curcumin and benzylideneacetone

curcumin has been researched along with benzylideneacetone* in 1 studies

Other Studies

1 other study(ies) available for curcumin and benzylideneacetone

Article	Year
Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues. Organic & biomolecular chemistry, 2012, Feb-14, Volume: 10, Issue:6 An efficient and easy procedure to synthesize the pyridinyl analogues of dibenzylideneacetone (pyr-dba) was developed by the condensation of substituted nicotinaldehyde and acetone in the presence of K(2)CO(3) in toluene-EtOH-H(2)O solvent system. Structurally diverse pyr-dba, including quinolinyl dba, can be prepared conveniently in moderate to excellent yields under mild conditions with this method. The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-κB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction. Topics: Antineoplastic Agents; Butanones; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HIV Integrase; HIV Integrase Inhibitors; Humans; Molecular Structure; NF-kappa B; Pyridines; Stereoisomerism; Structure-Activity Relationship	2012

Article

Year

Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues.

Organic & biomolecular chemistry, 2012, Feb-14, Volume: 10, Issue:6

An efficient and easy procedure to synthesize the pyridinyl analogues of dibenzylideneacetone (pyr-dba) was developed by the condensation of substituted nicotinaldehyde and acetone in the presence of K(2)CO(3) in toluene-EtOH-H(2)O solvent system. Structurally diverse pyr-dba, including quinolinyl dba, can be prepared conveniently in moderate to excellent yields under mild conditions with this method. The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-κB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction.

Topics: Antineoplastic Agents; Butanones; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HIV Integrase; HIV Integrase Inhibitors; Humans; Molecular Structure; NF-kappa B; Pyridines; Stereoisomerism; Structure-Activity Relationship

2012