curcumin and 4-4-difluoro-4-bora-3a-4a-diaza-s-indacene

With accumulating evidence suggesting that amyloid-β (Aβ) deposition is a good diagnostic biomarker for Alzheimer's disease (AD), the discovery of active Aβ probes has become an active area of research. Among the existing imaging methods, optical imaging targeting Aβ aggregates (fibrils or oligomers), especially using near-infrared (NIR) fluorescent probes, is increasingly recognized as a promising approach for the early diagnosis of AD due to its real time detection, low cost, lack of radioactive exposure and high-resolution. In the past decade, a variety of fluorescent probes have been developed and tested for efficiency in vitro, and several probes have shown efficacy in AD transgenic mice. This review classifies these representative probes based on their chemical structures and functional modes (dominant solvent-dependent mode and a novel solvent-independent mode). Moreover, the pharmaceutical characteristics of these representative probes are summarized and discussed. This review provides important perspectives for the future development of novel NIR Aβ diagnostic probes.

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Boron Compounds; Curcumin; Fluorescent Dyes; Humans; Optical Imaging; Stilbenes; Thiazoles; Thiophenes

Topics: Antineoplastic Agents; Apoptosis; Boron Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; Drug Screening Assays, Antitumor; Humans; Light; Microscopy, Confocal; Organoplatinum Compounds; Photochemotherapy; Photosensitizing Agents

In this paper we describe the synthesis of a novel bichromophoric system in which an efficient photoinduced intercomponent energy transfer process is active. The dyad consists of one subunit of curcumin and one of BODIPY and is able to emit in the far-red region, offering a large Stokes shift, capable of limiting light scattering processes for applications in microscopy. The system has been encapsulated in MCM-41 nanoparticles with dimensions between 50 and 80 nm. Both the molecular dyad and individual subunits were tested with different cell lines to study their effective applicability in bioimaging. MCM-41 nanoparticles showed no reduction in cell viability, indicating their biocompatibility and bio-inertness and making them capable of delivering organic molecules even in aqueous-based formulations, avoiding the toxicity of organic solvents. Encapsulation in the porous silica structure directed the location of the bichromophoric system within cytoplasm, while the dyad alone stains the nucleus of the hFOB cell line.

Topics: Boron Compounds; Curcumin; Nanoparticles; Silicon Dioxide

Topics: Antineoplastic Agents; Boron Compounds; Cell Line; Cell Proliferation; Coordination Complexes; Curcumin; Dose-Response Relationship, Drug; Humans; Light; Molecular Structure; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Structure-Activity Relationship; Zinc

Ternary oxidovanadium(IV) complexes of curcumin (Hcur), dipicolylamine (dpa) base, and its derivatives having pendant noniodinated and di-iodinated boron-dipyrromethene (BODIPY) moiety (L

Topics: Amines; Antineoplastic Agents; Apoptosis; Boron Compounds; Cell Line, Tumor; Coordination Complexes; Curcumin; DNA Cleavage; Drug Stability; G1 Phase Cell Cycle Checkpoints; Humans; Ligands; Light; Mitochondria; Photosensitizing Agents; Picolinic Acids; Reactive Oxygen Species; Singlet Oxygen; Vanadium

We previously designed the boron tracedrugs UTX-42, UTX-43, and UTX-44, which possess antioxidant potency. In order to explore their destructive dynamic effects when bombarded by weak thermal neutrons, we performed thermal neutron irradiation of bovine serum albumin (BSA) treated with the boron tracedrugs.. Boron tracedrugs, including the boron dipyrromethene (BODIPY)-containing compounds UTX-42, UTX-44, and UTX-47 and the curcuminoid compounds UTX-50 and UTX-51, were designed for neutron dynamic therapy based on their molecular orbital calculation. Newly designed UTX-47, UTX-50, and UTX-51 were synthesized. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was performed to detect decomposition by thermal neutron irradiation of BSA treated with these boron tracedrugs.. The combination of 1.0 μM BSA with 100 μM of each of the boron tracedrugs showed a decrease in band intensity after irradiation.. All boron tracedrugs tested caused destructive dynamic damage of BSA during thermal neutron irradiation, suggesting that boron tracedrugs could be used as dynamic drugs for neutron dynamic therapy.

Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cattle; Curcumin; Drug Design; Electrophoresis, Polyacrylamide Gel; Gamma Rays; Molecular Structure; Radiation-Sensitizing Agents; Serum Albumin, Bovine; Structure-Activity Relationship