curcumin and cangrelor

Curcumin is a natural polyphenol derived from the turmeric plant (Curcuma longa) which exhibits numerous beneficial effects on different cell types. Inhibition of platelet activation by curcumin is well known, however molecular mechanisms of its action on platelets are not fully defined. In this study, we used laser diffraction method for analysis of platelet aggregation and Western blot for analysis of intracellular signaling mechanisms of curcumin effects on platelets. We identified two new molecular mechanisms involved in the inhibitory effects of curcumin on platelet activation. Firstly, curcumin by activation of adenosine A

Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Cell Adhesion Molecules; Curcuma; Curcumin; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Gene Expression Regulation; Humans; Microfilament Proteins; Phosphoproteins; Phosphorylation; Plant Extracts; Platelet Activation; Platelet Aggregation Inhibitors; Primary Cell Culture; Purinergic P2Y Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P2Y12; Signal Transduction