Page last updated: 2024-09-03

cubebin and lignans

cubebin has been researched along with lignans in 31 studies

Compound Research Comparison

Studies (cubebin)	Trials (cubebin)	Recent Studies (post-2010) (cubebin)	Studies (lignans)	Trials (lignans)	Recent Studies (post-2010) (lignans)
34	0	17	7,024	95	4,172

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (41.94)	29.6817
2010's	16 (51.61)	24.3611
2020's	2 (6.45)	2.80

Authors

Authors	Studies
Bastos, JK; Carvalho, JC; de Souza, GH; Pedrazzi, AH; Sarti, SJ	1
Bastos, JK; Carvalho, JC; da Silva Filho, AA; da Silva, R; de Souza, VA; Donate, PM; e Silva, ML; Pereira, AC; Royo, Vde A; Souza, GH	1
Bortoli, SA; Lopes, LM; Murata, AT; Nascimento, IR	1
Asanuma, Y; Hirata, N; Kaihatsu, T; Kawaguchi, Y; Kubo, M; Matsuda, H; Naruto, S; Yamazaki, M	1
Albuquerque, S; Bastos, JK; da Silva Filho, AA; da Silva, R; de Souza, GH; de Souza, VA; Donate, PM; e Silva, ML; Grando, MD; Montanheiro, M; Pereira, AC; Royo, Vde A; Saraiva, J	1
Bastos, JK; Carvalho, JC; da Silva, AA; da Silva, R; de Matos Araújo, AL; de Souza, GH; de Souza, VA; Donate, PM; E Silva, ML; Pereira, AC; Royo, Vde A	1
de Pascoli, IC; Lopes, LM; Nascimento, IR	1
Almeida, VA; Bastos, JK; Carvalho, TC; Coímbra, HS; Costa, ES; Cunha, WR; Filho, AA; Furtado, NA; Lima, TC; Martins, CH; Pereira, AC; Royo, VA; Silva, ML; Silva, R; Vinhólis, AH	1
Akao, Y; Hirata, N; Iinuma, M; Matsuda, H; Naruto, S; Nozawa, Y; Ohguchi, K	1
Drewe, J; Kreuter, M; Yam, J	1
Dominguez, OP; Higuchi, Y; Horie, S; Ishikawa, T; Kumamoto, T; Matsumoto, K; Mochizuki, M; Nakanishi, W; Shimokawa, S; Tashima, K; Watanabe, T; Zhang, G	1
Andrade E Silva, ML; Barreto da Silva, V; Bastos, JK; Curti, C; de Albuquerque, S; de Paula da Silva, CH; Dorta, DJ; Saraiva, J; Silva, R; Siqueira, CM; Tudella, VG; Uyemura, SA	1
Hirata, N; Iinuma, M; Inaba, K; Itoh, K; Matsuda, H; Naruto, S; Tokunaga, M	1
Bastos, JK; Costa, ES; da Silva Ferreira, D; de Albuquerque, S; Esperandim, VR; Pereira, AC; Saraiva, J; Silva, ML	1
Andrade e Silva, ML; Bastos, JK; Cicarelli, RM; Cunha, WR; da Silva, R; de Albuquerque, S; Januário, AH; Luz, PP; Magalhães, LG; Pauletti, PM; Pereira, AC; Rezende, KC	1
de Souza, GH; Maistro, EL; Natel, AV; Perazzo, FF	1
Bastos, JK; Cunha, WR; de Andrade, HH; de Rezende, AA; e Silva, ML; Guterres, ZR; Lehmann, M; Rezende, KC; Silva, LP; Spanó, MA; Tavares, DC	1
Andrade E Silva, ML; Bastos, JK; Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; Esperandim, VR; Saraiva, J; Sousa Rezende, KC	1
Bastos, JK; Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; e Silva, ML; Esperandim, VR; Rezende, KC; Saraiva, J	1
Andrade E Silva, ML; Bastos, JK; Carvalho, MT; Celotto, AC; Cunha, WR; Evora, PR; Rezende, KC	1
Andrade E Silva, ML; de Oliveira, PF; de Rezende, AA; Ferreira, NH; Munari, CC; Rezende, KC; Spanó, MA; Tavares, DC	1
Andrade e Silva, ML; Cunha, WR; Fontana, AC; Magalhães, LG; Mortensen, OV; Pereira, AC; Souza Rezende, KC; Timple, JM	1
Andrade e Silva, ML; Barbosa, LC; Bastos, JK; Bertanha, HC; Costa, ES; Furtado, RA; Tavares, DC; Tomazella, IM	1
Adfa, M; Koketsu, M; Ninomiya, M; Rahmad, R; Tanaka, K; Yudha S, S	1
de Paula, NA; Maistro, EL; Mantovani, MS; Niwa, AM; Ribeiro, LR; Sartori, D; Vesenick, DC	1
Bahulayan, AK; Kabeer, FA; Madhusoodhanan, AR; Nair, MS; Prakasan, N; Prathapan, R; Rajalekshmi, DS; Varughese, S	1
Andriani, KF; Bastos, JK; Borges, A; Borges, CHG; Caramori, GF; Conforti, VA; Cunha, WR; da Silva Laurentiz, R; de Andrade, CQJ; E Silva, MLA; Januário, AH; Lima, TC; Lucarini, R; Parreira, RLT; Pauletti, PM; Símaro, GV; Souza, AMP; Volpe, AC	1
Ghumatkar, PJ; Laddha, KS; Mulik, MB; Nahire, MS; Parikh, AD; Sathaye, S; Somani, GS	1
Kimura, H; Koketsu, M; Nishina, A; Phay, N; Sato, D; Ukiya, M	1
Cunha, WR; Esperandim, VR; Ferreira, DS; Lima, TC; Molina, EF; Montagnini, D; Neres, NBR; Orenha, RP; Parreira, RLT; Silva, MLA	1
Ambrósio, SR; Braun, GH; de Souza, JM; Dias, GM; Januário, AH; Pauletti, PM; Pedroso, RCN; Pietro, RCLR; Pimenta, LP; Ramos, HP; Santos, MFC; Silva, MLA; Siqueira, KA; Soares, MA; Veneziani, RCS	1

