cuprizone has been researched along with myelin basic protein in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.33) | 18.7374 |
| 1990's | 3 (4.00) | 18.2507 |
| 2000's | 13 (17.33) | 29.6817 |
| 2010's | 50 (66.67) | 24.3611 |
| 2020's | 8 (10.67) | 2.80 |
| Authors | Studies |
|---|---|
| Bondy, CA; Hudson, LD; Komoly, S; Webster, HD | 1 |
| Jeyasingham, MD; Komoly, S; Lantos, PL; Pratt, OE | 1 |
| Barrett, CV; Hostettler, JD; Knapp, GW; Mason, JL; Matsushima, GK; Morell, P; Toews, AD | 1 |
| Cammer, W | 1 |
| Hostettler, J; Jurevics, H; Matsushima, GK; Morell, P; Muse, ED; Sammond, DW; Toews, AD | 1 |
| Hostettler, J; Jurevics, H; Kleindienst, A; Largent, C; Matsushima, GK; Morell, P; Sammond, DW; Toews, AD | 1 |
| Bacia, A; Soliven, B; Wollmann, R | 1 |
| Adamo, AM; Escobar Cabrera, OE; Franco, PG; Paez, PM; Pasquini, JM; Soto, EF; Wolfson, M | 1 |
| Bando, Y; Ito, S; Jiang, YP; Kishibe, M; Mitrovic, B; Nagai, Y; Takahashi, T; Terayama, R; Yoshida, S | 1 |
| Akita, M; Asou, H; Fukutake, M; Ishige, A; Sakai, R; Seiwa, C; Takeda, S; Tanaka, K; Ueki, T; Watanabe, K; Yagi, T; Yamamoto, M | 1 |
| Colomina, MT; Franco-Pons, N; Torrente, M; Vilella, E | 1 |
| Kusnecov, AW; Urbach-Ross, D | 1 |
| Franco, PG; Pasquini, JM; Silvestroff, L; Soto, EF | 1 |
| Biran, M; Brochet, B; Deloire, M; Dousset, V; Franconi, JM; Girard, C; Gonen, O; Inglese, M; Merle, M; Petry, KG; Raffard, G; Zaaraoui, W | 1 |
| Bando, Y; Ito, S; Kashiwayanagi, M; Takakusaki, K; Terayama, R; Yoshida, S | 1 |
| Browning, R; Clough, R; Li, XM; Xu, H; Yang, HJ; Zhang, Y | 1 |
| Brinkmann, BG; Brück, W; Glaser, R; Guedes, RC; Jürgens, T; Klinker, F; Liebetanz, D; Merkler, D; Paulus, W; Sereda, MW; Stadelmann-Nessler, C | 1 |
| Bartucci, S; Franco, P; Gallo, V; Pasquini, J; Silvestroff, L; Soto, E | 1 |
| Catania, A; Cicirata, F; Cicirata, V; La Delia, F; Parenti, R; Tress, O; Willecke, K; Zappalà, A | 1 |
| Choi, K; Darnall, L; Hu, T; Lane, TE; Liu, L; Ransohoff, RM | 1 |
| Gudi, V; Hildebrandt, H; Koutsoudaki, PN; Skripuletz, T; Škuljec, J; Stangel, M | 1 |
| Macklin, WB; Miller, RH; Popescu, DC; Wang, C; Wang, Y; Wu, C; Zhu, J | 1 |
| Bartucci, S; Franco, P; Pasquini, J; Silvestroff, L | 1 |
| Campagnoni, AT; Cheli, VT; Ghiani, CA; Handley, VW; Paez, PM; Spreuer, V | 1 |
| Bernard, F; Chédotal, A; Dumas, L; Fouquet, S; Heitz-Marchaland, C; Lee, X; Mi, S; Moreau-Fauvarque, C; Shao, Z; Zagar, Y | 1 |
| Acs, P; Kalman, B | 1 |
| Armstrong, RC; Hibbits, N; Le, TQ; Yoshino, J | 1 |
| Li, C; Liu, Z; Mei, F; Shen, HY; Wang, H; Xiao, L | 1 |
| Bando, Y; Murakami, K; Tanaka, T; Yoshida, S | 1 |
| Chan, JR; Etxeberria, A; He, Y; Liu, S; Mei, F; Niu, J; Wang, H; Wang, L; Xiao, L | 1 |
