curcumin and 1-7-bis(4-hydroxyphenyl)-1-4-6-heptatrien-3-one

curcumin has been researched along with 1-7-bis(4-hydroxyphenyl)-1-4-6-heptatrien-3-one* in 2 studies

Other Studies

2 other study(ies) available for curcumin and 1-7-bis(4-hydroxyphenyl)-1-4-6-heptatrien-3-one

Article	Year
Antimelanoma and antityrosinase from Alpinia galangal constituents. TheScientificWorldJournal, 2013, Volume: 2013 Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry. Topics: Alpinia; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Curcumin; Diarylheptanoids; Humans; Melanins; Monophenol Monooxygenase; Phenols; Rhizome	2013
A curcuminoid and sesquiterpenes as inhibitors of macrophage TNF-alpha release from Curcuma zedoaria. Planta medica, 2001, Volume: 67, Issue:6 Tumor necrosis factor-alpha (TNF-alpha) is one of the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. In the course of screening marketed oriental anti-inflammatory herbal drugs for TNF-alpha antagonistic activity, a crude methanolic extract of the rhizomes of Curcuma zedoaria exhibited significant activity. The activity-guided fractionation and repetitive chromatographic procedures with the EtOAc-soluble fraction resulted in the isolation of three active compounds. They were identified as 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (1), procurcumenol (2) and epiprocurcumenol (3) by spectral data analysis. They inhibited the production of TNF-alpha by lipopolysaccharide (LPS)-activated macrophages from the results of bioassay (IC(50) values of 1 and 2 are 12.3 and 310.5 microM, respectively) and Western blot assay. These results imply that the traditional use of C. zedoaria rhizome as anti-inflammatory drug may be explained at least in part, by the inhibition of TNF-alpha production. Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Blotting, Western; Cell Line; Cell Survival; Curcumin; Inhibitory Concentration 50; Macrophages; Magnetic Resonance Spectroscopy; Phenols; Plant Extracts; Plant Structures; Plants, Medicinal; Sesquiterpenes; Tumor Necrosis Factor-alpha; Zingiberaceae	2001

Article

Year

Antimelanoma and antityrosinase from Alpinia galangal constituents.

TheScientificWorldJournal, 2013, Volume: 2013

Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry.

Topics: Alpinia; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Curcumin; Diarylheptanoids; Humans; Melanins; Monophenol Monooxygenase; Phenols; Rhizome

2013

A curcuminoid and sesquiterpenes as inhibitors of macrophage TNF-alpha release from Curcuma zedoaria.

Planta medica, 2001, Volume: 67, Issue:6

Tumor necrosis factor-alpha (TNF-alpha) is one of the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. In the course of screening marketed oriental anti-inflammatory herbal drugs for TNF-alpha antagonistic activity, a crude methanolic extract of the rhizomes of Curcuma zedoaria exhibited significant activity. The activity-guided fractionation and repetitive chromatographic procedures with the EtOAc-soluble fraction resulted in the isolation of three active compounds. They were identified as 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (1), procurcumenol (2) and epiprocurcumenol (3) by spectral data analysis. They inhibited the production of TNF-alpha by lipopolysaccharide (LPS)-activated macrophages from the results of bioassay (IC(50) values of 1 and 2 are 12.3 and 310.5 microM, respectively) and Western blot assay. These results imply that the traditional use of C. zedoaria rhizome as anti-inflammatory drug may be explained at least in part, by the inhibition of TNF-alpha production.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Blotting, Western; Cell Line; Cell Survival; Curcumin; Inhibitory Concentration 50; Macrophages; Magnetic Resonance Spectroscopy; Phenols; Plant Extracts; Plant Structures; Plants, Medicinal; Sesquiterpenes; Tumor Necrosis Factor-alpha; Zingiberaceae

2001