Other Studies

31 other study(ies) available for cubebin and lignans

Article	Year
Anti-inflammatory activity of cubebin, a lignan from the leaves of Zanthoxyllum naranjillo Griseb. Journal of ethnopharmacology, 2001, Volume: 75, Issue:2-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Lignans; Male; Mice; Plant Leaves; Rats; Rats, Wistar; Rosales	2001
Analgesic and anti-inflammatory activities evaluation of (-)-O-acetyl, (-)-O-methyl, (-)-O-dimethylethylamine cubebin and their preparation from (-)-cubebin. Farmaco (Societa chimica italiana : 1989), 2004, Volume: 59, Issue:1 Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dioxoles; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Furans; Lignans; Male; Mice; Pain; Pain Measurement; Rats; Rats, Wistar	2004
Insecticidal activity of chemical constituents from Aristolochia pubescens against Anticarsia gemmatalis larvae. Pest management science, 2004, Volume: 60, Issue:4 Topics: Animals; Aristolochia; Aristolochic Acids; Biological Assay; Dioxoles; Diterpenes; Furans; Insecticides; Larva; Lepidoptera; Lignans; Plant Extracts	2004
Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leaf extract and its lignan constituents. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:10 Topics: Animals; Cell Proliferation; Lignans; Melanins; Melanoma, Experimental; Mice; Piper nigrum; Plant Extracts; Plant Leaves; Tumor Cells, Cultured	2004
Trypanocidal activity of (-)-cubebin derivatives against free amastigote forms of Trypanosoma cruzi. Bioorganic & medicinal chemistry letters, 2005, Jan-17, Volume: 15, Issue:2 Topics: 4-Butyrolactone; Animals; Benzodioxoles; Chagas Disease; Inhibitory Concentration 50; Lignans; Membrane Glycoproteins; Parasitic Sensitivity Tests; Protozoan Proteins; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi	2005
Synthesis and biological activity evaluation of lignan lactones derived from (-)-cubebin. Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Edema; Lactones; Lignans; Pain Threshold; Rats	2005
Configurational analysis of cubebins and bicubebin from Aristolochia lagesiana and Aristolochia pubescens. Phytochemistry, 2006, Volume: 67, Issue:7 Topics: 4-Butyrolactone; Aristolochia; Circular Dichroism; Lignans; Magnetic Resonance Spectroscopy; Molecular Conformation; Plant Extracts; Plants, Medicinal	2006
Evaluation of piper cubeba extract, (-)-cubebin and its semi-synthetic derivatives against oral pathogens. Phytotherapy research : PTR, 2007, Volume: 21, Issue:5 Topics: 4-Butyrolactone; Anti-Infective Agents; Benzodioxoles; Candida albicans; Dioxoles; Enterococcus faecalis; Lignans; Microbial Sensitivity Tests; Piper; Plant Extracts; Streptococcus	2007
Mechanism of the melanogenesis stimulation activity of (-)-cubebin in murine B16 melanoma cells. Bioorganic & medicinal chemistry, 2007, Jul-15, Volume: 15, Issue:14 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Enzymologic; Imidazoles; Lignans; Melanins; Melanoma; Mice; Monophenol Monooxygenase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger	2007
Piper cubeba targets multiple aspects of the androgen-signalling pathway. A potential phytotherapy against prostate cancer growth? Planta medica, 2008, Volume: 74, Issue:1 Topics: Androgen Antagonists; Androgen Receptor Antagonists; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Lignans; Male; Phytotherapy; Piper; Plant Extracts; Prostatic Neoplasms; Receptors, Androgen; Seeds; Signal Transduction	2008
Chemical constituents of Aristolochia constricta: antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid. Journal of natural products, 2008, Volume: 71, Issue:7 Topics: 4-Butyrolactone; Animals; Aristolochia; Benzodioxoles; Dioxoles; Diterpenes; Ecuador; Guinea Pigs; Ileum; Lignans; Medicine, Traditional; Parasympatholytics; Plants, Medicinal; Stereoisomerism	2008