| Li, XM; Xu, H; Yang, HJ | 1 |
| Chew, LJ; Fauveau, M; Gallo, V; Hong, E; Kerninon, C; Klopstein, A; Moll, NM; Nait Oumesmar, B; Naruse, M; Seilhean, D; Tepavcevic, V | 1 |
| Kishimoto, T; Makinodan, M; Morita, S; Okuda, H; Tatsumi, K; Wanaka, A | 1 |
| Boucher, C; El-Etr, M; Ghoumari, AM; Kumar, N; Liere, P; Pianos, A; Rame, M; Schumacher, M; Sitruk-Ware, R | 1 |
| Harada, C; Harada, T; Kimura, A; Matsumoto, Y; Namekata, K; Yoshida, H | 1 |
| Dreyfus, CF; Eyo, UB; Liu, J; Murugan, M; Tian, D; Wang, W; Wu, LJ | 1 |
| Fan, S; He, Y; Li, Z; Sun, B | 1 |
| Fujikawa, A; Kuboyama, K; Noda, M; Suzuki, R | 1 |
| Chopp, M; Elias, SB; Li, Y; Lu, M; Zhang, J; Zhang, Y; Zhang, ZG | 1 |
| Havemann-Reinecke, U; Salinas-Riester, G; Tomas-Roig, J; Wirths, O | 1 |
| Aoki, R; Furukawa, Y; Furuta, K; Nakajima, M; Okuyama, S; Shimizu, R; Sugino, M; Watanabe, T | 1 |
| Androutsellis-Theotokis, A; Arps-Forker, C; Bornstein, SR; Bosak, V; Chavakis, T; Friedrich, U; Grossklaus, S; Masjkur, J; Nikolakopoulou, P; Poser, SW; Toutouna, L; Troullinaki, M; Ziemssen, T | 1 |
| Bai, F; Ren, Q; Sun, J; Zhang, Z; Zhou, H | 1 |
| Campbell, IL; Castellano, B; Gonzalez, B; Petković, F | 2 |
| Ács, P; Bölcskei, K; Kemény, Á; Komoly, S; Pintér, E; Pohóczky, K; Sághy, É; Sándor, Z; Sétáló, G; Sipos, É; Szőke, É | 1 |
| Doi, T; Hamanoue, M; Hayakawa, K; Imamura, O; Morioka, K; Nagao, M; Ogata, T; Okazaki, R; Sawada, Y; Takishima, K; Tanaka, S | 1 |
| Mashayekhi, F; Salehi, Z | 1 |
| Banda, E; Castro-Borrero, W; Crocker, SJ; Guzzo, RM; Johnson, KM; Lo, AC; Nicaise, AM; Russomanno, K; Willis, CM | 1 |
| Chao, FL; Cheng, GH; Li, YD; Peng, C; Tang, Y; Wang, Y; Xiu, Y | 1 |
| Bleich, A; Gudi, V; Heckers, S; Held, N; Kronenberg, J; Skripuletz, T; Stangel, M | 1 |
| Bonetto, G; Charalampopoulos, I; Gravanis, A; Karagogeos, D | 1 |
| Caggiano, AO; Colburn, RW; Cui, C; Mullin, AP; Parry, TJ; Pavlopoulos, E; Troy, E; Wang, J; Wang, Y | 1 |
| Baba, H; Ishibashi, T; Yamaguchi, Y; Yamazaki, R | 1 |
| Fang, M; Liu, H; Wang, B; Zhai, J | 1 |
| Cao, T; Chen, N; Fan, H; Jiang, Z; Lu, G; Wu, M; Yao, R; Yu, H; Zhang, Y | 1 |
| Chen, M; Kurniawan, ND; Meyer-Schell, N; Reutens, D; Sullivan, R; Vegh, V; Ziser, L | 1 |
| Abrahám, H; Ács, P; Horváth, A; Komoly, S; Miseta, A; Pandur, E; Sipos, K; Varga, E | 1 |
| Alkhayer, K; Clements, R; Freeman, E; McDonough, J; Shelestak, J; Singhal, NK | 1 |
| Fan, Z; Jiang, C; Mei, R; Qiu, M; Teng, P; Yang, A; Yang, J; Yang, W; Zhao, X | 1 |
| Biemond, M; Fletcher, JL; Gonsalvez, DG; Hughes, RA; Jun, CMK; Murray, SS; Nguyen, HTH; Nguyen, J; Norman, EML; Northfield, SE; Prawdiuk, AR; Wood, RJ; Xiao, J | 1 |
| Cheng, G; Feng, L; Hu, Y; Wang, Q; Yu, X; Zeng, L; Zhang, L; Zhang, Y; Zhao, M | 1 |
