 |
Calcium ion mobilization in neuronal cells induced by PAF.
Topics: Adenosine Triphosphate; Animals; Brain; Calcium; Cell Line; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Embryo, Mammalian; Glioma; Kinetics; Mice; Mice, Inbred Strains; Neuroblastoma; Neurons; PC12 Cells; Phospholipid Ethers; Platelet Activating Factor; Prenylamine; Pyridinium Compounds; Rats; Synaptosomes | 1991 |
Platelet-activating factor detected in bronchoalveolar lavage fluids from an asthmatic patient.
Topics: Asthma; Bronchoalveolar Lavage Fluid; Child, Preschool; Chromatography, Thin Layer; Female; Furans; Humans; Infant; Infant, Newborn; Laryngostenosis; Lung; Male; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Aggregation | 1991 |
Presence of platelet-activating factor in pyuria in humans.
Topics: Animals; Chromatography, Thin Layer; Humans; Kinetics; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Pyridinium Compounds; Pyuria; Rabbits | 1991 |
Antagonism of platelet-activating factor in isolated rat colon: possible mechanism.
Topics: Animals; Calcium; Colon; Egtazic Acid; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Phospholipid Ethers; Piperazines; Platelet Activating Factor; Rats; Rats, Inbred Strains | 1991 |
The effect of CV-3988 and CV-6209 on the acute gastric erosions of rats due to water-immersion and restraint stress.
Topics: Analysis of Variance; Animals; Gastric Mucosa; Immersion; Indomethacin; Male; Phospholipid Ethers; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Restraint, Physical; Stomach; Stomach Ulcer; Stress, Physiological | 1991 |
Differential effect of a PAF antagonist CV-3988 on active and passive anaphylactic shock in various mouse strains.
Topics: Anaphylaxis; Animals; Bordetella pertussis; Disease Susceptibility; Immunoglobulin G; Male; Mice; Mice, Inbred Strains; Phospholipid Ethers; Platelet Activating Factor; Serum Albumin, Bovine; Species Specificity | 1991 |
Induction of platelet-activating factor in mice by intravenous administration of a neutral fraction of bakers' yeast mannan.
Topics: Albuterol; Animals; Bile; Blood Pressure; Chromatography, Ion Exchange; Hypotension; Mannans; Mice; Mice, Inbred Strains; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Saccharomyces cerevisiae; Thiazoles | 1991 |
Intravascular release of a platelet-activating factor-like lipid (PAF-LL) induced by cigarette smoking.
Topics: Adult; Age Factors; beta-Thromboglobulin; Biomarkers; Humans; In Vitro Techniques; Male; Middle Aged; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Reference Values; Smoking | 1991 |
[Platelet-activating factor (PAF) antagonists].
Topics: Animals; Azepines; Binding, Competitive; Diterpenes; Furans; Ginkgolides; Humans; Lactones; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
Gastric bleeding and increased gastric vascular permeability induced by platelet activating factor (PAF): effect of drugs that affect arachidonate metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caffeic Acids; Capillary Permeability; Dinoprostone; Gastric Mucosa; Gastrointestinal Hemorrhage; Hydrocortisone; Imidazoles; Indomethacin; Male; Perfusion; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains | 1991 |
[The effect of interleukin-1 on ocular inflammation in rabbit ocular tissue].
Topics: Animals; Aqueous Humor; Dinoprostone; Disease Models, Animal; Endophthalmitis; Eye Proteins; Indomethacin; Interleukin-1; Phospholipid Ethers; Platelet Activating Factor; Rabbits | 1991 |
Effects of platelet-activating factor antagonist CV-3988 in preservation of heart and lung for transplantation.
Topics: Animals; Carbon Dioxide; Deferoxamine; Extravascular Lung Water; Female; Heart-Lung Transplantation; Hemodynamics; Organ Preservation; Oxygen; Phospholipid Ethers; Platelet Activating Factor; Respiration; Swine | 1991 |
Platelet activating factor (PAF) effects on ciliary activity of human paranasal sinus mucosa in vitro.
Topics: Cells, Cultured; Cilia; Ethmoid Sinus; Humans; Mucous Membrane; Phospholipid Ethers; Platelet Activating Factor | 1991 |
Mechanism of acute gastrointestinal mucosal damage in endotoxic shock and the effect of Fragmin.
Topics: Acute Disease; Animals; Benzoquinones; Dogs; Gastric Mucosa; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Intestinal Mucosa; Leukotriene B4; Lipoxygenase Inhibitors; Necrosis; Phospholipid Ethers; Platelet Activating Factor; Shock, Septic | 1990 |
Fetal pulmonary vasodilation after exogenous platelet-activating factor.
Topics: Animals; Female; Fetus; Hemodynamics; Meclofenamic Acid; Phospholipid Ethers; Platelet Activating Factor; Pregnancy; Pulmonary Circulation; Sheep; Vasodilation | 1991 |
Stimulation of neutrophil adherence to vascular endothelial cells by histamine and thrombin and its inhibition by PAF antagonists and dexamethasone.
Topics: Animals; Azepines; Cell Adhesion; Cells, Cultured; Dexamethasone; Endothelium, Vascular; Furans; Histamine; Humans; In Vitro Techniques; Indomethacin; Male; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thrombin; Triazoles | 1991 |
Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood.
Topics: Adenosine Diphosphate; Adult; Aspirin; Creatine Kinase; Drug Synergism; Humans; In Vitro Techniques; Male; Phosphocreatine; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Verapamil; Vitamin E | 1990 |
Possible role for platelet-activating factor in neutrophil infiltration in allergic inflammation in rats.
Topics: Animals; Benzoquinones; Furans; Hypersensitivity; Immunization; Inflammation; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains | 1990 |
Distinct platelet-activating factor binding sites in synaptic endings and in intracellular membranes of rat cerebral cortex.