Cubebin and derivatives as inhibitors of mitochondrial complex I. Proposed interaction with subunit B8. Journal of enzyme inhibition and medicinal chemistry, 2009, Volume: 24, Issue:2 Topics: Animals; Cell Respiration; Cricetinae; Dose-Response Relationship, Drug; Electron Transport Complex I; Inhibitory Concentration 50; Kinetics; Lignans; Mitochondria, Liver; Models, Molecular; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Protein Conformation; Protein Subunits	2009
Histamine release inhibitory activity of Piper nigrum leaf. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:10 Topics: Animals; Dermatitis, Contact; Female; Histamine Release; Hypersensitivity, Immediate; Lignans; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; p-Methoxy-N-methylphenethylamine; Picryl Chloride; Piper nigrum; Plant Extracts; Plant Leaves	2008
Reduction of parasitism tissue by treatment of mice chronically infected with Trypanosoma cruzi with lignano lactones. Parasitology research, 2010, Volume: 107, Issue:3 Topics: 4-Butyrolactone; Animals; Benzodioxoles; beta-Galactosidase; Chagas Disease; Chronic Disease; Dioxoles; Heart; Karyometry; Lactones; Lignans; Liver; Mice; Mice, Inbred BALB C; Spleen; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi	2010
Trypanosoma cruzi: evaluation of (-)-cubebin derivatives activity in the messenger RNAs processing. Parasitology research, 2011, Volume: 109, Issue:2 Topics: Antiprotozoal Agents; Lignans; RNA, Messenger; Trans-Splicing; Trypanosoma cruzi	2011
Genotoxic effects of (-)-cubebin in somatic cells of mice. Journal of applied toxicology : JAT, 2011, Volume: 31, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Leukocytes; Lignans; Male; Mice; Micronucleus Tests; Mutagens; Piper; Seeds	2011
The effect of the dibenzylbutyrolactolic lignan (-)-cubebin on doxorubicin mutagenicity and recombinogenicity in wing somatic cells of Drosophila melanogaster. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:6 Topics: Animals; Antimutagenic Agents; Doxorubicin; Drosophila melanogaster; Drug Interactions; Female; Furans; Larva; Lignans; Male; Mutagenicity Tests; Mutagens; Piper; Plant Extracts; Recombination, Genetic; Wings, Animal	2011
In vivo infection by Trypanosoma cruzi: a morphometric study of tissue changes in mice. Parasitology research, 2013, Volume: 112, Issue:1 Topics: 4-Butyrolactone; Animals; Antiprotozoal Agents; Benzodioxoles; Biometry; Cell Line; Chagas Disease; Dioxoles; Disease Models, Animal; Fibroblasts; Karyotyping; Lignans; Liver; Macaca mulatta; Male; Mice; Mice, Inbred BALB C; Spleen; Trypanosoma cruzi	2013
Evaluation of the in vivo therapeutic properties of (-)-cubebin and (-)-hinokinin against Trypanosoma cruzi. Experimental parasitology, 2013, Volume: 133, Issue:4 Topics: 4-Butyrolactone; Animals; Benzodioxoles; Chagas Disease; Dioxoles; Lignans; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Piper; Trypanocidal Agents; Trypanosoma cruzi	2013
The lignan (-)-cubebin inhibits vascular contraction and induces relaxation via nitric oxide activation in isolated rat aorta. Phytotherapy research : PTR, 2013, Volume: 27, Issue:12 Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Lignans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Piper; Quinoxalines; Rats; Rats, Wistar; Vasodilation	2013
A comparative study of the modulatory effects of (-)-cubebin on the mutagenicity/recombinogenicity induced by different chemical agents. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 55 Topics: Animals; Antimutagenic Agents; Cell Line; Cricetinae; Drosophila melanogaster; Lignans; Mutagens; Recombination, Genetic	2013