| Bauch, J; Faissner, A; Ffrench-Constant, C; Kuhlmann, T; Ponimaskin, E; Ulc, A; van Leeuwen, S; Zeug, A | 1 |
| Correale, JD; Pasquini, JM; Pasquini, LA; Wies Mancini, VSB | 1 |
| Chrzanowski, U; Horn-Bochtler, A; Kipp, M; Nack, A; Schmitz, C | 1 |
| Antal, MC; Armspach, JP; Lamy, J; Loureiro de Sousa, P; Rousseau, F; Soustelle, L | 1 |
| Akulov, A; Anan'ina, T; Glazacheva, V; Khodanovich, M; Pan, E; Pishchelko, A; Svetlik, M; Tyumentseva, Y; Yarnykh, V | 1 |
| Bao, XQ; Liu, H; Zhang, D; Zhang, Z; Zhao, Z | 1 |
| Ganji, R; Ghasemi, N; Mardani, M; Razavi, S | 1 |
| Jin, L; Li, Y; Liu, C; Loers, G; Petridis, AK; Siebert, HC; Wang, Z; Yin, X; Zhang, N; Zhang, R; Zheng, X | 1 |
| Ahmad, I; Bø, L; Oveland, E; Wergeland, S | 1 |
| Grund, EM; Howe, CL; Standiford, MM | 1 |
| Gao, R; Gao, YH; Guo, YX; He, J; Li, X; Wang, LB; Xiao, Y; Zhang, Y; Zhao, ZH | 1 |
| Campos-Ordonez, T; Galvez-Contreras, AY; Gonzalez-Castañeda, RE; Gonzalez-Perez, O; Vega-Riquer, JM | 1 |
| Begum, Z; Gurusamy, K; Raghunath, G; Sivanesan, S; Subramanian, V; Vijayaraghavan, R | 1 |
75 other study(ies) available for cuprizone and myelin basic protein
| Article | Year |
|---|---|
Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Gene Expression; Glial Fibrillary Acidic Protein; Immunoenzyme Techniques; Insulin-Like Growth Factor I; Male; Mice; Myelin Basic Protein; Nerve Tissue Proteins; Nucleic Acid Hybridization; Proteolipids; Receptors, Cell Surface; Receptors, Somatomedin; RNA, Messenger | 1992 |
Decrease in oligodendrocyte carbonic anhydrase activity preceding myelin degeneration in cuprizone induced demyelination.
Topics: Animals; Brain; Carbonic Anhydrases; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Male; Mice; Myelin Basic Protein; Myelin Sheath; Nerve Degeneration; Neuroglia; Oligodendroglia; Time Factors | 1987 |
Gene expression in brain during cuprizone-induced demyelination and remyelination.
Topics: Animals; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diet; Galactosyltransferases; Gene Expression Regulation; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; Myelin Proteins; Myelin Sheath; Myelin-Associated Glycoprotein; N-Acylsphingosine Galactosyltransferase; Phagocytosis; RNA, Messenger; Transcription, Genetic | 1998 |
The neurotoxicant, cuprizone, retards the differentiation of oligodendrocytes in vitro.
Topics: Acridine Orange; Animals; Animals, Newborn; Cell Count; Cell Differentiation; Cells, Cultured; Coculture Techniques; Coloring Agents; Cuprizone; Dose-Response Relationship, Drug; Immunohistochemistry; Mitochondria; Myelin Basic Protein; Neuroglia; Oligodendroglia; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain.
