curcumin and amyloid-beta-protein-(17-42)

Beta-amyloid (Aβ) plaques are one of the hallmarks of Alzheimer's disease. Their presence in the brain leads to neurodegeneration and memory decline. Therefore, search for new drugs able to decrease formation of such deposits is of great interest. Our previously developed multifunctional compounds inhibited transformation of monomers into fibrils. Herein, we describe the computational approach for the assessment of inhibitory activity against Aβ aggregation. The influence of novel inhibitors on amyloid Aβ

Topics: Amyloid beta-Peptides; Curcumin; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Peptide Fragments; Phthalimides; Protein Multimerization