The lignan (-)-hinokinin displays modulatory effects on human monoamine and GABA transporter activities. Journal of natural products, 2013, Oct-25, Volume: 76, Issue:10 Topics: 4-Butyrolactone; Attention Deficit Disorder with Hyperactivity; Benzodioxoles; Dioxoles; Dopamine; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; Humans; Lignans; Molecular Structure; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism	2013
Chemopreventive effects of (-)-hinokinin against 1,2-dimethylhydrazine-induced genotoxicity and preneoplastic lesions in rat colon. Journal of natural products, 2014, Oct-24, Volume: 77, Issue:10 Topics: 1,2-Dimethylhydrazine; 4-Butyrolactone; Animals; Anticarcinogenic Agents; Benzodioxoles; Carcinogens; Colon; Comet Assay; Dimethylhydrazines; Dioxoles; DNA Damage; Lignans; Male; Molecular Structure; Piper; Rats; Rats, Wistar; Stereoisomerism	2014
Antileukemic activity of lignans and phenylpropanoids of Cinnamomum parthenoxylon. Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3 Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Benzodioxoles; Cell Proliferation; Cinnamomum; HL-60 Cells; Humans; Lignans; Plant Extracts; U937 Cells	2016
Evaluation of lignan (-)-cubebin extracted from Piper cubeba on human colon adenocarcinoma cells (HT29). Journal of toxicology and environmental health. Part A, 2016, Volume: 79, Issue:2 Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 8; Caspase 9; Cell Proliferation; Cell Survival; Colonic Neoplasms; DNA; HT29 Cells; Humans; Lignans; Micronucleus Tests; Piper	2016
Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives. Bioorganic & medicinal chemistry letters, 2016, Apr-01, Volume: 26, Issue:7 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Humans; Lignans; Models, Molecular; Neoplasms; Piper; Seeds	2016
In vivo and in silico anti-inflammatory mechanism of action of the semisynthetic (-)-cubebin derivatives (-)-hinokinin and (-)-O-benzylcubebin. Bioorganic & medicinal chemistry letters, 2017, 01-15, Volume: 27, Issue:2 Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Catalytic Domain; Computer Simulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyproheptadine; Dextrans; Dinoprostone; Dioxoles; Edema; Furans; Indomethacin; Ligands; Lignans; Male; Mice; Molecular Docking Simulation; Polysorbates; Rats, Wistar; Rutaceae	2017
Neuroprotective effect of Cubebin: A dibenzylbutyrolactone lignan on scopolamine-induced amnesia in mice. The Indian journal of medical research, 2017, Volume: 146, Issue:2 Topics: Acetylcholinesterase; Amnesia; Animals; Brain; Cholinesterase Inhibitors; Furans; Humans; Lignans; Maze Learning; Mice; Molecular Docking Simulation; Neuroprotective Agents; Oxidative Stress; Scopolamine	2017
(-)- Molecules (Basel, Switzerland), 2019, Dec-24, Volume: 25, Issue:1 Topics: 3T3-L1 Cells; Adipogenesis; Adiponectin; Animals; Berberine; Cell Death; Cell Membrane; Glucose Transporter Type 4; Lignans; Lipid Metabolism; MAP Kinase Signaling System; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; PPAR gamma; Protein Kinase Inhibitors; Rosiglitazone; Signal Transduction; Up-Regulation; Vitex	2019
In Vivo and in Silico Trypanocidal Activity Evaluation of (-)-Cubebin Encapsulated in PLGA Microspheres as Potential Treatment in Acute Phase. Chemistry & biodiversity, 2021, Volume: 18, Issue:6 Topics: Animals; Capsules; Injections, Intraperitoneal; Lignans; Male; Mice; Mice, Inbred BALB C; Microspheres; Molecular Docking Simulation; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi	2021
Optimization of (-)-cubebin biotransformation to (-)-hinokinin by the marine fungus Absidia coerulea 3A9. Archives of microbiology, 2021, Volume: 203, Issue:7 Topics: 4-Butyrolactone; Absidia; Aquatic Organisms; Benzodioxoles; Biotransformation; Lignans; Seawater	2021