Topics: Animals; Biomarkers; Brain; Brain Stem; Cerebellum; Cerebrosides; Cholesterol; Cuprizone; Galactosyltransferases; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl CoA Reductases; Male; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; N-Acylsphingosine Galactosyltransferase; Time Factors; Transcription, Genetic | 2001 |
Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination.
Topics: Animals; Biomarkers; Brain; Brain Stem; Cerebellum; Cerebrosides; Chelating Agents; Cholesterol; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Galactosyltransferases; Gene Expression Profiling; Gene Expression Regulation; Mice; Mice, Inbred C3H; Myelin Basic Protein; Myelin Sheath; N-Acylsphingosine Galactosyltransferase; Oligonucleotide Array Sequence Analysis; RNA, Messenger | 2002 |
K+ channel blockade impairs remyelination in the cuprizone model.
Topics: 4-Aminopyridine; Animals; Astrocytes; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Neuroglia; Oligodendroglia; Potassium Channel Blockers; Potassium Channels; Stem Cells | 2004 |
Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antigens; Apoproteins; Brain; Bromodeoxyuridine; CD11b Antigen; Cell Count; Cuprizone; Cytoskeletal Proteins; Demyelinating Diseases; Drug Interactions; Galactolipids; Glial Fibrillary Acidic Protein; Immunohistochemistry; Indoles; Myelin Basic Protein; Myelin Sheath; Proteoglycans; Rats; Rats, Wistar; Recovery of Function; Regeneration; Time Factors; Transferrin | 2006 |
Implications of protease M/neurosin in myelination during experimental demyelination and remyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glutathione S-Transferase pi; Immunohistochemistry; Interferon-gamma; Kallikreins; Mice; Mice, Inbred BALB C; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination.
Topics: Aging; Animals; Anti-Inflammatory Agents; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drugs, Chinese Herbal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Neuroprotective Agents; Neurotoxins; Proto-Oncogene Proteins c-fyn; Receptors, IgG; Recovery of Function; Signal Transduction | 2007 |
Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination.
Topics: Animals; Behavior, Animal; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Myelin Basic Protein | 2007 |
Effects of acute and repeated exposure to lipopolysaccharide on cytokine and corticosterone production during remyelination.
Topics: Acute Disease; Animals; Body Weight; CD11b Antigen; Chelating Agents; Chronic Disease; Corpus Callosum; Corticosterone; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Leukocyte Common Antigens; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Spleen | 2007 |
Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination.
Topics: Animals; Animals, Newborn; Antigens; Blood Coagulation Factors; Cell Differentiation; Cuprizone; Demyelinating Diseases; Gangliosides; Glial Fibrillary Acidic Protein; Hedgehog Proteins; Myelin Basic Protein; O Antigens; Oligodendroglia; Proteoglycans; Rats; Rats, Wistar; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Cell Surface; Stem Cells; Thyroid Hormones; Time Factors; Triiodothyronine | 2008 |
Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Magnetic Resonance Imaging; Magnetics; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins | 2008 |
Differential changes in axonal conduction following CNS demyelination in two mouse models.
Topics: Animals; Axons; Central Nervous System; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electric Stimulation; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Neurologic Mutants; Motor Cortex; Myelin Basic Protein; Nerve Fibers, Myelinated; Neural Conduction; Neural Pathways; Reaction Time; Wallerian Degeneration | 2008 |
Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Cuprizone; Demyelinating Diseases; Dopamine beta-Hydroxylase; Electrochemistry; Exploratory Behavior; Interpersonal Relations; Male; Maze Learning; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Neural Inhibition; Time Factors | 2009 |
Propagation of spreading depression inversely correlates with cortical myelin content.
Topics: Animals; Astrocytes; Cerebral Cortex; Cortical Spreading Depression; Cuprizone; Demyelinating Diseases; Electroencephalography; Encephalomyelitis, Autoimmune, Experimental; Female; Functional Laterality; Glial Fibrillary Acidic Protein; Gliosis; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neuregulin-1; Rats; Rats, Inbred Lew | 2009 |
Cuprizone-induced demyelination in CNP::GFP transgenic mice.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Astrocytes; Brain; Cell Count; Cell Proliferation; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Gliosis; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Myelin Basic Protein; Neurons; Oligodendroglia; Promoter Regions, Genetic | 2010 |
Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Animals, Newborn; Brain; Connexins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Developmental; Gliosis; HeLa Cells; Humans; Immunoprecipitation; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Neuronal Plasticity; Oligodendroglia; Transfection | 2010 |
Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells.
