curcumin and nimesulide

curcumin has been researched along with nimesulide* in 2 studies

Other Studies

2 other study(ies) available for curcumin and nimesulide

ArticleYear
Pharmacokinetic applicability of a validated liquid chromatography tandem mass spectroscopy method for orally administered curcumin loaded solid lipid nanoparticles to rats.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Dec-15, Volume: 878, Issue:32

    A simple and sensitive validated LC-MS/MS analytical method was used for determination of curcumin in rat plasma, using nimesulide as internal standard. Analyses were performed on an Agilent LC-MS/MS system using a Chromolith rodâ„¢ and isocratic elution with acetonitrile:10 mM ammonium acetate buffer (pH 3.5) (80:20, v/v) at a flow rate of 0.8 ml/min with a total run time of 3 min and an overall recovery of 77.15%. A triple quadrupole mass spectrometer, equipped with an electrospray ionization interface, operated in the negative mode was used. Calibration curve in plasma spiked with varying concentration of curcumin were linear over the concentration range of 10-2000 ng/ml with determination coefficient >0.99. The lower limit of quantification was 10 ng/ml. Intra and inter-day variability's (RSD) for extraction of curcumin from plasma were less than 10% and 15% respectively and accuracy was 102.43-108.5%. Multiple reaction monitoring was used to monitor the transition for curcumin (m/z; 367/217 [M-H](-)) and IS (m/z; 307/229). The method was applied for determining curcumin concentration in plasma after peroral administration of 50 mg/kg of free curcumin (C-S) or curcumin loaded solid lipid nanoparticles (C-SLNs) to rats. Results established selectivity and suitability of the method for pharmacokinetic studies of curcumin from C-SLNs.

    Topics: Administration, Oral; Animals; Chromatography, Liquid; Curcumin; Drug Delivery Systems; Least-Squares Analysis; Male; Nanoparticles; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Sulfonamides; Tandem Mass Spectrometry

2010
["Doing something good" for the body? Definitely not! Liver damage caused by food supplements].
    MMW Fortschritte der Medizin, 2010, Oct-28, Volume: 152, Issue:43

    Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Curcuma; Dietary Supplements; Drug-Related Side Effects and Adverse Reactions; Ephedra; Germany; Humans; Phytotherapy; Plant Extracts; Plant Preparations; Sulfonamides

2010