curcumin has been researched along with halofuginone* in 1 studies
1 other study(ies) available for curcumin and halofuginone
| Article | Year |
|---|---|
Exploitation of in silico potential in prediction, validation and elucidation of mechanism of anti-angiogenesis by novel compounds: comparative correlation between wet lab and in silico data.
This study describes in silico validation of the wet lab data from aeroplysinin-1, curcumin and halofuginone using Autodock Tools 4.0. The inhibition patterns of the vascular endothelial cell differentiation and capillary tube formation mediated by anti-angiogenic growth factors from these test compounds were found quite comparable with the in silico results using angiogenic targets (EFGR, bFGF and VEGFR-1). Successful validation of the wet lab results of the selected angiogenic targets by in silico method has led to exploit the hidden potential of in silico tools in preliminary screening of the unknown compounds for anti-angiogenic potential in a cost-effective manner. Topics: Acetonitriles; Angiogenesis Inhibitors; Binding Sites; Cell Differentiation; Computer Simulation; Curcumin; Cyclohexenes; Endothelial Cells; Endothelium, Vascular; ErbB Receptors; Fibroblast Growth Factor 2; Neovascularization, Physiologic; Piperidines; Quinazolinones; Vascular Endothelial Growth Factor Receptor-1 | 2013 |