curcumin and imidazole

curcumin has been researched along with imidazole* in 1 studies

Other Studies

1 other study(ies) available for curcumin and imidazole

Article	Year
One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer. ACS applied materials & interfaces, 2015, Oct-14, Volume: 7, Issue:40 A straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (CCM)-loaded nanoscale zeolitic imidazolate framework-8 (CCM@NZIF-8) nanoparticles (NPs). The as-synthesized CCM@NZIF-8 NPs possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. Confocal laser scanning microscopy and cytotoxicity experiments reveal that NZIF-8 based nanocarriers promote the cellular uptake of CCM and result in higher cytotoxicity of CCM@NZIF-8 than that of free CCM toward HeLa cells. The in vivo anticancer experiments indicate that CCM@NZIF-8 NPs exhibit much higher antitumor efficacy than free CCM. This work highlights the potential of using nanoscale metal organic framworks (NMOFs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment. Topics: Antineoplastic Agents; Biocompatible Materials; Cell Survival; Curcumin; Drug Carriers; Female; HeLa Cells; Humans; Imidazoles; Nanoparticles; Uterine Cervical Neoplasms; Zeolites	2015

Article

Year

One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer.

ACS applied materials & interfaces, 2015, Oct-14, Volume: 7, Issue:40

A straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (CCM)-loaded nanoscale zeolitic imidazolate framework-8 (CCM@NZIF-8) nanoparticles (NPs). The as-synthesized CCM@NZIF-8 NPs possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. Confocal laser scanning microscopy and cytotoxicity experiments reveal that NZIF-8 based nanocarriers promote the cellular uptake of CCM and result in higher cytotoxicity of CCM@NZIF-8 than that of free CCM toward HeLa cells. The in vivo anticancer experiments indicate that CCM@NZIF-8 NPs exhibit much higher antitumor efficacy than free CCM. This work highlights the potential of using nanoscale metal organic framworks (NMOFs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment.

Topics: Antineoplastic Agents; Biocompatible Materials; Cell Survival; Curcumin; Drug Carriers; Female; HeLa Cells; Humans; Imidazoles; Nanoparticles; Uterine Cervical Neoplasms; Zeolites

2015