curcumin and aluminum-acetate

curcumin has been researched along with aluminum-acetate* in 1 studies

Other Studies

1 other study(ies) available for curcumin and aluminum-acetate

Article	Year
Effects of curcumin and tannic acid on the aluminum- and lead-induced oxidative neurotoxicity and alterations in NMDA receptors. Toxicology mechanisms and methods, 2015, Volume: 25, Issue:2 Exposure to aluminum (Al) and lead (Pb) can cause brain damage. Also, Pb and Al exposure alters N-methyl-d-aspartate receptor (NMDAR) subunit expression. Polyphenols such as tannic acid and curcumin are very efficient chelator for metals. The effects of curcumin and tannic acid (polyphenols) on Al(3+)- and Pb(2+)-induced oxidative stress were examined by investigating lipid peroxidation (LPO) levels, antioxidant enzyme activities, acetyl cholinesterase (AChE) activity and also NMDA receptor subunits 2A and 2B concentrations in the brain tissue of rats sub-chronically. Rats were divided into seven groups as control, Al, Pb, aluminum-tannic acid treatment (AlT), aluminum-curcumin treatment (AlC), lead-tannic acid treatment (PbT) and lead-curcumin treatment (PbC). After 16 weeks of treatment, LPO levels in the brain and hippocampus were higher in Al(3+)-exposed rats than that of Pb(2+)-exposed group. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in brain tissue of Al- and Pb-exposed rats increased significantly compared with control, while catalase (CAT) and AChE activities decreased. It was observed that metal exposure affected NR2A concentrations more than NR2B concentrations and also that polyphenol treatments increased these receptor protein concentrations. Topics: Acetates; Acetylcholinesterase; Animals; Antioxidants; Brain; Catalase; Curcumin; Disease Models, Animal; Glutathione; Glutathione Peroxidase; GPI-Linked Proteins; Lead Poisoning, Nervous System; Lipid Peroxidation; Male; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Organometallic Compounds; Oxidative Stress; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Tannins; Up-Regulation	2015

Article

Year

Effects of curcumin and tannic acid on the aluminum- and lead-induced oxidative neurotoxicity and alterations in NMDA receptors.

Toxicology mechanisms and methods, 2015, Volume: 25, Issue:2

Exposure to aluminum (Al) and lead (Pb) can cause brain damage. Also, Pb and Al exposure alters N-methyl-d-aspartate receptor (NMDAR) subunit expression. Polyphenols such as tannic acid and curcumin are very efficient chelator for metals. The effects of curcumin and tannic acid (polyphenols) on Al(3+)- and Pb(2+)-induced oxidative stress were examined by investigating lipid peroxidation (LPO) levels, antioxidant enzyme activities, acetyl cholinesterase (AChE) activity and also NMDA receptor subunits 2A and 2B concentrations in the brain tissue of rats sub-chronically. Rats were divided into seven groups as control, Al, Pb, aluminum-tannic acid treatment (AlT), aluminum-curcumin treatment (AlC), lead-tannic acid treatment (PbT) and lead-curcumin treatment (PbC). After 16 weeks of treatment, LPO levels in the brain and hippocampus were higher in Al(3+)-exposed rats than that of Pb(2+)-exposed group. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in brain tissue of Al- and Pb-exposed rats increased significantly compared with control, while catalase (CAT) and AChE activities decreased. It was observed that metal exposure affected NR2A concentrations more than NR2B concentrations and also that polyphenol treatments increased these receptor protein concentrations.

Topics: Acetates; Acetylcholinesterase; Animals; Antioxidants; Brain; Catalase; Curcumin; Disease Models, Animal; Glutathione; Glutathione Peroxidase; GPI-Linked Proteins; Lead Poisoning, Nervous System; Lipid Peroxidation; Male; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Organometallic Compounds; Oxidative Stress; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Tannins; Up-Regulation

2015