Topics: Animals; Animals, Newborn; Antibodies; Bone Marrow; Cell Differentiation; Central Nervous System Stimulants; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Flow Cytometry; Freund's Adjuvant; Glycoproteins; In Vitro Techniques; Leukocyte Common Antigens; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Nerve Regeneration; Neurologic Examination; Oligodendroglia; Peptide Fragments; Picrotoxin; Proliferating Cell Nuclear Antigen; Receptors, Interleukin-8B; Recovery of Function; Severity of Illness Index; Stem Cells; Time Factors | 2010 |
Remyelination after cuprizone induced demyelination is accelerated in mice deficient in the polysialic acid synthesizing enzyme St8siaIV.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antigens; Antigens, Differentiation; Cell Count; Cell Differentiation; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Proteins; Myelin Proteolipid Protein; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neural Cell Adhesion Molecules; Neuroglia; Neurons; Nogo Proteins; Proteoglycans; Regeneration; Sialic Acids; Sialyltransferases | 2010 |
Longitudinal near-infrared imaging of myelination.
Topics: Analysis of Variance; Animals; Benzothiazoles; Carbocyanines; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Permeability; Protein Binding; Proto-Oncogene Proteins c-akt; Spectroscopy, Near-Infrared; Time Factors | 2011 |
Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination.
Topics: Administration, Intranasal; Animals; Axons; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Myelin Basic Protein; Myelin Sheath; Nerve Fibers, Myelinated; Oligodendroglia; Rats; Rats, Wistar; Thyroid Hormones | 2012 |
Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult mouse brain.
Topics: Animals; Astrocytes; Calcium; Cell Differentiation; Cell Proliferation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Macrophages; Mice; Mice, Knockout; Microglia; Myelin Basic Protein; Myelin Sheath; Neural Stem Cells; Oligodendroglia | 2012 |
Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.
Topics: Age Factors; Animals; Animals, Newborn; Antigens, Differentiation; Basic Helix-Loop-Helix Transcription Factors; Brain; Bromodeoxyuridine; Cell Differentiation; Cells, Cultured; Coculture Techniques; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Female; Ganglia, Spinal; Gene Expression Regulation, Developmental; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Mutation; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Nerve Tissue Proteins; Neurons; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Pregnancy; Ranvier's Nodes; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cell Surface; RNA, Messenger; Semaphorins; Stem Cells; Time Factors; Transcription Factors | 2012 |
Pathogenesis of multiple sclerosis: what can we learn from the cuprizone model.
Topics: Animals; Apoptosis; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Humans; Immunohistochemistry; Immunologic Techniques; Mice; Mice, Inbred C57BL; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Oligodendroglia | 2012 |
Astrogliosis during acute and chronic cuprizone demyelination and implications for remyelination.
Topics: Animals; Cell Proliferation; Chondroitin Sulfate Proteoglycans; Cicatrix; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Statistics as Topic; Time Factors | 2012 |
Cuprizone-induced demyelination in mice: age-related vulnerability and exploratory behavior deficit.
Topics: Age Factors; Analysis of Variance; Animals; Antigens, CD; Cell Adhesion Molecules; Chelating Agents; Cohort Studies; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Mental Disorders; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Oligodendroglia | 2013 |
Minocycline reduces remyelination by suppressing ciliary neurotrophic factor expression after cuprizone-induced demyelination.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Cells, Cultured; Ciliary Neurotrophic Factor; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Real-Time Polymerase Chain Reaction | 2013 |
Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Animals, Newborn; Arabidopsis Proteins; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcription Factors; Bromodeoxyuridine; Cell Differentiation; Cuprizone; Demyelinating Diseases; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Intramolecular Transferases; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Proteolipid Protein; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; ran GTP-Binding Protein; Transfection | 2013 |
Differential effects of antipsychotics on the development of rat oligodendrocyte precursor cells exposed to cuprizone.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Analysis of Variance; Animals; Antigens; Antipsychotic Agents; Catalase; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Chelating Agents; Cuprizone; Embryo, Mammalian; Lipid Peroxidation; Myelin Basic Protein; O Antigens; Oligodendroglia; Proteoglycans; Rats; Stem Cells | 2014 |
SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis.