Topics: Animals; Binding, Competitive; Cell Fractionation; Centrifugation, Density Gradient; Cerebral Cortex; Diterpenes; Ginkgolides; Intracellular Membranes; Lactones; Male; Microsomes; Mitochondria; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Synapses; Synaptic Membranes | 1990 |
Effect of CV-3988, a specific antagonist against platelet activating factor, on homologous passive cutaneous anaphylaxis in the mouse ear.
Topics: Alprostadil; Animals; Antibodies; Blood Vessels; Dinoprostone; Ear, External; Female; Histamine; Immunoglobulin E; Immunoglobulin G; Leukotriene E4; Mice; Mice, Inbred BALB C; Passive Cutaneous Anaphylaxis; Permeability; Phospholipid Ethers; Platelet Activating Factor; Serotonin; Skin; SRS-A | 1990 |
Evaluation and management of patients with inhalation injury.
Topics: Animals; Burns, Inhalation; Humans; Lung; Models, Biological; Oxygen; Phospholipid Ethers; Platelet Activating Factor; Sheep; Smoke Inhalation Injury | 1990 |
[Bronchial hyperresponsiveness to histamine in guinea pig induced by intravenous administration of platelet activating factor].
Topics: Airway Resistance; Animals; Bronchi; Guinea Pigs; Histamine; Infusions, Intravenous; Male; Muscle Contraction; Muscle, Smooth; Phospholipid Ethers; Platelet Activating Factor; Pyridinium Compounds | 1990 |
Failure of platelet-activating factor (PAF-acether) to induce decidualization in mice and failure of antagonists of PAF to inhibit implantation.
Topics: Animals; Azepines; Decidua; Diterpenes; Embryo Implantation; Estradiol; Female; Ginkgolides; Lactones; Mice; Mice, Inbred Strains; Ovariectomy; Phospholipid Ethers; Platelet Activating Factor; Pregnancy; Progesterone; Triazines; Triazoles | 1990 |
Assessment of vascular permeability increase in the mouse by dye leakage during paw edema.
Topics: Animals; Bradykinin; Capillary Permeability; Coloring Agents; Dose-Response Relationship, Drug; Edema; Foot; Histamine; Male; Mice; Mice, Inbred ICR; Phospholipid Ethers; Platelet Activating Factor; Pyrilamine; Tetradecanoylphorbol Acetate | 1990 |
Determination of a platelet activating factor antagonist (CV-3988): methodology and clinical application.
Topics: Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Phospholipid Ethers; Platelet Activating Factor; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1990 |
Production of active and passive anaphylactic shock in the WBB6F1 mouse, a mast cell-deficient strain.
Topics: Anaphylaxis; Animals; Cyproheptadine; Female; Histamine; Immunization, Passive; Mast Cells; Mice; Mice, Mutant Strains; Phospholipid Ethers; Platelet Activating Factor; Serotonin | 1990 |
Evidence for a role of platelet activating factor in the pathogenesis of irreversible but not reversible myocardial injury after reperfusion in dogs.
Topics: Animals; Chemical Phenomena; Chemistry; Diterpenes; Dogs; Electrophysiology; Ginkgolides; Lactones; Myocardial Reperfusion Injury; Phospholipid Ethers; Platelet Activating Factor; Time Factors | 1990 |
[The role of platelet activating factor in ovulation].
Topics: Animals; Dose-Response Relationship, Drug; Female; Mice; Ovary; Ovulation; Phospholipid Ethers; Platelet Activating Factor; Prostaglandins E; Prostaglandins F; Stimulation, Chemical | 1990 |
Effects of CV-3988, an antagonist of platelet-activating factor (PAF), on washed rabbit platelets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Epoprostenol; Female; Osmolar Concentration; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thiazoles | 1986 |
Histamine release from human leukocytes by platelet-activating factor.
Topics: Adult; Asthma; Basophils; Cytochalasin B; Edetic Acid; Histamine Release; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Leukocytes; Phospholipid Ethers; Platelet Activating Factor; Stimulation, Chemical | 1988 |
Desensitization of platelet-activating factor-stimulated protein phosphorylation in platelets.
Topics: Animals; Blood Platelets; In Vitro Techniques; Molecular Weight; Phospholipid Ethers; Phosphoproteins; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Quinolines; Quinolinium Compounds; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases | 1989 |
Antagonism of platelet activating factor receptor binding and stimulated phosphoinositide-specific phospholipase C in rabbit platelets.
Topics: Animals; Blood Platelets; Enzyme Activation; In Vitro Techniques; Phosphatidylinositols; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Quinolines; Quinolinium Compounds; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Type C Phospholipases | 1989 |
Effects of PAF and PAF antagonists on the shape of venous endothelial cells in vitro.
Topics: Animals; Calcimycin; Diterpenes; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Furans; Ginkgolides; Guinea Pigs; Lactones; Leukotriene E4; Lysophosphatidylcholines; Phospholipid Ethers; Platelet Activating Factor; SRS-A; Vena Cava, Inferior | 1989 |
Role of PAF in ischemia-reperfusion injury in the rat stomach.
Topics: Animals; Luminescent Measurements; Male; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Reperfusion Injury; Stomach | 1989 |
Platelet activating factor induced gastric damage in rats: participation of increased gastric vascular permeability.
Topics: Animals; Capillary Permeability; Gastrointestinal Hemorrhage; Hydrochloric Acid; Injections, Intravenous; Male; Perfusion; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Stomach | 1989 |
Effects of platelet activating factor on mouse oocyte fertilization in vitro.
Topics: Animals; Female; Fertilization; Male; Mice; Oocytes; Phospholipid Ethers; Platelet Activating Factor | 1989 |
Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland.
