Page last updated: 2024-09-04

cv 159 and nicardipine

cv 159 has been researched along with nicardipine in 3 studies

*Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [MeSH]

*Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [MeSH]

Compound Research Comparison

Studies
(cv 159)
Trials
(cv 159)
Recent Studies (post-2010)
(cv 159)
Studies
(nicardipine)
Trials
(nicardipine)
Recent Studies (post-2010) (nicardipine)
8002,646444312

Protein Interaction Comparison

ProteinTaxonomycv 159 (IC50)nicardipine (IC50)
Bile salt export pumpHomo sapiens (human)8.314
ATP-dependent translocase ABCB1Mus musculus (house mouse)8
ATP-dependent translocase ABCB1Homo sapiens (human)4.2992
Cytochrome P450 3A4Homo sapiens (human)0.42
Cytochrome P450 2C9 Homo sapiens (human)1.69
ATP-dependent translocase ABCB1Mus musculus (house mouse)2.5
Cytochrome P450 2J2Homo sapiens (human)1.69
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)4.925
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.8

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hidaka, H; Nunoki, K; Taira, N; Tanaka, T; Umekawa, H; Yamakawa, K1
Imai, H; Imai, S; Matsui, K; Nakagawa, Y; Nakazawa, M; Ochi, S1
Fujii, Y; Kamibayashi, M; Miyazaki, H; Nagashima, K; Nomura, Y; Okuma, Y; Shimizu, K; Tanaka, S; Uehara, T1

Other Studies

3 other study(ies) available for cv 159 and nicardipine

ArticleYear
Inhibition of calmodulin function by CV-159, a novel dihydropyridine compound.
    Biochemical pharmacology, 1988, Sep-15, Volume: 37, Issue:18

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Calcium; Calmodulin; Cattle; Dansyl Compounds; Dihydropyridines; Myosin-Light-Chain Kinase; Nicardipine

1988
Effects of the new dihydropyridine derivative 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester on the cardiohemodynamics and the energy metabolism of ischemic myocardium.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:12

    Topics: Animals; Blood Pressure; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Coronary Circulation; Coronary Disease; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Energy Metabolism; Esters; Female; Heart; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Nicardipine; Rats

1987
Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury.
    Life sciences, 1999, Volume: 64, Issue:10

    Topics: Animals; Body Temperature; Brain Edema; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cerebral Infarction; Dihydropyridines; Hemodynamics; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Neuroprotective Agents; Nicardipine; Nifedipine; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Water

1999