Topics: Aged; Animals; Antigens; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcription Factors; Brain; Bromodeoxyuridine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Humans; Intracellular Signaling Peptides and Proteins; Leukocyte Common Antigens; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Middle Aged; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Proteoglycans; SOXF Transcription Factors; Time Factors; Up-Regulation | 2013 |
Geissoschizine methyl ether, an alkaloid from the Uncaria hook, improves remyelination after cuprizone-induced demyelination in medial prefrontal cortex of adult mice.
Topics: Animals; Cuprizone; Demyelinating Diseases; Indole Alkaloids; Indoles; Mice; Myelin Basic Protein; Prefrontal Cortex; Regeneration | 2014 |
Progesterone and nestorone promote myelin regeneration in chronic demyelinating lesions of corpus callosum and cerebral cortex.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Progesterone; Stem Cells | 2015 |
Dock3 protects myelin in the cuprizone model for demyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Carrier Proteins; Cells, Cultured; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroretinography; Extracellular Signal-Regulated MAP Kinases; Guanine Nucleotide Exchange Factors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendroglia; Optic Nerve; Retina; Signal Transduction | 2014 |
Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage.
Topics: Animals; Chelating Agents; Cuprizone; Demyelinating Diseases; Ion Channels; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Myelin Basic Protein; NADPH Oxidases; Neural Stem Cells; Oxidative Stress; Postural Balance; Reactive Oxygen Species | 2015 |
Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination.
Topics: Animals; Behavior, Animal; Brain; Cell Differentiation; Clemastine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Motor Activity; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Schizophrenia | 2015 |
Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells.
Topics: Amyloid beta-Protein Precursor; Animals; Antigens; Carrier Proteins; Cell Differentiation; Cells, Cultured; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendroglia; Proteoglycans; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Stem Cells; Tumor Suppressor Protein p53 | 2015 |
Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chelating Agents; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Proteolipid Protein; Oligodendroglia; Peptide Fragments; Proteoglycans; Quinazolines; Stem Cells; Thymosin; Time Factors; Tyrphostins | 2016 |
The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone-Induced Central Nervous System Demyelination.
Topics: Animals; Benzoxazines; Cell Differentiation; Cell Line, Transformed; Central Nervous System; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Morpholines; Myelin Basic Protein; Naphthalenes; Neuroprotective Agents; Oligodendroglia; Prepulse Inhibition; Transcriptome | 2016 |
Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Coumarins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Injections, Intraperitoneal; Male; Mice, 129 Strain; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; Nerve Tissue Proteins; Neuroprotective Agents; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptor, Platelet-Derived Growth Factor alpha; Stem Cells | 2016 |
Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Culture Techniques; Culture Media, Conditioned; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Motor Cortex; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Repressor Proteins; RNA, Messenger | 2016 |
Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Axonal Transport; Axons; Cognition; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fluorescent Antibody Technique; Hippocampus; Humans; Kinesins; Male; Maze Learning; Membrane Proteins; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Neurofilament Proteins; Phosphorylation; tau Proteins | 2016 |
Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation.
Topics: Amyloid beta-Protein Precursor; Animals; Astrocytes; Calcium-Binding Proteins; Caspase 3; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Green Fluorescent Proteins; Interleukin-6; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Receptors, Immunologic | 2016 |
TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis.
Topics: Adenomatous Polyposis Coli; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Body Weight; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fibroblast Growth Factor 2; Gene Expression Regulation; Gliosis; Mice; Mice, Knockout; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendroglia; Signal Transduction; TRPA1 Cation Channel | 2016 |
The crucial role of Erk2 in demyelinating inflammation in the central nervous system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cuprizone; Cytokines; Demyelinating Autoimmune Diseases, CNS; Disease Models, Animal; Embryo, Mammalian; Enzyme Activation; Female; Gene Expression Regulation; Gliosis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Monoamine Oxidase Inhibitors; Motor Disorders; Myelin Basic Protein; Nestin; Neuroglia; Neurons; Rats; Rats, Wistar | 2016 |
Administration of vitamin D3 induces CNPase and myelin oligodendrocyte glycoprotein expression in the cerebral cortex of the murine model of cuprizone-induced demyelination.