Topics: Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cats; Fatty Acids, Unsaturated; Glucosamine; Glycoconjugates; Hydrazines; In Vitro Techniques; Indomethacin; Kinetics; Methysergide; Mucous Membrane; Phospholipid Ethers; Platelet Activating Factor; Radioisotope Dilution Technique; Thromboxane A2; Trachea; Tritium | 1989 |
The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin.
Topics: Acetylcholine; Animals; Azepines; Bronchi; Diterpenes; Ginkgolides; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Lactones; Male; Phospholipid Ethers; Platelet Activating Factor; Propranolol; Respiratory Hypersensitivity; Triazines; Triazoles | 1989 |
Analysis of bronchoconstrictor responses to platelet-activating factor in the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Cats; Fatty Acids, Unsaturated; Female; Hydrazines; Lung Compliance; Male; Meclofenamic Acid; Phospholipid Ethers; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1989 |
Inhibition of antigen-induced contraction of guinea pig trachea by ICI 198,615.
Topics: Animals; Antigens; Guinea Pigs; In Vitro Techniques; Indazoles; Indomethacin; Leukotrienes; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phospholipid Ethers; Platelet Activating Factor; Pyrazoles; Pyrilamine; SRS-A; Trachea | 1989 |
Endotoxin-induced ascites formation in the rat: partial mediation by platelet-activating factor.
Topics: Animals; Ascitic Fluid; Duodenum; Furans; Gastric Mucosa; Hypotension; Lipopolysaccharides; Liver; Lung; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Salmonella typhi | 1989 |
Antagonism of the vasodilator effects of a platelet activating factor precursor in anesthetized spontaneously hypertensive rats.
Topics: Animals; Captopril; Diacylglycerol Cholinephosphotransferase; Glyceryl Ethers; Hemodynamics; Male; Nitroprusside; Phospholipid Ethers; Platelet Activating Factor; Quinolines; Rats; Rats, Inbred SHR; Vasodilator Agents | 1988 |
A platelet-aggregating and hypotensive phospholipid isolated from bovine brain.
Topics: Animals; Blood Pressure; Brain Chemistry; Cattle; Diazomethane; In Vitro Techniques; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains; Thiazoles | 1986 |
Characterization of the activity of a platelet activating factor antagonist, CV-3988.
Topics: Alprazolam; Animals; Autacoids; Blood Pressure; Capillary Permeability; Dose-Response Relationship, Drug; Male; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Skin; Thiazoles | 1987 |
Occurrence of platelet-activating factor (PAF) in normal rat stomach and alteration of PAF level by water immersion stress.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Immersion; Male; Phospholipases A; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rats; Serotonin; Stomach; Stomach Ulcer; Stress, Physiological | 1989 |
Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet.
Topics: Animals; Blood Platelets; Depression, Chemical; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Species Specificity; Thiazoles; Tritium | 1985 |
Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists.
Topics: Animals; Blood Platelets; Female; Guinea Pigs; In Vitro Techniques; Macrophages; Peritoneal Cavity; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 1985 |
trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor.
Topics: Animals; Benzofurans; Benzopyrans; Blood Platelets; Bradykinin; Capillary Permeability; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Furans; Histamine; Humans; Lignans; Magnesium; Mathematics; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sodium; Thiazoles | 1985 |
Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock.
Topics: Anaphylaxis; Animals; Blood Platelets; Hypotension; Mice; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Thiazoles | 1985 |
Evidence for distinct systemic extravasation effects of platelet activating factor, leukotrienes B4, C4, D4 and histamine in the guinea pig.
Topics: Animals; Chromones; Diphenhydramine; Dose-Response Relationship, Drug; Guinea Pigs; Hematocrit; Hemorrhage; Histamine; Injections, Intravenous; Leukotriene B4; Male; Phospholipid Ethers; Plasma; Platelet Activating Factor; SRS-A; Thiazoles; Time Factors | 1986 |
PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung.
Topics: Alprazolam; Angiotensin II; Animals; Blood Platelets; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Muscle Contraction; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Artery; Pulmonary Circulation; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; SRS-A; Thiazoles; Vasodilation | 1986 |
Species difference in the specific receptors of platelet activating factor.
Topics: Animals; Benzofurans; Blood Platelets; Cell Membrane; Diterpenes; Furans; Ginkgolides; Humans; Lactones; Lignans; Lung; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Thiophenes | 1986 |
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Benzofurans; Benzopyrans; Blood Platelets; Diterpenes; Ginkgolides; Humans; In Vitro Techniques; Lactones; Lignans; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Thiazoles | 1986 |
Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Crotalid Venoms; Cyclooxygenase Inhibitors; Diterpenes; Ginkgolides; Glyceryl Ethers; Humans; Lactones; Lectins, C-Type; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Pyridines; Thiazoles; Thrombin | 1987 |
A lethal role of platelet activating factor in anaphylactic shock in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Dexamethasone; Male; Mice; Mice, Inbred Strains; Naloxone; Phospholipid Ethers; Platelet Activating Factor; Pyrazoles; SRS-A; Thiazoles | 1987 |
Platelet-activating factor in the inflammatory exudate in the anaphylactic phase of allergic inflammation in rats.
Topics: Adenosine Diphosphate; Anaphylaxis; Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Exudates and Transudates; Inflammation; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
The effect of drugs which affect the arachidonate cascade in burned rabbits.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation; Blood Platelets; Burns; Epoprostenol; Fibrinolysis; Kidney; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Thromboxane-A Synthase | 1986 |
Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro.
Topics: Animals; Atropine; Blood Platelets; Dogs; Female; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Phospholipid Ethers; Platelet Activating Factor; Serotonin; Tachyphylaxis; Trachea | 1988 |
Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis.
