curcumin has been researched along with 2-3-trimethylene-4-quinazolone* in 1 studies
1 other study(ies) available for curcumin and 2-3-trimethylene-4-quinazolone
| Article | Year |
|---|---|
Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
A series of multitarget ligands was designed by introducing several structurally diverse aminoacetamide groups at position 6 of the deoxyvasicinone group, with the aim of obtaining novel multifunctional anti-Alzheimer's disease agents using deoxyvasicinone as the substrate. In vitro studies showed that almost all of the derivatives were potent inhibitors of human recombinant acetylcholinesterase (hAChE) and human serum butyrylcholinesterase (hBChE), with IC Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Kinetics; Ligands; Molecular Structure; Peptide Fragments; Protein Aggregates; Quinazolines; Structure-Activity Relationship | 2017 |