Topics: Animals; Cerebral Cortex; Cholecalciferol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred BALB C; Myelin Basic Protein; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia | 2016 |
iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response.
Topics: Aged; Animals; Apoptosis; Axons; Cell Differentiation; Clemastine; Culture Media, Conditioned; Cuprizone; Female; Humans; Induced Pluripotent Stem Cells; Male; Mice, Inbred C57BL; Miconazole; Middle Aged; Monoamine Oxidase Inhibitors; Multiple Sclerosis, Chronic Progressive; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Oligodendroglia | 2017 |
Ultrastructural abnormalities and loss of myelinated fibers in the corpus callosum of demyelinated mice induced by cuprizone.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Myelin Basic Protein; Nerve Fibers, Myelinated; Rotarod Performance Test | 2017 |
Investigation of Cuprizone Inactivation by Temperature.
Topics: Adenomatous Polyposis Coli Protein; Agglutinins; Animals; Cell Differentiation; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Hot Temperature; Mice; Myelin Basic Protein; Oligodendroglia; Primary Cell Culture; Rats | 2017 |
The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone-induced death, through the NGF receptor TrkA.
Topics: Animals; Brain; Caspase 3; Cell Death; Cell Proliferation; Cells, Cultured; Cuprizone; Dehydroepiandrosterone; Glial Fibrillary Acidic Protein; Ki-67 Antigen; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Nerve Growth Factors; Oligodendroglia; Receptors, Nerve Growth Factor | 2017 |
rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination.
Topics: Analysis of Variance; Animals; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunoglobulin M; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Optic Nerve; Receptor, Platelet-Derived Growth Factor alpha; Remyelination; Time Factors | 2017 |
Reduced cuprizone-induced cerebellar demyelination in mice with astrocyte-targeted production of IL-6 is associated with chronically activated, but less responsive microglia.
Topics: Animals; Astrocytes; Calcium-Binding Proteins; Cerebellum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Myelin Basic Protein; Time Factors | 2017 |
Expression of Unconventional Myosin VI in Oligodendrocytes.
Topics: Animals; Cell Differentiation; Cell Lineage; Central Nervous System; Cuprizone; Demyelinating Diseases; Female; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Neurogenesis; Neurons; Oligodendroglia | 2017 |
Olig2 Silence Ameliorates Cuprizone-Induced Schizophrenia-Like Symptoms in Mice.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Cuprizone; Disease Models, Animal; Glial Fibrillary Acidic Protein; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Schizophrenia; Up-Regulation | 2017 |
Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; NLR Family, Pyrin Domain-Containing 3 Protein; Oligodendroglia; Prednisone; Signal Transduction | 2018 |
Utility of gradient recalled echo magnetic resonance imaging for the study of myelination in cuprizone mice treated with fingolimod.
Topics: Animals; Cuprizone; Fingolimod Hydrochloride; Gray Matter; Magnetic Resonance Imaging; Mice; Microglia; Myelin Basic Protein; Myelin Sheath; Parvalbumins | 2018 |
Cuprizone Administration Alters the Iron Metabolism in the Mouse Model of Multiple Sclerosis.
Topics: Animals; Axons; Cation Transport Proteins; Corpus Callosum; Cuprizone; Cytosol; Disease Models, Animal; Gene Expression Regulation; Hepcidins; Iron; Lipid Metabolism; Liver; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neuroglia; RNA, Messenger | 2018 |
Erythropoietin Upregulates Brain Hemoglobin Expression and Supports Neuronal Mitochondrial Activity.
Topics: Animals; Aspartic Acid; Brain; Cell Respiration; Cuprizone; Disease Models, Animal; Electron Transport Complex III; Erythropoietin; Hemoglobins; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Mitochondria; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neurons; Up-Regulation | 2018 |
AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.