Topics: Anaphylaxis; Animals; Blood Cells; Blood Platelets; Bronchi; Furans; Guinea Pigs; Hematocrit; Leukocytes; Male; Phospholipid Ethers; Platelet Activating Factor | 1988 |
Platelet activating factor induces dopamine release in PC-12 cell line.
Topics: Adrenal Gland Neoplasms; Animals; Atropine; Calcium; Carbachol; Cell Line; Diterpenes; Dopamine; Ginkgolides; Kinetics; Lactones; Pheochromocytoma; Phospholipid Ethers; Platelet Activating Factor | 1988 |
[Effects of a platelet activating factor (PAF) antagonist CV-3988 on acute gastric erosions in rats by water immersion and restrained stress, and by ethanol].
Topics: Acute Disease; Animals; Ethanol; Immersion; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Restraint, Physical; Stomach; Stomach Ulcer; Stress, Physiological | 1988 |
Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists.
Topics: Animals; Blood Pressure; Disease Models, Animal; Diterpenes; Escherichia coli Infections; Ethanol; Ginkgolides; Glyceryl Ethers; Intestine, Small; Lactones; Lipopolysaccharides; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock, Septic; Stomach; Thiazoles | 1987 |
[The effect of a specific antagonist of PAF (CV-3988) on airway hyperresponsiveness induced by ozone exposure in beagles].
Topics: Animals; Bronchi; Dogs; Female; Methacholine Chloride; Methacholine Compounds; Ozone; Phospholipid Ethers; Platelet Activating Factor; Thiazoles; Thromboxane B2 | 1987 |
Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Dogs; Gas Chromatography-Mass Spectrometry; Half-Life; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity.
Topics: Animals; Cattle; Furans; Gas Chromatography-Mass Spectrometry; Myocardium; Phospholipid Ethers; Plasmalogens; Platelet Activating Factor; Platelet Aggregation | 1988 |
Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein.
Topics: C-Reactive Protein; Humans; In Vitro Techniques; Luminescent Measurements; Male; Neutrophils; Phospholipid Ethers; Platelet Activating Factor | 1988 |
[Recent topics on platelet-activating-factor (PAF)].
Topics: Animals; Blood Pressure; Humans; Mice; Phospholipid Ethers; Platelet Activating Factor; Platelet Adhesiveness; Platelet Aggregation; Rabbits; Rats | 1988 |
Derivatives of 2-methylenepropane-1,3-diol as new antagonists of platelet activating factor.
Topics: Animals; Blood Pressure; Bronchi; Female; Guinea Pigs; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Pyridinium Compounds; Rabbits; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazoles | 1988 |
Neuroregulatory and neuropathological actions of the ether-phospholipid platelet-activating factor.
Topics: Adrenergic Fibers; Animals; Benzodiazepines; Calcium; Calcium Channel Blockers; Cell Line; Cell Survival; Cholinergic Fibers; Neurons; Neurotoxins; Phospholipid Ethers; Platelet Activating Factor | 1988 |
Interference of the Paf antagonist Ro 19-3704 with Paf and antigen-induced bronchoconstriction in the guinea-pig.
Topics: Aerosols; Animals; Blood Cell Count; Bronchodilator Agents; Female; Glyceryl Ethers; Guinea Pigs; In Vitro Techniques; Macrophage Activation; Macrophages; Male; Ovalbumin; Phospholipid Ethers; Platelet Activating Factor; Pulmonary Alveoli; Thiazoles | 1988 |
[Effects of a PAF antagonist CV-3988 on the acute gastric erosions of rats by water-immersion stress].
Topics: Acute Disease; Animals; Immersion; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological | 1988 |
Lack of involvement of leukotriene and platelet activating factor in passive cutaneous anaphylaxis in rats.
Topics: Animals; Capillary Permeability; Female; Histamine; Male; Passive Cutaneous Anaphylaxis; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serotonin; SRS-A | 1988 |
Bronchoconstriction induced by platelet-activating factor in the guinea pig and its inhibition by CV-3988, a PAF antagonist: serial changes in findings of lung histology and bronchoalveolar lavage cell population.
Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Guinea Pigs; Lung; Male; Phospholipid Ethers; Platelet Activating Factor; Respiratory Physiological Phenomena | 1988 |
Platelet activating factor (PAF) is a potent stimulator of porcine tracheal fluid secretion in vitro.
Topics: Animals; Body Fluids; In Vitro Techniques; Muscle, Smooth; Phospholipid Ethers; Platelet Activating Factor; Swine; Thiazoles; Trachea | 1987 |
Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats.
Topics: Animals; Azo Compounds; Bradykinin; Capillary Permeability; Dexamethasone; Guinea Pigs; Histamine; Indomethacin; Inflammation; Injections; Leukocyte Count; Male; Methysergide; Phospholipid Ethers; Platelet Activating Factor; Pleural Effusion; Pleurisy; Prostaglandins; Pyrilamine; Rabbits; Rats; Rats, Inbred Strains; Serotonin; Skin; Skin Physiological Phenomena; Thiazoles; Trypan Blue | 1986 |
Gastrointestinal plasma leakage in endotoxic shock. Inhibition by prostaglandin E2 and by a platelet-activating factor antagonist.
Topics: Animals; Blood Pressure; Blood Proteins; Digestive System; Dinoprostone; Male; Phospholipid Ethers; Platelet Activating Factor; Prostaglandins E; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Shock, Septic; Thiazoles | 1987 |
Effects of the PAF-antagonist CV-3988 on PAF-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets.
Topics: Animals; Asthma; Blood Cells; Ferrets; Mucus; Phospholipid Ethers; Platelet Activating Factor; Thiazoles | 1987 |
Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats.
