curcumin and maltodextrin

Topics: Administration, Oral; Animals; Curcumin; Desiccation; Hippocampus; In Vitro Techniques; Male; Nanocapsules; Neuroprotection; Particle Size; Polysaccharides; Powders; Rats, Wistar

Turmeric nanofibers (TNF) were used as reinforcement in the gum arabic (GA), maltodextrin (MDX) and polyethylene glycol (PEG) matrices to enhance the physicochemical properties. The TNF were prepared from turmeric spent by acid hydrolysis accompanied by high pressure homogenization. The thermal and mechanical properties, structure morphology and antimicrobial activities of the prepared nanocomposites were investigated. Differential scanning calorimetry (DSC) data indicate that the addition of TNF significantly increased the onset temperature (T

Topics: Anti-Bacterial Agents; Bacillus cereus; Calorimetry, Differential Scanning; Curcuma; Escherichia coli; Gum Arabic; Microscopy, Electron, Scanning; Nanocomposites; Nanofibers; Polyethylene Glycols; Polysaccharides; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus; Temperature

On the basis of preliminary in vitro experience, we assessed whether an enriched nutritional formulation with estrogen receptor (ER)-beta agonist and anti-inflammatory properties may prevent inflammation-associated colorectal cancer (CRC) in an animal model. Study sample enclosed 110 C57BL/6J male mice. Forty underwent dietary supplement safety assessment (20 standard diet and 20 enriched formulation). Seventy were treated with azoxymethane (AOM)/dextran sulfate sodium and divided into two groups: 35 received standard diet and 35 enriched formulation (curcumin, boswellic acids, silymarin and maltodextrins). Miniature colonoscopy demonstrated colitis and solid lesion development in five mice/group 100 days after first AOM injection. Mice were killed after 10 days. In each group, four subgroups received intraperitoneal bromodeoxyuridine (BrdU) injection at 24th/48th/72nd/96th hour before killing. Anti-inflammatory effect and chemoprevention were evaluated by lesion number/size, histological inflammation/dysplasia/neoplasia assessment, pro-inflammatory cytokine messenger RNA (mRNA), ER-beta/ER-alpha/BrdU immunohistochemistry and TUNEL immunofluorescence. Standard formulation assumption was associated with colon shortening compared with enriched one (P = 0.04), which reduced solid lesion number and size (P < 0.001 for both), histological inflammation score (P = 0.04), pro-inflammatory cytokine mRNA expression (P < 0.001), number of low-grade dysplasia (LGD; P = 0.03) and high-grade dysplasia (P < 0.001) areas. CRC was observed in 69.6% in standard and 23.5% in enriched formulation assuming animals (P < 0.001). Enriched formulation induced lower ER-alpha expression in CRC (P < 0.001) and higher ER-beta expression in LGD (P < 0.001) being associated to higher epithelial turnover (BrdU; P<0.001) in normal mucosa and increased apoptosis in LGD and CRC (P < 0.001 for both). Our results are promising for a successful anti-inflammatory and chemopreventive effect of enriched formulation in CRC arising from inflamed tissue.

Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Azoxymethane; Chemoprevention; Colitis; Colon; Colonoscopy; Colorectal Neoplasms; Curcumin; Cytokines; Dextran Sulfate; Disease Models, Animal; Food, Fortified; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Polysaccharides; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Silymarin; Triterpenes

Development of curcumin-loaded mixed polymeric micelles based on chitosan, alginate, maltodextrin, pluronic F127, pluronic P123, and tween 80, by thin-film hydration method has been investigated in Bisphenol A induced diabetics rats. Curcumin (C

Topics: Alginates; Animals; Biological Availability; Blood Glucose; Chitosan; Curcumin; Diabetes Mellitus, Type 2; Drug Carriers; Hypoglycemic Agents; Insulin-Secreting Cells; Micelles; Poloxalene; Poloxamer; Polysaccharides; Polysorbates; Rats; Wound Healing

Stability of potassium norbixinate and curcumin by microencapsulation with maltodextrin DE20 and freeze-drying was evaluated as a function of exposition to light, air, different pH, water solubility, and in food applications. The best results were obtained with microencapsulated potassium norbixinate 1:20, which, when vacuum-packed and in the presence of natural light, showed color retention of 78%, while microencapsulated curcumin 1:20 showed color retention of 71%. Differential scanning calorimetry and thermogravimetry provided an indication of interaction between colorants and maltodextrin. Photoacoustic spectroscopy (PAS) showed that free and microencapsulated colorants exhibited high rates of absorption throughout the measured spectral region. This work evidenced that the freeze-drying process is favorable for microencapsulation of curcumin by maltodextrin, providing improved solubility to the microencapsulated colorant. Both microencapsulated colorants showed relevant results for use in a wide range of pH and food applications. The PAS technique was useful for the evaluation of the stability of free and microencapsulated colorants.

Topics: Carotenoids; Color; Curcumin; Drug Compounding; Drug Stability; Food Coloring Agents; Food Technology; Freeze Drying; Hydrogen-Ion Concentration; Light; Photoacoustic Techniques; Polysaccharides; Solubility; Spectrum Analysis