Topics: Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Embryo, Mammalian; Gene Expression Regulation, Developmental; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; RNA, Small Interfering | 2018 |
Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cell Division; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Infusion Pumps, Implantable; Infusions, Intraventricular; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Targeted Therapy; Myelin Basic Protein; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Peptides, Cyclic; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Remyelination; Specific Pathogen-Free Organisms | 2018 |
N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination.
Topics: Animals; Cell Differentiation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Quinazolines; Rats; Remyelination; Signal Transduction; Time Factors | 2018 |
The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions.
Topics: Animals; Caspase 3; Cell Differentiation; Cells, Cultured; Chelating Agents; Cuprizone; Disease Models, Animal; GTP Phosphohydrolases; Ki-67 Antigen; Leukoencephalopathies; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Basic Protein; Nerve Fibers, Myelinated; Oligodendrocyte Precursor Cells; Organ Culture Techniques; Proto-Oncogene Proteins c-vav; Remyelination; rhoA GTP-Binding Protein | 2019 |
Microglial modulation through colony-stimulating factor-1 receptor inhibition attenuates demyelination.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Bromodeoxyuridine; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Myelin Basic Protein; Nerve Tissue Proteins; Nitric Oxide Synthase Type II; Picolinic Acids; Receptors, Colony-Stimulating Factor; Time Factors | 2019 |
Evaluation strategy to determine reliable demyelination in the cuprizone model.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Oligodendroglia | 2019 |
Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fluorescence; Magnetic Resonance Imaging; Mice, Inbred C57BL; Myelin Basic Protein | 2019 |
Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gray Matter; Magnetic Resonance Imaging; Male; Mesothelin; Mice; Myelin Basic Protein; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination; White Matter | 2019 |
Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation.
Topics: Animals; Astrocytes; Brain; Cuprizone; Cytokines; Disease Models, Animal; Drug Discovery; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Basic Protein; Oligodendroglia; Phloroglucinol; Remyelination; Treatment Outcome | 2020 |
Improvement of Remyelination in Demyelinated Corpus Callosum Using Human Adipose-Derived Stem Cells (hADSCs) and Pregnenolone in the Cuprizone Rat Model of Multiple Sclerosis.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Corpus Callosum; Cuprizone; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Pregnenolone; Rats; Rats, Wistar | 2020 |
Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Astrocytes; Body Weight; Brain; Chemokine CXCL10; Cuprizone; Cytokines; Demyelinating Diseases; Diet, Ketogenic; Disease Models, Animal; Down-Regulation; Glial Fibrillary Acidic Protein; Histone Deacetylases; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Weight Loss | 2020 |
A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
Topics: Animals; Brain; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gray Matter; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Myelin Proteins; Myelin Sheath; Oligodendroglia; Remyelination; White Matter | 2021 |
Citrullinated myelin induces microglial TNFα and inhibits endogenous repair in the cuprizone model of demyelination.
Topics: Animals; Cells, Cultured; Chelating Agents; Citrulline; Cuprizone; Cytokines; Demyelinating Diseases; Mice; Mice, Inbred C57BL; Microglia; Microinjections; Motor Cortex; Myelin Basic Protein; Myelin Sheath; Tumor Necrosis Factor-alpha | 2021 |
A targeted extracellular vesicles loaded with montelukast in the treatment of demyelinating diseases.
Topics: Acetates; Animals; Cell Differentiation; Cell Lineage; Cuprizone; Cyclopropanes; Demyelinating Diseases; Disease Models, Animal; Drug Delivery Systems; Exosomes; Extracellular Vesicles; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Neurons; Oligodendrocyte Precursor Cells; Oligodendroglia; Phagocytosis; Quinolines; Receptor, Platelet-Derived Growth Factor alpha; Regeneration; Stem Cells; Sulfides | 2022 |
Phenytoin promotes the proliferation of oligodendrocytes and enhances the expression of myelin basic protein in the corpus callosum of mice demyelinated by cuprizone.
Topics: Animals; Cell Differentiation; Cell Proliferation; Corpus Callosum; Cuprizone; Female; Humans; Male; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Phenytoin | 2022 |
Efficacy of different intensity of aquatic exercise in enhancing remyelination and neuronal plasticity using cuprizone model in male Wistar rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Male; Methylprednisolone; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Wistar; Remyelination | 2022 |