Topics: Animals; Blood Pressure; Endotoxins; Hemodynamics; Lung; Male; Neutropenia; Phospholipid Ethers; Platelet Activating Factor; Pulmonary Circulation; Quinolinium Compounds; Rats; Rats, Inbred Strains; Salmonella enteritidis; Thiazoles; Time Factors; Vasoconstriction; Vinblastine | 1987 |
Pharmacologic analysis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced increases in cutaneous vascular permeability in the rat.
Topics: Animals; Capillary Permeability; Chromones; Dose-Response Relationship, Drug; Indomethacin; Masoprocol; Methysergide; Nifedipine; Phenoxybenzamine; Phospholipid Ethers; Platelet Activating Factor; Pyrilamine; Rats; Theophylline; Thiazoles | 1987 |
Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Guinea Pigs; In Vitro Techniques; Male; Meclofenamic Acid; Phospholipid Ethers; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; SRS-A; Thiazoles; Trachea | 1987 |
Platelet aggregation induced by ether-linked phospholipids. 2. Mechanism of desensitization of rabbit platelets by platelet activating factor and reversibility of inhibitory actions of its antagonists.
Topics: Animals; In Vitro Techniques; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serum Albumin, Bovine; Structure-Activity Relationship; Thiazoles | 1987 |
Selective antagonism of platelet-activating factor (PAF)-induced aggregation and secretion in washed rabbit platelets by CV-3988, L-652731, triazolam and alprazolam.
Topics: Alprazolam; Animals; Blood Platelets; Furans; In Vitro Techniques; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serotonin; Thiazoles; Triazolam | 1987 |
Platelet aggregation induced by ether-linked phospholipids. 1. Inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor.
Topics: Animals; Cats; Cattle; Ethers; Humans; Lysophospholipids; Phosphatidic Acids; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serum Albumin, Bovine; Structure-Activity Relationship; Thiazoles | 1987 |
Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay.
Topics: Benzofurans; Diterpenes; Exocytosis; Fluorescence; Ginkgolides; Humans; Lactones; Lignans; Methods; Neutrophils; Pancreatic Elastase; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Pyridines; Thiazoles | 1987 |
Negative inotropic effect of platelet-activating factor on human myocardium: a pharmacological study.
Topics: Calcium; Depression, Chemical; Dose-Response Relationship, Drug; Humans; Indomethacin; Myocardial Contraction; Phospholipid Ethers; Platelet Activating Factor; Quinolinium Compounds; SRS-A; Thiazoles | 1987 |
CV3988 inhibits in vivo platelet aggregation induced by PAF-acether and collagen.
Topics: Animals; Blood Pressure; Collagen; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Rabbits; Rats; Species Specificity; Thiazoles; Thromboxane B2; Time Factors | 1986 |
Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor.
Topics: Animals; Blood Pressure; Endotoxins; Lipopolysaccharides; Male; Peptic Ulcer; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Salmonella typhi; Thiazoles | 1986 |
Possible role of platelet activating factor (PAF) in disseminated intravascular coagulation (DIC), evidenced by use of a PAF antagonist, CV-3988.
Topics: Animals; Disseminated Intravascular Coagulation; Endotoxins; Phospholipid Ethers; Platelet Activating Factor; Rats; Thiazoles | 1986 |
Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver.
Topics: Animals; Dose-Response Relationship, Drug; Glucose; Liver; Liver Glycogen; Male; Perfusion; Phenylephrine; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Inbred Strains; Thiazoles; Vasoconstriction; Venous Pressure | 1986 |
Platelet-activating factor contracts human myometrium in vitro.
Topics: Adult; Chromones; Female; Humans; In Vitro Techniques; Myometrium; Oxytocin; Phospholipid Ethers; Platelet Activating Factor; Pregnancy; Thiazoles; Uterine Contraction | 1986 |
In vitro contractile effect of platelet-activating factor on guinea-pig myometrium.
Topics: Animals; Chromones; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Myometrium; Oxytocin; Phospholipid Ethers; Platelet Activating Factor; Prostaglandins; Thiazoles; Uterine Contraction | 1986 |
Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat.
Topics: Animals; Blood Pressure; Decerebrate State; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock; Shock, Hemorrhagic; Shock, Septic; Thiazoles | 1986 |
Polymorphonuclear leukocyte-platelet interactions: acetylglyceryl ether phosphocholine-induced platelet activation under stimulation with chemotactic peptide.
Topics: Animals; Blood Platelets; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thiazoles | 1986 |
Suppression of phorbol myristate acetate-induced pleurisy by CV-3988, an antagonist of platelet-activating factor.
Topics: Animals; Male; Phospholipid Ethers; Platelet Activating Factor; Pleurisy; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thiazoles | 1986 |
Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation.
Topics: Animals; Blood Platelets; Kinetics; Phosphatidic Acids; Phosphatidylinositols; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serotonin; Thiazoles | 1985 |
A possible role of antihypertensive polar renomedullary lipid (APRL) and prostaglandin E2 in the kidney in the antihypertensive action of pindolol.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dinoprostone; Electrolytes; Indomethacin; Kidney; Male; Phospholipid Ethers; Pindolol; Platelet Activating Factor; Prostaglandins E; Rats; Rats, Inbred SHR; Thiazoles | 1985 |
Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin.
Topics: Animals; Blood Platelets; Calcium; Colforsin; Diterpenes; Dose-Response Relationship, Drug; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Models, Biological; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Sugar Phosphates; Thiazoles; Time Factors | 1985 |
Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988.
Topics: Acute Disease; Animals; Blood Platelets; Capillary Permeability; Cell Movement; Inflammation; Leukocytes; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Regional Blood Flow; Serum Albumin; Skin; Thiazoles; Thrombocytopenia | 1986 |
Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988).
Topics: Blood Platelets; Dose-Response Relationship, Drug; Humans; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Thiazoles | 1985 |
Is platelet activating factor (PAF) a mediator of endotoxin shock?
