curcumin has been researched along with bicyclol* in 1 studies
1 other study(ies) available for curcumin and bicyclol
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Bioactive Sesquiterpenoid and Polyacetylene Glycosides from Atractylodes lancea.
Nine new sesquiterpenoids (1-9), five new polyacetylenes (10-14), and six known compounds were isolated from the rhizomes of Atractylodes lancea. These new chemical structures were established using NMR, MS, and ECD data. Notably, compounds 3-5, the aglycone of which possesses two stereogenic centers (C-5 and C-7), exhibited similar ECD spectra to compounds 1 and 2, the aglycone of which possesses one stereogenic center (C-7). Such a difference was supported by the experimental and calculated ECD data and single-crystallographic analyses of 3a. In addition, compound 3 inhibited lipopolysaccharide-induced NO production in BV2 cells with an IC50 value of 11.39 μM (positive control curcumin, IC50 = 4.77 μM); compound 4 showed better hepatoprotective activity against N-acetyl-p-aminophenol-induced HepG2 cell injury than the positive drug (bicyclol) at a concentration of 10 μM (p < 0.001). Topics: Acetaminophen; Atractylodes; Biphenyl Compounds; Curcumin; Glycosides; Hep G2 Cells; Humans; Lipopolysaccharides; Liver; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Polyynes; Rhizome; Sesquiterpenes; Structure-Activity Relationship | 2016 |