curcumin and butane

An amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 ± 0.4 nm (n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker-1,4-Bis(3-[2-pyridyldithio]propionamido)butane (DPDPB). The drug loading efficiency of the reticulated and non-reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin. Results suggest that crosslinked nanogel exhibit higher stability upon dilution and drug loading efficiency and proves to be a redox sensitive material. The nanogels hold great potential as stealth carriers of lipophilic drugs.

Topics: Butanes; Colloids; Cross-Linking Reagents; Cryoelectron Microscopy; Curcumin; Drug Delivery Systems; Hyaluronic Acid; Hydrodynamics; Light; Molecular Weight; Nanogels; Oxidation-Reduction; Particle Size; Polyethylene Glycols; Polyethyleneimine; Proton Magnetic Resonance Spectroscopy; Scattering, Radiation; Scattering, Small Angle; Simvastatin; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; X-Ray Diffraction