Topics: Animals; Blood Pressure; Endotoxins; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock, Septic; Thiazoles | 1985 |
Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig.
Topics: Animals; Calcium Channel Blockers; Capillary Permeability; Guinea Pigs; Hematocrit; Histamine; Male; Phospholipid Ethers; Platelet Activating Factor; Thiazoles; Thromboxane-A Synthase | 1985 |
The role of antihypertensive polar renomedullary lipid in the pathogenesis of hypertension.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Dinoprostone; Dogs; Epoprostenol; Female; Histamine; Hypertension, Renal; Kidney; Kidney Medulla; Male; Norepinephrine; Phospholipid Ethers; Platelet Activating Factor; Prostaglandins E; Rats; Rats, Inbred Strains; Thiazoles | 1984 |
CV-3988 - a specific antagonist of platelet activating factor (PAF).
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Calcimycin; Collagen; Dose-Response Relationship, Drug; Male; Micelles; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thiazoles | 1983 |
Effect of 1-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine inhibitor on the reduction of one-kidney, one clip hypertension after unclipping in the rat.
Topics: Animals; Blood Pressure; Hypertension, Renovascular; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Renal Artery; Thiazoles | 1984 |
Human endothelial cells are targets for platelet-activating factor (PAF). Activation of alpha and beta protein kinase C isozymes in endothelial cells stimulated by PAF.
Topics: Actins; Amino Acid Sequence; Antibodies; Cell Membrane; Cells, Cultured; Chromatography, Ion Exchange; Cytoskeletal Proteins; Cytosol; Diglycerides; Diterpenes; Endothelium, Vascular; Enzyme Activation; Ginkgolides; Humans; Isoenzymes; Kinetics; Lactones; Molecular Sequence Data; Naphthalenes; Peptides; Phospholipid Ethers; Platelet Activating Factor; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Thiazoles; Vinculin | 1994 |
Histamine release from rabbit platelets by platelet-activating factor (PAF).
Topics: Adenosine Triphosphate; Animals; Blood Platelets; Guinea Pigs; Histamine Release; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits | 1994 |
Platelet activating factor induces transformation of human fibroblasts.
Topics: Alkaloids; Analysis of Variance; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Genistein; Growth Inhibitors; Humans; Indomethacin; Infant, Newborn; Isoflavones; Phospholipid Ethers; Platelet Activating Factor; Protein Kinase C; Skin; Staurosporine | 1995 |
Protein-tyrosine kinase p72syk is activated by platelet activating factor in platelets.
Topics: Animals; Apyrase; Aspirin; Blood Platelets; Calcium; Enzyme Activation; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Phospholipid Ethers; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Stimulation, Chemical; Swine; Syk Kinase | 1994 |
Effect of platelet activating factor antagonist (CV-3988) on 6-keto-PGF1 alpha and thromboxane B2 in dogs with experimental endotoxin-induced shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dog Diseases; Dogs; Hemodynamics; Phospholipid Ethers; Platelet Activating Factor; Shock, Septic; Thromboxane B2 | 1995 |
Endotoxin-induced platelet aggregation in heparinised equine whole blood in vitro.
Topics: Animals; Apyrase; Aspirin; Dose-Response Relationship, Drug; Endotoxins; Heparin; Horses; In Vitro Techniques; Limulus Test; Microscopy; Microscopy, Electron; Nephelometry and Turbidimetry; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation | 1994 |
Inhibition of antigen-induced airway hyperresponsiveness in rats: effects of ozagrel (a thromboxane A2 synthase inhibitor) and of CV-3988 (a platelet activating factor antagonist).
Topics: Acetylcholine; Animals; Antigens, Helminth; Ascaris; Bronchial Hyperreactivity; Dinitrobenzenes; Lung; Male; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar; Respiration; Thromboxane A2; Thromboxane-A Synthase; Vaccination | 1994 |
Platelet-activating factor plays an important role in reperfusion injury in myocardium. Efficacy of platelet-activating factor receptor antagonist (CV-3988) as compared with leukocyte-depleted reperfusion.
Topics: Animals; Heart; Myocardial Reperfusion; Myocardial Reperfusion Injury; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Swine | 1994 |
Pharmacological studies of platelet-activating factor (PAF)-induced augmentation of response to histamine in guinea-pigs.
Topics: Animals; Benzoquinones; Bridged Bicyclo Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capillary Permeability; Chromones; Drug Interactions; Fatty Acids, Monounsaturated; Guinea Pigs; Histamine; Indomethacin; Leukocyte Count; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Pressure; Respiratory Physiological Phenomena; Respiratory System; Thromboxane A2 | 1994 |
LTC4/LTB4 alterations in rat forebrain ischemia and reperfusion and effects of AA-861, CV-3988.
Topics: Animals; Benzoquinones; Brain Edema; Brain Ischemia; Injections, Intraperitoneal; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Phospholipid Ethers; Platelet Activating Factor; Premedication; Prosencephalon; Rats; Rats, Wistar; Reperfusion Injury | 1994 |
Pharmacological analysis of neutrophil chemotactic factor production by leucocytes and roles of PAF in allergic inflammation in rats.
Topics: Animals; Azepines; Benzoquinones; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Furans; Hypersensitivity; Immunization; Interleukin-8; Isoelectric Focusing; Leukocytes; Lipoxygenase Inhibitors; Phospholipid Ethers; Platelet Activating Factor; Rats; Triazoles | 1994 |
Platelet-activating factor antagonists and implantation in rabbits.
Topics: Animals; Drug Administration Schedule; Embryo Implantation; Female; Phospholipid Ethers; Platelet Activating Factor; Pregnancy; Rabbits | 1994 |
A flow cytometric assay reveals an enhancement of phagocytosis by platelet activating factor in murine peritoneal macrophages.
Topics: Animals; Azepines; Calcium; Female; Flow Cytometry; In Vitro Techniques; Latex; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Phagocytosis; Phospholipid Ethers; Platelet Activating Factor; Triazoles | 1994 |
Evidence for production of platelet-activating factor by yeast Saccharomyces cerevisiae cells.
Topics: Chromatography, Thin Layer; Furans; Gas Chromatography-Mass Spectrometry; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Protein Precursors; Pyridinium Compounds; Saccharomyces cerevisiae | 1994 |
Effects of platelet activating factor on human sperm function in vitro.
Topics: Acrosome; Animals; Cricetinae; Female; Fertilization; Humans; In Vitro Techniques; Male; Oocytes; Phospholipid Ethers; Platelet Activating Factor; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa | 1993 |
Differential antagonism of platelet activating factor-induced neutrophilia and gastric hemorrhage in the rat.
Topics: Animals; Gastric Mucosa; Gastrointestinal Hemorrhage; Hemoglobins; Hypotension; Injections, Intravenous; Male; Neutrophils; Phenanthridines; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazines | 1993 |
[Evaluation of the mechanism of endothelin-induced rat gastric mucosal lesion formation].
Topics: Animals; Calcium; Chromones; Diltiazem; Endothelins; Gastric Mucosa; Leukotrienes; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; SRS-A | 1994 |
Platelet activating factor, an endogenous mediator of inflammation, induces phenotypic transformation of rat embryo cells.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media; Embryo, Mammalian; Inflammation; Phenotype; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1993 |
Sodium fluoride induced activation of phospholipase C in intact human platelets does not depend on ADP, PAF or arachidonate products.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Enzyme Activation; GTP-Binding Proteins; Humans; Lysine; Phospholipid Ethers; Platelet Activating Factor; Sodium Fluoride; Type C Phospholipases | 1993 |
An airway hyperresponsiveness model in rat allergic asthma.
Topics: Acetylcholine; Animals; Ascaris; Asthma; Bronchial Hyperreactivity; Capillary Permeability; Chromones; Depression, Chemical; Dinitrophenols; Disease Models, Animal; Male; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar; SRS-A; Thromboxane-A Synthase; Tissue Extracts | 1993 |
Effect of platelet activating factor antagonist (TCV-309) on lung injury in dogs with experimentally endotoxin-induced shock.
Topics: Animals; Dogs; Escherichia coli; Isoquinolines; Lipopolysaccharides; Lung; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pulmonary Edema; Pulmonary Surfactants; Pyridinium Compounds; Shock, Septic; Tetrahydroisoquinolines | 1995 |
Biochemical evidence of platelet-activating factor (PAF) in human middle ear effusions.
Topics: Arachidonic Acids; Humans; Indomethacin; Otitis Media with Effusion; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation | 1995 |
Platelet activating factor and lyso-phosphatidylcholines from strawberry.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Fruit; In Vitro Techniques; Lysophosphatidylcholines; Phospholipid Ethers; Plant Leaves; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pollen; Rabbits; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Platelet-activating-factor-mediated pathogenesis in Lyme disease.
Topics: Animals; Lyme Disease; Male; Mice; Mice, Inbred C3H; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 1996 |
Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azepines; Carbazoles; Clonixin; Endotoxins; Heparin; Horses; In Vitro Techniques; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinacrine; Thromboxane A2; Triazoles | 1996 |
Determination of 1-O-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, platelet-activating factor and related phospholipids in biological samples by high-performance liquid chromatography--tandem mass spectrometry.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Humans; Linear Models; Lysophosphatidylcholines; Mass Spectrometry; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Reference Standards; Umbilical Veins | 1996 |
Stimulation of development in vitro by platelet-activating factor receptor ligands released by mouse preimplantation embryos.
Topics: Animals; Blastocyst; Cell Culture Techniques; Embryonic and Fetal Development; Isoquinolines; Mice; Mice, Inbred Strains; Phospholipid Ethers; Platelet Activating Factor; Stimulation, Chemical | 1996 |
Platelet-activating factor (PAF) and PAF acetylhydrolase activity in rat uterus and placenta during the late stages of pregnancy.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Biological Assay; Female; Isoquinolines; Phospholipases A; Phospholipid Ethers; Placenta; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy, Animal; Pyridinium Compounds; Rabbits; Rats; Rats, Wistar; Reference Values; Tetrahydroisoquinolines; Time Factors; Uterus | 1997 |
PAF antagonists as possible inhibitors of corneal epithelial defects and ulceration.
Topics: Azepines; Cornea; Corneal Injuries; Diterpenes; Enzyme Activation; Epithelium; Extracellular Matrix Proteins; Fibrinolytic Agents; Ginkgolides; Lactones; Metalloendopeptidases; Phospholipid Ethers; Platelet Activating Factor; Thienopyridines; Triazoles; Urokinase-Type Plasminogen Activator; Wound Healing | 1997 |
Platelet-activating factor and antagonists modulate DNA synthesis in human bone marrow stromal cell cultures.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Blood; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Culture Media; Diterpenes; DNA Replication; Fibrinolytic Agents; Fibroblast Growth Factor 2; Ginkgolides; Humans; Lactones; Phospholipases A; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Primary Myelofibrosis; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stromal Cells; Thymidine | 1997 |
Receptor-mediated and protein kinase-dependent growth enhancement of primary human fibroblasts by platelet activating factor.
Topics: Animals; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Fibroblasts; Genistein; Humans; Indomethacin; Infant, Newborn; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Protein Kinase C; Protein Kinases; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sepharose; Skin; Staurosporine; Transcription, Genetic; Up-Regulation | 1997 |
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Neutrophils; P-Selectin; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles | 1998 |
Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Dinoprostone; Guinea Pigs; Histamine; Horse Diseases; Horses; In Vitro Techniques; Leukotriene D4; Lung; Lung Diseases, Obstructive; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Poaceae; Prostaglandin Antagonists; Quinolines; Reference Values; Seasons; Trachea; Xanthenes; Xanthones | 1998 |
The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat.
Topics: Azepines; Chemotaxis; Gene Products, tat; HIV-1; Humans; Monocytes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; tat Gene Products, Human Immunodeficiency Virus; Triazoles | 1999 |
Role of nitric oxide and platelet-activating factor in cardiac alterations induced by tumor necrosis factor-alpha in the guinea-pig papillary muscle.
Topics: Action Potentials; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Azepines; Cyclooxygenase Inhibitors; Depression, Chemical; Guinea Pigs; Heart; In Vitro Techniques; Indomethacin; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Propranolol; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis.
Topics: Azepines; Cell Movement; Diterpenes; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gene Products, tat; Ginkgolides; HIV-1; Humans; Lactones; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sarcoma, Kaposi; tat Gene Products, Human Immunodeficiency Virus; Triazoles; Tumor Cells, Cultured | 1999 |
Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model.
Topics: Animals; Azepines; Cell Movement; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Lymphokines; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Skin; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Interaction between platelet-aggregating response and vasoconstrictive response to platelet activating factor.
Topics: Animals; Arteries; Blood Platelets; Bucladesine; Collagen; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth, Vascular; Norepinephrine; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Vasoconstriction | 1999 |
Regulation of immunoglobulin G2 production by prostaglandin E(2) and platelet-activating factor.
Topics: Aggressive Periodontitis; Cells, Cultured; Dinoprostone; Humans; Immunoglobulin G; Indomethacin; Macrophages; Monocytes; Phospholipid Ethers; Platelet Activating Factor | 2000 |
PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis.
Topics: Animals; Azepines; Breast Neoplasms; Cell Division; Cell Movement; Female; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Neovascularization, Pathologic; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Cells, Cultured | 2000 |
Bisxanthones from Hypericum japonicum: inhibitors of PAF-induced hypotension.
Topics: Animals; Blood Pressure; Drugs, Chinese Herbal; Hypericum; Hypotension; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred Strains; Molecular Structure; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Aggregation Inhibitors; Xanthenes; Xanthones | 2002 |
Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Leak Syndrome; Capillary Permeability; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cysteine; Diterpenes; Eicosanoids; Enzyme Induction; Ginkgolides; Histamine Release; Indoles; Indomethacin; Isoenzymes; Lactones; Leukotriene C4; Leukotrienes; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Male; Mast Cells; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Nitrobenzenes; Peritonitis; Phospholipid Ethers; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Quinolines; Sulfonamides; Thioglycolates; Zymosan | 2002 |
Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation.
Topics: Azepines; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Fatty Acids, Omega-3; Humans; Intercellular Adhesion Molecule-1; Monocytes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2002 |
Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Calcimycin; Calcium; Colforsin; Corticosterone; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Drug Synergism; Enzyme Activation; Guinea Pigs; Hydrocortisone; Ionophores; Isoquinolines; Male; Perfusion; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyridinium Compounds; Receptors, G-Protein-Coupled; Secretory Rate | 2005 |
Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice.
Topics: Animals; Antihypertensive Agents; Bronchial Hyperreactivity; Carbachol; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Male; Mice; Mice, Inbred BALB C; Oligopeptides; Ovalbumin; Peptide Fragments; Phospholipid Ethers; Piperidines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptor, Endothelin B; Thromboxane A2 | 2007 |
STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells.
Topics: Adenocarcinoma; Arachidonic Acids; Barrett Esophagus; Cell Line, Tumor; Enzyme Inhibitors; Esophageal Neoplasms; Flavonoids; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; MAP Kinase Kinase 1; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NADPH Oxidase 5; NADPH Oxidases; Phospholipases A2, Cytosolic; Phospholipid Ethers; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT5 Transcription Factor; Transfection; Up-Regulation | 2008 |
Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.
Topics: Animals; Apoptosis; Carbon; Caspases; Cell Line; Cerebellum; Gene Expression Regulation; Mice; Micelles; Neurons; Neuroprotective Agents; Neurotoxins; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction | 2008 |
Platelet activating factor production and proinflammatory gene expression in endotoxin-challenged bovine mammary endothelial cells.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Cattle; Cells, Cultured; Cytokines; Endothelial Cells; Endotoxins; Escherichia coli; Female; Gene Expression Regulation; Intercellular Adhesion Molecule-1; Mammary Glands, Animal; Phosphatidic Acids; Phospholipase D; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Time Factors | 2008 |
Tryptase activates calcium-independent phospholipase A2 and releases PGE2 in airway epithelial cells.
Topics: Cell Adhesion; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Humans; Neutrophils; Phospholipases A2, Calcium-Independent; Phospholipid Ethers; Platelet Activating Factor; Respiratory System; Subcellular Fractions; Tryptases | 2008 |
Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.
Topics: Animals; Azepines; Cell Degranulation; Eosinophils; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles | 2010 |
Lung endothelial cell platelet-activating factor production and inflammatory cell adherence are increased in response to cigarette smoke component exposure.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Cell Adhesion; Cell Line; Endothelial Cells; Group VI Phospholipases A2; Humans; Inflammation; Lung; Mice; Mice, Knockout; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Disease, Chronic Obstructive; Receptors, G-Protein-Coupled; Tobacco Smoke Pollution | 2012 |
Platelet-activating factor mediates the cytotoxicity induced by W7FW14F apomyoglobin amyloid aggregates in neuroblastoma cells.
Topics: Amyloid; Apoproteins; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Myoglobin; Neuroblastoma; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Aggregates; Receptors, G-Protein-Coupled | 2014 |